ZA935968B - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds

Info

Publication number: ZA935968B
Authority: ZA; South Africa
Prior art keywords: pct; nco2r11; nhco; alkyl; sec
Prior art date: 1992-08-14

Application number

ZA935968A

Other languages

English (en)

Inventor

Mark Anthony David Collins

Maria Ines Chicarelli-Robinson

John Richardson Shaw

Justin Stephen Bryans

Stephen James Brocchini

Christopher John Latham

Original Assignee

Xenova Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-14

Filing date

1993-08-16

Publication date

1995-02-16

1993-08-16 Application filed by Xenova Ltd filed Critical Xenova Ltd

1995-02-16 Publication of ZA935968B publication Critical patent/ZA935968B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

ZA935968A 1992-08-14 1993-08-16 Pharmaceutical compounds ZA935968B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929217331A GB9217331D0 (en)	1992-08-14	1992-08-14	Pharmaceutical compounds

Publications (1)

Publication Number	Publication Date
ZA935968B true ZA935968B (en)	1995-02-16

Family

ID=10720385

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA935968A ZA935968B (en)	1992-08-14	1993-08-16	Pharmaceutical compounds
ZA935969A ZA935969B (en)	1992-08-14	1993-08-16	Pharmaceutical compounds

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ZA935969A ZA935969B (en)	1992-08-14	1993-08-16	Pharmaceutical compounds

Country Status (24)

