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YU49221B - Novi derivati eritromicina, postupak za njihovo dobivanje i njihova primena kao lekova - Google Patents

Novi derivati eritromicina, postupak za njihovo dobivanje i njihova primena kao lekova

Info

Publication number
YU49221B
YU49221B YU21695A YU21695A YU49221B YU 49221 B YU49221 B YU 49221B YU 21695 A YU21695 A YU 21695A YU 21695 A YU21695 A YU 21695A YU 49221 B YU49221 B YU 49221B
Authority
YU
Yugoslavia
Prior art keywords
carbon atoms
hydrogen atom
heteroatoms
medicines
procedure
Prior art date
Application number
YU21695A
Other languages
English (en)
Other versions
YU21695A (sh
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel-Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel-Uclaf filed Critical Roussel-Uclaf
Publication of YU21695A publication Critical patent/YU21695A/sh
Publication of YU49221B publication Critical patent/YU49221B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Jedinjenja opšte formule (I): gde: ili R1 i R2, su identični ili različiti, predstavljaju atom vodonika ili ugljovodonični radikal koji može da ima najviše 24 atoma ugljenika, zasićenih ili nezasićenih, eventualno prekinuti sa jednim ili više heteroatoma i koji po potrebi imaju jednu ili više funkcionalnih grupa, ili R1 i R2, sa atomom azota za koji su vezani, grade heterocikl koji po potrebi sadrži jedan ili više heteroatoma odabranih od azota, kiseonika i sumpora, ili R1 i R2, zajedno grade radikal gde R'1 i R'2, su isti ili različiti, predstavljaju atom vodonika ili ugljovodonični radikal sa najviše 23 atoma ugljenika, zasićenih ili nezasićenih, po potrebi prekinut sa jednim ili više heteroatoma, i koji nosi još jednu ili više funkcionalnih grupa, a Z predstavlja atom vodonika ili ostatak karboksilne kiseline koji može imati do 18 atoma ugljenika, krivudava crta na položaju 10 označava da metil može biti R ili S konfiguracije ili smeša R i S konfiguracija, kao i njegove adicione soli sa kiselinama jedinjenja formule (I). Prijava sadrži još 2 nezavisna zahteva i 18 zavisnih zahteva.
YU21695A 1994-04-08 1995-04-05 Novi derivati eritromicina, postupak za njihovo dobivanje i njihova primena kao lekova YU49221B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
YU21695A YU21695A (sh) 1997-12-05
YU49221B true YU49221B (sh) 2004-11-25

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
YU21695A YU49221B (sh) 1994-04-08 1995-04-05 Novi derivati eritromicina, postupak za njihovo dobivanje i njihova primena kao lekova

Country Status (49)

Country Link
US (2) US5656607A (sh)
EP (1) EP0676409B1 (sh)
JP (1) JP3000023B2 (sh)
KR (1) KR100317148B1 (sh)
CN (1) CN1059445C (sh)
AP (1) AP587A (sh)
AT (1) ATE234853T1 (sh)
AU (1) AU684939B2 (sh)
BG (1) BG61916B1 (sh)
BR (1) BR9506147A (sh)
CA (1) CA2164638C (sh)
CO (1) CO4370097A1 (sh)
CZ (1) CZ296005B6 (sh)
DE (1) DE69529934T2 (sh)
DK (1) DK0676409T3 (sh)
DZ (1) DZ1869A1 (sh)
EE (1) EE04498B1 (sh)
ES (1) ES2189820T3 (sh)
FI (1) FI111264B (sh)
FR (1) FR2718450B1 (sh)
GB (1) GB2288174A (sh)
GE (1) GEP19991836B (sh)
HR (1) HRP950217B1 (sh)
HU (1) HU215396B (sh)
IL (1) IL112954A (sh)
IS (1) IS1865B (sh)
JO (1) JO1850B1 (sh)
LV (1) LV11182B (sh)
MA (1) MA23501A1 (sh)
MD (1) MD663G2 (sh)
MY (1) MY114672A (sh)
NO (1) NO308361B1 (sh)
NZ (1) NZ284498A (sh)
OA (1) OA10200A (sh)
PE (1) PE2896A1 (sh)
PL (1) PL180837B1 (sh)
PT (1) PT676409E (sh)
RO (1) RO115634B1 (sh)
RU (1) RU2141965C1 (sh)
SA (1) SA97170757A (sh)
SI (1) SI0676409T1 (sh)
SK (1) SK284079B6 (sh)
SV (1) SV1995000018A (sh)
TN (1) TNSN95026A1 (sh)
TW (1) TW316908B (sh)
UA (1) UA44705C2 (sh)
WO (1) WO1995027720A1 (sh)
YU (1) YU49221B (sh)
ZA (1) ZA952059B (sh)

