WO2010082001A2 - Product for preventing or treating hair greying - Google Patents

Abstract

The invention relates to a product for preventing or treating hair greying, including an extract of the Radix Polygoni Multiflori root and an active ingredient enhancing or maintaining hair growth packaged together in a single composition or else separately in two separate compositions, the composition including the extract of the Radix Polygoni Multiflori root being exclusively for topical application and not for oral administration. The invention also relates to the use thereof and to methods enabling the administration thereof.

Description

 i

Product for preventing or treating hair whitening

FIELD OF THE INVENTION

The invention relates to a product for preventing or treating whitening of hair, eyelashes and hair, its use, and methods for its administration. In the remainder of the present application, the hair, eyelashes and hair will be generically referred to as "hair".

BACKGROUND OF THE INVENTION

Hair whitening is a clear clinical sign of aging, often felt as distressing by people with it when they are still young.

Currently, the existing solutions are essentially based on the use of hair coloring products, allowing artificial hair coloring. However, consumers are looking for new products, which would not only treat hair whitening but would prevent or delay this effect, not by an artificial process but by acting on the natural process of pigmentation of hair fibers.

The results published by Arck et al. in FASEB J., 2006, (9): 1567-1569, attribute the bleaching of hair to oxidative phenomena which would lead in the long term to the disappearance of melanocytes in the hair follicles. In this same study, it was shown that white hair follicles (without melanocytes) had a higher growth rate than pigmented hair follicles. It therefore seems that the process of pigmentation of hair follicles slows hair growth. In order to fight against whitening of hair over time, it must therefore be possible to reconcile hair pigmentation and maintain their optimum growth. In traditional Chinese medicine, based on ancestral use of natural products, it is mentioned the use of plants to prevent hair whitening, or even to repigment the hair. This is in particular the root Radix Polygoni Multiflori, known in China as Shou Wu, He Shou Wu or Black Shou Wu, and noted BSW throughout the present application. For information, it is interesting to note that "Shou Wu" means "Black Head".

The reference manual of traditional Chinese medicine (Chinese Pharmacopoeia, 2005, edited by the State Food and Drug Administration, Beijing, China) specifies that the BSW acts on "the vital essence of the kidneys and liver", which are considered organs "Nourishing the hair". This means that in this design, the BSW can only act orally, because the targets are the kidneys and the liver. The expected effect on the strength and vigor of the hair is then only a consequence of the action of the BSW on "the vital essence of the kidneys and liver". This product, in that it is administered orally, has the disadvantage of exposing the person who ingests it to the risk of general adverse effects, as reported in the medical literature and more particularly by Park GJ -H Mann SP and Ngu MC in J. Gastroenterol. Hepatol., 2001, 16 (1): 15-1-17, and by Cardenas et al. in J. Clin. Gastroenterol., 2006, 40 (7): 629-632. However, topical hair products (shampoos, lotions) containing BSW exist in the Asian market. The argument put forward to value these products is that this asset would act favorably on the strength of the hair. In this regard, patent application GB2240715 describes a composition for promoting hair growth comprising an alcohol, an oil and at least one phytotherapic compound chosen from laurel, angelica, ginseng or polygonum extracts. Furthermore, US Patent 6495174, Patent Application KR20080008206 and Patent Application JP0217118 describe compositions comprising a multitude of possible plant extracts, including an extract of Poligoni multiflori, used as a hair tonic lotion or for treatment baldness.

Patent EP 1 915 997 also discloses a composition intended to promote the growth and regrowth of the hair, and also to repigment the hair. This composition comprises semi-mature soybean seeds and / or extracts of these seeds (said seeds having undergone a prior treatment), and at least one of the group consisting of the Radix Polygoni Multiflori root and extracts thereof. root (said root having been pre-treated), Cynanchum bungei Decne plant and extracts thereof (said pre-treated plant), and further preferably Longan seeds and / or extracts of these seeds, and possibly many other components. This composition is effective for regrowth and repigmentation of hair when administered orally. It can also be applied directly to the hair, for the sole purpose of toning the hair. There is currently a concrete need for solutions to treat or prevent hair whitening while maintaining or promoting hair growth.

SUMMARY OF THE INVENTION

The present invention has been realized for the purpose of providing a product to prevent or treat hair whitening, while avoiding their fall.

Surprisingly, it has been shown by the inventors that the use of a Radix Polygoni Multiflori root extract makes it possible to increase the pigmentation of the hair follicle in vitro. fast and direct way, without any metabolization (in particular digestive or blood) and without hepatic or renal stimulation, contrary to what is described in the Chinese pharmacopoeia. It has also been shown by the inventors that, in combination with an active promoting or maintaining hair growth, there is a synergistic effect to maintain the growth rate of the hair follicle over time. This unexpected result indicates that this association can, in humans, perpetuate an abundant hair by limiting its whitening, and this by applying the root extract of Radix Polygoni Multiflori topically on the skin or integuments.

