ZA200605160B - Pyrrolotriazine compounds as kinase inhibitors - Google Patents

Pyrrolotriazine compounds as kinase inhibitors Download PDF

Info

Publication number: ZA200605160B
Authority: ZA; South Africa
Prior art keywords: amino; methyl; triazin; pyrrolo; compound
Prior art date: 2003-12-29

Application number

ZA200605160A

Other languages

English (en)

Inventor

Brian E Fink

Ashvinikumar V Gavai

Gregory D Vite

Chen Ping

Mastalerz Harold

Derek J Norris

John S Tokarski

Zhao Yufen

Han Wen-Ching

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-29

Filing date

2006-06-22

Publication date

2007-12-27

2006-06-22 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2007-12-27 Publication of ZA200605160B publication Critical patent/ZA200605160B/en

Links

229940043355 kinase inhibitor Drugs 0.000 title claims description 6
239000003757 phosphotransferase inhibitor Substances 0.000 title claims description 6
150000003921 pyrrolotriazines Chemical class 0.000 title description 6
150000001875 compounds Chemical class 0.000 claims description 553
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 470
-1 4-Amino-1-piperidinyl Chemical group 0.000 claims description 264
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 162
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 153
239000000203 mixture Substances 0.000 claims description 134
QQOWHRYOXYEMTL-UHFFFAOYSA-N triazin-4-amine Chemical compound N=C1C=CN=NN1 QQOWHRYOXYEMTL-UHFFFAOYSA-N 0.000 claims description 75
BIWOSRSKDCZIFM-UHFFFAOYSA-N piperidin-3-ol Chemical compound OC1CCCNC1 BIWOSRSKDCZIFM-UHFFFAOYSA-N 0.000 claims description 70
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 62
238000000034 method Methods 0.000 claims description 44
229910052739 hydrogen Inorganic materials 0.000 claims description 43
125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 41
125000000217 alkyl group Chemical group 0.000 claims description 33
VSPXQZSDPSOPRO-UHFFFAOYSA-N pyrrolo[2,1-f][1,2,4]triazin-4-amine Chemical compound NC1=NC=NN2C=CC=C12 VSPXQZSDPSOPRO-UHFFFAOYSA-N 0.000 claims description 26
239000001257 hydrogen Substances 0.000 claims description 25
150000003839 salts Chemical class 0.000 claims description 24
125000003118 aryl group Chemical group 0.000 claims description 23
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125000000623 heterocyclic group Chemical group 0.000 claims description 21
LKLQWOKKPWCIAW-UHFFFAOYSA-N piperidin-3-yl carbamate Chemical compound NC(=O)OC1CCCNC1 LKLQWOKKPWCIAW-UHFFFAOYSA-N 0.000 claims description 21
108091000080 Phosphotransferase Proteins 0.000 claims description 19
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QCQKTGJRAPFKRX-UHFFFAOYSA-N piperidine-3,5-diol Chemical compound OC1CNCC(O)C1 QCQKTGJRAPFKRX-UHFFFAOYSA-N 0.000 claims description 14
125000000714 pyrimidinyl group Chemical group 0.000 claims description 14
125000003107 substituted aryl group Chemical group 0.000 claims description 14
150000002431 hydrogen Chemical class 0.000 claims description 13
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
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ZA200605160A 2003-12-29 2006-06-22 Pyrrolotriazine compounds as kinase inhibitors ZA200605160B (en)

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US53333503P	2003-12-29	2003-12-29

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ZA200605160A ZA200605160B (en)	2003-12-29	2006-06-22	Pyrrolotriazine compounds as kinase inhibitors

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US (4)	US7141571B2 (pl)
EP (2)	EP1699797B1 (pl)
JP (1)	JP4740878B2 (pl)
KR (1)	KR100839716B1 (pl)
CN (1)	CN1922182B (pl)
AR (1)	AR047076A1 (pl)
AT (1)	ATE443706T1 (pl)
AU (1)	AU2004312413C1 (pl)
BR (1)	BRPI0418231A (pl)
CA (1)	CA2552107C (pl)
CL (1)	CL2009001492A1 (pl)
CY (1)	CY1109662T1 (pl)
DE (1)	DE602004023324D1 (pl)
DK (1)	DK1699797T3 (pl)
ES (1)	ES2331842T3 (pl)
GE (1)	GEP20105081B (pl)
HR (1)	HRP20090601T1 (pl)
IL (1)	IL176450A0 (pl)
MX (1)	MXPA06007038A (pl)
MY (1)	MY145634A (pl)
NO (1)	NO20062763L (pl)
NZ (2)	NZ548070A (pl)
PE (1)	PE20050679A1 (pl)
PL (1)	PL1699797T3 (pl)
PT (1)	PT1699797E (pl)
RU (1)	RU2373209C2 (pl)
SI (1)	SI1699797T1 (pl)
TW (1)	TWI332840B (pl)
UA (1)	UA89038C2 (pl)
WO (1)	WO2005066176A1 (pl)
ZA (1)	ZA200605160B (pl)

