ZA935968B - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds

Info

Publication number: ZA935968B
Authority: ZA; South Africa
Prior art keywords: pct; nco2r11; nhco; alkyl; sec
Prior art date: 1992-08-14

Application number

ZA935968A

Other languages

English (en)

Inventor

Mark Anthony David Collins

Maria Ines Chicarelli-Robinson

John Richardson Shaw

Justin Stephen Bryans

Stephen James Brocchini

Christopher John Latham

Original Assignee

Xenova Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-14

Filing date

1993-08-16

Publication date

1995-02-16

1993-08-16 Application filed by Xenova Ltd filed Critical Xenova Ltd

1995-02-16 Publication of ZA935968B publication Critical patent/ZA935968B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

ZA935968A 1992-08-14 1993-08-16 Pharmaceutical compounds ZA935968B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929217331A GB9217331D0 (en)	1992-08-14	1992-08-14	Pharmaceutical compounds

Publications (1)

Publication Number	Publication Date
ZA935968B true ZA935968B (en)	1995-02-16

Family

ID=10720385

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA935969A ZA935969B (en)	1992-08-14	1993-08-16	Pharmaceutical compounds
ZA935968A ZA935968B (en)	1992-08-14	1993-08-16	Pharmaceutical compounds

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ZA935969A ZA935969B (en)	1992-08-14	1993-08-16	Pharmaceutical compounds

Country Status (24)

Country	Link
US (1)	US5700804A (xx)
EP (2)	EP0672036A1 (xx)
JP (2)	JPH08504176A (xx)
KR (2)	KR950702967A (xx)
AT (1)	ATE162186T1 (xx)
AU (2)	AU678172B2 (xx)
BG (2)	BG99495A (xx)
BR (2)	BR9306905A (xx)
CA (2)	CA2141939A1 (xx)
CZ (2)	CZ38395A3 (xx)
DE (1)	DE69316370T2 (xx)
DK (1)	DK0655060T3 (xx)
ES (1)	ES2111169T3 (xx)
FI (2)	FI950616A7 (xx)
GB (2)	GB9217331D0 (xx)
GR (1)	GR3026272T3 (xx)
HU (2)	HUT71593A (xx)
IL (2)	IL106695A0 (xx)
PL (2)	PL307437A1 (xx)
RU (2)	RU95108759A (xx)
SK (2)	SK19595A3 (xx)
TW (1)	TW334427B (xx)
WO (2)	WO1994004512A1 (xx)
ZA (2)	ZA935969B (xx)

Families Citing this family (56)

