| Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5 … TH Marsilje, W Pei, B Chen, W Lu, T Uno, Y Jin, T Jiang, S Kim, N Li, ... Journal of medicinal chemistry 56 (14), 5675-5690, 2013 | 489 | 2013 |
| Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2 JM Enright, MB Toomey, S Sato, SE Temple, JR Allen, R Fujiwara, ... Current Biology 25 (23), 3048-3057, 2015 | 203 | 2015 |
| Interstrand DNA–DNA cross-link formation between adenine residues and abasic sites in duplex DNA NE Price, KM Johnson, J Wang, MI Fekry, Y Wang, KS Gates Journal of the American Chemical Society 136 (9), 3483-3490, 2014 | 160 | 2014 |
| Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent … G Lelais, R Epple, TH Marsilje, YO Long, M McNeill, B Chen, W Lu, ... Journal of medicinal chemistry 59 (14), 6671-6689, 2016 | 131 | 2016 |
| Discovery and characterization of clinical candidate LXE408 as a kinetoplastid-selective proteasome inhibitor for the treatment of leishmaniases A Nagle, A Biggart, C Be, H Srinivas, A Hein, D Caridha, RJ Sciotti, ... Journal of Medicinal Chemistry 63 (19), 10773-10781, 2020 | 117 | 2020 |
| On the formation and properties of interstrand DNA–DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5′-CAp sequences in duplex DNA KM Johnson, NE Price, J Wang, MI Fekry, S Dutta, DR Seiner, Y Wang, ... Journal of the American Chemical Society 135 (3), 1015-1025, 2013 | 109 | 2013 |
| A non-covalent ligand reveals biased agonism of the TRPA1 ion channel C Liu, R Reese, S Vu, L Rougé, SD Shields, S Kakiuchi-Kiyota, H Chen, ... Neuron 109 (2), 273-284. e4, 2021 | 98 | 2021 |
| Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNA MJ Catalano, S Liu, N Andersen, Z Yang, KM Johnson, NE Price, Y Wang, ... Journal of the American Chemical Society 137 (11), 3933-3945, 2015 | 60 | 2015 |
| Tetrahydrofuran-based transient receptor potential ankyrin 1 (TRPA1) antagonists: ligand-based discovery, activity in a rodent asthma model, and mechanism-of-action via … JA Terrett, H Chen, DG Shore, E Villemure, R Larouche-Gauthier, M Dery, ... Journal of Medicinal Chemistry 64 (7), 3843-3869, 2021 | 53 | 2021 |
| Discovery of trifluoromethyl (pyrimidin-2-yl) azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure–activity relationships, lead … DP Phillips, W Gao, Y Yang, G Zhang, IK Lerario, TL Lau, J Jiang, X Wang, ... Journal of Medicinal Chemistry 57 (8), 3263-3282, 2014 | 51 | 2014 |
| Formation and repair of an interstrand DNA cross-link arising from a common endogenous lesion K Housh, JS Jha, Z Yang, T Haldar, KM Johnson, J Yin, Y Wang, ... Journal of the American Chemical Society 143 (37), 15344-15357, 2021 | 49 | 2021 |
| In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds N Mast, KW Anderson, KM Johnson, TTN Phan, FP Guengerich, ... Journal of Biological Chemistry 292 (31), 12934-12946, 2017 | 49 | 2017 |
| Human cytochrome P450 27C1 catalyzes 3, 4‐desaturation of retinoids VM Kramlinger, LD Nagy, R Fujiwara, KM Johnson, TTN Phan, Y Xiao, ... FEBS letters 590 (9), 1304-1312, 2016 | 48 | 2016 |
| Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA Z Yang, NE Price, KM Johnson, Y Wang, KS Gates Nucleic acids research 45 (11), 6275-6283, 2017 | 42 | 2017 |
| Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3, 4-dehydroretinol KM Johnson, TTN Phan, ME Albertolle, FP Guengerich Journal of Biological Chemistry 292 (33), 13672-13687, 2017 | 38 | 2017 |
| A new cross-link for an old cross-linking drug: the nitrogen mustard anticancer agent mechlorethamine generates cross-links derived from abasic sites in addition to the … MI Nejad, KM Johnson, NE Price, KS Gates Biochemistry 55 (50), 7033-7041, 2016 | 33 | 2016 |
| Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1, 2, 4 … KM Johnson, ZD Parsons, CL Barnes, KS Gates The Journal of organic chemistry 79 (16), 7520-7531, 2014 | 32 | 2014 |
| Inherent steroid 17α, 20-lyase activity in defunct cytochrome P450 17A enzymes E Gonzalez, KM Johnson, PS Pallan, TTN Phan, W Zhang, L Lei, ... Journal of Biological Chemistry 293 (2), 541-556, 2018 | 29 | 2018 |
| Characterization of interstrand DNA–DNA cross-links derived from abasic sites using bacteriophage ϕ29 DNA polymerase Z Yang, NE Price, KM Johnson, KS Gates Biochemistry 54 (27), 4259-4266, 2015 | 27 | 2015 |
| The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and … T Siu, J Brubaker, P Fuller, L Torres, H Zeng, J Close, DM Mampreian, ... Journal of Medicinal Chemistry 60 (23), 9676-9690, 2017 | 22 | 2017 |
Valerie M KramlingerVanderbilt UniversityVerified email at vanderbilt.edu