The invention thus relates to a product comprising an extract of the root Radix Polygoni Multiflori and an active promoting or maintaining hair growth, both of which are packaged in one and the same composition intended for topical application or else each separately in two separate compositions, the composition comprising the Radix Polygoni Multiflori root extract being solely for topical administration and not for oral administration, and the composition comprising the asset promoting or maintaining hair growth can be administered either topically or orally.

The invention also relates to the topical use of an extract of Radix polygoni multiflori, in particular a root extract, or a cosmetic composition comprising an extract of the root Radix Poligoni Multiflori, in a quantity effective, to prevent, delay or treat the whitening of eyelashes, hair or hair.

The invention also relates to a cosmetic product for topical application comprising an effective amount of a single active agent capable of preventing, delaying or treating whitening of hair, eyelashes or hair, said single active agent consisting of in an extract of Radix Poligoni Multiflori. A further object of the invention relates to the use of an extract of Racine

Radix Poligoni Multiflori for the manufacture of a product intended to prevent canities and / or to prevent or limit the whitening of eyelashes, hair or hair.

The invention also relates to the use of a combination of at least (i) an extract of the root of Radix Poligoni Multiflori and (ii) at least one other active that decreases or prevents hair loss or promotes their growth, for promote growth or prevent hair loss or limit the heterogeneity of capillary diameters and / or delay or limit the natural whitening of hair or hair.

Another object of the invention is the use of a combination consisting of (i) an extract of the root of Radix Poligoni Multiflori and (ii) at least one active diminishing or preventing hair loss or promoting or maintaining growth pilaire for the manufacture of a product to prevent bleaching of eyelashes, hair or hair while maintaining or promoting hair growth. A further object according to the invention is a product comprising, in an effective amount, the combination of (i) an extract of Radix Poligoni Multiflori and (ii) an active promoting or maintaining hair growth to prevent, delay or treat bleaching. hair, eyelashes and hair and / or to maintain or promote hair growth.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graph showing the result of a cytotoxicity study carried out on a melanocyte culture derived from a healthy human skin biopsy (FK: forskolin).

Figure 2 shows two graphs showing both the effect of BSW on whole hair follicle pigmentation in vitro, measured following incorporation of [ ¹⁴ C] thiouracil in a human hair follicle model in survival (cpm: counts per minute).

Figure 3 shows two graphs both showing the effect of BSW on whole hair follicle growth in vitro in a surviving human hair follicle model.

Figure 4 is a graph showing the effect of a C-glycoside derivative, and the association of BSW and an asset promoting or maintaining hair growth such as a C-glycoside derivative, on follicle growth. whole hair in vitro, in a model of human hair follicle in survival.

DETAILED DESCRIPTION OF THE INVENTION

The invention relates to a product comprising an extract of the root Radix Polygoni Multiflori and an active promoting or maintaining hair growth both being packaged in a single composition or each separately in two separate compositions, the composition comprising the Radix Polygoni Multiflori root extract being intended for topical administration only and not for oral administration.

Thus, in the case of a single composition, it is intended for topical administration, and, in the case of two separate compositions, either these are both intended for topical administration, or the composition comprising BSW is intended for topical administration, while that comprising the asset promoting or maintaining hair growth is for oral administration.

By topical means an application on keratin materials such as skin, mucous membranes and integuments, and more particularly the hair and / or hair.

The invention may therefore relate to a combination product of two compositions, one comprising an extract of the root Radix Polygoni Multiflori, the other comprising an active promoting or maintaining hair growth, these two compositions may be used simultaneously, separately or spread over time, Radix Polygoni's extract

Multiflori being intended for external topical application. The extract of the root Radix Polygoni Multiflori that can be used according to the invention corresponds to any powder of this root or to any extract of this root, the root having or not previously undergone a treatment, according to the traditional methods or not, before being reduced to powder or prior to extraction. The active ingredient which promotes or maintains hair growth or prevents hair loss and hair loss which can be used according to the invention is chosen especially from the group consisting of 2,4-diaminopyrimidine oxide or an organic acid salt or mineral of this one; C-glycoside derivatives; taurine; flavonoids; aromatic compounds of natural origin; esters of sugars and fatty acids; narcotic agents such as derivatives or esters of nicotinic acid; cysteine; specific or non-specific inhibitors of 15-PGDH; prostaglandins; analogs or derivatives thereof, physiologically acceptable; and mixtures thereof, in all proportions.

The oxide of 2,4-diaminopyrimidine (Aminexil ^®) and its derivatives are described in EP 540 629. Among the usable flavonoids according to the invention, it is preferred catechins, especially epigallocatechin-3-gallate.

For the purpose of the present invention, the term "aromatic compounds of natural origin" is intended to mean aromatic compounds of natural origin as described by Harada N. et al. in Growth Horm. IGF Res., 2008, 18 (4): 335-344. For the purposes of the present invention, the term "sugar esters of fatty acids" is intended to mean esters of sugars and of fatty acids as described in document US 2007/123471.