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GB9217331D0 (en) *	1992-08-14	1992-09-30	Xenova Ltd	Pharmaceutical compounds
DK85193D0 (da)	1993-07-16	1993-07-16	Cancerforskningsfondet Af 1989	Suppression of inhibitors
GB9402805D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
GB9402807D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
IL112627A0 (en) *	1994-02-14	1995-05-26	Xenova Ltd	Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9402809D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
GB9410387D0 (en) *	1994-05-24	1994-07-13	Xenova Ltd	Pharmaceutical compounds
GB9426090D0 (en) *	1994-12-23	1995-02-22	Xenova Ltd	Pharmaceutical compounds
GB2310854B (en) *	1994-12-23	1998-09-09	Xenova Ltd	Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB9426071D0 (en) *	1994-12-23	1995-02-22	Xenova Ltd	Pharmaceutical compounds
GB2311781B (en) *	1994-12-23	1998-09-16	Xenova Ltd	Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB9426224D0 (en) *	1994-12-23	1995-02-22	Xenova Ltd	Pharmaceutical compounds
US5891877A (en) *	1995-02-14	1999-04-06	Xenova Limited	Pharmaceutical compounds
AU779230C (en) *	1999-12-03	2006-05-25	Emory University	Curcumin analogues for treating cancer
US7288545B2 (en) *	2000-05-09	2007-10-30	Angiorx Corporation	Piperazinedione compounds
WO2001095858A2 (en) *	2000-05-09	2001-12-20	Adpharma, Inc.	Piperazinedione compounds
DK1311269T3 (da)	2000-08-04	2012-03-26	Dmi Biosciences Inc	Fremgangsmåde til anvendelse af diketopiperaziner og sammensætning, som indeholder dem
US7220414B2 (en)	2000-09-06	2007-05-22	A.P. Pharma, Inc.	Degradable polyacetal polymers
US6693099B2 (en)	2000-10-17	2004-02-17	The Procter & Gamble Company	Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
WO2002062797A2 (en)	2000-12-29	2002-08-15	Celltech R & D, Inc.	Pharmaceutical uses and synthesis of diketopiperazines
GB2372740A (en) *	2001-01-17	2002-09-04	Xenova Ltd	Diketopiperazines
CA2478522A1 (en) *	2002-03-08	2003-09-18	Emory University	Novel curcuminoid-factor viia constructs as suppressors of tumor growth and angiogenesis
US7919497B2 (en)	2002-08-02	2011-04-05	Nereus Pharmaceuticals, Inc.	Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en)	2003-08-01	2011-05-03	Nereus Pharmaceuticals, Inc.	Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
MXPA05001217A (es)	2002-08-02	2005-05-16	Nereus Pharmaceuticals Inc	Deshidrofenilahistinas y sus analogos y la sintesis de deshidrofenilahistinas y sus analogos.
DE10238144A1 (de) *	2002-08-15	2004-02-26	Basf Ag	Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
EP1571970B1 (en)	2002-10-02	2011-08-17	DMI Biosciences, Inc.	Diagnosis and monitoring of diseases
ES2572975T3 (es)	2003-05-15	2016-06-03	Ampio Pharmaceuticals, Inc.	Tratamiento de enfermedades mediadas por los linfocitos T
GB0314738D0 (en)	2003-06-24	2003-07-30	Glaxo Group Ltd	Novel compounds
WO2006105051A2 (en) *	2005-03-29	2006-10-05	Nereus Pharmaceuticals, Inc.	Synthesis of diketopiperazines
WO2007098504A1 (en) *	2006-02-24	2007-08-30	Emory University	Prodrugs of curcumin analogs
US8129527B2 (en)	2006-11-03	2012-03-06	Nereus Pharmacuticals, Inc.	Analogs of dehydrophenylahistins and their therapeutic use
WO2009146320A1 (en)	2008-05-27	2009-12-03	Dmi Life Sciences, Inc.	Therapeutic methods and compounds
US8507496B2 (en)	2010-09-07	2013-08-13	Dmi Acquisition Corp.	Treatment of diseases
SG10201600967VA (en) *	2011-02-10	2016-03-30	Mannkind Corp	Formation of n-protected bis-3,6-(4-aminoalkyl) -2,5,diketopiperazine
BR112014007657A2 (pt)	2011-10-10	2017-04-11	Ampio Pharmaceuticals Inc	dispositivos médicos implantáveis com tolerância imune aperfeiçoada e métodos para produção e implantação
BR112014007675A2 (pt)	2011-10-10	2017-04-18	Ampio Pharmaceuticals Inc	tratamento de doença articular degenerativa
WO2013063413A1 (en)	2011-10-28	2013-05-02	Ampio Pharmaceuticals, Inc.	Treatment of rhinitis
US9808454B2 (en)	2013-03-15	2017-11-07	Ampio Pharmaceuticals, Inc.	Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
CN103396372B (zh) *	2013-08-09	2015-05-20	中国科学院南海海洋研究所	一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
CN105272968B (zh) *	2014-06-10	2018-03-13	首都医科大学	(3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用
EP3183240A4 (en)	2014-08-18	2018-06-27	Ampio Pharmaceuticals, Inc.	Treatment of joint conditions
CN104610170B (zh) *	2015-01-14	2017-02-01	中国科学院南海海洋研究所	2,5‑二酮哌嗪衍生物及其制备方法和应用
SG10202008673WA (en)	2015-03-06	2020-10-29	Beyondspring Pharmaceuticals Inc	Method of treating cancer associated with a ras mutation
RU2728796C2 (ru)	2015-03-06	2020-07-31	Бейондспринг Фармасьютикалс, Инк.	Способ лечения опухоли головного мозга
HK1246669A1 (zh)	2015-06-22	2018-09-14	Ampio Pharmaceuticals, Inc.	人血清白蛋白低分子量组分在疾病治疗中的应用
CN109516981B (zh)	2015-07-13	2019-10-22	大连万春布林医药有限公司	普那布林组合物
US10912748B2 (en)	2016-02-08	2021-02-09	Beyondspring Pharmaceuticals, Inc.	Compositions containing tucaresol or its analogs
KR20240091084A (ko)	2016-06-06	2024-06-21	비욘드스프링 파마수티컬스, 인코포레이티드.	호중구감소증을 줄이는 조성물 및 방법
JP2020503363A (ja)	2017-01-06	2020-01-30	ビヨンドスプリングファーマシューティカルズ，インコーポレイテッド	チューブリン結合化合物およびその治療的使用
IL268305B2 (en)	2017-02-01	2024-08-01	Beyondspring Pharmaceuticals Inc	Plinabulin in combination with one or more g-csf drug for use in the therapeutic treatment of docetaxel-induced
CN110054619A (zh) *	2018-01-18	2019-07-26	西北农林科技大学	新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
US11786523B2 (en)	2018-01-24	2023-10-17	Beyondspring Pharmaceuticals, Inc.	Composition and method for reducing thrombocytopenia
WO2021195265A1 (en)	2020-03-24	2021-09-30	Ampio Pharmaceuticals, Inc.	Methods for treating diseases associated with respiratory viruses
JP2024513505A (ja)	2021-04-09	2024-03-25	ビヨンドスプリングファーマシューティカルズ，インコーポレイテッド	腫瘍を治療するための組成物及び方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE621862C (de) *	1932-07-01	1935-11-14	Guenther Schiemann Dr	Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde
BE584914A (xx) *	1958-11-24
JPS5747357A (en) *	1980-09-04	1982-03-18	Ricoh Co Ltd	Novel disazo compound and its preparation
GB9217331D0 (en) *	1992-08-14	1992-09-30	Xenova Ltd	Pharmaceutical compounds

