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HRP970351B1 - Process of preparing phenyl heterocycles useful as cox-2 inhibitors - Google Patents

Process of preparing phenyl heterocycles useful as cox-2 inhibitors

Info

Publication number
HRP970351B1
HRP970351B1 HR970351A HRP970351A HRP970351B1 HR P970351 B1 HRP970351 B1 HR P970351B1 HR 970351 A HR970351 A HR 970351A HR P970351 A HRP970351 A HR P970351A HR P970351 B1 HRP970351 B1 HR P970351B1
Authority
HR
Croatia
Prior art keywords
cox
inhibitors
preparing phenyl
phenyl heterocycles
heterocycles useful
Prior art date
Application number
HR970351A
Other languages
English (en)
Inventor
Richard Desmond
Ulf H Dolling
Lisa F Frey
Richard D Tillyer
David M Tschaen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP970351A2 publication Critical patent/HRP970351A2/hr
Publication of HRP970351B1 publication Critical patent/HRP970351B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
HR970351A 1996-07-03 1997-06-27 Process of preparing phenyl heterocycles useful as cox-2 inhibitors HRP970351B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2120096P 1996-07-03 1996-07-03
GBGB9615867.0A GB9615867D0 (en) 1996-07-03 1996-07-29 Process of preparing phenyl heterocycles useful as cox-2 inhibitors

Publications (2)

Publication Number Publication Date
HRP970351A2 HRP970351A2 (en) 1998-06-30
HRP970351B1 true HRP970351B1 (en) 2003-02-28

Family

ID=26309770

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970351A HRP970351B1 (en) 1996-07-03 1997-06-27 Process of preparing phenyl heterocycles useful as cox-2 inhibitors

Country Status (25)

Country Link
US (1) US5840924A (xx)
EP (1) EP0912537B1 (xx)
JP (1) JP3071472B2 (xx)
CN (1) CN1097046C (xx)
AR (1) AR007695A1 (xx)
AT (1) ATE266651T1 (xx)
AU (1) AU717835B2 (xx)
BR (1) BR9710099A (xx)
CA (1) CA2258048C (xx)
CZ (1) CZ297257B6 (xx)
DE (1) DE69729096T2 (xx)
DK (1) DK0912537T3 (xx)
EA (1) EA001629B1 (xx)
ES (1) ES2218691T3 (xx)
GB (1) GB9615867D0 (xx)
HR (1) HRP970351B1 (xx)
HU (1) HU224840B1 (xx)
NZ (1) NZ333379A (xx)
PL (1) PL195025B1 (xx)
PT (1) PT912537E (xx)
RS (1) RS49591B (xx)
SK (1) SK283997B6 (xx)
TW (1) TW419474B (xx)
UA (1) UA57029C2 (xx)
WO (1) WO1998000416A1 (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
WO1999045913A1 (en) * 1998-03-13 1999-09-16 Merck & Co., Inc. Combination therapy and composition for acute coronary ischemic syndrome and related conditions
US6031108A (en) * 1998-09-16 2000-02-29 Bayer Corporation Process for the preparation of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone)
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
AU2001258677A1 (en) * 2000-05-22 2001-12-03 Dr. Reddy's Research Foundation Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them
US20060167074A1 (en) * 2001-06-19 2006-07-27 Norbert Muller Methods and compositions for the treatment of psychiatric disorders
DE10129320A1 (de) * 2001-06-19 2003-04-10 Norbert Mueller Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen
AU2002214243A1 (en) * 2001-10-10 2003-04-22 Shasun Chemicals And Drugs Limited 1-((4-methyl thio)phenyl)-2-(phenyl acetoxy)-1-ethanone and a process for preparing the same
MXPA04006572A (es) * 2002-01-10 2005-11-04 Upjohn Co Terapia de combinacion antivirica.
TW200403072A (en) * 2002-01-23 2004-03-01 Upjohn Co Combination therapy for the treatment of bacterial infections
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US20040220155A1 (en) * 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
EP1534305B9 (en) * 2003-05-07 2007-03-07 Osteologix A/S Treating cartilage / bone conditions with water-soluble strontium salts
PT2266585E (pt) * 2003-05-07 2013-07-09 Osteologix As Sais de estrôncio hidrossolúveis para uso no tratamento de afeções cartilagíneas e/ou ósseas
WO2005009342A2 (en) * 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
US20050113409A1 (en) * 2003-09-03 2005-05-26 Pharmacia Corporation Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith
EP1784179A4 (en) 2004-08-24 2010-03-31 Merck Sharp & Dohme COMBINATION THERAPY FOR THE TREATMENT OF CYCLOOXYGENASE-2-MEDIATED DISEASES OR CONDITIONS IN PATIENTS WITH RISK TO THROMBOTIC CARDIOVASCULAR EVENTS
AU2006244393B2 (en) * 2005-05-05 2012-06-21 Cook Biotech Incorporated Implantable materials and methods for inhibiting tissue adhesion formation
CN104774186A (zh) * 2015-04-28 2015-07-15 江苏中旗作物保护股份有限公司 农药除草剂异恶唑草酮的合成方法
WO2018049027A1 (en) 2016-09-07 2018-03-15 Trustees Of Tufts College Combination therapies using immuno-dash inhibitors and pge2 antagonists
MX2021005967A (es) 2018-11-21 2021-10-13 Tremeau Pharmaceuticals Inc Formas purificadas de rofecoxib, métodos de fabricación y uso.
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5916884A (ja) * 1982-07-19 1984-01-28 Fujisawa Pharmaceut Co Ltd 新規フラン化合物
US4968817A (en) * 1984-07-27 1990-11-06 National Distillers And Chemical Corporation Manufacture of gamma-crotonolactone by carbonylation of glycidol
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
DE3718527A1 (de) * 1987-06-03 1988-12-15 Basf Ag Verfahren zur herstellung von 2(5h)-furanonen
DE4014420A1 (de) * 1989-09-23 1991-04-04 Bayer Ag 5h-furan-2-on-derivate
US5207817A (en) * 1989-09-23 1993-05-04 Bayer Aktiengesellschaft Herbicidal 5H-furan-2-one derivatives
CA2078771A1 (en) * 1990-04-17 1991-10-18 Gary C. M. Lee 2(5h)-furanones substituted in the 5 and or in the 4 position, as anti-inflammatory agents
US5393150A (en) * 1991-09-05 1995-02-28 Fort; Chris Bifurcated keyboard arrangement
IT1254558B (it) * 1992-03-26 1995-09-25 Mini Ricerca Scient Tecnolog Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3
WO1994015932A1 (en) * 1993-01-15 1994-07-21 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
SK20396A3 (en) * 1993-08-19 1997-03-05 Warner Lambert Co Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base
EP0739340A1 (en) * 1994-01-10 1996-10-30 Merck Frosst Canada Inc. Phenyl heterocycles as cox-2 inhibitors
US5475995A (en) * 1994-05-16 1995-12-19 Livingston; George G. Truck spare tire locking rod

