PT676409E - Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos - Google Patents

Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos

Info

Publication number: PT676409E
Authority: PT; Portugal
Prior art keywords: erythromycine; medicines; application; preparation process; new derivatives
Prior art date: 1994-04-08

Application number

PT95400763T

Other languages

English (en)

Inventor

Alexis Denis

Constantin Agouridas

Jean-Francois Chantot

Yannick Benedetti

Odile Le Martret

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-08

Filing date

1995-04-06

Publication date

2003-08-29

1995-04-06 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2003-08-29 Publication of PT676409E publication Critical patent/PT676409E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT95400763T 1994-04-08 1995-04-06 Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos PT676409E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9404154A FR2718450B1 (fr)	1994-04-08	1994-04-08	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number	Publication Date
PT676409E true PT676409E (pt)	2003-08-29

Family

ID=9461886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95400763T PT676409E (pt)	1994-04-08	1995-04-06	Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos

Country Status (49)

Country	Link
US (2)	US5656607A (pt)
EP (1)	EP0676409B1 (pt)
JP (1)	JP3000023B2 (pt)
KR (1)	KR100317148B1 (pt)
CN (1)	CN1059445C (pt)
AP (1)	AP587A (pt)
AT (1)	ATE234853T1 (pt)
AU (1)	AU684939B2 (pt)
BG (1)	BG61916B1 (pt)
BR (1)	BR9506147A (pt)
CA (1)	CA2164638C (pt)
CO (1)	CO4370097A1 (pt)
CZ (1)	CZ296005B6 (pt)
DE (1)	DE69529934T2 (pt)
DK (1)	DK0676409T3 (pt)
DZ (1)	DZ1869A1 (pt)
EE (1)	EE04498B1 (pt)
ES (1)	ES2189820T3 (pt)
FI (1)	FI111264B (pt)
FR (1)	FR2718450B1 (pt)
GB (1)	GB2288174A (pt)
GE (1)	GEP19991836B (pt)
HR (1)	HRP950217B1 (pt)
HU (1)	HU215396B (pt)
IL (1)	IL112954A (pt)
IS (1)	IS1865B (pt)
JO (1)	JO1850B1 (pt)
LV (1)	LV11182B (pt)
MA (1)	MA23501A1 (pt)
MD (1)	MD663G2 (pt)
MY (1)	MY114672A (pt)
NO (1)	NO308361B1 (pt)
NZ (1)	NZ284498A (pt)
OA (1)	OA10200A (pt)
PE (1)	PE2896A1 (pt)
PL (1)	PL180837B1 (pt)
PT (1)	PT676409E (pt)
RO (1)	RO115634B1 (pt)
RU (1)	RU2141965C1 (pt)
SA (1)	SA97170757A (pt)
SI (1)	SI0676409T1 (pt)
SK (1)	SK284079B6 (pt)
SV (1)	SV1995000018A (pt)
TN (1)	TNSN95026A1 (pt)
TW (1)	TW316908B (pt)
UA (1)	UA44705C2 (pt)
WO (1)	WO1995027720A1 (pt)
YU (1)	YU49221B (pt)
ZA (1)	ZA952059B (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2732023B1 (fr) *	1995-03-22	1997-04-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) *	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) *	1996-02-28	1998-05-29	Roussel Uclaf	Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) *	1997-04-04	1998-05-12	Abbott Laboratories	3-descladinose-2,3-anhydroerythromycin derivatives
CA2253451A1 (en) *	1996-05-07	1997-11-13	Abbott Laboratories	3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) *	1996-05-14	1998-08-14	Hoechst Marion Roussel Inc	Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) *	1996-07-24	1998-10-16	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
EP1291351B1 (en) *	1996-09-04	2005-07-13	Abbott Laboratories	6-0 substituted ketolides having antibacterial activity
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) *	1996-12-12	1999-06-11	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) *	1997-02-27	1999-04-30	Hoechst Marion Roussel Inc	Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
WO1998040392A1 (fr) *	1997-03-10	1998-09-17	Taisho Pharmaceutical Co., Ltd.	Derives d'erythromycine a
AU6421398A (en) *	1997-03-24	1998-10-20	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives
AU6932098A (en) *	1997-05-09	1998-12-08	Pfizer Products Inc.	Erythromycin derivatives
US5922683A (en) *	1997-05-29	1999-07-13	Abbott Laboratories	Multicyclic erythromycin derivatives
PL337606A1 (en) *	1997-06-11	2000-08-28	Pfizer Prod Inc	Derivatives of erythromycin 9-oxime
