DK1699797T3 - Pyrrolotriazinforbindelser som kinasehæmmere - Google Patents

Pyrrolotriazinforbindelser som kinasehæmmere

Info

Publication number: DK1699797T3
Authority: DK; Denmark
Prior art keywords: kinase inhibitors; pyrrolotriazine compounds; pyrrolotriazine; compounds; kinase
Prior art date: 2003-12-29

Application number

DK04815269T

Other languages

English (en)

Inventor

Brian E Fink

Ashvinikumar V Gavai

Gregory D Vite

Ping Chen

Harold Mastalerz

Derek J Norris

John S Tokarski

Yufen Zhao

Wen-Ching Han

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-29

Filing date

2004-12-23

Publication date

2010-01-04

2004-12-23 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2010-01-04 Application granted granted Critical

2010-01-04 Publication of DK1699797T3 publication Critical patent/DK1699797T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK04815269T 2003-12-29 2004-12-23 Pyrrolotriazinforbindelser som kinasehæmmere DK1699797T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53333503P	2003-12-29	2003-12-29
PCT/US2004/043169 WO2005066176A1 (en)	2003-12-29	2004-12-23	Pyrrolotriazine compounds as kinase inhibitors

Publications (1)

Publication Number	Publication Date
DK1699797T3 true DK1699797T3 (da)	2010-01-04

Family

ID=34748887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04815269T DK1699797T3 (da)	2003-12-29	2004-12-23	Pyrrolotriazinforbindelser som kinasehæmmere

Country Status (31)

Country	Link
US (4)	US7141571B2 (da)
EP (2)	EP1699797B1 (da)
JP (1)	JP4740878B2 (da)
KR (1)	KR100839716B1 (da)
CN (1)	CN1922182B (da)
AR (1)	AR047076A1 (da)
AT (1)	ATE443706T1 (da)
AU (1)	AU2004312413C1 (da)
BR (1)	BRPI0418231A (da)
CA (1)	CA2552107C (da)
CL (1)	CL2009001492A1 (da)
CY (1)	CY1109662T1 (da)
DE (1)	DE602004023324D1 (da)
DK (1)	DK1699797T3 (da)
ES (1)	ES2331842T3 (da)
GE (1)	GEP20105081B (da)
HR (1)	HRP20090601T1 (da)
IL (1)	IL176450A0 (da)
MX (1)	MXPA06007038A (da)
MY (1)	MY145634A (da)
NO (1)	NO20062763L (da)
NZ (2)	NZ548070A (da)
PE (1)	PE20050679A1 (da)
PL (1)	PL1699797T3 (da)
PT (1)	PT1699797E (da)
RU (1)	RU2373209C2 (da)
SI (1)	SI1699797T1 (da)
TW (1)	TWI332840B (da)
UA (1)	UA89038C2 (da)
WO (1)	WO2005066176A1 (da)
ZA (1)	ZA200605160B (da)