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FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
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FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
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FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
KR20020007374A (ko) * 1999-04-16 2002-01-26 추후제출 매크롤라이드 항감염제
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US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
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ES2564097T3 (es) 2010-03-22 2016-03-17 Cempra Pharmaceuticals, Inc. Formas cristalinas de un macrólido, y usos de las mismas
ES2636948T3 (es) 2010-05-20 2017-10-10 Cempra Pharmaceuticals, Inc. Procesos para preparar macrólidos y cetólidos e intermediarios para los mismos
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IN2014DN08939A (sh) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CN105163785A (zh) 2013-03-14 2015-12-16 森普拉制药公司 用于治疗呼吸道疾病的方法及其制剂
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Also Published As

Publication number Publication date
AU2310795A (en) 1995-10-30
AU684939B2 (en) 1998-01-08
FI955913A0 (fi) 1995-12-08
DK0676409T3 (da) 2003-06-23
US5760233A (en) 1998-06-02
RO115634B1 (ro) 2000-04-28
US5656607A (en) 1997-08-12
TW316908B (sh) 1997-10-01
LV11182A (lv) 1996-04-20
CA2164638A1 (fr) 1995-10-19
DE69529934D1 (de) 2003-04-24
MA23501A1 (fr) 1995-12-31
JP3000023B2 (ja) 2000-01-17
CZ296005B6 (cs) 2005-12-14
FI111264B (fi) 2003-06-30
OA10200A (fr) 1996-12-18
LV11182B (en) 1997-04-20
BR9506147A (pt) 1996-04-16
SA97170757A (ar) 2005-12-03
SV1995000018A (es) 1997-10-24
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
RU2141965C1 (ru) 1999-11-27
CO4370097A1 (es) 1996-10-07
GEP19991836B (en) 1999-11-05
PL180837B1 (pl) 2001-04-30
CN1126997A (zh) 1996-07-17
FI955913A7 (fi) 1995-12-08
CN1059445C (zh) 2000-12-13
MD663G2 (ro) 1997-07-31
MY114672A (en) 2002-12-31
EP0676409A1 (fr) 1995-10-11
EE9500080A (et) 1996-12-16
GB9506856D0 (en) 1995-05-24
NO954942D0 (no) 1995-12-06
GB2288174A (en) 1995-10-11
WO1995027720A1 (fr) 1995-10-19
IL112954A (en) 2000-07-16
HRP950217B1 (en) 2004-06-30
NO954942L (no) 1996-02-07
IL112954A0 (en) 1995-06-29
YU21695A (sh) 1997-12-05
UA44705C2 (uk) 2002-03-15
FR2718450B1 (fr) 1997-01-10
SI0676409T1 (en) 2003-06-30
CA2164638C (fr) 2003-12-30
HU9503505D0 (en) 1996-02-28
IS1865B (is) 2003-05-02
ES2189820T3 (es) 2003-07-16
DZ1869A1 (fr) 2002-02-17
SK154695A3 (en) 1996-10-02
PL311871A1 (en) 1996-03-18
HRP950217A2 (en) 1997-08-31
NO308361B1 (no) 2000-09-04
JPH07278177A (ja) 1995-10-24
SK284079B6 (sk) 2004-09-08
KR100317148B1 (ko) 2002-06-22
CZ322395A3 (en) 1996-08-14
IS4309A (is) 1995-11-17
NZ284498A (en) 1997-07-27
AP9500743A0 (en) 1995-07-31
BG61916B1 (bg) 1998-09-30
HU215396B (hu) 1998-12-28
ZA952059B (en) 1996-03-13
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
TNSN95026A1 (fr) 1996-02-06
PT676409E (pt) 2003-08-29
PE2896A1 (es) 1996-02-12
BG100150A (bg) 1996-06-28
MD663F1 (ro) 1997-01-31
FR2718450A1 (fr) 1995-10-13
EE04498B1 (et) 2005-06-15
AP587A (en) 1997-04-29
DE69529934T2 (de) 2003-09-04

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