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YU59298A - Postupak za dobijanje fenil heterociklusa korisnih kao inhibitora cox-2 - Google Patents

Postupak za dobijanje fenil heterociklusa korisnih kao inhibitora cox-2

Info

Publication number
YU59298A
YU59298A YU59298A YU59298A YU59298A YU 59298 A YU59298 A YU 59298A YU 59298 A YU59298 A YU 59298A YU 59298 A YU59298 A YU 59298A YU 59298 A YU59298 A YU 59298A
Authority
YU
Yugoslavia
Prior art keywords
cox
inhibitors
preparing phenyl
phenyl heterocycles
heterocycles useful
Prior art date
Application number
YU59298A
Other languages
English (en)
Inventor
Richard Desmond
Ulf H. Dolling
Lisa F. Frey
Richard D. Tillyer
David M. Tschaen
Original Assignee
Merck & Co.Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co.Inc. filed Critical Merck & Co.Inc.
Publication of YU59298A publication Critical patent/YU59298A/sh
Publication of RS49591B publication Critical patent/RS49591B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Pronalazak obuhvata postupak za dobijanje jedinjenja formule I korisnih u tretiranju inflamacija i drugih bolesti prouzrokovanih ciklooksigenazom-2.
YUP-592/98A 1996-07-03 1997-06-27 Postupak za dobijanje fenil heterociklusa korisnih kao inhibitora cox-2 RS49591B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2120096P 1996-07-03 1996-07-03
GBGB9615867.0A GB9615867D0 (en) 1996-07-03 1996-07-29 Process of preparing phenyl heterocycles useful as cox-2 inhibitors

Publications (2)

Publication Number Publication Date
YU59298A true YU59298A (sh) 2000-03-21
RS49591B RS49591B (sr) 2007-06-04

Family

ID=26309770

Country Status (25)

Country Link
US (1) US5840924A (sh)
EP (1) EP0912537B1 (sh)
JP (1) JP3071472B2 (sh)
CN (1) CN1097046C (sh)
AR (1) AR007695A1 (sh)
AT (1) ATE266651T1 (sh)
AU (1) AU717835B2 (sh)
BR (1) BR9710099A (sh)
CA (1) CA2258048C (sh)
CZ (1) CZ297257B6 (sh)
DE (1) DE69729096T2 (sh)
DK (1) DK0912537T3 (sh)
EA (1) EA001629B1 (sh)
ES (1) ES2218691T3 (sh)
GB (1) GB9615867D0 (sh)
HR (1) HRP970351B1 (sh)
HU (1) HU224840B1 (sh)
NZ (1) NZ333379A (sh)
PL (1) PL195025B1 (sh)
PT (1) PT912537E (sh)
RS (1) RS49591B (sh)
SK (1) SK283997B6 (sh)
TW (1) TW419474B (sh)
UA (1) UA57029C2 (sh)
WO (1) WO1998000416A1 (sh)

Families Citing this family (24)