FR2771008B1 (fr) *	1997-11-17	2000-04-28	Hoechst Marion Roussel Inc	Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) *	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
HRP980189B1 (en) *	1998-04-06	2004-04-30	Pliva Pharm & Chem Works	Novel 15-membered lactams ketolides
ES2243066T3 (es) *	1998-09-22	2005-11-16	Pfizer Products Inc.	Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) *	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1749832A3 (en) *	1998-12-10	2008-03-26	Pfizer Products Incorporated	Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) *	1998-12-10	2006-11-02	Pfizer Products Inc.	Carbamate and Carbazate Ketolide Antibiotics
AU6484199A (en)	1998-12-10	2000-06-26	Pfizer Products Inc.	Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) *	1999-02-04	2001-10-05	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
US6395710B1 (en) *	1999-04-16	2002-05-28	Kosan Biosciences, Inc.	Macrolide antiinfective agents
CN1373767A (zh)	1999-04-16	2002-10-09	奥索-麦克尼尔药品公司	酮式大环内酯抗菌剂
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
KR20020016799A (ko) *	1999-05-24	2002-03-06	데이비드 존 우드	13-메틸-에리트로마이신 유도체
CA2451391A1 (en)	2001-07-03	2003-01-16	Chiron Corporation	C12 modified erythromycin macrolides and ketolides having antibacterial activity
US7332304B2 (en)	2002-07-01	2008-02-19	Arkion Life Sciences Llc	Process and materials for production of glucosamine and N-acetylglucosamine
CA2529817C (en)	2003-03-10	2013-02-12	Optimer Pharmaceuticals, Inc.	Novel antibacterial agents
US7332476B2 (en) *	2003-04-25	2008-02-19	Novartis Ag	Pyridyl substituted ketolide antibiotics
JP2006524706A (ja) *	2003-04-25	2006-11-02	カイロンコーポレイション	新規なケトライド誘導体
AU2008316830B2 (en) *	2007-10-25	2016-03-17	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
WO2010048600A1 (en) *	2008-10-24	2010-04-29	Cempra Pharmaceuticals, Inc.	Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
US9480679B2 (en)	2009-09-10	2016-11-01	Cempra Pharmaceuticals, Inc.	Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr)	2010-03-22	2016-03-25	Cempra Pharmaceuticals Inc	Kristalne forme makrolida i njihova uporaba
EP2571506B1 (en)	2010-05-20	2017-05-10	Cempra Pharmaceuticals, Inc.	Processes for preparing macrolides and ketolides and intermediates therefor
KR20130120458A (ko)	2010-09-10	2013-11-04	셈프라 파마슈티컬스, 인크.	질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2013148891A1 (en)	2012-03-27	2013-10-03	Cempra Pharmaceuticals, Inc.	Parenteral formulations for administering macrolide antibiotics
EP2968801B1 (en)	2013-03-14	2018-09-26	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
MX356772B (es)	2013-03-15	2018-06-13	Cempra Pharmaceuticals Inc	Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
CN105246334A (zh)	2013-04-04	2016-01-13	哈佛大学的校长及成员们	大环内酯及其制备和使用方法
HK1242920A1 (zh) *	2014-10-08	2018-07-06	哈佛大学的校长及成员们	14-元酮内酯及其制备和使用方法
WO2016154591A1 (en)	2015-03-25	2016-09-29	President And Fellows Of Harvard College	Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) *	2017-05-31	2018-08-31	ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ	Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja)	2019-12-25	2023-01-06	旭精工株式会社	硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3868414A (en) *	1973-01-22	1975-02-25	Merck & Co Inc	Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) *	1975-04-07	1978-04-25	Thomae Gmbh Dr K	Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) *	1978-09-30	1980-04-10	Merck Patent Gmbh	Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) *	1990-11-21	1999-12-22	Roussel Uclaf	Intermediates for the preparation of erythromycin derivatives
FR2692579B1 (fr) *	1992-06-19	1995-06-02	Roussel Uclaf	Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) *	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
HRP930014A2 (en) *	1993-01-08	1994-08-31	Pliva Pharm & Chem Works	9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) *	1993-03-09	1995-04-28	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