Of the sugar and fatty acid esters which may be used according to the invention, esters, and more particularly monoesters, of glucose and of linoleic, oleic, palmitic or stearic acid, the glucose being preferably esterified in the 1-position, are preferred. and / or 6, as described by Vingler et al. in Int. J. Cosmet. Sci., 2007, 29 (2): 85-95.

Among the rustfillers that can be used according to the invention, the salts of nicotinic acid, more particularly triethanolamine nicotinate, are preferred; esters of nicotinic acid, more particularly methyl nicotinate, as described by Draelos et al. in J. Cosmetol. Dermatol., 2005, 4 (4): 258-261, ethyl nicotinate, hexyl nicotinate, phenyl nicotinate, benzyl nicotinate, xanthinol nicotinate and α-tocopherol nicotinate; and the esters of nicotinyl alcohol, more particularly tartrate and nicotinate of nicotinyl alcohol.

Among the specific or non-specific inhibitors of 15-PGDH, natural inhibitors of 15-PGDH, and more particularly those described by Cho and Taï in Leukot Prostaglandins, are preferred. Essent. Fatty Acids, 2002, 67 (6): 461-465, including resveratrol and curcumin. Inhibitors of 15-PGDH suitable for the implementation of the invention are also described in applications WO 03/090699 and WOO 4/073594. Among the C-glycoside derivatives that may be used according to the invention, the C-glycoside derivatives described in patent WO 02/051828 in the name of L'Oreal are preferred.

In a preferred embodiment, the asset promoting or maintaining hair growth or preventing or limiting hair and hair loss is selected from the group consisting of C-glycoside derivatives.

C-glycoside derivatives having the following formula are preferably used:

S-CH ₂ -XR in which:

S represents a monosaccharide or a polysaccharide comprising up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form, and L and / or D series, said monosaccharide or polysaccharide having at least one function hydroxyl necessarily free, and optionally one or more amine functions optionally protected; the S-CH ₂ -X bond represents a bond of C-anoménque nature, which may be α or β; X represents a radical chosen from the groups -CO-, -CH (NR ₁ R ₂ ) - -

C (= CHR ₃ ) - and -CH (R ₄ ) -, where R ₁ , R ₂ and R ₃ represent, independently of one another, a hydrogen atom or an R radical, and where R ₄ represents a hydrogen atom, an OH group or an R radical; and

R represents a saturated linear alkyl radical: C ₁ to C ₂₀ , preferably C ₁ to C ₁₀ ;

linear unsaturated C ₂ to C ₂₀ , preferably C ₂ to C ₁₀ ;

- branched or cyclic, saturated or unsaturated, C ₃ to C ₂₀ , preferably C ₃ to C ₁₀ ; or a hydrofluoroalkyl or perfluoroalkyl radical:

linear saturated C ₁ to C ₂₀ , preferably C ₁ to C ₁₀ ; linear unsaturated C ₂ to C ₂₀ , preferably C ₂ to C ₁₀ ,

- branched or cyclic, saturated or unsaturated, C ₃ to C ₂₀ , preferably C ₃ to C ₁₀ ; or a phenyl or benzyl radical, the hydrocarbon chain of said radicals possibly being interrupted by one or more heteroatoms chosen from oxygen, sulfur, nitrogen and silicon, and possibly being substituted by at least one radical chosen from OR ₅ , -SR ₅ , -NR ₅ R ₆ , -COOR ₅ , -CONHR ₅ , -CN, a halogen atom, a C ₁ -C ₆ hydrofluoroalkyl or perfluoroalkyl radical, a C ₃ cycloalkyl or heterocycloalkyl radical; at C ₈ , and / or by at least one optionally substituted C ₅ to C ₁₈ cycloalkyl, aryl or heterocyclic radical, where R ₅ and R ₆ may represent, independently of one another, an atom of hydrogen, an alkyl radical, perfluoroalkyl or hydrofluoroalkyl, linear saturated C ₁ to C ₃₀ , preferably C ₁ to C ₁₂ , or linear unsaturated C ₂ to C ₃₀ , preferably C ₂ to C ₁₂ , or branched or cyclic, saturated or unsaturated, C ₃ to C ₃₀ , preferably C ₃ at C ₁₂ ; Preferably, the C-glycoside derivatives corresponding to the preceding formula are those for which S represents a monosaccharide or a polysaccharide containing up to 6 sugar units, in pyranose and / or furanose form, and of L and / or D series, said monosaccharide or polysaccharide having at least one hydroxyl function necessarily free, and optionally one or more amine functions compulsorily protected, X and R otherwise retaining all of the previously given definitions.

Advantageously, the preferred monosaccharides are chosen from D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose and L-rhamnose. D-glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, and advantageously denotes D-glucose, D-xylose, N-acetyl-D-glucosamine or L-fucose, and very preferentially D-xylose.

