ZA200305006B - Use of -1-phenyl-3-dimethylaminopropane compounds for treating urinary incontinence - Google Patents
Use of -1-phenyl-3-dimethylaminopropane compounds for treating urinary incontinence Download PDFInfo
- Publication number
- ZA200305006B ZA200305006B ZA200305006A ZA200305006A ZA200305006B ZA 200305006 B ZA200305006 B ZA 200305006B ZA 200305006 A ZA200305006 A ZA 200305006A ZA 200305006 A ZA200305006 A ZA 200305006A ZA 200305006 B ZA200305006 B ZA 200305006B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- unsubstituted
- saturated
- dimethylamino
- singly
- Prior art date
Links
- 206010046543 Urinary incontinence Diseases 0.000 title claims description 13
- 229920006395 saturated elastomer Polymers 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 15
- 206010027566 Micturition urgency Diseases 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- -1 1-phenyl-3-dimethylaminopropane compound Chemical class 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000000335 thiazolyl group Chemical group 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 4
- UMTBGMDYYBKESP-ZWNOBZJWSA-N 3-[(2r,3r)-4-(dimethylamino)-2-hydroxy-3-methylbutan-2-yl]phenol Chemical compound CN(C)C[C@@H](C)[C@@](C)(O)C1=CC=CC(O)=C1 UMTBGMDYYBKESP-ZWNOBZJWSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- WDVAIHBIAZDPOF-UHFFFAOYSA-N 1-[1-[(dimethylamino)methyl]cyclohexyl]-1-(3-methoxyphenyl)propan-1-ol Chemical compound C1CCCCC1(CN(C)C)C(O)(CC)C1=CC=CC(OC)=C1 WDVAIHBIAZDPOF-UHFFFAOYSA-N 0.000 claims 1
- GYDHGSUDUMBHNZ-UHFFFAOYSA-N 3-(4-chlorophenyl)-1-(dimethylamino)-2-methylpentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=C(Cl)C=C1 GYDHGSUDUMBHNZ-UHFFFAOYSA-N 0.000 claims 1
- CBFGWFWDTULPPI-CXAGYDPISA-N [(2r,3r)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-yl] acetate Chemical compound CN(C)C[C@@H](C)[C@](OC(C)=O)(CC)C1=CC=CC(OC)=C1 CBFGWFWDTULPPI-CXAGYDPISA-N 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 206010021639 Incontinence Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000003708 urethra Anatomy 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 210000005070 sphincter Anatomy 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 description 1
- 206010020853 Hypertonic bladder Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- QPCVHQBVMYCJOM-UHFFFAOYSA-N Propiverine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(OCCC)C(=O)OC1CCN(C)CC1 QPCVHQBVMYCJOM-UHFFFAOYSA-N 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- 208000029162 bladder disease Diseases 0.000 description 1
- 201000000563 bladder tuberculosis Diseases 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960000855 flavoxate Drugs 0.000 description 1
- SPIUTQOUKAMGCX-UHFFFAOYSA-N flavoxate Chemical compound C1=CC=C2C(=O)C(C)=C(C=3C=CC=CC=3)OC2=C1C(=O)OCCN1CCCCC1 SPIUTQOUKAMGCX-UHFFFAOYSA-N 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960004801 imipramine Drugs 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 208000024449 overflow incontinence Diseases 0.000 description 1
- 229960005434 oxybutynin Drugs 0.000 description 1
- 230000002445 parasympatholytic effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 229960003510 propiverine Drugs 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 208000022170 stress incontinence Diseases 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10059412A DE10059412A1 (de) | 2000-11-30 | 2000-11-30 | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200305006B true ZA200305006B (en) | 2007-11-28 |
Family
ID=7665210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200305006A ZA200305006B (en) | 2000-11-30 | 2003-06-26 | Use of -1-phenyl-3-dimethylaminopropane compounds for treating urinary incontinence |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6841575B2 (fr) |
| EP (1) | EP1438034B1 (fr) |
| JP (1) | JP4284066B2 (fr) |
| KR (1) | KR100853364B1 (fr) |
| CN (1) | CN100421654C (fr) |
| AT (1) | ATE402694T1 (fr) |
| AU (2) | AU2002233210B2 (fr) |
| BR (1) | BR0115882A (fr) |
| CA (1) | CA2430332C (fr) |
| CY (1) | CY1108377T1 (fr) |
| CZ (1) | CZ20031508A3 (fr) |
| DE (2) | DE10059412A1 (fr) |
| DK (1) | DK1438034T3 (fr) |
| EC (1) | ECSP034635A (fr) |
| ES (1) | ES2311030T3 (fr) |
| HU (1) | HU228827B1 (fr) |
| IL (2) | IL156170A0 (fr) |
| MX (1) | MXPA03004712A (fr) |
| NO (1) | NO334109B1 (fr) |
| NZ (1) | NZ526603A (fr) |
| PL (1) | PL205081B1 (fr) |
| PT (1) | PT1438034E (fr) |
| RU (1) | RU2286768C2 (fr) |
| SI (1) | SI1438034T1 (fr) |
| SK (1) | SK287420B6 (fr) |