1994
- 1994-04-08 FR FR9404154A patent/FR2718450B1/fr not_active Expired - Fee Related
1995
- 1995-01-05 LV LVP-95-363A patent/LV11182B/lv unknown
- 1995-03-10 IL IL11295495A patent/IL112954A/xx not_active IP Right Cessation
- 1995-03-13 ZA ZA952059A patent/ZA952059B/xx unknown
- 1995-03-17 AP APAP/P/1995/000743A patent/AP587A/en active
- 1995-03-19 JO JO19951850A patent/JO1850B1/en active
- 1995-03-31 US US08/414,503 patent/US5656607A/en not_active Expired - Lifetime
- 1995-04-02 DZ DZ950037A patent/DZ1869A1/fr active
- 1995-04-03 PE PE1995265509A patent/PE2896A1/es not_active IP Right Cessation
- 1995-04-03 GB GB9506856A patent/GB2288174A/en not_active Withdrawn
- 1995-04-05 CO CO95013829A patent/CO4370097A1/es unknown
- 1995-04-05 JP JP7103170A patent/JP3000023B2/ja not_active Expired - Lifetime
- 1995-04-05 MA MA23828A patent/MA23501A1/fr unknown
- 1995-04-05 YU YU21695A patent/YU49221B/sh unknown
- 1995-04-06 AT AT95400763T patent/ATE234853T1/de active
- 1995-04-06 EE EE9500080A patent/EE04498B1/xx unknown
- 1995-04-06 SI SI9530633T patent/SI0676409T1/xx unknown
- 1995-04-06 PT PT95400763T patent/PT676409E/pt unknown
- 1995-04-06 PL PL95311871A patent/PL180837B1/pl unknown
- 1995-04-06 CA CA002164638A patent/CA2164638C/fr not_active Expired - Lifetime
- 1995-04-06 DK DK95400763T patent/DK0676409T3/da active
- 1995-04-06 MD MD95-0431A patent/MD663G2/ro not_active IP Right Cessation
- 1995-04-06 SK SK1546-95A patent/SK284079B6/sk not_active IP Right Cessation
- 1995-04-06 HU HU9503505A patent/HU215396B/hu unknown
- 1995-04-06 TN TNTNSN95026A patent/TNSN95026A1/fr unknown
- 1995-04-06 RU RU96101139A patent/RU2141965C1/ru active
- 1995-04-06 BR BR9506147A patent/BR9506147A/pt not_active IP Right Cessation
- 1995-04-06 ES ES95400763T patent/ES2189820T3/es not_active Expired - Lifetime
- 1995-04-06 WO PCT/FR1995/000441 patent/WO1995027720A1/fr not_active Ceased
- 1995-04-06 KR KR1019950705537A patent/KR100317148B1/ko not_active Expired - Lifetime
- 1995-04-06 DE DE69529934T patent/DE69529934T2/de not_active Expired - Lifetime
- 1995-04-06 AU AU23107/95A patent/AU684939B2/en not_active Expired
- 1995-04-06 RO RO95-02126A patent/RO115634B1/ro unknown
- 1995-04-06 UA UA95125173A patent/UA44705C2/uk unknown
- 1995-04-06 CZ CZ19953223A patent/CZ296005B6/cs not_active IP Right Cessation
- 1995-04-06 EP EP95400763A patent/EP0676409B1/fr not_active Expired - Lifetime
- 1995-04-06 NZ NZ284498A patent/NZ284498A/en not_active IP Right Cessation
- 1995-04-06 CN CN95190283A patent/CN1059445C/zh not_active Expired - Lifetime
- 1995-04-07 HR HR950217A patent/HRP950217B1/xx not_active IP Right Cessation
- 1995-04-07 SV SV1995000018A patent/SV1995000018A/es not_active Application Discontinuation
- 1995-04-07 MY MYPI95000907A patent/MY114672A/en unknown
- 1995-04-08 GE GEAP19952968A patent/GEP19991836B/en unknown
- 1995-06-05 TW TW084105604A patent/TW316908B/zh not_active IP Right Cessation
- 1995-11-17 IS IS4309A patent/IS1865B/is unknown
- 1995-11-20 BG BG100150A patent/BG61916B1/bg unknown
- 1995-12-06 NO NO954942A patent/NO308361B1/no not_active IP Right Cessation
- 1995-12-08 OA OA60752A patent/OA10200A/fr unknown
- 1995-12-08 FI FI955913A patent/FI111264B/fi not_active IP Right Cessation
1997
- 1997-02-25 US US08/805,439 patent/US5760233A/en not_active Expired - Lifetime
- 1997-03-29 SA SA97170757A patent/SA97170757A/ar unknown

