ZA884277B - Benzothiazole derivative - Google Patents
Benzothiazole derivativeInfo
- Publication number
- ZA884277B ZA884277B ZA884277A ZA884277A ZA884277B ZA 884277 B ZA884277 B ZA 884277B ZA 884277 A ZA884277 A ZA 884277A ZA 884277 A ZA884277 A ZA 884277A ZA 884277 B ZA884277 B ZA 884277B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzothiazole derivative
- effective
- affections
- nr5r6
- affection
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- -1 benzothiazole compound Chemical class 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Paper (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15098787 | 1987-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA884277B true ZA884277B (en) | 1989-03-29 |
Family
ID=15508808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA884277A ZA884277B (en) | 1987-06-17 | 1988-06-15 | Benzothiazole derivative |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4929623A (xx) |
| EP (1) | EP0295656B1 (xx) |
| JP (1) | JP2793195B2 (xx) |
| KR (1) | KR910005709B1 (xx) |
| CN (1) | CN1030757A (xx) |
| AT (1) | ATE82276T1 (xx) |
| AU (1) | AU610186B2 (xx) |
| CA (1) | CA1322369C (xx) |
| DD (1) | DD282686A5 (xx) |
| DE (1) | DE3875809T2 (xx) |
| DK (1) | DK328888A (xx) |
| ES (1) | ES2045017T3 (xx) |
| FI (1) | FI91859C (xx) |
| GR (1) | GR3006207T3 (xx) |
| HU (1) | HU205347B (xx) |
| NO (1) | NO170929C (xx) |
| NZ (1) | NZ224946A (xx) |
| PH (1) | PH26553A (xx) |
| PT (1) | PT87747B (xx) |
| SU (1) | SU1731051A3 (xx) |
| ZA (1) | ZA884277B (xx) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0375510B1 (fr) * | 1988-12-15 | 1992-11-11 | Rhone-Poulenc Sante | Dérivés d'imino-2 polyfluoroalcoxy-6 benzothiazole, leurs procédés de préparation et les médicaments les contenant |
| IL97249A (en) * | 1990-02-23 | 1995-01-24 | Takeda Chemical Industries Ltd | Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or |
| IE920921A1 (en) * | 1991-04-04 | 1992-10-07 | Eisai Co Ltd | Benzothiazole derivative |
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| US5350760A (en) * | 1993-08-04 | 1994-09-27 | Merck Frosst Canada, Inc. | Aza-5,5-fused hetrocyclic acids as leukotriene antagonists |
| WO1997048694A1 (en) | 1996-06-20 | 1997-12-24 | Board Of Regents, The University Of Texas System | Compounds and methods for providing pharmacologically active preparations and uses thereof |
| AU8477998A (en) * | 1997-11-13 | 1999-06-07 | Histatek, Llc | Small peptides and methods for treatment of asthma and inflammation |
| GB9815696D0 (en) * | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
| WO2000045635A1 (en) * | 1999-02-08 | 2000-08-10 | Lion Bioscience Ag | Thiazole derivatives and combinatorial libraries thereof |
| DE60020556T2 (de) * | 1999-05-12 | 2005-10-27 | Neurosearch A/S | Ionenkanal modulierende mittel |
| US6495549B1 (en) | 1999-07-15 | 2002-12-17 | Pfizer Inc | FKBP inhibitors |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| EP1278744A1 (en) * | 2000-05-05 | 2003-01-29 | Millenium Pharmaceuticals, Inc. | Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors |
| US6750238B1 (en) * | 2000-05-12 | 2004-06-15 | The University Of Toledo | Aralkyl ester soft drugs |
| US7049326B2 (en) * | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| US6756047B2 (en) * | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| CN1234358C (zh) | 2000-06-21 | 2006-01-04 | 弗·哈夫曼-拉罗切有限公司 | 苯并噻唑衍生物 |
