ZA200906462B - Hydrochloride salt of 5-[-3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2, 2-diphenylhexanamide - Google Patents

Hydrochloride salt of 5-[-3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2, 2-diphenylhexanamide

Info

Publication number: ZA200906462B
Authority: ZA; South Africa
Prior art keywords: diphenylhexanamide; hydroxyphenoxy; azetidin; methyl; hydrochloride salt
Prior art date: 2007-03-16

Application number

ZA200906462A

Other languages

English (en)

Inventor

Paul Alan Glossop

Kim James

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-16

Filing date

2009-09-16

Publication date

2010-06-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39591485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200906462(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-09-16 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2010-06-30 Publication of ZA200906462B publication Critical patent/ZA200906462B/xx

Links

QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1
125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200906462A 2007-03-16 2009-09-16 Hydrochloride salt of 5-[-3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2, 2-diphenylhexanamide ZA200906462B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US89516307P	2007-03-16	2007-03-16

Publications (1)

Publication Number	Publication Date
ZA200906462B true ZA200906462B (en)	2010-06-30

Family

ID=39591485

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200906462A ZA200906462B (en)	2007-03-16	2009-09-16	Hydrochloride salt of 5-[-3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2, 2-diphenylhexanamide

Country Status (23)

Country	Link
US (1)	US8263583B2 (xx)
EP (1)	EP2125714B1 (xx)
JP (1)	JP4277051B2 (xx)
KR (1)	KR101120227B1 (xx)
CN (2)	CN101641327A (xx)
AR (1)	AR065714A1 (xx)
AT (1)	ATE512132T1 (xx)
AU (1)	AU2008247095B2 (xx)
BR (1)	BRPI0808413A2 (xx)
CA (1)	CA2678683C (xx)
CY (1)	CY1111701T1 (xx)
DK (1)	DK2125714T3 (xx)
ES (1)	ES2364727T3 (xx)
IL (1)	IL200403A (xx)
MX (1)	MX2009009952A (xx)
NZ (1)	NZ579056A (xx)
PL (1)	PL2125714T3 (xx)
PT (1)	PT2125714E (xx)
RU (1)	RU2422439C2 (xx)
SI (1)	SI2125714T1 (xx)
TW (1)	TWI348907B (xx)
WO (1)	WO2008135819A1 (xx)
ZA (1)	ZA200906462B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2010321738B2 (en)	2009-11-23	2016-07-14	Palatin Technologies, Inc.	Melanocortin-1 receptor-specific cyclic peptides
BR112012011780A2 (pt)	2009-11-23	2019-09-24	Palatin Technologies, Inc	peptídeo linear,composição farmacêutica,métodopara tratamento de umadoença,indicação,condição ou sídrome mediadsa por receptor de melanocortina emum mamífero humano ou não humano e método para tratamento de uma condição responsiva ás alterações em função de receptor de melanocortina em um mamifero humano ou não humano
EP2578570A1 (en)	2011-10-07	2013-04-10	Almirall, S.A.	Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en)	2012-03-20	2013-09-25	Almirall, S.A.	Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
US20200031769A1 (en)	2017-03-15	2020-01-30	Mylan Laboratories Limited	Novel polymorphs of (5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide hydrochloride
PT3691620T (pt)	2017-10-05	2022-10-06	Fulcrum Therapeutics Inc	Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
EP3990091A4 (en) *	2019-06-25	2023-07-12	Mylan Laboratories Ltd.	METHODS AND INTERMEDIATES FOR THE PREPARATION OF 5-[3-(3-HYDROXYPHENOXY)AZETIDINE-1-YL]-5-METHYL-2,2-DIPHENYLHEXANAMIDE HYDROCHLORIDE SALT
US20230293430A1 (en) *	2020-06-26	2023-09-21	Mylan Pharma Uk Limited	Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide
CN113577059B (zh) *	2021-08-02	2022-05-20	山东大学齐鲁医院(青岛)	一种用于小儿哮喘的活性药物
WO2025095813A1 (ru) *	2023-11-03	2025-05-08	Общество С Ограниченной Ответственностью "Валента-Интеллект"	Новые соединения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0001118A3 (en) *	1996-12-02	2001-06-28	Kyorin Seiyaku Kk	N-substituted pyrrolidine derivatives, process for preparing the same and pharmaceutical compositions containing them
JPH11100366A (ja)	1997-09-29	1999-04-13	Kyorin Pharmaceut Co Ltd	新規ｎ−置換環状アミン誘導体及びその製造法
DE10064398A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Gmbh	Neue Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP1928821B1 (en) *	2005-09-21	2009-01-07	Pfizer Limited	Carboxamide derivatives as muscarinic receptor antagonists
JP2010504316A (ja) *	2006-09-22	2010-02-12	ファイザー・リミテッド	ムスカリン様受容体アンタゴニストとしてのアゼチジン誘導体

