TWI348907B - Hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide - Google Patents

Hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide

Info

Publication number: TWI348907B
Authority: TW; Taiwan
Prior art keywords: diphenylhexanamide; hydroxyphenoxy; azetidin; methyl; hydrochloride salt
Prior art date: 2007-03-16

Application number

TW097109223A

Other languages

English (en)

Other versions

TW200904408A (en

Inventor

Paul Alan Glossop

Kim James

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-16

Filing date

2008-03-14

Publication date

2011-09-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39591485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI348907(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-03-14 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2009-02-01 Publication of TW200904408A publication Critical patent/TW200904408A/zh

2011-09-21 Application granted granted Critical

2011-09-21 Publication of TWI348907B publication Critical patent/TWI348907B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW097109223A 2007-03-16 2008-03-14 Hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide TWI348907B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US89516307P	2007-03-16	2007-03-16

Publications (2)

Publication Number	Publication Date
TW200904408A TW200904408A (en)	2009-02-01
TWI348907B true TWI348907B (en)	2011-09-21

Family

ID=39591485

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW097109223A TWI348907B (en)	2007-03-16	2008-03-14	Hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide

Country Status (23)

Country	Link
US (1)	US8263583B2 (zh)
EP (1)	EP2125714B1 (zh)
JP (1)	JP4277051B2 (zh)
KR (1)	KR101120227B1 (zh)
CN (2)	CN101641327A (zh)
AR (1)	AR065714A1 (zh)
AT (1)	ATE512132T1 (zh)
AU (1)	AU2008247095B2 (zh)
BR (1)	BRPI0808413A2 (zh)
CA (1)	CA2678683C (zh)
CY (1)	CY1111701T1 (zh)
DK (1)	DK2125714T3 (zh)
ES (1)	ES2364727T3 (zh)
IL (1)	IL200403A (zh)
MX (1)	MX2009009952A (zh)
NZ (1)	NZ579056A (zh)
PL (1)	PL2125714T3 (zh)
PT (1)	PT2125714E (zh)
RU (1)	RU2422439C2 (zh)
SI (1)	SI2125714T1 (zh)
TW (1)	TWI348907B (zh)
WO (1)	WO2008135819A1 (zh)
ZA (1)	ZA200906462B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011063366A1 (en)	2009-11-23	2011-05-26	Palatin Technologies, Inc.	Melanocortin-1 receptor-specific cyclic peptides
KR20120102716A (ko)	2009-11-23	2012-09-18	팔라틴 테크놀로지스 인코포레이티드	멜라노코르틴-1 수용체 특이적 선형 펩티드
EP2578570A1 (en)	2011-10-07	2013-04-10	Almirall, S.A.	Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en)	2012-03-20	2013-09-25	Almirall, S.A.	Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
US20200031769A1 (en)	2017-03-15	2020-01-30	Mylan Laboratories Limited	Novel polymorphs of (5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide hydrochloride
PT3691620T (pt)	2017-10-05	2022-10-06	Fulcrum Therapeutics Inc	Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2020261160A1 (en) *	2019-06-25	2020-12-30	Mylan Laboratories Limited	Methods and intermediates for preparing hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide
US20230293430A1 (en) *	2020-06-26	2023-09-21	Mylan Pharma Uk Limited	Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide
CN113577059B (zh) *	2021-08-02	2022-05-20	山东大学齐鲁医院(青岛)	一种用于小儿哮喘的活性药物
WO2025095813A1 (ru) *	2023-11-03	2025-05-08	Общество С Ограниченной Ответственностью "Валента-Интеллект"	Новые соединения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4167302B2 (ja) *	1996-12-02	2008-10-15	杏林製薬株式会社	新規ｎ―置換ピロリジン誘導体及びその製造法
JPH11100366A (ja)	1997-09-29	1999-04-13	Kyorin Pharmaceut Co Ltd	新規ｎ−置換環状アミン誘導体及びその製造法
DE10064398A1 (de) *	2000-12-21	2002-06-27	Aventis Pharma Gmbh	Neue Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
JP4221447B1 (ja) *	2005-09-21	2009-02-12	ファイザー・リミテッド	ムスカリン様受容体アンタゴニストとしてのカルボキサミド誘導体
CA2664057A1 (en) *	2006-09-22	2008-03-27	Pfizer Limited	Azetidine derivatives as muscarinic receptor antagonists

2008
- 2008-03-06 NZ NZ579056A patent/NZ579056A/en not_active IP Right Cessation
- 2008-03-06 AT AT08719316T patent/ATE512132T1/de active
- 2008-03-06 US US12/530,573 patent/US8263583B2/en active Active
- 2008-03-06 ES ES08719316T patent/ES2364727T3/es active Active
- 2008-03-06 PL PL08719316T patent/PL2125714T3/pl unknown
- 2008-03-06 WO PCT/IB2008/000622 patent/WO2008135819A1/en not_active Ceased
- 2008-03-06 BR BRPI0808413-0A patent/BRPI0808413A2/pt not_active Application Discontinuation
- 2008-03-06 CN CN200880008581A patent/CN101641327A/zh active Pending
- 2008-03-06 CA CA2678683A patent/CA2678683C/en active Active
- 2008-03-06 RU RU2009134512/04A patent/RU2422439C2/ru active
- 2008-03-06 SI SI200830366T patent/SI2125714T1/sl unknown
- 2008-03-06 MX MX2009009952A patent/MX2009009952A/es active IP Right Grant
- 2008-03-06 PT PT08719316T patent/PT2125714E/pt unknown
- 2008-03-06 EP EP08719316A patent/EP2125714B1/en active Active
- 2008-03-06 CN CN201310280277.XA patent/CN103351367B/zh active Active
- 2008-03-06 KR KR1020097019239A patent/KR101120227B1/ko not_active Expired - Fee Related
- 2008-03-06 AU AU2008247095A patent/AU2008247095B2/en active Active
- 2008-03-06 DK DK08719316.5T patent/DK2125714T3/da active
- 2008-03-13 AR ARP080101025A patent/AR065714A1/es not_active Application Discontinuation
- 2008-03-14 TW TW097109223A patent/TWI348907B/zh not_active IP Right Cessation
- 2008-03-14 JP JP2008065066A patent/JP4277051B2/ja not_active Expired - Fee Related
2009
- 2009-08-13 IL IL200403A patent/IL200403A/en not_active IP Right Cessation
- 2009-09-16 ZA ZA200906462A patent/ZA200906462B/xx unknown
2011
- 2011-07-08 CY CY20111100664T patent/CY1111701T1/el unknown