| US6620811B2 (en) * | 2001-11-19 | 2003-09-16 | Hoffmann-La Roche Inc. | Isonicotin- and nicotinamide derivatives of benzothiazoles |
| US6624163B2 (en) * | 2001-11-29 | 2003-09-23 | Hoffman-La Roche Inc. | Benzothiazole derivatives |
| US7338956B2 (en) * | 2002-08-07 | 2008-03-04 | Sanofi-Aventis Deutschland Gmbh | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
| US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
| RU2340612C2 (ru) * | 2003-05-13 | 2008-12-10 | Ф.Хоффманн-Ля Рош Аг | 2-имидазобензотиазолы как лиганды аденозинового рецептора |
| AU2004251814B2 (en) * | 2003-05-19 | 2009-07-23 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives as adenosine receptor ligands |
| ES2280964T3 (es) * | 2003-05-21 | 2007-09-16 | F. Hoffmann-La Roche Ag | Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina. |
| DK1633355T3 (da) * | 2003-05-30 | 2008-08-04 | Hoffmann La Roche | Benzothiazol-derivater og anvendelse deraf i behandlingen af sygdomme der er relateret til adenosin A2A-receptoren |
| AU2004263442B2 (en) | 2003-08-12 | 2008-05-29 | Shionogi & Co., Ltd. | Compounds having thrombopoietin receptor agonism |
| US20050118291A1 (en) * | 2003-09-10 | 2005-06-02 | Mian-Ying Wang | Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane |
| EP1753760B1 (en) | 2004-05-24 | 2008-01-02 | F.Hoffmann-La Roche Ag | 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide |
| WO2006013054A1 (en) * | 2004-08-05 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituted n-acyl-2-aminothiazoles |
| CN101056857B (zh) | 2004-11-05 | 2010-12-01 | 弗·哈夫曼-拉罗切有限公司 | 异烟酸衍生物的制备方法 |
| KR100973609B1 (ko) | 2005-03-23 | 2010-08-03 | 에프. 호프만-라 로슈 아게 | ｍＧｌｕＲ2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체 |
| CA2623721C (en) | 2005-09-27 | 2014-05-13 | F. Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists |
| KR101280333B1 (ko) | 2006-03-28 | 2013-07-02 | 하이 포인트 파마슈티칼스, 엘엘씨 | 히스타민 ｈ３ 수용체 활성을 갖는 벤조티아졸 |
| RS52712B (sr) * | 2008-04-11 | 2013-08-30 | Janssen Pharmaceutica N.V. | Tiazolopiridin-2-iloksi-fenil i tiazolopirazin-2-iloksi-fenil amini kao modulatori leukotrien a4 hidrolaze |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| EP2408769A1 (en) * | 2009-03-17 | 2012-01-25 | Glaxo Group Limited | Pyrimidine derivatives used as itk inhibitors |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| CN102872012B (zh) * | 2011-11-03 | 2015-03-25 | 成都医学院 | 一种抑制蛋白激酶化合物的用途 |
| CN113959911B (zh) * | 2020-07-20 | 2024-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 抗血小板聚集干扰的检测方法、试剂及其应用 |
| CN113959912B (zh) * | 2020-07-20 | 2024-06-21 | 深圳迈瑞生物医疗电子股份有限公司 | 抗血小板聚集干扰的白细胞检测方法、试剂及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2617198A (en) * | 1945-06-13 | 1952-11-11 | Better Packages Inc | Pull-out measuring tape dispenser |
| DE927507C (de) * | 1953-02-24 | 1955-05-09 | Bayer Ag | Verfahren zur Herstellung von Derivaten des 6-Oxy-2-aminobenzthiazols |
| GB808191A (en) * | 1956-07-13 | 1959-01-28 | Robert Ronald Davies | New dyestuff intermediates |
| AR204835A1 (es) * | 1973-07-18 | 1976-03-05 | Scherico Ltd | Procedimiento para preparar benzotiazol-2-carbamatos de etilo |
| US4006242A (en) * | 1973-07-18 | 1977-02-01 | Schering Corporation | Certain benzothiazoles used in the treatment of helminthiasis |
| DK148476C (da) * | 1975-04-25 | 1985-12-16 | Scherico Ltd | Analogifremgangsmaade til fremstilling af methyl-6-n-propoxybenzothiazol-2-carbamat |
