ZA200508247B - New non-ionic surfactants for solubilizing poorly soluble molecules - Google Patents
New non-ionic surfactants for solubilizing poorly soluble molecules Download PDFInfo
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- ZA200508247B ZA200508247B ZA200508247A ZA200508247A ZA200508247B ZA 200508247 B ZA200508247 B ZA 200508247B ZA 200508247 A ZA200508247 A ZA 200508247A ZA 200508247 A ZA200508247 A ZA 200508247A ZA 200508247 B ZA200508247 B ZA 200508247B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- compound according
- stearate
- acyl
- compound
- Prior art date
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- 230000003381 solubilizing effect Effects 0.000 title claims description 4
- 239000002736 nonionic surfactant Substances 0.000 title description 12
- 150000001875 compounds Chemical class 0.000 claims description 64
- -1 cyano, carboxy, carbamoyl Chemical group 0.000 claims description 53
- 239000000194 fatty acid Substances 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 33
- 229930195729 fatty acid Natural products 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 32
- 238000006243 chemical reaction Methods 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 24
- 239000004094 surface-active agent Substances 0.000 claims description 22
- 102000004190 Enzymes Human genes 0.000 claims description 21
- 108090000790 Enzymes Proteins 0.000 claims description 21
- 238000009472 formulation Methods 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 230000015572 biosynthetic process Effects 0.000 claims description 18
- 150000002148 esters Chemical class 0.000 claims description 18
- 125000002252 acyl group Chemical group 0.000 claims description 12
- 125000003342 alkenyl group Chemical group 0.000 claims description 12
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 12
- 101710098554 Lipase B Proteins 0.000 claims description 11
- 241001661345 Moesziomyces antarcticus Species 0.000 claims description 11
- 230000007928 solubilization Effects 0.000 claims description 11
- 238000005063 solubilization Methods 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 125000005702 oxyalkylene group Chemical group 0.000 claims description 8
- 230000003301 hydrolyzing effect Effects 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 5
- 125000004414 alkyl thio group Chemical group 0.000 claims description 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
- 230000002255 enzymatic effect Effects 0.000 claims description 5
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 125000001624 naphthyl group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 5
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 5
- 125000001424 substituent group Chemical group 0.000 claims description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000006561 solvent free reaction Methods 0.000 claims description 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 4
- 150000001346 alkyl aryl ethers Chemical class 0.000 claims 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 125000003827 glycol group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 57
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- 239000002904 solvent Substances 0.000 description 27
- 239000000047 product Substances 0.000 description 26
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 22
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical class CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 19
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- 238000001704 evaporation Methods 0.000 description 17
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 16
- 238000003756 stirring Methods 0.000 description 16
- 238000001914 filtration Methods 0.000 description 15
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- 229920006395 saturated elastomer Polymers 0.000 description 12
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- 238000004587 chromatography analysis Methods 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 230000008588 hemolysis Effects 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 10