Also Published As

Publication number	Publication date
EP2125714B1 (en)	2011-06-08
DK2125714T3 (da)	2011-07-25
HK1189591A1 (zh)	2014-06-13
MX2009009952A (es)	2009-10-08
BRPI0808413A2 (pt)	2014-07-15
WO2008135819A1 (en)	2008-11-13
CN103351367A (zh)	2013-10-16
IL200403A0 (en)	2010-04-29
ATE512132T1 (de)	2011-06-15
KR101120227B1 (ko)	2012-03-20
RU2009134512A (ru)	2011-03-20
SI2125714T1 (sl)	2011-10-28
CN101641327A (zh)	2010-02-03
KR20090110944A (ko)	2009-10-23
AU2008247095A1 (en)	2008-11-13
US8263583B2 (en)	2012-09-11
PT2125714E (pt)	2011-07-14
ZA200906462B (en)	2010-06-30
US20100113409A1 (en)	2010-05-06
PL2125714T3 (pl)	2011-10-31
CA2678683A1 (en)	2008-11-13
CY1111701T1 (el)	2015-10-07
CN103351367B (zh)	2015-06-10
RU2422439C2 (ru)	2011-06-27
JP4277051B2 (ja)	2009-06-10
IL200403A (en)	2014-08-31
TW200904408A (en)	2009-02-01
JP2009001543A (ja)	2009-01-08
AR065714A1 (es)	2009-06-24
CA2678683C (en)	2012-05-15
EP2125714A1 (en)	2009-12-02
WO2008135819A8 (en)	2009-08-27
ES2364727T3 (es)	2011-09-13
NZ579056A (en)	2011-07-29
AU2008247095B2 (en)	2012-12-13

Publication	Publication Date	Title
IL200403A0 (en)	2010-04-29	Hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2- diphenylhexanamide
ZA201001901B (en)	2010-12-29	5-substituted 2-(alkoxymethyl)furans
IL212186A0 (en)	2011-06-30	Fungicidal heterocyclic compounds
ZA201103887B (en)	2012-10-31	Isoxazole derivatives for use as fungicides
IL224109A (en)	2015-06-30	Isoxazole derivatives for use as fungicides
ZA200806350B (en)	2009-11-25	Stable, concentrated herbicidal compositions
AP2010005364A0 (en)	2010-08-31	Novel heterocyclic compounds.
ZA200904108B (en)	2010-04-28	Pyrido-pyrazine derivatives useful as herbicidal compounds
ZA201100371B (en)	2012-03-28	Heterocyclic compounds used as pesticides
IL207854A0 (en)	2010-12-30	Crystal forms of 5-[3-(2,5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl)[1,2,4]oxadiazol-5-yl]-3-nit robenzene-1,2-diol
IL206765A0 (en)	2010-12-30	4,5-dihydro-oxazol-2-yl-amine derivatives
ZA201008657B (en)	2011-10-26	4,5-dihydro-oxazol-2-yl derivatives
IL194549A0 (en)	2009-08-03	2-(pyridin-2-yl)-pyrimidines for use as fungicides
ZA200801788B (en)	2009-07-29	Controlling torsional shaft oscillation
IL229712A (en)	2015-09-24	The aryl sulfonamide compounds are converted into two positions 2 and 5
GB0804270D0 (en)	2008-04-16	Duloxetine formulation
ZA201008262B (en)	2011-07-27	Heterocyclic compounds
IL205289A0 (en)	2010-12-30	Amino 1, 2, 4 - triazole derivatives as modulators of mglur5
IL215727A0 (en)	2012-01-31	2,5-disubstituted arylsulfonamide ccr3 antagonists
IL214110A0 (en)	2011-08-31	2,3-diaryl-or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
PT2523963E (pt)	2014-11-06	Derivados de oxazolopirimidina substituídos em 2,5 como agonistas do edg-1
ZA200809554B (en)	2010-01-27	3-(pyridin-2-yl)-[1,2,4]-triazines for use as fungicides
IL213328A0 (en)	2011-07-31	Regeneration of 2,2'-cyclopropylidene-bis (oxazolines)
HK1155153A (zh)	2012-05-11	1，2-二取代杂环化合物
AU2007900027A0 (en)	2007-01-18	Heterocyclic compounds

Legal Events

Date	Code	Title	Description
2025-06-21	MM4A	Annulment or lapse of patent due to non-payment of fees