More preferably, a polysaccharide of the invention containing up to 6 sugar units may be chosen from D-maltose, D-lactose, D-cellobiose and D-maltotriose, a disaccharide associating a uronic acid chosen from D-iduronic acid or D-glucuronic acid with a hexosamine selected from D-galactosamine, D-glucosamine, N-acetyl-D-galactosamine and N-acetyl-D-glucosamine, and an oligosaccharide containing at least a xylose advantageously chosen from xylobiose, methyl-β-xylobioside, xylotriose, xylotetraose, xylopentaose and xylohexaose, and preferably xylobiose which is composed of two xylose molecules linked by a 1 -4 linkage. In particular, S may represent a monosaccharide selected from D-xylose, D-glucose, D-galactose, L-fucose, and more particularly D-xylose.

More preferably, the C-glycoside derivatives corresponding to the above formula are those for which X represents a group chosen from -CO-, -CH (OH) -, -CH (NR ₁ R ₂ ) -, -CH (R) - preferably a -CO-, -CH (OH) -, -CH (NH ₂ ) -, - CH (NHCH ₂ CH ₂ CH ₂ OH) -, -CH (NHPh) -, -CH (CH ₃ ) -, more preferably a group - CO-, -CH (OH) -, -CH (NH ₂ ) -, and more particularly a group -CH (OH) -, S and R otherwise preserving all the definitions previously data.

Preferably still, the C-glycoside derivatives corresponding to the preceding formula are those for which R represents a linear C ₁ to C ₂₀ , preferably C ₁ to C ₁₀ , saturated alkyl radical, or a C ₂ unsaturated linear alkyl radical. at C ₂₀ , preferably C ₂ to C ₁₀ , or a branched or cyclic alkyl radical, saturated or unsaturated, C ₃ to C ₂₀ , preferably C ₃ to C ₁₀ , and optionally substituted as previously described, S and X retaining all the definitions previously given. More preferably, R represents a linear C ₁ to C ₄ , preferably C ₁ to C ₃ , alkyl radical optionally substituted with -OH, -COOH, or -COOR ₇ , R ₇ being a linear C ₁ to C ₁ saturated alkyl radical. C ₄ , especially the ethyl radical. In particular, R represents an unsubstituted linear C ₁ -C ₄ , preferably C ₁ -C ₂ , alkyl radical, preferably the ethyl radical. Among the C-glycoside derivatives corresponding to the preceding formula, use is preferably made of those for which:

R represents a saturated linear alkyl radical at C ₂ o, preferably Ci-Ci _0, or an unsaturated linear alkyl radical at C ₂ -C ₂ o, preferably C ₂ to Ci _0, or a branched alkyl radical or cyclic, saturated or unsaturated, C ₃ to C ₂₀ , preferably C ₃ to C ₁₀ , and optionally substituted as previously described;

S represents a monosaccharide, as previously described; and

X represents a group selected from -CO-, -CH (OH) -, -CH (NRiR ₂ ) - or -CH (R) - as previously described. Among the C-glycoside derivatives corresponding to the preceding formula, use is more preferably made of those for which:

R represents a saturated linear C 1 to C ₄ , preferably C 1 to C ₃ , alkyl radical optionally substituted with -OH, -COOH or -COOR ₇ , R ₇ being a linear C ₁ to C ₄ saturated alkyl radical, in particular the ethyl radical; S represents a monosaccharide, as previously described; and

X represents a group chosen from -CO-, -CH (OH) -, -CH (NH ₂ ) -, -CH (NHCH ₂ CH ₂ CH ₂ OH) -, -CH (NHPh) -, -CH (CH ₃ ) -, more preferably a group - CO-, -CH (OH) -, -CH (NH ₂ ) -, and especially a group -CH (OH) -.

Among the C-glycoside derivatives corresponding to the preceding formula, those for which:

R represents a saturated linear unsubstituted C ₁ -C ₄ , preferably C ₁ -C ₂ , alkyl radical, in particular the ethyl radical;

S represents a monosaccharide, as previously described, in particular D-glucose, D-xylose, N-acetyl-D-glucosamine or L-fucose, and more particularly D-xylose; and

X represents a group chosen from -CO-, -CH (OH) -, -CH (NH ₂ ) -, and more particularly a group -CH (OH) -.