Also Published As

Publication number	Publication date
MD663G2 (ro)	1997-07-31
MD663F1 (ro)	1997-01-31
YU21695A (sh)	1997-12-05
EE04498B1 (et)	2005-06-15
FR2718450A1 (fr)	1995-10-13
NO308361B1 (no)	2000-09-04
KR100317148B1 (ko)	2002-06-22
HU9503505D0 (en)	1996-02-28
FR2718450B1 (fr)	1997-01-10
AU2310795A (en)	1995-10-30
CN1059445C (zh)	2000-12-13
SK284079B6 (sk)	2004-09-08
GEP19991836B (en)	1999-11-05
BG61916B1 (bg)	1998-09-30
NO954942L (no)	1996-02-07
IS1865B (is)	2003-05-02
PL180837B1 (pl)	2001-04-30
CN1126997A (zh)	1996-07-17
TNSN95026A1 (fr)	1996-02-06
DK0676409T3 (da)	2003-06-23
TW316908B (pt)	1997-10-01
CA2164638A1 (fr)	1995-10-19
HRP950217A2 (en)	1997-08-31
IS4309A (is)	1995-11-17
EP0676409B1 (fr)	2003-03-19
DE69529934D1 (de)	2003-04-24
JPH07278177A (ja)	1995-10-24
HU215396B (hu)	1998-12-28
OA10200A (fr)	1996-12-18
AP9500743A0 (en)	1995-07-31
CZ322395A3 (en)	1996-08-14
US5760233A (en)	1998-06-02
WO1995027720A1 (fr)	1995-10-19
UA44705C2 (uk)	2002-03-15
IL112954A (en)	2000-07-16
GB2288174A (en)	1995-10-11
JO1850B1 (en)	1995-12-27
NO954942D0 (no)	1995-12-06
ES2189820T3 (es)	2003-07-16
BR9506147A (pt)	1996-04-16
DE69529934T2 (de)	2003-09-04
MA23501A1 (fr)	1995-12-31
LV11182B (en)	1997-04-20
MY114672A (en)	2002-12-31
AU684939B2 (en)	1998-01-08
FI955913A0 (fi)	1995-12-08
PL311871A1 (en)	1996-03-18
IL112954A0 (en)	1995-06-29
LV11182A (lv)	1996-04-20
BG100150A (bg)	1996-06-28
CZ296005B6 (cs)	2005-12-14
CA2164638C (fr)	2003-12-30
FI955913A7 (fi)	1995-12-08
CO4370097A1 (es)	1996-10-07
AP587A (en)	1997-04-29
SK154695A3 (en)	1996-10-02
US5656607A (en)	1997-08-12
HRP950217B1 (en)	2004-06-30
DZ1869A1 (fr)	2002-02-17
SV1995000018A (es)	1997-10-24
RU2141965C1 (ru)	1999-11-27
EP0676409A1 (fr)	1995-10-11
SI0676409T1 (en)	2003-06-30
FI111264B (fi)	2003-06-30
EE9500080A (et)	1996-12-16
SA97170757A (ar)	2005-12-03
ATE234853T1 (de)	2003-04-15
ZA952059B (en)	1996-03-13
PE2896A1 (es)	1996-02-12
YU49221B (sh)	2004-11-25
GB9506856D0 (en)	1995-05-24
RO115634B1 (ro)	2000-04-28
NZ284498A (en)	1997-07-27
HUT73772A (en)	1996-09-30
JP3000023B2 (ja)	2000-01-17