Country	Link
US (1)	US5700804A (fr)
EP (2)	EP0672036A1 (fr)
JP (2)	JPH08504176A (fr)
KR (2)	KR950702968A (fr)
AT (1)	ATE162186T1 (fr)
AU (2)	AU693420B2 (fr)
BG (2)	BG99495A (fr)
BR (2)	BR9306905A (fr)
CA (2)	CA2141939A1 (fr)
CZ (2)	CZ38395A3 (fr)
DE (1)	DE69316370T2 (fr)
DK (1)	DK0655060T3 (fr)
ES (1)	ES2111169T3 (fr)
FI (2)	FI950616A7 (fr)
GB (2)	GB9217331D0 (fr)
GR (1)	GR3026272T3 (fr)
HU (2)	HUT71592A (fr)
IL (2)	IL106695A0 (fr)
PL (2)	PL307438A1 (fr)
RU (2)	RU95108759A (fr)
SK (2)	SK19495A3 (fr)
TW (1)	TW334427B (fr)
WO (2)	WO1994004513A1 (fr)
ZA (2)	ZA935968B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9217331D0 (en) *	1992-08-14	1992-09-30	Xenova Ltd	Pharmaceutical compounds
DK85193D0 (da)	1993-07-16	1993-07-16	Cancerforskningsfondet Af 1989	Suppression of inhibitors
GB9402809D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
GB9402805D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
IL112627A0 (en) *	1994-02-14	1995-05-26	Xenova Ltd	Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9402807D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
GB9410387D0 (en) *	1994-05-24	1994-07-13	Xenova Ltd	Pharmaceutical compounds
GB2310854B (en) *	1994-12-23	1998-09-09	Xenova Ltd	Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB9426224D0 (en) *	1994-12-23	1995-02-22	Xenova Ltd	Pharmaceutical compounds
GB2311781B (en) *	1994-12-23	1998-09-16	Xenova Ltd	Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB9426090D0 (en) *	1994-12-23	1995-02-22	Xenova Ltd	Pharmaceutical compounds
GB9426071D0 (en) *	1994-12-23	1995-02-22	Xenova Ltd	Pharmaceutical compounds
US5891877A (en) *	1995-02-14	1999-04-06	Xenova Limited	Pharmaceutical compounds
EP1242379A1 (fr) *	1999-12-03	2002-09-25	Emory University	Analogues de circumine destines au traitement du cancer
US7288545B2 (en) *	2000-05-09	2007-10-30	Angiorx Corporation	Piperazinedione compounds
DE60137037D1 (de) *	2000-05-09	2009-01-29	Angiorx Corp	Piperazindion-verbindungen
ES2381775T3 (es)	2000-08-04	2012-05-31	Dmi Biosciences, Inc.	Procedimiento del uso de dicetopiperazinas y composición que las contiene
AU2001288829A1 (en)	2000-09-06	2002-03-22	Ap Pharma, Inc.	Degradable polyacetal polymers
US6693099B2 (en)	2000-10-17	2004-02-17	The Procter & Gamble Company	Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
WO2002062797A2 (fr) *	2000-12-29	2002-08-15	Celltech R & D, Inc.	Utilisations pharmaceutiques et synthese de dicetopiperazines
GB2372740A (en) *	2001-01-17	2002-09-04	Xenova Ltd	Diketopiperazines
JP2005529080A (ja) *	2002-03-08	2005-09-29	エモリー　ユニバーシティ	腫瘍の増殖および脈管形成のサプレッサとしての新規のクルクミノイド−第ＶＩＩａ因子構築物
US7935704B2 (en)	2003-08-01	2011-05-03	Nereus Pharmaceuticals, Inc.	Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
ATE374767T1 (de)	2002-08-02	2007-10-15	Nereus Pharmaceuticals Inc	Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon
US7919497B2 (en)	2002-08-02	2011-04-05	Nereus Pharmaceuticals, Inc.	Analogs of dehydrophenylahistins and their therapeutic use
DE10238144A1 (de) *	2002-08-15	2004-02-26	Basf Ag	Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
US7575929B2 (en)	2002-10-02	2009-08-18	Dmi Life Sciences, Inc.	Diagnosis of multiple sclerosis with diketopiperazines
CN101947306B (zh)	2003-05-15	2014-06-18	安皮奥制药股份有限公司	T-细胞介导的疾病的治疗
GB0314738D0 (en)	2003-06-24	2003-07-30	Glaxo Group Ltd	Novel compounds
WO2006105051A2 (fr) *	2005-03-29	2006-10-05	Nereus Pharmaceuticals, Inc.	Synthese de dicetopiperazines
WO2007098504A1 (fr) *	2006-02-24	2007-08-30	Emory University	Promedicaments d'analogues de curcumine
US8129527B2 (en)	2006-11-03	2012-03-06	Nereus Pharmacuticals, Inc.	Analogs of dehydrophenylahistins and their therapeutic use
JP5856843B2 (ja)	2008-05-27	2016-02-10	アンピオファーマシューティカルズ，インコーポレイテッド	ジケトピペラジンを用いた医薬組成物
US8507496B2 (en)	2010-09-07	2013-08-13	Dmi Acquisition Corp.	Treatment of diseases
KR20140027937A (ko) *	2011-02-10	2014-03-07	맨카인드 코포레이션	Ｎ보호된 비스３，６（４아미노알킬）２，５，디케토피페라진의 생성
EP2765968A4 (fr)	2011-10-10	2015-01-21	Ampio Pharmaceuticals Inc	Dispositifs médicaux implantables ayant une tolérance immunitaire accrue, et leurs procédés de fabrication et d'implantation
KR102032400B1 (ko)	2011-10-10	2019-10-15	앰피오 파마슈티컬스 인코퍼레이티드	퇴행성 관절 질환의 치료
SG10201605205VA (en)	2011-10-28	2016-08-30	Ampio Pharmaceuticals Inc	Treatment of rhinitis
KR20150132508A (ko)	2013-03-15	2015-11-25	앰피오 파마슈티컬스 인코퍼레이티드	줄기세포의 가동화, 회귀, 증식 및 분화를 위한 조성물 및 이의 사용 방법
CN103396372B (zh) *	2013-08-09	2015-05-20	中国科学院南海海洋研究所	一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
CN105272968B (zh) *	2014-06-10	2018-03-13	首都医科大学	(3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用
EP4066836A1 (fr)	2014-08-18	2022-10-05	Ampio Pharmaceuticals, Inc.	Traitement de maladies articulaires
CN104610170B (zh) *	2015-01-14	2017-02-01	中国科学院南海海洋研究所	2,5‑二酮哌嗪衍生物及其制备方法和应用
EP3265091A4 (fr)	2015-03-06	2018-08-01	Beyondspring Pharmaceuticals Inc.	Méthode de traitement d'une tumeur cérébrale
JP6769982B2 (ja)	2015-03-06	2020-10-14	ビヨンドスプリングファーマシューティカルズ，インコーポレイテッド	Ｒａｓ変異と関連するがんの治療方法
EP3310375A4 (fr)	2015-06-22	2019-02-20	Ampio Pharmaceuticals, Inc.	Utilisation de fractions d'albumine de sérum humain de bas poids moléculaire pour traiter les maladies
CN108026075B (zh)	2015-07-13	2021-06-29	大连万春布林医药有限公司	普那布林组合物
RU2753543C1 (ru)	2016-02-08	2021-08-17	Бейондспринг Фармасьютикалс, Инк.	Композиции, содержащие тукаресол или его аналоги
EP3463337A4 (fr)	2016-06-06	2020-02-12	Beyondspring Pharmaceuticals, Inc.	Composition et méthode permettant de réduire la neutropénie
WO2018129381A1 (fr)	2017-01-06	2018-07-12	Beyondspring Pharmaceuticals, Inc.	Composés se liant à la tubuline et leur usage thérapeutique
SG11201907023UA (en)	2017-02-01	2019-08-27	Beyondspring Pharmaceuticals Inc	Method of reducing neutropenia
CN110054619A (zh) *	2018-01-18	2019-07-26	西北农林科技大学	新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
BR112020014960A2 (pt)	2018-01-24	2020-12-22	Beyondspring Pharmaceuticals, Inc.	Composição e método para redução de trombocitopenia
US11129878B1 (en)	2020-03-24	2021-09-28	Ampio Pharmaceuticals, Inc.	Methods for treating diseases associated with respiratory viruses
JP2024513505A (ja)	2021-04-09	2024-03-25	ビヨンドスプリングファーマシューティカルズ，インコーポレイテッド	腫瘍を治療するための組成物及び方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE621862C (de) *	1932-07-01	1935-11-14	Guenther Schiemann Dr	Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde
BE584914A (fr) *	1958-11-24
JPS5747357A (en) *	1980-09-04	1982-03-18	Ricoh Co Ltd	Novel disazo compound and its preparation
GB9217331D0 (en) *	1992-08-14	1992-09-30	Xenova Ltd	Pharmaceutical compounds