Also Published As

Publication number Publication date
BR9710099A (pt) 1999-08-10
CZ297257B6 (cs) 2006-10-11
CA2258048C (en) 2006-08-15
AU3588697A (en) 1998-01-21
PL330750A1 (en) 1999-05-24
EP0912537A1 (en) 1999-05-06
JP3071472B2 (ja) 2000-07-31
CZ436898A3 (cs) 1999-06-16
EP0912537B1 (en) 2004-05-12
JPH11514002A (ja) 1999-11-30
TW419474B (en) 2001-01-21
DE69729096T2 (de) 2005-04-28
ATE266651T1 (de) 2004-05-15
AR007695A1 (es) 1999-11-10
RS49591B (sr) 2007-06-04
HRP970351A2 (en) 1998-06-30
GB9615867D0 (en) 1996-09-11
ES2218691T3 (es) 2004-11-16
US5840924A (en) 1998-11-24
EA199900079A1 (ru) 1999-06-24
SK179398A3 (en) 2000-04-10
PT912537E (pt) 2004-08-31
DK0912537T3 (da) 2004-08-30
YU59298A (sh) 2000-03-21
NZ333379A (en) 2000-09-29
CN1097046C (zh) 2002-12-25
DE69729096D1 (de) 2004-06-17
HUP9903836A3 (en) 2001-06-28
HUP9903836A2 (hu) 2001-05-28
CN1224422A (zh) 1999-07-28
CA2258048A1 (en) 1998-01-08
EA001629B1 (ru) 2001-06-25
HK1017355A1 (en) 1999-11-19
SK283997B6 (sk) 2004-07-07
AU717835B2 (en) 2000-04-06
UA57029C2 (uk) 2003-06-16
PL195025B1 (pl) 2007-08-31
HU224840B1 (en) 2006-03-28
WO1998000416A1 (en) 1998-01-08

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20110621

Year of fee payment: 15

PBON Lapse due to non-payment of renewal fee

Effective date: 20120628