Among the C-glycoside derivatives of the preceding formula which can be used according to the invention, C-β-D-xylopyranoside-n-propan-2-one is particularly preferred; C-α-D-xylopyranoside-n-propan-2-one; 1-phenyl-2- (C-β-D-xylopyranoside) -ethane-1-one; 1-phenyl-2- (C-α-D-xylopyranoside) -ethane-1-one; 1- [2- (3-hydroxy-propylamino) -propyl] -C-β-D-xylopyranose; 1- [2- (3-hydroxy-propylamino) -propyl] -C-α-D-xylopyranose; C-β-D-xylopyranoside-2-hydroxypropane; C-α-D-xylopyranoside-2-hydroxypropane; C-β-D-xylopyranoside-2-amino-propane; C-α-D-xylopyranoside-2-amino-propane; C-β-D-xylopyranoside-2-phenylamino propane; C-α-D-xylopyranoside-2-phenylamino propane; 3-methyl-4- (C-β-D-xylopyranoside) -butyric acid ethyl ester; - ethyl ester of 3-methyl-4- (C-α-D-xylopyranoside) -butyric acid; 6- (C-β-D-xylopyranoside) -5-keto hexanoic acid; 6- (C-α-D-xylopyranoside) -5-keto hexanoic acid; 6- (C-β-D-xylopyranoside) -5-hydroxy-hexanoic acid; 6- (C-α-D-xylopyranoside) -5-hydroxy-hexanoic acid; 6- (C-β-D-xylopyranoside) -5-aminohexanoic acid; 6- (C-α-D-xylopyranoside) -5-aminohexanoic acid; 6- (C-β-D-xylopyranoside) -5-phenylaminohexanoic acid; 6- (C-α-D-xylopyranoside) -5-phenylaminohexanoic acid; 1- (C-β-D-xylopyranoside) -hexane-2,6-diol; 1 - (C-α-D-xylopyranoside) -hexane-2,6-diol; 5- (C-β-D-xylopyranoside) -4-keto-pentanoic acid; 5- (C-α-D-xylopyranoside) -4-keto-pentanoic acid; 5- (C-β-D-xylopyranoside) -4-hydroxy-pentanoic acid; 5- (C-α-D-xylopyranoside) -4-hydroxy-pentanoic acid; 5- (C-β-D-xylopyranoside) -4-amino-pentanoic acid; 5- (C-α-D-xylopyranoside) -4-amino-pentanoic acid; 5- (C-β-D-xylopyranoside) -4-phenylaminopentanoic acid; 5- (C-α-D-xylopyranoside) -4-phenylaminopentanoic acid; 1- (C-β-D-xylopyranoside) -pentane-2,5-diol; 1- (C-α-D-xylopyranoside) -pentane-2,5-diol; 1 - (C-β-D-fucopyranoside) -propan-2-one; 1- (C-α-D-fucopyranoside) -propan-2-one; 1- (C-β-L-fucopyranoside) -propan-2-one; 1 - (C-α-L-fucopyranoside) -propan-2-one; 1 - (C-β-D-fucopyranoside) -2-hydroxy-propane; 1 - (C-α-D-fucopyranoside) -2-hydroxypropane; 1- (C-β-L-fucopyranoside) -2-hydroxypropane; 1 - (C-α-L-fucopyranoside) -2-hydroxypropane; 1- (C-β-D-fucopyranoside) -2-amino-propane; 1- (C-α-D-fucopyranoside) -2-amino-propane; 1 - (C-β-L-fucopyranoside) -2-amino-propane; 1- (C-α-L-fucopyranoside) -2-amino-propane; 1- (C-β-D-fucopyranoside) -2-phenylamino propane; 1- (C-α-D-fucopyranoside) -2-phenylamino propane; 1- (C-β-L-fucopyranoside) -2-phenylamino propane; 1- (C-α-L-fucopyranoside) -2-phenylamino propane; - ethyl ester of 3-methyl-4- (C-β-D-fucopyranoside) -butyric acid; 3-methyl-4- (C-α-D-fucopyranoside) -butyric acid ethyl ester; 3-methyl-4- (C-β-L-fucopyranoside) -butyric acid ethyl ester; 3-methyl-4- (C-α-L-fucopyranoside) -butyric acid ethyl ester; 6- (C-β-D-fucopyranoside) -5-keto hexanoic acid; 6- (C-α-D-fucopyranoside) -5-keto hexanoic acid; 6- (C-β-L-fucopyranoside) -5-keto hexanoic acid; 6- (C-α-L-fucopyranoside) -5-keto hexanoic acid; 6- (C-β-D-fucopyranoside) -5-hydroxy-hexanoic acid; 6- (C-α-D-fucopyranoside) -5-hydroxy-hexanoic acid; 6- (C-β-L-fucopyranoside) -5-hydroxy-hexanoic acid; 6- (C-α-L-fucopyranoside) -5-hydroxy-hexanoic acid; 6- (C-β-D-fucopyranoside) -5-aminohexanoic acid; 6- (C-α-D-fucopyranoside) -5-aminohexanoic acid; 6- (C-β-L-fucopyranoside) -5-aminohexanoic acid; 6- (C-α-L-fucopyranoside) -5-aminohexanoic acid; 1- (C-β-D-fucopyranoside) -hexane-2,6-diol; 1- (C-α-D-fucopyranoside) -hexane-2,6-diol; 1- (C-β-L-fucopyranoside) -hexane-2,6-diol; 1- (C-α-L-fucopyranoside) -ranexane-2,6-diol; 5- (C-β-D-fucopyranoside) -4-keto-pentanoic acid; 5- (C-α-D-fucopyranoside) -4-keto-pentanoic acid; 5- (C-β-L-fucopyranoside) -4-keto-pentanoic acid; 5- (C-α-L-fucopyranoside) -4-keto-pentanoic acid; 5- (C-β-D-fucopyranoside) -4-hydroxy-pentanoic acid; 5- (C-α-D-fucopyranoside) -4-hydroxy-pentanoic acid; 5- (C-β-L-fucopyranoside) -4-hydroxy-pentanoic acid; 5- (C-α-L-fucopyranoside) -4-hydroxy-pentanoic acid; 5- (C-β-D-fucopyranoside) -4-amino-pentanoic acid; 5- (C-α-D-fucopyranoside) -4-amino-pentanoic acid; 5- (C-β-L-fucopyranoside) -4-amino-pentanoic acid; 5- (C-α-L-fucopyranoside) -4-amino-pentanoic acid; 1 - (C-β-D-fucopyranoside) -pentane-2,5-diol; 1 - (C-α-D-fucopyranoside) -pentane-2,5-diol 1 - (C-β-L-fucopyranoside) -pentane-2,5-diol; 1- (C-α-L-fucopyranoside) -pentane-2,5-diol; 1- (C-β-D-glucopyranosyl) -2-hydroxypropane; 1- (C-α-D-glucopyranosyl) -2-hydroxypropane; 1- (C-β-D-glucopyranosyl) -2-amino-propane; 1- (C-α-D-glucopyranosyl) -2-amino-propane; 1- (C-β-D-glucopyranosyl) -2-phenylamino propane; 1- (C-α-D-glucopyranosyl) -2-phenylamino