| UA (1) | UA74608C2 (fr) |
| WO (1) | WO2002043715A2 (fr) |
| ZA (1) | ZA200305006B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
| DE10224108A1 (de) * | 2002-05-29 | 2004-01-29 | Grünenthal GmbH | 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung |
| US7410965B2 (en) | 2002-05-29 | 2008-08-12 | Gruenenthal Gmbh | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol |
| DE10224624A1 (de) * | 2002-05-30 | 2003-12-11 | Gruenenthal Gmbh | Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol |
| DE10224556A1 (de) * | 2002-05-31 | 2004-01-08 | Grünenthal GmbH | 1-Dimethylamino- 3-(3-methoxy-phenyl)2-methyl-pentan-3-ol entaltendes Arzneimittel in verschiedenen Formulierungen |
| DE10225315A1 (de) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol |
| ES2640404T3 (es) | 2002-11-22 | 2017-11-02 | Grünenthal GmbH | Combinación de analgésicos seleccionados con inhibidores de la COX II |
| WO2010028088A2 (fr) * | 2008-09-05 | 2010-03-11 | Acucela, Inc. | Composants à liaison soufre pour le traitement de maladies et de troubles ophtalmiques |
| US8853393B2 (en) | 2011-07-29 | 2014-10-07 | Anhui New Star Pharmaceutical Development Co., Ltd. | Intermediate for preparing tapentadol or analogues thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213219B (it) * | 1984-09-28 | 1989-12-14 | Consiglio Nazionale Ricerche | Derivati amminoalchilnaftalenici ad attivita' farmacologica. |
| SE9202218D0 (sv) * | 1992-07-22 | 1992-07-22 | Kabi Pharmacia Ab | Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| US5561154A (en) * | 1994-07-27 | 1996-10-01 | Institut De Recherches Chimiques Et Bioloques Appliquees Irceba | Treatment of acute urinary retention |
| WO1998046216A1 (fr) * | 1997-04-11 | 1998-10-22 | Nippon Shinyaku Co., Ltd. | Traitements des mictions frequentes et de l'incontinence urinaire |
| DE19933421A1 (de) * | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
-
2000
- 2000-11-30 DE DE10059412A patent/DE10059412A1/de not_active Withdrawn
-
2001
- 2001-11-28 SK SK663-2003A patent/SK287420B6/sk not_active IP Right Cessation
- 2001-11-28 IL IL15617001A patent/IL156170A0/xx active IP Right Grant
- 2001-11-28 UA UA2003066043A patent/UA74608C2/uk unknown
- 2001-11-28 WO PCT/EP2001/013918 patent/WO2002043715A2/fr not_active Ceased
- 2001-11-28 RU RU2003117707/15A patent/RU2286768C2/ru not_active IP Right Cessation
- 2001-11-28 ES ES01984781T patent/ES2311030T3/es not_active Expired - Lifetime
- 2001-11-28 PT PT01984781T patent/PT1438034E/pt unknown
- 2001-11-28 AU AU2002233210A patent/AU2002233210B2/en not_active Ceased
- 2001-11-28 CN CNB018223478A patent/CN100421654C/zh not_active Expired - Fee Related
- 2001-11-28 CZ CZ20031508A patent/CZ20031508A3/cs unknown
- 2001-11-28 BR BR0115882-1A patent/BR0115882A/pt not_active Application Discontinuation
- 2001-11-28 DE DE50114181T patent/DE50114181D1/de not_active Expired - Lifetime
- 2001-11-28 CA CA2430332A patent/CA2430332C/fr not_active Expired - Fee Related
- 2001-11-28 MX MXPA03004712A patent/MXPA03004712A/es active IP Right Grant
- 2001-11-28 PL PL366051A patent/PL205081B1/pl unknown
- 2001-11-28 KR KR1020037007270A patent/KR100853364B1/ko not_active Expired - Fee Related
- 2001-11-28 SI SI200130874T patent/SI1438034T1/sl unknown
- 2001-11-28 DK DK01984781T patent/DK1438034T3/da active
- 2001-11-28 AT AT01984781T patent/ATE402694T1/de active
- 2001-11-28 JP JP2002545686A patent/JP4284066B2/ja not_active Expired - Fee Related
- 2001-11-28 HU HU0302430A patent/HU228827B1/hu not_active IP Right Cessation
- 2001-11-28 NZ NZ526603A patent/NZ526603A/en not_active IP Right Cessation
- 2001-11-28 EP EP01984781A patent/EP1438034B1/fr not_active Expired - Lifetime
- 2001-11-28 AU AU3321002A patent/AU3321002A/xx active Pending
-
2003
- 2003-05-27 NO NO20032406A patent/NO334109B1/no not_active IP Right Cessation
- 2003-05-28 IL IL156170A patent/IL156170A/en not_active IP Right Cessation
- 2003-05-30 US US10/448,454 patent/US6841575B2/en not_active Expired - Fee Related
- 2003-05-30 EC EC2003004635A patent/ECSP034635A/es unknown
- 2003-06-26 ZA ZA200305006A patent/ZA200305006B/en unknown
-
2008
- 2008-09-25 CY CY20081101059T patent/CY1108377T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200305006B (en) | Use of -1-phenyl-3-dimethylaminopropane compounds for treating urinary incontinence | |
| ZA200304999B (en) | Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence. | |
| CA2430279C (fr) | Utilisation de composes 6-dimethylaminomethyle-1-phenyl-cyclohexane pour traiter l'incontinence urinaire |