[go: up one dir, main page]

NO20062763L - Pyrrolotriazinforbindelser som kinaseinhibitorer - Google Patents

Pyrrolotriazinforbindelser som kinaseinhibitorer

Info

Publication number
NO20062763L
NO20062763L NO20062763A NO20062763A NO20062763L NO 20062763 L NO20062763 L NO 20062763L NO 20062763 A NO20062763 A NO 20062763A NO 20062763 A NO20062763 A NO 20062763A NO 20062763 L NO20062763 L NO 20062763L
Authority
NO
Norway
Prior art keywords
compounds
formula
kinase inhibitors
useful
growth factor
Prior art date
Application number
NO20062763A
Other languages
English (en)
Inventor
Gregory D Vite
Ashvinikumar Gavai
Wen-Ching Han
Ping Chen
Harold Mastalerz
John S Tokarski
Brian E Fink
Derek J Norris
Yufen Zhao
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20062763L publication Critical patent/NO20062763L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel I og farmasøytisk akseptable salter derav. Forbindelsene med formel I hemmer tyrosinkinase-aktivitet til vekstfaktor-reseptorer så som HERI, HER2 og HER4 og gjør dem derved anvendelige som antiproliferative midler. Forbindelsene med formel I er også anvendelige for behandling av andre sykdommer forbundet med signaltransduksjonsbaner som opererer gjennom vekstfaktor-reseptorer.
NO20062763A 2003-12-29 2006-06-13 Pyrrolotriazinforbindelser som kinaseinhibitorer NO20062763L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53333503P 2003-12-29 2003-12-29
PCT/US2004/043169 WO2005066176A1 (en) 2003-12-29 2004-12-23 Pyrrolotriazine compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20062763L true NO20062763L (no) 2006-09-11

Family

ID=34748887

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062763A NO20062763L (no) 2003-12-29 2006-06-13 Pyrrolotriazinforbindelser som kinaseinhibitorer

Country Status (31)