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WO2003090912A1 (en) *	2002-04-23	2003-11-06	Bristol-Myers Squibb Company	Pyrrolo-triazine aniline compounds useful as kinase inhibitors
US20060014741A1 (en) *	2003-12-12	2006-01-19	Dimarco John D	Synthetic process, and crystalline forms of a pyrrolotriazine compound
MY145634A (en) *	2003-12-29	2012-03-15	Bristol Myers Squibb Co	Pyrrolotriazine compounds as kinase inhibitors
US7102002B2 (en) *	2004-06-16	2006-09-05	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US7173031B2 (en) *	2004-06-28	2007-02-06	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US7253167B2 (en) *	2004-06-30	2007-08-07	Bristol-Myers Squibb Company	Tricyclic-heteroaryl compounds useful as kinase inhibitors
TW200600513A (en) *	2004-06-30	2006-01-01	Bristol Myers Squibb Co	A method for preparing pyrrolotriazine compounds
US7504521B2 (en) *	2004-08-05	2009-03-17	Bristol-Myers Squibb Co.	Methods for the preparation of pyrrolotriazine compounds
PE20060421A1 (es)	2004-08-12	2006-06-01	Bristol Myers Squibb Co	Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
TW200635927A (en) *	2004-12-22	2006-10-16	Bristol Myers Squibb Co	Synthetic process
ES2319462T3 (es)	2005-03-28	2009-05-07	Bristol-Myers Squibb Company	Inhibidores competitivos de atp cinasas.
US20060235020A1 (en) *	2005-04-18	2006-10-19	Soojin Kim	Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
MY150958A (en)	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
CA2631732C (en) *	2005-12-02	2012-12-18	Bayer Healthcare Llc	Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
US8063208B2 (en) *	2006-02-16	2011-11-22	Bristol-Myers Squibb Company	Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
EP2086549A1 (en) *	2006-11-01	2009-08-12	Bristol-Myers Squibb Company	Therapeutic combination of a panher/vegfr2 kinase inhibitor and a platinum compound
US7820421B2 (en)	2007-02-08	2010-10-26	Codexis, Inc.	Ketoreductases and uses thereof
US20090076034A1 (en) *	2007-09-14	2009-03-19	Protia, Llc	Deuterium-enriched bms-690514
DK2231662T3 (da) *	2007-12-19	2011-08-29	Genentech Inc	8-Anilinoimidazopyridiner og deres anvendelse som anticancer- og/eller antiinflammatoriske midler
JP2010209058A (ja) *	2008-09-29	2010-09-24	Sumitomo Chemical Co Ltd	１−置換−トランス−４−（置換アミノ）ピペリジン−３−オールの製造方法
CN102245610B (zh) *	2008-10-08	2014-04-30	百时美施贵宝公司	吡咯并三嗪激酶抑制剂
TW201035100A (en)	2008-12-19	2010-10-01	Cephalon Inc	Pyrrolotriazines as ALK and JAK2 inhibitors
AU2010206161B2 (en)	2009-01-21	2014-08-07	Basilea Pharmaceutica Ag	Novel bicyclic antibiotics
WO2011013656A1 (ja) *	2009-07-28	2011-02-03	第一三共株式会社	ピロロ［２，３－ｄ］ピリミジン誘導体
US8431575B2 (en)	2010-02-18	2013-04-30	Transtech Pharma, Inc.	Phenyl-heteroaryl derivatives and methods of use thereof
WO2012002577A1 (ja)	2010-06-30	2012-01-05	富士フイルム株式会社	新規なニコチンアミド誘導体またはその塩
CN102153558B (zh) *	2011-02-23	2012-11-21	扬州永济医药新技术有限公司	多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
DE102011119127A1 (de) *	2011-11-22	2013-05-23	Merck Patent Gmbh	3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
CN103450204B (zh)	2012-05-31	2016-08-17	中国科学院上海药物研究所	吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
US9724352B2 (en)	2012-05-31	2017-08-08	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
TW201414737A (zh)	2012-07-13	2014-04-16	必治妥美雅史谷比公司	作爲激酶抑制劑之咪唑并三□甲腈
WO2015054358A1 (en)	2013-10-11	2015-04-16	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
SI3094329T1 (sl) *	2014-01-13	2019-02-28	Aurigene Discovery Technologies Limited	Biciklični heterociklilni derivati kot inhibitorji IRAK4
EP3143392B1 (en) *	2014-05-12	2023-02-22	Quest Diagnostics Investments Incorporated	Quantitation of tamoxifen metabolites by mass spectrometry
AR112027A1 (es)	2017-06-15	2019-09-11	Biocryst Pharm Inc	Inhibidores de alk 2 quinasa que contienen imidazol
CN112105618B (zh) *	2018-05-08	2022-05-31	南京明德新药研发有限公司	作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用
WO2021088987A1 (zh) *	2019-11-08	2021-05-14	南京明德新药研发有限公司	作为选择性her2抑制剂的盐型、晶型及其应用
MX2023002233A (es)	2020-08-24	2023-03-15	Gilead Sciences Inc	Compuestos fosfolipidos y usos de estos.
EP4577549A1 (en) *	2022-08-22	2025-07-02	Iambic Therapeutics, Inc.	Compounds and methods for modulating her2
CN120271495B (zh) *	2025-06-12	2025-09-19	成都道合尔医药技术有限公司	一种(3r,4r)-n-pg-4-氨基-3-甲基哌啶的合成方法