propane; - ethyl ester of 3-methyl-4- (C-β-D-glucopyranosyl) butyric acid; 3-methyl-4- (C-α-D-glucopyranosyl) -butyric acid ethyl ester; 6- (C-β-D-glucopyranosyl) -5-keto hexanoic acid; 6- (C-α-D-glucopyranosyl) -5-keto hexanoic acid; 6- (C-β-D-glucopyranosyl) -5-hydroxy-hexanoic acid; 6- (C-α-D-glucopyranosyl) -5-hydroxy-hexanoic acid; 6- (C-β-D-glucopyranosyl) -5-aminohexanoic acid; 6- (C-α-D-glucopyranosyl) -5-aminohexanoic acid; 6- (C-β-D-glucopyranosyl) -5-phenylaminohexanoic acid; 6- (C-α-D-glucopyranosyl) -5-phenylaminohexanoic acid; 1 - (C-β-D-glucopyranosyl) -hexane-2,6-diol; 1- (C-α-D-glucopyranosyl) hexane-2,6-diol; 6- (C-β-D-glucopyranosyl) -5-keto-pentanoic acid; 6- (C-α-D-glucopyranosyl) -5-keto-pentanoic acid; 6- (C-β-D-glucopyranosyl) -5-hydroxy-pentanoic acid; 6- (C-α-D-glucopyranosyl) -5-hydroxy-pentanoic acid; 6- (C-β-D-glucopyranosyl) -5-amino-pentanoic acid; 6- (C-α-D-glucopyranosyl) -5-amino-pentanoic acid; 6- (C-β-D-glucopyranosyl) -5-phenylaminopentanoic acid; 6- (C-α-D-glucopyranosyl) -5-phenylaminopentanoic acid; 1 - (C-β-D-glucopyranosyl) -pentane-2,5-diol; 1- (C-α-D-glucopyranosyl) -pentane-2,5-diol; 1- (C-β-D-galactopyranosyl) -2-hydroxypropane; 1 - (C-α-D-galactopyranosyl) -2-hydroxypropane; 1- (C-β-D-galactopyranosyl) -2-amino-propane; 1 - (C-α-D-galactopyranosyl) -2-amino-propane; 1- (C-β-D-galactopyranosyl) -2-phenylamino propane; 1- (C-α-D-galactopyranosyl) -2-phenylamino propane; 3-methyl-4- (β-D-galactopyranosyl) -butyric acid ethyl ester; 3-methyl-4- (α-D-galactopyranosyl) -butyric acid ethyl ester; 6- (C-β-D-galactopyranosyl) -5-keto hexanoic acid; 6- (C-α-D-galactopyranosyl) -5-keto hexanoic acid; 6- (C-β-D-galactopyranosyl) -5-hydroxy-hexanoic acid; 6- (C-α-D-galactopyranosyl) -5-hydroxyhexanoic acid; 6- (C-β-D-galactopyranosyl) -5-aminohexanoic acid; 6- (C-α-D-galactopyranosyl) -5-aminohexanoic acid; 6- (C-β-D-galactopyranosyl) -5-phenylaminohexanoic acid; 6- (C-α-D-galactopyranosyl) -5-phenylaminohexanoic acid; 1- (C-β-D-galactopyranosyl) -hexane-2,6-diol; 1- (C-α-D-galactopyranosyl) hexane-2,6-diol; 6- (C-β-D-galactopyranosyl) -5-keto-pentanoic acid; 6- (C-α-D-galactopyranosyl) -5-keto-pentanoic acid; 6- (C-β-D-galactopyranosyl) -5-hydroxy-pentanoic acid; 6- (C-α-D-galactopyranosyl) -5-hydroxy-pentanoic acid; 6- (C-β-D-galactopyranosyl) -5-amino-pentanoic acid; 6- (C-α-D-galactopyranosyl) -5-amino-pentanoic acid; 6- (C-β-D-galactopyranosyl) -5-phenylaminopentanoic acid; 6- (C-α-D-galactopyranosyl) -5-phenylaminopentanoic acid; 1- (C-β-D-galactopyranosyl) -pentane-2,5-diol; 1- (C-α-D-galactopyranosyl) -pentane-2,5-diol; 1- (C-β-D-fucofuranosyl) propan-2-one; 1- (C-α-D-fucofuranosyl) propan-2-one; 1- (C-β-L-fucofuranosyl) propan-2-one; 1- (C-α-L-fucofuranosyl) propan-2-one; 3 '- (acetamido-C-β-D-glucopyranosyl) propan-2'-one; 3 '- (acetamido-C-α-D-glucopyranosyl) propan-2'-one; 1 - (acetamido-C-β-D-glucopyranosyl) -2-hydroxypropane; 1 - (acetamido-C-α-D-glucopyranosyl) -2-hydroxylpropane; 1 - (acetamido-C-β-D-glucopyranosyl) -2-amino-propane; 1 - (acetamido-C-α-D-glucopyranosyl) -2-amino-propane; 1 - (acetamido-C-β-D-glucopyranosyl) -2-phenylamino propane; 1 - (acetamido-C-α-D-glucopyranosyl) -2-phenylaminopropane; - ethyl ester of 3-methyl-4- (acetamido-C-β-D-glucopyranosyl) -butyric acid; 3-methyl-4- (acetamido-C-α-D-glucopyranosyl) -butyric acid ethyl ester; 6- (acetamido-C-β-D-glucopyranosyl) -5-keto hexanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-keto hexanoic acid; 6- (acetamido-C-β-D-glucopyranosyl) -5-hydroxy-hexanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-hydroxyhexanoic acid; 6- (acetamido-C-β-D-glucopyranosyl) -5-aminohexanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-aminohexanoic acid; 6- (acetamido-C-β-D-glucopyranosyl) -5-phenylaminohexanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-phenylaminohexanoic acid; 1 - (acetamido-C-β-D-glucopyranosyl) -hexane-2,6-diol; 1 - (acetamido-C-α-D-glucopyranosyl) hexane-2,6-diol; 6- (acetamido-C-β-D-glucopyranosyl) -5-keto-pentanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-keto-pentanoic acid; 6- (acetamido-C-β-D-glucopyranosyl) -5-hydroxy-pentanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-hydroxy-pentanoic acid; 6- (acetamido-C-β-D-glucopyranosyl) -5-amino-pentanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-amino-pentanoic acid; 6- (acetamido-C-β-D-glucopyranosyl) -5-phenylaminopentanoic acid; 6- (acetamido-C-α-D-glucopyranosyl) -5-phenylaminopentanoic acid; 1 - (acetamido-C-β-D-glucopyranosyl) -pentane-2,5-diol; and 1 - (acetamido-C-α-D-glucopyranosyl) -pentane-2,5-diol.