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US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
JP2002506024A (ja) * 1998-03-13 2002-02-26 メルク エンド カムパニー インコーポレーテッド 急性冠動脈虚血症候群および関連状態に対する併用療法および組成物
US6031108A (en) * 1998-09-16 2000-02-29 Bayer Corporation Process for the preparation of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone)
US6649645B1 (en) * 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US6686390B2 (en) * 2000-05-22 2004-02-03 Dr. Reddy's Laboratories Limited Compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
US20060167074A1 (en) * 2001-06-19 2006-07-27 Norbert Muller Methods and compositions for the treatment of psychiatric disorders
DE10129320A1 (de) * 2001-06-19 2003-04-10 Norbert Mueller Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen
US7049459B2 (en) * 2001-10-10 2006-05-23 Shasun Chemicals And Drugs Limited 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and a process for preparing the same
IL162726A0 (en) * 2002-01-10 2005-11-20 Pharmacia & Upjohn Co Llc Use of cox-2 inhibitors in combination with antiviral agents for the treatment of papilloma virus infections
TW200403072A (en) * 2002-01-23 2004-03-01 Upjohn Co Combination therapy for the treatment of bacterial infections
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US20040220155A1 (en) * 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
PT1745791E (pt) * 2003-05-07 2013-07-23 Osteologix As Tratamento de afeções cartilagíneas/ósseas com sais de estrôncio hidrossolúveis
DE602004002832T2 (de) * 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
US20050014729A1 (en) * 2003-07-16 2005-01-20 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
US20050113409A1 (en) * 2003-09-03 2005-05-26 Pharmacia Corporation Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith
EP2494992A1 (en) 2004-08-24 2012-09-05 Merck Sharp & Dohme Corp. Combination therapy for treating cyclooxygenase-2 mediated diseases or conditions in patients at risk of thrombotic cardiovascular events
CA2607913C (en) * 2005-05-05 2014-03-18 Cook Biotech Incorporated Implantable materials and methods for inhibiting tissue adhesion formation
CN104774186A (zh) * 2015-04-28 2015-07-15 江苏中旗作物保护股份有限公司 农药除草剂异恶唑草酮的合成方法
WO2018049014A1 (en) 2016-09-07 2018-03-15 Trustees Of Tufts College Dash inhibitors, and uses related thereto
CN113660934A (zh) 2018-11-21 2021-11-16 特默罗制药股份有限公司 罗非昔布的纯化形式、制备方法和用途
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5916884A (ja) * 1982-07-19 1984-01-28 Fujisawa Pharmaceut Co Ltd 新規フラン化合物
US4968817A (en) * 1984-07-27 1990-11-06 National Distillers And Chemical Corporation Manufacture of gamma-crotonolactone by carbonylation of glycidol
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
DE3718527A1 (de) * 1987-06-03 1988-12-15 Basf Ag Verfahren zur herstellung von 2(5h)-furanonen
US5207817A (en) * 1989-09-23 1993-05-04 Bayer Aktiengesellschaft Herbicidal 5H-furan-2-one derivatives
DE4014420A1 (de) * 1989-09-23 1991-04-04 Bayer Ag 5h-furan-2-on-derivate
AU7559691A (en) * 1990-04-17 1991-11-11 Allergan, Inc. 2(5h)-furanones substituted in the 5 and or in the 4 position, as anti-inflammatory agents
US5393150A (en) * 1991-09-05 1995-02-28 Fort; Chris Bifurcated keyboard arrangement
IT1254558B (it) * 1992-03-26 1995-09-25 Mini Ricerca Scient Tecnolog Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3
EP0679157B1 (en) * 1993-01-15 1997-11-19 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
KR960703901A (ko) * 1993-08-19 1996-08-31 로즈 암스트롱 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists)
CN1143365A (zh) * 1994-01-10 1997-02-19 麦克弗罗斯特(加拿大)有限公司 作为cox-2抑制剂的苯基杂环类化合物
US5475995A (en) * 1994-05-16 1995-12-19 Livingston; George G. Truck spare tire locking rod

Also Published As

Publication number Publication date
PL195025B1 (pl) 2007-08-31
SK179398A3 (en) 2000-04-10
CZ297257B6 (cs) 2006-10-11
SK283997B6 (sk) 2004-07-07
EA199900079A1 (ru) 1999-06-24
PL330750A1 (en) 1999-05-24
CA2258048C (en) 2006-08-15
BR9710099A (pt) 1999-08-10
AU717835B2 (en) 2000-04-06
JP3071472B2 (ja) 2000-07-31
GB9615867D0 (en) 1996-09-11
NZ333379A (en) 2000-09-29
EP0912537A1 (en) 1999-05-06
ATE266651T1 (de) 2004-05-15
HUP9903836A2 (hu) 2001-05-28
DK0912537T3 (da) 2004-08-30
EP0912537B1 (en) 2004-05-12
TW419474B (en) 2001-01-21
HRP970351A2 (en) 1998-06-30
EA001629B1 (ru) 2001-06-25
WO1998000416A1 (en) 1998-01-08
CA2258048A1 (en) 1998-01-08
JPH11514002A (ja) 1999-11-30
CZ436898A3 (cs) 1999-06-16
RS49591B (sr) 2007-06-04
AU3588697A (en) 1998-01-21
DE69729096T2 (de) 2005-04-28
DE69729096D1 (de) 2004-06-17
PT912537E (pt) 2004-08-31
HUP9903836A3 (en) 2001-06-28
CN1224422A (zh) 1999-07-28
HK1017355A1 (en) 1999-11-19
UA57029C2 (uk) 2003-06-16
US5840924A (en) 1998-11-24
CN1097046C (zh) 2002-12-25
ES2218691T3 (es) 2004-11-16
HRP970351B1 (en) 2003-02-28
HU224840B1 (en) 2006-03-28
AR007695A1 (es) 1999-11-10

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