| JPS5221054A (en) * | 1975-08-11 | 1977-02-17 | Teijin Ltd | Polyamide composition |
| DE2656468A1 (de) * | 1976-12-14 | 1978-06-15 | Boehringer Mannheim Gmbh | N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung |
| DE2963316D1 (en) * | 1978-01-18 | 1982-09-02 | Hoechst Ag | Process for the preparation of 2-amino-arylenothiazole compounds and their ring n-substituted derivatives |
| JPS5740492A (en) * | 1980-08-22 | 1982-03-06 | Yamanouchi Pharmaceut Co Ltd | Novel 2-phenylimidazo 2,1-b benzothiazole derivative |
| US4581457A (en) * | 1984-09-21 | 1986-04-08 | American Home Products Corporation | Heterocyclic sulfonamides |
-
1988
- 1988-06-07 FI FI882692A patent/FI91859C/fi not_active IP Right Cessation
- 1988-06-08 NZ NZ224946A patent/NZ224946A/xx unknown
- 1988-06-15 DE DE8888109552T patent/DE3875809T2/de not_active Expired - Fee Related
- 1988-06-15 NO NO882627A patent/NO170929C/no unknown
- 1988-06-15 EP EP88109552A patent/EP0295656B1/en not_active Expired - Lifetime
- 1988-06-15 CA CA000569598A patent/CA1322369C/en not_active Expired - Fee Related
- 1988-06-15 JP JP63147141A patent/JP2793195B2/ja not_active Expired - Lifetime
- 1988-06-15 AT AT88109552T patent/ATE82276T1/de active
- 1988-06-15 ZA ZA884277A patent/ZA884277B/xx unknown
- 1988-06-15 ES ES88109552T patent/ES2045017T3/es not_active Expired - Lifetime
- 1988-06-16 DK DK328888A patent/DK328888A/da not_active Application Discontinuation
- 1988-06-16 SU SU884356028A patent/SU1731051A3/ru active
- 1988-06-16 HU HU883098A patent/HU205347B/hu not_active IP Right Cessation
- 1988-06-16 PT PT87747A patent/PT87747B/pt not_active IP Right Cessation
- 1988-06-16 AU AU17699/88A patent/AU610186B2/en not_active Ceased
- 1988-06-16 US US07/207,329 patent/US4929623A/en not_active Expired - Fee Related
- 1988-06-16 DD DD88316839A patent/DD282686A5/de not_active IP Right Cessation
- 1988-06-17 KR KR1019880007320A patent/KR910005709B1/ko not_active Expired
- 1988-06-17 CN CN88103660A patent/CN1030757A/zh active Pending
- 1988-08-08 PH PH37022A patent/PH26553A/en unknown
-
1992
- 1992-11-12 GR GR920401328T patent/GR3006207T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1030757A (zh) | 1989-02-01 |
| DD282686A5 (de) | 1990-09-19 |
| KR910005709B1 (ko) | 1991-08-02 |
| NO170929C (no) | 1993-01-06 |
| DK328888A (da) | 1988-12-18 |
| HU205347B (en) | 1992-04-28 |
| PT87747A (pt) | 1988-07-01 |
| HUT47554A (en) | 1989-03-28 |
| SU1731051A3 (ru) | 1992-04-30 |
| DE3875809T2 (de) | 1993-04-15 |
| NZ224946A (en) | 1990-07-26 |
| PH26553A (en) | 1992-08-19 |
| FI91859C (fi) | 1994-08-25 |
| JPS6479162A (en) | 1989-03-24 |
| PT87747B (pt) | 1992-10-30 |
| AU610186B2 (en) | 1991-05-16 |
| NO170929B (no) | 1992-09-21 |
| FI882692A0 (fi) | 1988-06-07 |
| CA1322369C (en) | 1993-09-21 |
| DE3875809D1 (de) | 1992-12-17 |
| GR3006207T3 (xx) | 1993-06-21 |
| DK328888D0 (da) | 1988-06-16 |
| EP0295656B1 (en) | 1992-11-11 |
| NO882627D0 (no) | 1988-06-15 |
| EP0295656A1 (en) | 1988-12-21 |
| JP2793195B2 (ja) | 1998-09-03 |
| ATE82276T1 (de) | 1992-11-15 |
| US4929623A (en) | 1990-05-29 |
| NO882627L (no) | 1988-12-19 |
| ES2045017T3 (es) | 1994-01-16 |
| AU1769988A (en) | 1988-12-22 |
| KR890000451A (ko) | 1989-03-14 |
| FI882692L (fi) | 1988-12-18 |
| FI91859B (fi) | 1994-05-13 |
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