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YU34202A - Stabilni polimorf n-(3-etinilfenilamino)-6,7-bis(2- metoksietoksi)-4-kvinazolinamin hidrohlorida, postupci proizvodnje i njegova farmaceutska upotreba - Google Patents

Stabilni polimorf n-(3-etinilfenilamino)-6,7-bis(2- metoksietoksi)-4-kvinazolinamin hidrohlorida, postupci proizvodnje i njegova farmaceutska upotreba

Info

Publication number
YU34202A
YU34202A YU34202A YUP34202A YU34202A YU 34202 A YU34202 A YU 34202A YU 34202 A YU34202 A YU 34202A YU P34202 A YUP34202 A YU P34202A YU 34202 A YU34202 A YU 34202A
Authority
YU
Yugoslavia
Prior art keywords
bis
production
methods
methoxyethony
ethynylphenylamino
Prior art date
Application number
YU34202A
Other languages
English (en)
Inventor
Richard D. Connell
James D. Moyer
Michael J. Morin
Shama M. Kajiji
Barbara A. Foster
Karen J. Ferrante
Timothy Norris
Jeffrey W. Raggon
Sandra L. Silberman
Original Assignee
Osi Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU34202(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Osi Pharmaceuticals Inc. filed Critical Osi Pharmaceuticals Inc.
Priority to MEP-363/08A priority Critical patent/MEP36308A/xx
Publication of YU34202A publication Critical patent/YU34202A/sh
Publication of RS51198B publication Critical patent/RS51198B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Predmetni pronalazak odnosi se na stabilni kristalni oblik N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kvinazolinamin hidrohlorida označen kao polimorf B, njegove produkte u esencijalno čistom obliku i njegovu upotrebu. Pronalazak se takodje odnosi na farmaceutske preparate koji sadrže stabilni oblik polimorfa B N-(3-etinilfenll)-6,7-bis(2-metoksietoksi)-4-kvinazolinamina kao hidrohlorid, kao i druge oblike jedinjenja i njihovu upotrebu kod tretiranja hiperproliferativnih poremećaja kao što je kancer.[The present invention relates to a stable crystalline form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph B form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- quinazolinamine as hydrochloride, as well as other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
YUP-342/02A 1999-11-11 2000-11-09 Stabilni polimorf n-(3-etinilfenilamino)-6,7-bis(2- metoksietoksi)-4-kvinazolinamin hidrohlorida, postupci proizvodnje i njegova farmaceutska upotreba RS51198B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-363/08A MEP36308A (en) 1999-11-11 2000-11-09 Stable polymorph of n-(3-ethynylphenylamino)-6,7-bis (2-methoxyethoxy)- 4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16490799P 1999-11-11 1999-11-11
US19319100P 2000-03-30 2000-03-30
US20642000P 2000-05-23 2000-05-23

Publications (2)

Publication Number Publication Date
YU34202A true YU34202A (sh) 2005-06-10
RS51198B RS51198B (sr) 2010-12-31

Family

ID=27389075

Country Status (38)

Country Link
US (1) US6900221B1 (sh)
EP (4) EP2168581A3 (sh)
JP (1) JP4689916B2 (sh)
KR (1) KR100769264B1 (sh)
CN (1) CN100351241C (sh)
AP (1) AP1434A (sh)
AR (1) AR035563A1 (sh)
AT (1) ATE420645T1 (sh)
AU (3) AU784243B2 (sh)
BG (1) BG65880B1 (sh)
BR (1) BR0015544A (sh)
CA (2) CA2389333C (sh)
CL (1) CL2010000616A1 (sh)
CY (1) CY1112671T1 (sh)
CZ (1) CZ303897B6 (sh)
DE (1) DE60041415D1 (sh)
DK (1) DK1233948T3 (sh)
EA (1) EA005318B1 (sh)
ES (1) ES2320408T3 (sh)
GE (1) GEP20053503B (sh)
HK (1) HK1049663B (sh)
HR (1) HRP20020388B1 (sh)
HU (1) HU226857B1 (sh)
IL (2) IL149222A0 (sh)
IS (1) IS2612B (sh)
MA (1) MA25570A1 (sh)
ME (2) MEP36308A (sh)
MY (1) MY129348A (sh)
NO (1) NO327082B1 (sh)
NZ (1) NZ518406A (sh)
PL (1) PL223486B1 (sh)
PT (1) PT1233948E (sh)
RS (1) RS51198B (sh)
SI (1) SI1233948T1 (sh)
SK (1) SK286995B6 (sh)
TW (1) TWI249528B (sh)
UA (1) UA74803C2 (sh)
WO (1) WO2001034574A1 (sh)

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