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RU2127274C1 (ru) *	1992-09-25	1999-03-10	Эли Лилли Энд Компани	СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
CA2163399A1 (en)	1994-11-24	1996-05-25	Katsuhiro Kawano	Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor
EP0923582B1 (en)	1996-08-28	2006-09-20	Pfizer Inc.	Substituted 6,5-hetero-bicyclic derivatives
PL204437B1 (pl) *	1999-05-21	2010-01-29	Bristol Myers Squibb Co	Pochodna pirolotriazyny i jej zastosowanie oraz kompozycja farmaceutyczna i jej zastosowanie
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US7151176B2 (en)	2004-10-21	2006-12-19	Bristol-Myers Squibb Company	Pyrrolotriazine compounds

2004
- 2004-12-09 MY MYPI20045093A patent/MY145634A/en unknown
- 2004-12-22 US US11/019,901 patent/US7141571B2/en not_active Expired - Lifetime
- 2004-12-22 TW TW093140035A patent/TWI332840B/zh not_active IP Right Cessation
- 2004-12-23 NZ NZ548070A patent/NZ548070A/en unknown
- 2004-12-23 EP EP04815269A patent/EP1699797B1/en not_active Expired - Lifetime
- 2004-12-23 NZ NZ573544A patent/NZ573544A/en unknown
- 2004-12-23 WO PCT/US2004/043169 patent/WO2005066176A1/en not_active Ceased
- 2004-12-23 GE GEAP20049544A patent/GEP20105081B/en unknown
- 2004-12-23 HR HR20090601T patent/HRP20090601T1/hr unknown
- 2004-12-23 RU RU2006127396/04A patent/RU2373209C2/ru not_active IP Right Cessation
- 2004-12-23 EP EP09153694A patent/EP2058314A1/en not_active Withdrawn
- 2004-12-23 CN CN2004800421984A patent/CN1922182B/zh not_active Expired - Fee Related
- 2004-12-23 MX MXPA06007038A patent/MXPA06007038A/es active IP Right Grant
- 2004-12-23 KR KR1020067012936A patent/KR100839716B1/ko not_active Expired - Fee Related
- 2004-12-23 DE DE602004023324T patent/DE602004023324D1/de not_active Expired - Lifetime
- 2004-12-23 UA UAA200608400A patent/UA89038C2/ru unknown
- 2004-12-23 AU AU2004312413A patent/AU2004312413C1/en not_active Ceased
- 2004-12-23 JP JP2006547328A patent/JP4740878B2/ja not_active Expired - Fee Related
- 2004-12-23 SI SI200431286T patent/SI1699797T1/sl unknown
- 2004-12-23 BR BRPI0418231-6A patent/BRPI0418231A/pt not_active IP Right Cessation
- 2004-12-23 PT PT04815269T patent/PT1699797E/pt unknown
- 2004-12-23 CA CA2552107A patent/CA2552107C/en not_active Expired - Fee Related
- 2004-12-23 ES ES04815269T patent/ES2331842T3/es not_active Expired - Lifetime
- 2004-12-23 DK DK04815269T patent/DK1699797T3/da active
- 2004-12-23 AT AT04815269T patent/ATE443706T1/de active
- 2004-12-23 PL PL04815269T patent/PL1699797T3/pl unknown
- 2004-12-29 AR ARP040104947A patent/AR047076A1/es not_active Application Discontinuation
2005
- 2005-01-03 PE PE2005000015A patent/PE20050679A1/es not_active Application Discontinuation
2006
- 2006-06-13 NO NO20062763A patent/NO20062763L/no not_active Application Discontinuation
- 2006-06-20 IL IL176450A patent/IL176450A0/en unknown
- 2006-06-22 ZA ZA200605160A patent/ZA200605160B/en unknown
- 2006-06-26 US US11/426,479 patent/US7297695B2/en not_active Expired - Lifetime
2008
- 2008-09-24 US US11/869,910 patent/US7846931B2/en not_active Expired - Lifetime
2009
- 2009-06-26 CL CL2009001492A patent/CL2009001492A1/es unknown
- 2009-12-21 CY CY20091101326T patent/CY1109662T1/el unknown
2010
- 2010-10-25 US US12/911,299 patent/US20110039838A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060264438A1 (en)	2006-11-23
KR100839716B1 (ko)	2008-06-19
AR047076A1 (es)	2006-01-04
UA89038C2 (en)	2009-12-25
AU2004312413B2 (en)	2010-07-22
HK1088332A1 (en)	2006-11-03
US7141571B2 (en)	2006-11-28
NZ573544A (en)	2010-04-30
DE602004023324D1 (de)	2009-11-05
MY145634A (en)	2012-03-15
TWI332840B (en)	2010-11-11
US20110039838A1 (en)	2011-02-17
AU2004312413A1 (en)	2005-07-21
US20090048244A1 (en)	2009-02-19
NZ548070A (en)	2009-02-28
CA2552107A1 (en)	2005-07-21
HRP20090601T1 (hr)	2009-12-31
JP4740878B2 (ja)	2011-08-03
CN1922182B (zh)	2010-08-18
US7297695B2 (en)	2007-11-20
EP2058314A1 (en)	2009-05-13
MXPA06007038A (es)	2006-08-31
ATE443706T1 (de)	2009-10-15
BRPI0418231A (pt)	2007-04-27
ZA200605160B (en)	2007-12-27
RU2373209C2 (ru)	2009-11-20
SI1699797T1 (sl)	2010-04-30
US7846931B2 (en)	2010-12-07
KR20060107828A (ko)	2006-10-16
IL176450A0 (en)	2006-10-05
EP1699797A1 (en)	2006-09-13
WO2005066176A1 (en)	2005-07-21
JP2007518721A (ja)	2007-07-12
CL2009001492A1 (es)	2010-01-15
AU2004312413C1 (en)	2011-01-27
TW200526226A (en)	2005-08-16
ES2331842T3 (es)	2010-01-18
US20050182058A1 (en)	2005-08-18
PE20050679A1 (es)	2005-09-25
CY1109662T1 (el)	2014-08-13
RU2006127396A (ru)	2008-02-10
NO20062763L (no)	2006-09-11
CA2552107C (en)	2011-10-18
PT1699797E (pt)	2009-12-29
CN1922182A (zh)	2007-02-28
PL1699797T3 (pl)	2010-02-26
EP1699797B1 (en)	2009-09-23
GEP20105081B (en)	2010-09-27