1992
- 1992-08-14 GB GB929217331A patent/GB9217331D0/en active Pending
1993
- 1993-08-15 IL IL106695A patent/IL106695A0/xx unknown
- 1993-08-15 IL IL106696A patent/IL106696A0/xx unknown
- 1993-08-16 BR BR9306905A patent/BR9306905A/pt not_active Application Discontinuation
- 1993-08-16 CA CA002141939A patent/CA2141939A1/fr not_active Abandoned
- 1993-08-16 GB GB9502859A patent/GB2284420B/en not_active Expired - Fee Related
- 1993-08-16 HU HU9500436A patent/HUT71592A/hu unknown
- 1993-08-16 DE DE69316370T patent/DE69316370T2/de not_active Expired - Fee Related
- 1993-08-16 EP EP93918033A patent/EP0672036A1/fr not_active Ceased
- 1993-08-16 HU HU9500437A patent/HUT71593A/hu unknown
- 1993-08-16 JP JP6506029A patent/JPH08504176A/ja active Pending
- 1993-08-16 WO PCT/GB1993/001735 patent/WO1994004513A1/fr not_active Ceased
- 1993-08-16 AU AU47264/93A patent/AU693420B2/en not_active Ceased
- 1993-08-16 AU AU47265/93A patent/AU678172B2/en not_active Ceased
- 1993-08-16 FI FI950616A patent/FI950616A7/fi not_active Application Discontinuation
- 1993-08-16 JP JP6506028A patent/JPH08504175A/ja active Pending
- 1993-08-16 US US08/381,932 patent/US5700804A/en not_active Expired - Fee Related
- 1993-08-16 RU RU95108759/04A patent/RU95108759A/ru unknown
- 1993-08-16 PL PL93307438A patent/PL307438A1/xx unknown
- 1993-08-16 KR KR1019950700556A patent/KR950702968A/ko not_active Withdrawn
- 1993-08-16 BR BR9306904A patent/BR9306904A/pt not_active Application Discontinuation
- 1993-08-16 ZA ZA935968A patent/ZA935968B/xx unknown
- 1993-08-16 PL PL93307437A patent/PL307437A1/xx unknown
- 1993-08-16 ZA ZA935969A patent/ZA935969B/xx unknown
- 1993-08-16 WO PCT/GB1993/001734 patent/WO1994004512A1/fr not_active Ceased
- 1993-08-16 CZ CZ95383A patent/CZ38395A3/cs unknown
- 1993-08-16 AT AT93918032T patent/ATE162186T1/de active
- 1993-08-16 EP EP93918032A patent/EP0655060B1/fr not_active Expired - Lifetime
- 1993-08-16 SK SK194-95A patent/SK19495A3/sk unknown
- 1993-08-16 CZ CZ95381A patent/CZ38195A3/cs unknown
- 1993-08-16 KR KR1019950700555A patent/KR950702967A/ko not_active Withdrawn
- 1993-08-16 CA CA002141938A patent/CA2141938A1/fr not_active Abandoned
- 1993-08-16 DK DK93918032.9T patent/DK0655060T3/da active
- 1993-08-16 SK SK195-95A patent/SK19595A3/sk unknown
- 1993-08-16 RU RU95108387/04A patent/RU95108387A/ru unknown
- 1993-08-16 ES ES93918032T patent/ES2111169T3/es not_active Expired - Lifetime
- 1993-10-29 TW TW082109040A patent/TW334427B/zh active
1995
- 1995-02-13 FI FI950617A patent/FI950617A7/fi not_active Application Discontinuation
- 1995-03-13 BG BG99495A patent/BG99495A/xx unknown
- 1995-03-13 BG BG99496A patent/BG99496A/xx unknown
1998
- 1998-03-03 GR GR980400450T patent/GR3026272T3/el unknown