- 229920001223 polyethylene glycol Polymers 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 9
- XXHBLSWAKHZVLN-UHFFFAOYSA-N 12-PAHSA Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CCCCCC)CCCCCCCCCCC(O)=O XXHBLSWAKHZVLN-UHFFFAOYSA-N 0.000 description 8
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 8
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- 239000011780 sodium chloride Substances 0.000 description 7
- HCUIHIKPUYHKSQ-UHFFFAOYSA-N 12-(octadecanoyloxy)octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(CCCCCC)CCCCCCCCCCC(O)=O HCUIHIKPUYHKSQ-UHFFFAOYSA-N 0.000 description 6
- JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
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- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 6
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 6
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 6
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- 238000000746 purification Methods 0.000 description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
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- UFWKRGRNASAHAQ-UHFFFAOYSA-N ethyl 12-hexadecanoyloxyoctadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CCCCCC)CCCCCCCCCCC(=O)OCC UFWKRGRNASAHAQ-UHFFFAOYSA-N 0.000 description 5
- BSMBMQPHJRPVMH-UHFFFAOYSA-N ethyl 12-octadecanoyloxyoctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(CCCCCC)CCCCCCCCCCC(=O)OCC BSMBMQPHJRPVMH-UHFFFAOYSA-N 0.000 description 5
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
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- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000658 coextraction Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- NQGIJDNPUZEBRU-UHFFFAOYSA-N dodecanoyl chloride Chemical compound CCCCCCCCCCCC(Cl)=O NQGIJDNPUZEBRU-UHFFFAOYSA-N 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- ARBOVOVUTSQWSS-UHFFFAOYSA-N hexadecanoyl chloride Chemical compound CCCCCCCCCCCCCCCC(Cl)=O ARBOVOVUTSQWSS-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229940072106 hydroxystearate Drugs 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- WTBAHSZERDXKKZ-UHFFFAOYSA-N octadecanoyl chloride Chemical compound CCCCCCCCCCCCCCCCCC(Cl)=O WTBAHSZERDXKKZ-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 239000002461 renin inhibitor Substances 0.000 description 1
- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000009475 tablet pressing Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- KMIOJWCYOHBUJS-HAKPAVFJSA-N vorolanib Chemical compound C1N(C(=O)N(C)C)CC[C@@H]1NC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C KMIOJWCYOHBUJS-HAKPAVFJSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyethers (AREA)
- Enzymes And Modification Thereof (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0301119A SE0301119D0 (sv) | 2003-04-14 | 2003-04-14 | New non-ionic surfactants for solubilizing poorly soluble molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508247B true ZA200508247B (en) | 2007-03-28 |
Family
ID=20291043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508247A ZA200508247B (en) | 2003-04-14 | 2005-10-12 | New non-ionic surfactants for solubilizing poorly soluble molecules |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7491836B2 (xx) |
| EP (1) | EP1615874B1 (xx) |
| JP (1) | JP4589917B2 (xx) |
| KR (1) | KR101091324B1 (xx) |
| CN (1) | CN1774414B (xx) |
| AU (1) | AU2004228602B2 (xx) |
| BR (1) | BRPI0408972A (xx) |
| CA (1) | CA2521612C (xx) |
| ES (1) | ES2445821T3 (xx) |
| IL (1) | IL171058A (xx) |
| MX (1) | MXPA05010893A (xx) |
| NO (1) | NO20055331L (xx) |
| NZ (1) | NZ542752A (xx) |
| SE (1) | SE0301119D0 (xx) |
| WO (1) | WO2004089869A1 (xx) |
| ZA (1) | ZA200508247B (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090280429A1 (en) * | 2008-05-08 | 2009-11-12 | Xerox Corporation | Polyester synthesis |
| GB201115634D0 (en) * | 2011-09-09 | 2011-10-26 | Univ Liverpool | Compositions of lopinavir |
| WO2013166431A1 (en) | 2012-05-03 | 2013-11-07 | Beth Isreal Deaconess Medical Center, Inc. | Lipids that increase insulin sensitivity and methods of using the same |