Country Link
US (4) US7141571B2 (no)
EP (2) EP2058314A1 (no)
JP (1) JP4740878B2 (no)
KR (1) KR100839716B1 (no)
CN (1) CN1922182B (no)
AR (1) AR047076A1 (no)
AT (1) ATE443706T1 (no)
AU (1) AU2004312413C1 (no)
BR (1) BRPI0418231A (no)
CA (1) CA2552107C (no)
CL (1) CL2009001492A1 (no)
CY (1) CY1109662T1 (no)
DE (1) DE602004023324D1 (no)
DK (1) DK1699797T3 (no)
ES (1) ES2331842T3 (no)
GE (1) GEP20105081B (no)
HR (1) HRP20090601T1 (no)
IL (1) IL176450A0 (no)
MX (1) MXPA06007038A (no)
MY (1) MY145634A (no)
NO (1) NO20062763L (no)
NZ (2) NZ573544A (no)
PE (1) PE20050679A1 (no)
PL (1) PL1699797T3 (no)
PT (1) PT1699797E (no)
RU (1) RU2373209C2 (no)
SI (1) SI1699797T1 (no)
TW (1) TWI332840B (no)
UA (1) UA89038C2 (no)
WO (1) WO2005066176A1 (no)
ZA (1) ZA200605160B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
HRP20040988A2 (en) * 2002-04-23 2005-06-30 Bristol-Myers Squibb Company A Delaware (Usa) Corp Pyrrolo-triazine aniline compounds useful as kinas
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7102002B2 (en) 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US20050288290A1 (en) * 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
US7253167B2 (en) * 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
TW200600513A (en) * 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US7504521B2 (en) * 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
US7148348B2 (en) 2004-08-12 2006-12-12 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
TW200635927A (en) * 2004-12-22 2006-10-16 Bristol Myers Squibb Co Synthetic process
ES2319462T3 (es) 2005-03-28 2009-05-07 Bristol-Myers Squibb Company Inhibidores competitivos de atp cinasas.
US20060235020A1 (en) * 2005-04-18 2006-10-19 Soojin Kim Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
US8338594B2 (en) * 2005-12-02 2012-12-25 Bayer Healthcare Llc Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
US8063208B2 (en) * 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
WO2008057863A1 (en) * 2006-11-01 2008-05-15 Bristol-Myers Squibb Company Therapeutic combination of a panher/vegfr2 kinase inhibitor and a platinum compound
JP2010517574A (ja) 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
US20090076034A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched bms-690514
CA2704125A1 (en) * 2007-12-19 2009-07-09 Genentech, Inc. 8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents
JP2010209058A (ja) * 2008-09-29 2010-09-24 Sumitomo Chemical Co Ltd １−置換−トランス−４−（置換アミノ）ピペリジン−３−オールの製造方法
JP5592890B2 (ja) * 2008-10-08 2014-09-17 ブリストル−マイヤーズ スクイブ カンパニー ピロロトリアジンキナーゼ阻害剤
TW201035100A (en) 2008-12-19 2010-10-01 Cephalon Inc Pyrrolotriazines as ALK and JAK2 inhibitors
WO2010084152A1 (en) 2009-01-21 2010-07-29 Basilea Pharmaceutica Ag Novel bicyclic antibiotics
JPWO2011013656A1 (ja) * 2009-07-28 2013-01-07 宇部興産株式会社 ピロロ［２，３−ｄ］ピリミジン誘導体
JP5894540B2 (ja) 2010-02-18 2016-03-30 ブイティーブイ・セラピューティクス・エルエルシー フェニル−ヘテロアリール誘導体とその使用の方法
PH12012502572A1 (en) 2010-06-30 2022-03-30 Fujifilm Corp Novel nicotinamide derivative or salt thereof
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
DE102011119127A1 (de) * 2011-11-22 2013-05-23 Merck Patent Gmbh 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
TW201414737A (zh) 2012-07-13 2014-04-16 必治妥美雅史谷比公司 作爲激酶抑制劑之咪唑并三□甲腈
ES2678877T3 (es) 2013-10-11 2018-08-20 Bristol-Myers Squibb Company Inhibidores de pirrolotriazina quinasa
HRP20181795T1 (hr) * 2014-01-13 2019-01-25 Aurigene Discovery Technologies Limited Biciklički heterociklilni derivati kao inhibitori irak4
EP3143392B1 (en) * 2014-05-12 2023-02-22 Quest Diagnostics Investments Incorporated Quantitation of tamoxifen metabolites by mass spectrometry
AR112027A1 (es) 2017-06-15 2019-09-11 Biocryst Pharm Inc Inhibidores de alk 2 quinasa que contienen imidazol
EP3792263B1 (en) * 2018-05-08 2023-03-01 Medshine Discovery Inc. Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective her2 inhibitors and application thereof
WO2021088987A1 (zh) * 2019-11-08 2021-05-14 南京明德新药研发有限公司 作为选择性her2抑制剂的盐型、晶型及其应用
US11773122B2 (en) 2020-08-24 2023-10-03 Gilead Sciences. Inc. Phospholipid compounds and uses thereof
TW202417458A (zh) * 2022-08-22 2024-05-01 美商依安彼克醫療有限公司 調節her2的化合物及方法
CN120271495B (zh) * 2025-06-12 2025-09-19 成都道合尔医药技术有限公司 一种(3r,4r)-n-pg-4-氨基-3-甲基哌啶的合成方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
CA2163399A1 (en) 1994-11-24 1996-05-25 Katsuhiro Kawano Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor
CA2263566C (en) 1996-08-28 2003-09-09 Pfizer Inc. Substituted 6,5-hetero-bicyclic derivatives
WO2000071129A1 (en) * 1999-05-21 2000-11-30 Bristol-Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6982265B1 (en) 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6787545B1 (en) * 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
US6670357B2 (en) 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
GEP20063915B (en) 2000-11-17 2006-09-11 Bristol Myers Squibb Co PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND USE THEREOF FOR TREATING p38 KINASE-ASSOCIATED CONDITIONS
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
ATE418546T1 (de) 2002-04-23 2009-01-15 Bristol Myers Squibb Co Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen
HRP20040988A2 (en) 2002-04-23 2005-06-30 Bristol-Myers Squibb Company A Delaware (Usa) Corp Pyrrolo-triazine aniline compounds useful as kinas
US6894066B2 (en) 2002-05-09 2005-05-17 Bernard Charles Sherman Magnesium salt of S-omeprazole
TW200407143A (en) 2002-05-21 2004-05-16 Bristol Myers Squibb Co Pyrrolotriazinone compounds and their use to treat diseases
TWI272271B (en) 2002-07-19 2007-02-01 Bristol Myers Squibb Co Process for preparing certain pyrrolotriazine compounds
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
AU2003265349A1 (en) 2002-08-02 2004-02-23 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
US7102001B2 (en) 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7064203B2 (en) 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
US7102002B2 (en) 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7102003B2 (en) 2004-07-01 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine compounds
US7151176B2 (en) 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds

Also Published As

Publication number Publication date
US20060264438A1 (en) 2006-11-23
US7141571B2 (en) 2006-11-28
GEP20105081B (en) 2010-09-27
HK1088332A1 (en) 2006-11-03
US20090048244A1 (en) 2009-02-19
PE20050679A1 (es) 2005-09-25
UA89038C2 (en) 2009-12-25
TWI332840B (en) 2010-11-11
AR047076A1 (es) 2006-01-04
ZA200605160B (en) 2007-12-27
NZ548070A (en) 2009-02-28
DE602004023324D1 (de) 2009-11-05
SI1699797T1 (sl) 2010-04-30
AU2004312413B2 (en) 2010-07-22
CN1922182B (zh) 2010-08-18
EP2058314A1 (en) 2009-05-13
CL2009001492A1 (es) 2010-01-15
PT1699797E (pt) 2009-12-29
CY1109662T1 (el) 2014-08-13
JP2007518721A (ja) 2007-07-12
AU2004312413A1 (en) 2005-07-21
US20050182058A1 (en) 2005-08-18
JP4740878B2 (ja) 2011-08-03
US7297695B2 (en) 2007-11-20
CN1922182A (zh) 2007-02-28
HRP20090601T1 (hr) 2009-12-31
ES2331842T3 (es) 2010-01-18
IL176450A0 (en) 2006-10-05
BRPI0418231A (pt) 2007-04-27
NZ573544A (en) 2010-04-30
RU2006127396A (ru) 2008-02-10
CA2552107A1 (en) 2005-07-21
EP1699797B1 (en) 2009-09-23
US20110039838A1 (en) 2011-02-17
DK1699797T3 (da) 2010-01-04
AU2004312413C1 (en) 2011-01-27
KR100839716B1 (ko) 2008-06-19
MXPA06007038A (es) 2006-08-31
TW200526226A (en) 2005-08-16
ATE443706T1 (de) 2009-10-15
MY145634A (en) 2012-03-15
EP1699797A1 (en) 2006-09-13
US7846931B2 (en) 2010-12-07
WO2005066176A1 (en) 2005-07-21
RU2373209C2 (ru) 2009-11-20
CA2552107C (en) 2011-10-18
KR20060107828A (ko) 2006-10-16
PL1699797T3 (pl) 2010-02-26

Similar Documents

Publication Publication Date Title
NO20062763L (no) Pyrrolotriazinforbindelser som kinaseinhibitorer
NO20052733L (no) C-6 modifiserte indazolylpyrrolotriaziner
MXPA04004492A (es) Indazolilpirrolotriazinas c-5 modificadas.
NO20091708L (no) Nye kinase inhibitorer
MXPA05000715A (es) Inhibidores novedosos de cinasas.
WO2004001059A3 (en) Heterocyclic inhibitors of kinases
NO20090025L (no) Pyrrolotriazinkinaseinhibitorer
NO20062136L (no) Imidazopyrazintyrosin-kinaseinhibitorer
NO20090580L (no) Syklopenta[D]pyrimidiner som AKT-proteinkinaseinhibitorer
JO2764B1 (en) Indole derivatives or benzimidazole derivatives to modify the enzyme AKP kinase
TW200613306A (en) Imidazotriazines as protein kinase inhibitors
WO2006007378A3 (en) Pyrrolotriazine kinase inhibitors
NO20090581L (no) Hydroksylerte og metoksylerte syklopenta[D]pyrimidiner som AKT-proteinkinaseinhibitorer
YU84603A (sh) Novi inhibitori tirozin kinaze
MY141220A (en) Pyrazole derivatives as inhibitors of receptor tyrosine kinases
WO2004009542A3 (en) Process for preparing certain pyrrolotriazine compounds
GB0112348D0 (en) Compounds
NO20092035L (no) Tiazolylforbindelser anvendbare som kinaseinhibitorer
TW200519096A (en) Quinazoline analogs as receptor tyrosine kinase inhibitors
WO2005065266A3 (en) Di-substituted pyrrolotriazine compounds
DE602005023732D1 (de) Pyrrolotriazinverbindungen
NO20063324L (no) 3-cyano-kinolinderivater med antiproliferativ aktivitet
DE60221813D1 (de) Thiazolopyrimidinderivate und deren verwendung als antagonisten des cx3cr1 rezeptors
NO20072667L (no) Fremstillingsmetode
UA90659C2 (ru) Аналоги хиназолина как ингибиторы рецепторных тирозинкиназ

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application