By way of nonlimiting illustration, C-glycoside derivatives that are more particularly suitable for the invention, may be mentioned in particular: C-β-D-xylopyranoside-n-propan-2-one; C-α-D-xylopyranoside-n-propan-2-one; C-β-D-xylopyranoside-2-hydroxypropane; C-α-D-xylopyranoside-2-hydroxypropane; 1 - (C-β-D-fucopyranoside) -propan-2-one; 1- (C-α-D-fucopyranoside) -propan-2-one; 1- (C-β-L-fucopyranoside) -propan-2-one; 1 - (C-α-L-fucopyranoside) -propan-2-one; 1 - (C-β-D-fucopyranoside) -2-hydroxypropane; 1 - (C-α-D-fucopyranoside) -2-hydroxypropane; 1- (C-β-L-fucopyranoside) -2-hydroxypropane; 1 - (C-α-L-fucopyranoside) -2-hydroxypropane; 1 - (C-β-D-glucopyranosyl) -2-hydroxypropane; 1 - (C-α-D-glucopyranosyl) -2-hydroxypropane; 1- (C-β-D-galactopyranosyl) -2-hydroxypropane; 1 - (C-α-D-galactopyranosyl) -2-hydroxypropane; 1- (C-β-D-fucofuranosyl) propan-2-one; 1- (C-α-D-fucofuranosyl) propan-2-one; 1- (C-β-L-fucofuranosyl) propan-2-one; 1- (C-α-L-fucofuranosyl) propan-2-one; C-β-D-maltopyranoside-n-propan-2-one; C-α-D-maltopyranoside-n-propan-2-one; C-β-D-maltopyranoside-2-hydroxypropane; C-α-D-maltopyranoside-2-hydroxypropane; and - their isomers and mixtures thereof.