Publication	Publication Date	Title
PT676409E (pt)	2003-08-29	Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos
BR9707709A (pt)	1999-04-06	Derivados da eritromicina seu processo de preparação e sua aplicação como medicamentos
PT1004592E (pt)	2003-12-31	Novos derivados da eritromicina seu processo de preparacao e sua aplicacao como medicamentos
BR9610503A (pt)	1999-07-06	Novos derivados da 5-o-desosaminil 6-o-metil eritronolida a seu processo de preparação e sua aplicação para a preparação de produtos biologicamente ativos
BR9404114A (pt)	1995-06-13	Composição farmacêutica e seu processo de preparação
BR9507700A (pt)	1997-08-19	Novos derivados da eritromicida proceso de preparação dos mesmos e aplicação dos mesmos como medicamentos
BR9609420A (pt)	1999-05-18	Derivados de 4-fenilaminotiazol seu processo de preparação e as composições farmacêuticas contendo os mesmos
PT1006110E (pt)	2004-05-31	Derivados de acil-piperazinil-pirimidinas sua preparacao e aplicacao como medicamentos
BR9611198A (pt)	1999-04-06	Composto processo de preparação do mesmo e composição farmacêutica
PT1016669E (pt)	2003-07-31	Novos derivados da eritromicina, seu processo de preparacao e a sua aplicacao como medicamentos
FI972580L (fi)	1997-08-19	Valmisteita ja menetelmiä ihoärsytyksen vähentämiseksi
PT83608B (pt)	1989-05-31	Processo de preparacao de derivados da paroxetina
BR9400475A (pt)	1995-09-19	Processo de preparação de zeólita modificada e zeólita modificada
FI953479A0 (fi)	1995-07-18	1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
FI953981A7 (fi)	1995-08-24	2-Bentsyyli-polysykliset guaniinijohdannaiset ja menetelmä niiden valmistamiseksi
PT1119557E (pt)	2004-04-30	Derivados de indeno- nafto- e benzociclohepta-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorecticos
BR9408463A (pt)	1997-08-26	Novos derivados de ginkgolide e processo para sua preparação
BR9408425A (pt)	1997-08-26	Sílica, seu processo de preparação utilização da sílica e composição dentifrícia
FI953919A7 (fi)	1995-08-21	Pyrrolydeenimetyylijohdannaiset ja menetelmä niiden valmistamiseksi
BR9002736A (pt)	1991-08-20	Curral dobravel aperfeicoado e seu processo de montagem
BR8906844A (pt)	1990-09-25	Composicao alvejante liquida e processo de preparacao da mesma
BR9507931A (pt)	1997-11-18	Composição de alvejamento aquosa e processo de preparação da mesma
PT946566E (pt)	2004-03-31	Formas pro-farmacos e analogos da camptotecina sua aplicacao como medicamentos
BR9707613A (pt)	1999-07-27	Misturas isentas de derivados poliferólicos processo de pre paração de misturas i e ii medicamentos e utilização das misturas
BR9610959A (pt)	1999-03-02	Novos derivados da 5-0-desosaminil 6-0-metil eritronolida a seu processo de preparo e sua aplicação ao preparo e sua aplicação ao preparo de produtos biologicamente ativos