| EP2972399B1 (en) | 2013-03-15 | 2020-09-02 | Beth Israel Deaconess Medical Center, Inc. | Lipids that increase insulin sensitivity and methods of using the same |
| US9284583B2 (en) * | 2014-07-16 | 2016-03-15 | Eastman Chemical Company | Enzyme-catalyzed polyoxyalkylene esters |
| WO2017214527A1 (en) | 2016-06-10 | 2017-12-14 | Beth Israel Deaconess Medical Center, Inc. | Fatty acid esters of hydroxy fatty acids (fahfas) for use in the treatment of type 1 diabetes |
| CN107664676A (zh) * | 2016-07-29 | 2018-02-06 | 中国石油化工股份有限公司 | 基于增粘型乳液增溶水速率分析方法 |
| WO2020049010A1 (en) * | 2018-09-05 | 2020-03-12 | Lonza Guangzhou Nansha Ltd. | Method for making poyoxyethylene 1,4 sorbitan fatty acid ester |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2911241A1 (de) | 1979-03-22 | 1980-10-02 | Basf Ag | Alkoxylierte fettsaeuren, verfahren zu deren herstellung und ihre anwendung als loesungsvermittler |
| JPS5969135A (ja) | 1982-10-12 | 1984-04-19 | Nippon Oil & Fats Co Ltd | 可溶化または乳化剤 |
| JPS61187795A (ja) * | 1985-02-15 | 1986-08-21 | Dai Ichi Kogyo Seiyaku Co Ltd | ポリグリセリン脂肪酸エステルの製造法 |
| SK164796A3 (en) * | 1994-11-03 | 1997-06-04 | Dresden Arzneimittel | Novel cyclosporine preparation forms for oral administration of and process for producing them |
| JP3533043B2 (ja) * | 1995-06-19 | 2004-05-31 | 三菱化学株式会社 | ポリグリセリン脂肪酸エステルの曇点測定方法、該方法を用いる物性評価及び製造方法。 |
| FR2746106B1 (fr) * | 1996-03-15 | 1998-08-28 | Combustible emulsionne et l'un de ses procedes d'obtention | |
| JP3610509B2 (ja) * | 1996-03-26 | 2005-01-12 | サンノプコ株式会社 | 消泡剤 |
| DE19622214C2 (de) * | 1996-06-03 | 2000-09-28 | Cognis Deutschland Gmbh | Verwendung von Hydroxycarbonsäureestern |
| DE19851777A1 (de) * | 1998-11-10 | 2000-05-11 | Basf Ag | Verwendung von Estern oder Amiden hydroxylierter Carbonsäuren als Solubilisatoren |
-
2003
- 2003-04-14 SE SE0301119A patent/SE0301119D0/xx not_active Application Discontinuation
-
2004
- 2004-04-13 WO PCT/SE2004/000572 patent/WO2004089869A1/en not_active Ceased
- 2004-04-13 MX MXPA05010893A patent/MXPA05010893A/es active IP Right Grant
- 2004-04-13 US US10/553,275 patent/US7491836B2/en not_active Expired - Lifetime
- 2004-04-13 JP JP2006508018A patent/JP4589917B2/ja not_active Expired - Lifetime
- 2004-04-13 ES ES04727166.3T patent/ES2445821T3/es not_active Expired - Lifetime
- 2004-04-13 NZ NZ542752A patent/NZ542752A/en not_active IP Right Cessation
- 2004-04-13 CN CN2004800098771A patent/CN1774414B/zh not_active Expired - Lifetime
- 2004-04-13 AU AU2004228602A patent/AU2004228602B2/en not_active Ceased
- 2004-04-13 EP EP04727166.3A patent/EP1615874B1/en not_active Expired - Lifetime
- 2004-04-13 KR KR1020057019461A patent/KR101091324B1/ko not_active Expired - Fee Related
- 2004-04-13 CA CA2521612A patent/CA2521612C/en not_active Expired - Fee Related
- 2004-04-13 BR BRPI0408972-3A patent/BRPI0408972A/pt not_active IP Right Cessation
-
2005
- 2005-09-22 IL IL171058A patent/IL171058A/en not_active IP Right Cessation
- 2005-10-12 ZA ZA200508247A patent/ZA200508247B/en unknown
- 2005-11-11 NO NO20055331A patent/NO20055331L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004228602A1 (en) | 2004-10-21 |
| US20060287542A1 (en) | 2006-12-21 |
| NO20055331D0 (no) | 2005-11-11 |
| HK1089747A1 (en) | 2006-12-08 |
| AU2004228602B2 (en) | 2007-06-14 |
| MXPA05010893A (es) | 2005-11-25 |
| CA2521612A1 (en) | 2004-10-21 |
| NZ542752A (en) | 2007-05-31 |
| BRPI0408972A (pt) | 2006-04-04 |
| US7491836B2 (en) | 2009-02-17 |
| CN1774414A (zh) | 2006-05-17 |
| CA2521612C (en) | 2012-02-07 |
| KR20060004937A (ko) | 2006-01-16 |
| WO2004089869A1 (en) | 2004-10-21 |
| EP1615874A1 (en) | 2006-01-18 |
| JP4589917B2 (ja) | 2010-12-01 |
| NO20055331L (no) | 2006-01-16 |
| CN1774414B (zh) | 2010-12-08 |
| SE0301119D0 (sv) | 2003-04-14 |
| EP1615874B1 (en) | 2013-12-25 |
| IL171058A (en) | 2011-04-28 |
| JP2006526048A (ja) | 2006-11-16 |
| KR101091324B1 (ko) | 2011-12-07 |
| ES2445821T3 (es) | 2014-03-05 |
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