2008
- 2008-03-06 PT PT08719316T patent/PT2125714E/pt unknown
- 2008-03-06 NZ NZ579056A patent/NZ579056A/en not_active IP Right Cessation
- 2008-03-06 BR BRPI0808413-0A patent/BRPI0808413A2/pt not_active Application Discontinuation
- 2008-03-06 AT AT08719316T patent/ATE512132T1/de active
- 2008-03-06 PL PL08719316T patent/PL2125714T3/pl unknown
- 2008-03-06 EP EP08719316A patent/EP2125714B1/en active Active
- 2008-03-06 CN CN200880008581A patent/CN101641327A/zh active Pending
- 2008-03-06 WO PCT/IB2008/000622 patent/WO2008135819A1/en not_active Ceased
- 2008-03-06 MX MX2009009952A patent/MX2009009952A/es active IP Right Grant
- 2008-03-06 ES ES08719316T patent/ES2364727T3/es active Active
- 2008-03-06 AU AU2008247095A patent/AU2008247095B2/en active Active
- 2008-03-06 SI SI200830366T patent/SI2125714T1/sl unknown
- 2008-03-06 CN CN201310280277.XA patent/CN103351367B/zh active Active
- 2008-03-06 DK DK08719316.5T patent/DK2125714T3/da active
- 2008-03-06 US US12/530,573 patent/US8263583B2/en active Active
- 2008-03-06 RU RU2009134512/04A patent/RU2422439C2/ru active
- 2008-03-06 CA CA2678683A patent/CA2678683C/en active Active
- 2008-03-06 KR KR1020097019239A patent/KR101120227B1/ko not_active Expired - Fee Related
- 2008-03-13 AR ARP080101025A patent/AR065714A1/es not_active Application Discontinuation
- 2008-03-14 JP JP2008065066A patent/JP4277051B2/ja active Active
- 2008-03-14 TW TW097109223A patent/TWI348907B/zh not_active IP Right Cessation
2009
- 2009-08-13 IL IL200403A patent/IL200403A/en not_active IP Right Cessation
- 2009-09-16 ZA ZA200906462A patent/ZA200906462B/xx unknown
2011
- 2011-07-08 CY CY20111100664T patent/CY1111701T1/el unknown

Also Published As

Publication number	Publication date
EP2125714B1 (en)	2011-06-08
CA2678683A1 (en)	2008-11-13
US8263583B2 (en)	2012-09-11
ATE512132T1 (de)	2011-06-15
TW200904408A (en)	2009-02-01
EP2125714A1 (en)	2009-12-02
DK2125714T3 (da)	2011-07-25
PT2125714E (pt)	2011-07-14
WO2008135819A8 (en)	2009-08-27
KR20090110944A (ko)	2009-10-23
CN103351367B (zh)	2015-06-10
PL2125714T3 (pl)	2011-10-31
JP4277051B2 (ja)	2009-06-10
CY1111701T1 (el)	2015-10-07
KR101120227B1 (ko)	2012-03-20
MX2009009952A (es)	2009-10-08
AR065714A1 (es)	2009-06-24
JP2009001543A (ja)	2009-01-08
TWI348907B (en)	2011-09-21
RU2422439C2 (ru)	2011-06-27
US20100113409A1 (en)	2010-05-06
BRPI0808413A2 (pt)	2014-07-15
AU2008247095B2 (en)	2012-12-13
WO2008135819A1 (en)	2008-11-13
CN101641327A (zh)	2010-02-03
ES2364727T3 (es)	2011-09-13
CA2678683C (en)	2012-05-15
IL200403A (en)	2014-08-31
CN103351367A (zh)	2013-10-16
SI2125714T1 (sl)	2011-10-28
RU2009134512A (ru)	2011-03-20
HK1189591A1 (en)	2014-06-13
NZ579056A (en)	2011-07-29
IL200403A0 (en)	2010-04-29
AU2008247095A1 (en)	2008-11-13

Publication	Publication Date	Title
ZA200906462B (en)	2010-06-30	Hydrochloride salt of 5-[-3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2, 2-diphenylhexanamide
HUS000509I2 (hu)	2021-03-29	Abemaciklib vagy egy gyógyászatilag elfogadható sója
TWI371277B (en)	2012-09-01	Salt form
IL200122A0 (en)	2010-04-15	Diaminopyrimidines as fungicides
ZA201002608B (en)	2011-07-27	Azolecarboxamide compound or salt thereof
PL2136629T3 (pl)	2015-10-30	Fenoksyfenyloamidyny jako fungicydy
HUE072202T2 (hu)	2025-10-28	Eltrombopag-olamint tartalmazó tabletták
EP2305641A4 (en)	2012-08-22	SULPHONAMIDE COMPOUND OR SALT THEREOF
IL196845A (en)	2015-11-30	The terroyl compounds containing sulphamate
EP2141990A4 (en)	2011-07-06	ACTIVE COMPOUNDS ON 11BETA-HSD1
GB0704906D0 (en)	2007-04-25	Fungicides
GB0717258D0 (en)	2007-10-17	Novel fungicides
AP2010005175A0 (en)	2010-04-30	Novel fungicides
EP2166859A4 (en)	2011-09-07	QUINAZOLINE SALT COMPOUNDS
GB0702382D0 (en)	2007-03-21	New salt
IL212403A0 (en)	2011-06-30	Carbamate compound or salt thereof
GB0717256D0 (en)	2007-10-17	Novel fungicides
IL201625A0 (en)	2010-05-31	Arylamide pyrimidone compounds
IL214110A0 (en)	2011-08-31	2,3-diaryl-or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
HU0600293D0 (en)	2006-05-29	New rosuvastatine salt
IL211062A0 (en)	2011-04-28	Pharmaceutical uses of lanosta-8,24-dien-3-ols
GB0703998D0 (en)	2007-04-11	Novel salt
GB0800840D0 (en)	2008-02-27	Novel salt
HK1147247A (en)	2011-08-05	New salt
GB0806341D0 (en)	2008-05-14	Reduced sodium salt