| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 575 | 2018 |
| Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based … T Koudriakova, E Iatsimirskaia, I Utkin, E Gangl, P Vouros, E Storozhuk, ... Drug Metabolism and Disposition 26 (6), 552-561, 1998 | 313 | 1998 |
| Reduction of signal suppression effects in ESI-MS using a nanosplitting device ET Gangl, M Annan, N Spooner, P Vouros Analytical chemistry 73 (23), 5635-5644, 2001 | 231 | 2001 |
| Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ... Journal of medicinal chemistry 63 (23), 14530-14559, 2020 | 119 | 2020 |
| Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy CM Patterson, SB Balachander, I Grant, P Pop-Damkov, B Kelly, ... Communications Biology 4 (1), 112, 2021 | 100 | 2021 |
| Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes JM Sutton, DE Clark, SJ Dunsdon, G Fenton, A Fillmore, NV Harris, ... Bioorganic & medicinal chemistry letters 22 (3), 1464-1468, 2012 | 92 | 2012 |
| Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors W McCoull, RD Abrams, E Anderson, K Blades, P Barton, M Box, ... Journal of Medicinal Chemistry 60 (10), 4386-4402, 2017 | 90 | 2017 |
| Subatmospheric electrospray interface for coupling of microcolumn separations with mass spectrometry F Foret, H Zhou, E Gangl, BL Karger ELECTROPHORESIS: An International Journal 21 (7), 1363-1371, 2000 | 85 | 2000 |
| Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography–mass spectrometry E Gangl, I Utkin, N Gerber, P Vouros Journal of Chromatography A 974 (1-2), 91-101, 2002 | 83 | 2002 |
| AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia SB Balachander, SW Criscione, KF Byth, J Cidado, A Adam, P Lewis, ... Clinical Cancer Research 26 (24), 6535-6549, 2020 | 72 | 2020 |
| Determination of in vitro-and in vivo-formed DNA adducts of 2-amino-3-methylimidazo [4, 5-f] quinoline by capillary liquid chromatography/microelectrospray mass spectrometry ET Gangl, RJ Turesky, P Vouros Chemical research in toxicology 12 (10), 1019-1027, 1999 | 64 | 1999 |
| The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and … M Lawson, N Cureton, S Ros, A Cheraghchi-Bashi, J Urosevic, S D'Arcy, ... Cancer research 83 (23), 3989-4004, 2023 | 53 | 2023 |
| Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids MJ LaMarche, JA Leeds, K Amaral, JT Brewer, SM Bushell, JM Dewhurst, ... Journal of medicinal chemistry 54 (23), 8099-8109, 2011 | 53 | 2011 |
| Detection of in vivo formed DNA adducts at the part-per-billion level by capillary liquid chromatography/microelectrospray mass spectrometry ET Gangl, RJ Turesky, P Vouros Analytical chemistry 73 (11), 2397-2404, 2001 | 52 | 2001 |
| In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound TA Keating, JV Newman, NB Olivier, LG Otterson, B Andrews, ... ACS chemical biology 7 (11), 1866-1872, 2012 | 50 | 2012 |
| Structure–activity relationships, pharmacokinetics, and in vivo activity of CYP11B2 and CYP11B1 inhibitors JPN Papillon, CM Adams, QY Hu, C Lou, AK Singh, C Zhang, J Carvalho, ... Journal of Medicinal Chemistry 58 (11), 4749-4770, 2015 | 45 | 2015 |
| Antibiotic optimization and chemical structure stabilization of thiomuracin A MJ LaMarche, JA Leeds, J Dzink-Fox, E Gangl, P Krastel, G Neckermann, ... Journal of Medicinal Chemistry 55 (15), 6934-6941, 2012 | 41 | 2012 |
| Tricyclic indazoles—a novel class of selective estrogen receptor degrader antagonists JS Scott, A Bailey, D Buttar, RJ Carbajo, J Curwen, PRJ Davey, ... Journal of Medicinal Chemistry 62 (3), 1593-1608, 2019 | 38 | 2019 |
| Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization KJ Goodwin, E Gangl, U Sarkar, P Pop-Damkov, N Jones, A Borodovsky, ... Analytical Biochemistry 568, 78-88, 2019 | 37 | 2019 |
| Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers AW Hird, JP Secrist, A Adam, MA Belmonte, E Gangl, F Gibbons, ... Cancer Research 77 (13_Supplement), DDT01-02-DDT01-02, 2017 | 30 | 2017 |