Also Published As

Publication number	Publication date
GB9502859D0 (en)	1995-04-05
JPH08504175A (ja)	1996-05-07
CA2141939A1 (fr)	1994-03-03
BG99495A (bg)	1995-12-29
US5700804A (en)	1997-12-23
FI950616L (fi)	1995-04-13
HUT71592A (en)	1996-01-29
BG99496A (bg)	1995-12-29
JPH08504176A (ja)	1996-05-07
FI950617A0 (fi)	1995-02-13
WO1994004513A1 (fr)	1994-03-03
ZA935969B (en)	1995-02-16
SK19595A3 (en)	1995-09-13
HUT71593A (en)	1996-01-29
BR9306905A (pt)	1998-12-08
ATE162186T1 (de)	1998-01-15
SK19495A3 (en)	1995-11-08
PL307437A1 (en)	1995-05-29
AU693420B2 (en)	1998-07-02
EP0672036A1 (fr)	1995-09-20
AU678172B2 (en)	1997-05-22
IL106695A0 (en)	1993-12-08
AU4726493A (en)	1994-03-15
GB2284420A (en)	1995-06-07
WO1994004512A1 (fr)	1994-03-03
FI950616A0 (fi)	1995-02-13
DE69316370D1 (de)	1998-02-19
CZ38395A3 (en)	1995-10-18
KR950702967A (ko)	1995-08-23
CZ38195A3 (en)	1995-09-13
RU95108759A (ru)	1996-12-10
FI950617A7 (fi)	1995-04-13
GB9217331D0 (en)	1992-09-30
ES2111169T3 (es)	1998-03-01
DK0655060T3 (da)	1998-02-09
IL106696A0 (en)	1993-12-08
DE69316370T2 (de)	1998-07-16
RU95108387A (ru)	1996-12-10
HU9500436D0 (en)	1995-04-28
HU9500437D0 (en)	1995-04-28
PL307438A1 (en)	1995-05-29
GR3026272T3 (en)	1998-06-30
TW334427B (en)	1998-06-21
AU4726593A (en)	1994-03-15
KR950702968A (ko)	1995-08-23
FI950616A7 (fi)	1995-04-13
BR9306904A (pt)	1998-12-08
EP0655060B1 (fr)	1998-01-14
EP0655060A1 (fr)	1995-05-31
GB2284420B (en)	1996-09-25
CA2141938A1 (fr)	1994-03-03

Publication	Publication Date	Title
ZA935969B (en)	1995-02-16	Pharmaceutical compounds
TW274547B (fr)	1996-04-21
NZ511739A (en)	2002-11-26	New esters derived from substituted phenyl-cyclohexyl compounds
GR3036688T3 (en)	2001-12-31	5-azabicyclo(3.1.0)hexylalkyl-2-piperidones and -glutarimides as neurokinin receptor antagonists
ZA963939B (en)	1997-01-21	Diaryldiamine derivatives
IL105715A (en)	1997-07-13	7b SUBSTITUTED-4-AZA-5a- ANDROSTAN-3-ONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IL98681A (en)	1997-06-10	Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
DE69328721D1 (de)	2000-06-29	Poly(oxyalkylen)hydroxyaromatische ester und diese enthaltende brennstoffzusammensetzungen
MY131387A (en)	2007-08-30	Novel 4-benzoylisoxazole derivatives, compositions containing them, processes for their preparation, intermediates in their and their use as herbicides
MX9304761A (es)	1994-05-31	Nuevos compuestos catalizadores y procesos para supreparacion.
TW283704B (fr)	1996-08-21
IL107389A (en)	1997-07-13	N-substituted carbonyloxyalkyl- pyrroles and insecticidal, acaricidal and molluscicidal compositions containing them
NO950529L (no)	1995-04-05	Farmasöytisk aktive diketopiperaziner
GB2284602A (en)	1995-06-14	Pharmaceutically active diketopiperazines
MX9707201A (es)	1998-06-28	Derivados de 1-carba-(detia)-cefalosporina.