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2004
- 2004-12-09 MY MYPI20045093A patent/MY145634A/en unknown
- 2004-12-22 TW TW093140035A patent/TWI332840B/zh not_active IP Right Cessation
- 2004-12-22 US US11/019,901 patent/US7141571B2/en not_active Expired - Lifetime
- 2004-12-23 ES ES04815269T patent/ES2331842T3/es not_active Expired - Lifetime
- 2004-12-23 AT AT04815269T patent/ATE443706T1/de active
- 2004-12-23 WO PCT/US2004/043169 patent/WO2005066176A1/en not_active Ceased
- 2004-12-23 NZ NZ548070A patent/NZ548070A/en unknown
- 2004-12-23 CA CA2552107A patent/CA2552107C/en not_active Expired - Fee Related
- 2004-12-23 EP EP04815269A patent/EP1699797B1/en not_active Expired - Lifetime
- 2004-12-23 PT PT04815269T patent/PT1699797E/pt unknown
- 2004-12-23 GE GEAP20049544A patent/GEP20105081B/en unknown
- 2004-12-23 KR KR1020067012936A patent/KR100839716B1/ko not_active Expired - Fee Related
- 2004-12-23 DE DE602004023324T patent/DE602004023324D1/de not_active Expired - Lifetime
- 2004-12-23 CN CN2004800421984A patent/CN1922182B/zh not_active Expired - Fee Related
- 2004-12-23 SI SI200431286T patent/SI1699797T1/sl unknown
- 2004-12-23 EP EP09153694A patent/EP2058314A1/en not_active Withdrawn
- 2004-12-23 MX MXPA06007038A patent/MXPA06007038A/es active IP Right Grant
- 2004-12-23 BR BRPI0418231-6A patent/BRPI0418231A/pt not_active IP Right Cessation
- 2004-12-23 AU AU2004312413A patent/AU2004312413C1/en not_active Ceased
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- 2004-12-23 PL PL04815269T patent/PL1699797T3/pl unknown
- 2004-12-23 RU RU2006127396/04A patent/RU2373209C2/ru not_active IP Right Cessation
- 2004-12-23 DK DK04815269T patent/DK1699797T3/da active
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- 2004-12-23 HR HR20090601T patent/HRP20090601T1/hr unknown
- 2004-12-23 UA UAA200608400A patent/UA89038C2/ru unknown
- 2004-12-29 AR ARP040104947A patent/AR047076A1/es not_active Application Discontinuation
2005
- 2005-01-03 PE PE2005000015A patent/PE20050679A1/es not_active Application Discontinuation
2006
- 2006-06-13 NO NO20062763A patent/NO20062763L/no not_active Application Discontinuation
- 2006-06-20 IL IL176450A patent/IL176450A0/en unknown
- 2006-06-22 ZA ZA200605160A patent/ZA200605160B/en unknown
- 2006-06-26 US US11/426,479 patent/US7297695B2/en not_active Expired - Lifetime
2008
- 2008-09-24 US US11/869,910 patent/US7846931B2/en not_active Expired - Lifetime
2009
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- 2009-12-21 CY CY20091101326T patent/CY1109662T1/el unknown
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- 2010-10-25 US US12/911,299 patent/US20110039838A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2004312413A1 (en)	2005-07-21
ATE443706T1 (de)	2009-10-15
CL2009001492A1 (es)	2010-01-15
TWI332840B (en)	2010-11-11
US20050182058A1 (en)	2005-08-18
AR047076A1 (es)	2006-01-04
TW200526226A (en)	2005-08-16
MXPA06007038A (es)	2006-08-31
RU2006127396A (ru)	2008-02-10
ES2331842T3 (es)	2010-01-18
CN1922182A (zh)	2007-02-28
RU2373209C2 (ru)	2009-11-20
US7846931B2 (en)	2010-12-07
WO2005066176A1 (en)	2005-07-21
HRP20090601T1 (hr)	2009-12-31
NO20062763L (no)	2006-09-11
US20110039838A1 (en)	2011-02-17
US7297695B2 (en)	2007-11-20
CN1922182B (zh)	2010-08-18
JP2007518721A (ja)	2007-07-12
US20060264438A1 (en)	2006-11-23
BRPI0418231A (pt)	2007-04-27
EP1699797A1 (en)	2006-09-13
DE602004023324D1 (de)	2009-11-05
PE20050679A1 (es)	2005-09-25
CA2552107A1 (en)	2005-07-21
NZ548070A (en)	2009-02-28
NZ573544A (en)	2010-04-30
JP4740878B2 (ja)	2011-08-03
HK1088332A1 (en)	2006-11-03
EP2058314A1 (en)	2009-05-13
US7141571B2 (en)	2006-11-28
MY145634A (en)	2012-03-15
EP1699797B1 (en)	2009-09-23
GEP20105081B (en)	2010-09-27
US20090048244A1 (en)	2009-02-19
UA89038C2 (en)	2009-12-25
SI1699797T1 (sl)	2010-04-30
AU2004312413B2 (en)	2010-07-22
KR20060107828A (ko)	2006-10-16
IL176450A0 (en)	2006-10-05
PL1699797T3 (pl)	2010-02-26
AU2004312413C1 (en)	2011-01-27
KR100839716B1 (ko)	2008-06-19
CY1109662T1 (el)	2014-08-13
CA2552107C (en)	2011-10-18
DK1699797T3 (da)	2010-01-04
PT1699797E (pt)	2009-12-29