Publication	Publication Date	Title
DK1699797T3 (da)	2010-01-04	Pyrrolotriazinforbindelser som kinasehæmmere
DK1585749T3 (da)	2008-09-22	Diazepinoindol-derivater som kinaseinhibitorer
NO20055680D0 (no)	2005-12-01	Heksahydropyridoisokinoliner som DPP-IV-inhibitorer
DK2039685T3 (da)	2013-03-25	Heterobicycliske forbindelser som P38-inhibitorer
DK1720882T3 (da)	2011-04-11	Pyrazolopyrimidin-derivater som cyclin-afhængige kinaseinhibitorer
NO20044560L (no)	2004-11-10	Pyrrolotriazin anilin forbindelser nyttige som kinase inhibitorer
ATE452891T1 (de)	2010-01-15	Pyrimidopyrimidone als kinaseinhibitoren
DE602004025258D1 (de)	2010-03-11	Aminotriazol-verbindungen als proteinkinase-hemmer
DK1603570T3 (da)	2013-05-21	Aminoheteroarylforbindelser som proteinkinaseinhibitorer
IS7534A (is)	2004-11-16	Pýrazóló-pýrimídín anilín efnasambönd, gagnleg sem kínasatálmar
ATE505471T1 (de)	2011-04-15	Azaindol-kinaseinhibitoren
DK1605897T3 (da)	2012-08-20	Polyethelen-glycol-link-glp-1-forbindelser
IS8108A (is)	2005-10-31	Ný efnasambönd
DK1711481T4 (da)	2013-08-26	Krystallinsk monohydrat som kinaseinhibitorer
DK1789041T3 (da)	2008-09-08	Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK1797042T3 (da)	2009-03-02	Indozolonderivater som 11B-HSD1-inhibitorer
DK1660090T3 (da)	2012-12-17	Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
DK1763517T3 (da)	2011-06-06	Pyrimidinderivater som 11beta-HSD1-inhibitorer
IS8228A (is)	2006-01-11	Ný asetídínefnasambönd
DE602004026905D1 (de)	2010-06-10	2-aminoaryloxazol-verbindungen als tyrosinkinase-hemmer
EP1778693A4 (en)	2009-11-11	AS KINASEINHIBITORS USEFUL COMPOUNDS OF TRICYCLIC HETEROARYL
IS8089A (is)	2005-10-25	Efnasambönd
IS8292A (is)	2006-02-09	Ný efnasambönd
NO20031736D0 (no)	2003-04-15	Forbindelser
SE0303452D0 (sv)	2003-12-18	New compounds