1992
- 1992-08-14 GB GB929217331A patent/GB9217331D0/en active Pending
1993
- 1993-08-15 IL IL106695A patent/IL106695A0/xx unknown
- 1993-08-15 IL IL106696A patent/IL106696A0/xx unknown
- 1993-08-16 PL PL93307437A patent/PL307437A1/xx unknown
- 1993-08-16 ZA ZA935969A patent/ZA935969B/xx unknown
- 1993-08-16 HU HU9500437A patent/HUT71593A/hu unknown
- 1993-08-16 CZ CZ95383A patent/CZ38395A3/cs unknown
- 1993-08-16 RU RU95108759/04A patent/RU95108759A/ru unknown
- 1993-08-16 WO PCT/GB1993/001734 patent/WO1994004512A1/en not_active Ceased
- 1993-08-16 GB GB9502859A patent/GB2284420B/en not_active Expired - Fee Related
- 1993-08-16 SK SK195-95A patent/SK19595A3/sk unknown
- 1993-08-16 ES ES93918032T patent/ES2111169T3/es not_active Expired - Lifetime
- 1993-08-16 PL PL93307438A patent/PL307438A1/xx unknown
- 1993-08-16 CZ CZ95381A patent/CZ38195A3/cs unknown
- 1993-08-16 JP JP6506029A patent/JPH08504176A/ja active Pending
- 1993-08-16 RU RU95108387/04A patent/RU95108387A/ru unknown
- 1993-08-16 BR BR9306905A patent/BR9306905A/pt not_active Application Discontinuation
- 1993-08-16 AU AU47265/93A patent/AU678172B2/en not_active Ceased
- 1993-08-16 AT AT93918032T patent/ATE162186T1/de active
- 1993-08-16 EP EP93918033A patent/EP0672036A1/en not_active Ceased
- 1993-08-16 JP JP6506028A patent/JPH08504175A/ja active Pending
- 1993-08-16 WO PCT/GB1993/001735 patent/WO1994004513A1/en not_active Ceased
- 1993-08-16 CA CA002141939A patent/CA2141939A1/en not_active Abandoned
- 1993-08-16 BR BR9306904A patent/BR9306904A/pt not_active Application Discontinuation
- 1993-08-16 HU HU9500436A patent/HUT71592A/hu unknown
- 1993-08-16 ZA ZA935968A patent/ZA935968B/xx unknown
- 1993-08-16 SK SK194-95A patent/SK19495A3/sk unknown
- 1993-08-16 CA CA002141938A patent/CA2141938A1/en not_active Abandoned
- 1993-08-16 DK DK93918032.9T patent/DK0655060T3/da active
- 1993-08-16 AU AU47264/93A patent/AU693420B2/en not_active Ceased
- 1993-08-16 KR KR1019950700555A patent/KR950702967A/ko not_active Withdrawn
- 1993-08-16 US US08/381,932 patent/US5700804A/en not_active Expired - Fee Related
- 1993-08-16 KR KR1019950700556A patent/KR950702968A/ko not_active Withdrawn
- 1993-08-16 EP EP93918032A patent/EP0655060B1/en not_active Expired - Lifetime
- 1993-08-16 FI FI950616A patent/FI950616A7/fi not_active Application Discontinuation
- 1993-08-16 DE DE69316370T patent/DE69316370T2/de not_active Expired - Fee Related
- 1993-10-29 TW TW082109040A patent/TW334427B/zh active
1995
- 1995-02-13 FI FI950617A patent/FI950617A7/fi not_active Application Discontinuation
- 1995-03-13 BG BG99495A patent/BG99495A/xx unknown
- 1995-03-13 BG BG99496A patent/BG99496A/xx unknown
1998
- 1998-03-03 GR GR980400450T patent/GR3026272T3/el unknown

Also Published As

Publication number	Publication date
JPH08504176A (ja)	1996-05-07
GB2284420A (en)	1995-06-07
FI950616L (fi)	1995-04-13
CZ38195A3 (en)	1995-09-13
JPH08504175A (ja)	1996-05-07
CZ38395A3 (en)	1995-10-18
PL307437A1 (en)	1995-05-29
AU678172B2 (en)	1997-05-22
WO1994004512A1 (en)	1994-03-03
RU95108759A (ru)	1996-12-10
EP0655060B1 (en)	1998-01-14
BR9306905A (pt)	1998-12-08
GB9217331D0 (en)	1992-09-30
KR950702967A (ko)	1995-08-23
ZA935969B (en)	1995-02-16
US5700804A (en)	1997-12-23
FI950617A0 (fi)	1995-02-13
FI950616A0 (fi)	1995-02-13
HUT71592A (en)	1996-01-29
KR950702968A (ko)	1995-08-23
TW334427B (en)	1998-06-21
DE69316370T2 (de)	1998-07-16
RU95108387A (ru)	1996-12-10
IL106696A0 (en)	1993-12-08
GB2284420B (en)	1996-09-25
WO1994004513A1 (en)	1994-03-03
DE69316370D1 (de)	1998-02-19
AU693420B2 (en)	1998-07-02
AU4726493A (en)	1994-03-15
BG99496A (bg)	1995-12-29
GR3026272T3 (en)	1998-06-30
HU9500436D0 (en)	1995-04-28
EP0672036A1 (en)	1995-09-20
BG99495A (bg)	1995-12-29
CA2141939A1 (en)	1994-03-03
HUT71593A (en)	1996-01-29
DK0655060T3 (da)	1998-02-09
FI950617A7 (fi)	1995-04-13
PL307438A1 (en)	1995-05-29
CA2141938A1 (en)	1994-03-03
SK19495A3 (en)	1995-11-08
BR9306904A (pt)	1998-12-08
GB9502859D0 (en)	1995-04-05
HU9500437D0 (en)	1995-04-28
EP0655060A1 (en)	1995-05-31
AU4726593A (en)	1994-03-15
ATE162186T1 (de)	1998-01-15
FI950616A7 (fi)	1995-04-13
SK19595A3 (en)	1995-09-13
IL106695A0 (en)	1993-12-08
ES2111169T3 (es)	1998-03-01

Publication	Publication Date	Title
GB9217331D0 (en)	1992-09-30	Pharmaceutical compounds
TW274547B (xx)	1996-04-21
NZ511739A (en)	2002-11-26	New esters derived from substituted phenyl-cyclohexyl compounds
GR3036688T3 (en)	2001-12-31	5-azabicyclo(3.1.0)hexylalkyl-2-piperidones and -glutarimides as neurokinin receptor antagonists
ZA963939B (en)	1997-01-21	Diaryldiamine derivatives
IL105715A (en)	1997-07-13	7b SUBSTITUTED-4-AZA-5a- ANDROSTAN-3-ONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE69328721D1 (de)	2000-06-29	Poly(oxyalkylen)hydroxyaromatische ester und diese enthaltende brennstoffzusammensetzungen
MY131387A (en)	2007-08-30	Novel 4-benzoylisoxazole derivatives, compositions containing them, processes for their preparation, intermediates in their and their use as herbicides
MX9304761A (es)	1994-05-31	Nuevos compuestos catalizadores y procesos para supreparacion.
TW283704B (xx)	1996-08-21
IL107389A (en)	1997-07-13	N-substituted carbonyloxyalkyl- pyrroles and insecticidal, acaricidal and molluscicidal compositions containing them
NO950529L (no)	1995-04-05	Farmasöytisk aktive diketopiperaziner
GB2284602A (en)	1995-06-14	Pharmaceutically active diketopiperazines
MX9707201A (es)	1998-06-28	Derivados de 1-carba-(detia)-cefalosporina.