In certain embodiments of the product according to the invention, the asset promoting or maintaining hair growth is selected from C-glycoside derivatives corresponding to the formula mentioned above.

S-CH ₂ -XR in which

R represents a saturated linear unsubstituted Ci-C ₄ alkyl radical such that the methyl, ethyl, propyl, butyl and isopropyl radicals S represents D-xylose; and

X represents a group chosen from -CO-, -CH (OH) -, -CH (NH ₂ ) -, and in particular, -CH (OH) -.

Particularly preferably, C-β-D-xylopyranoside-2-hydroxy-propane or C-α-D-xylopyranoside-2-hydroxypropane, and better still C-β-D-xylopyranoside-2-hydroxy- propane, can be advantageously used for the preparation of a composition according to the invention. The active promoting or maintaining hair growth can be indifferently administered topically or orally.

Orally is preferably used an active ingredient selected from the group consisting of taurine; flavonoids; analogs or derivatives thereof, physiologically acceptable; and mixtures thereof, in all proportions. It is particularly preferred to use the flavonoids described above or mixtures thereof in all proportions.

Topically, an active agent selected from the group consisting of 2,4-diaminopyrimidine oxide is preferably used; C-glycoside derivatives; taurine; aromatic compounds of natural origin; esters of sugars and fatty acids; narcotic agents such as derivatives or esters of nicotinic acid; specific or non-specific inhibitors of 15-PGDH; analogs or derivatives thereof, physiologically acceptable; and mixtures thereof, in all proportions. It is particularly preferred to use the C-glycoside derivatives described above or their mixtures in all proportions. In a first embodiment of the invention, the root extract Radix Polygoni Multiflori and the active promoting or maintaining hair growth are both packaged in a single composition for topical administration.

The method for administering such a product according to the first embodiment of the invention comprises the steps of: a) providing a composition comprising the Radix Polygoni Multiflori root extract and the active promoting or maintaining the hair growth, and b) topically administering the composition of step a).

In a second embodiment of the invention, the root extract Radix Polygoni Multiflori and the active promoting or maintaining hair growth are each individually packaged in two separate compositions both for topical administration.

Thus, the product corresponding to the second embodiment of the invention may be presented in a kit combining the two separate compositions, both for topical administration.

There are two different methods for administering such a product according to the second embodiment of the invention.

The first method comprises the steps of: a) providing a composition comprising the Radix Polygoni Multiflori root extract, b) providing a composition comprising the asset promoting or maintaining hair growth, c) mixing the composition of the step a) and the composition of step b), and d) topically administering the composition resulting from step c). The second method comprises the steps of: a) providing a composition comprising Radix Polygoni Multiflori root extract, b) providing a composition comprising the asset promoting or maintaining hair growth, and c) administering one after the else topically the composition of step a) and the composition of step b), in any order.

In a third embodiment of the invention, the root extract Radix Polygoni Multiflori is packaged in a composition for topical administration, while the asset promoting or maintaining hair growth is packaged in a separate composition. intended for oral administration.

Thus, the product corresponding to the third embodiment of the invention may be presented in a kit combining the two separate compositions intended for topical administration and the other for oral administration.

The method for administering such a product according to the third embodiment of the invention comprises the steps of: a) providing a composition comprising the root extract Radix Polygoni Multiflori, b) providing a composition comprising the asset promoting or maintaining hair growth, c) topically administering the composition of step a) and orally the composition of step b), the moment when the composition is administered of step a) being completely independent of that in which the composition of step b) is administered. Considering all the embodiments of the invention, the field of application of the present invention is the cosmetological field, and the compositions according to the invention must be physiologically acceptable. The product according to the invention can thus be in any galenical form used in cosmetology. In a manner well known to a person skilled in the art, a specialist in this field, in addition to the extract of the root Radix Polygoni Multiflori and the asset promoting or maintaining hair growth, the product according to the invention can therefore comprise solvents and additives. conventionally used in the cosmetological field, in quantities also conventionally used.

Those skilled in the art can refer to the reference work "International Cosmetic Ingredient Dictionary and Handbook, Volume 2, Eighth Edition (ISBN: 1-882621 -22-0)" to formulate in a suitable manner the product according to the invention .

The field of application of the present invention encompasses the pharmaceutical field, and in particular the dermatological field. In this case, the compositions according to the invention must be pharmaceutically acceptable. The product according to the invention can then be in all the galenical forms used in the pharmaceutical and dermatological fields. In a manner well known to a person skilled in the art, a specialist in these fields, besides the extract of the root Radix Polygoni Multiflori and the active promoting or maintaining hair growth, the product according to the invention can therefore comprise solvents and additives. conventionally used in these fields, in quantities also conventionally used.

Preferably, according to the invention, the composition intended for topical administration is formulated in the form of a shampoo or a lotion.

In the case of a shampoo, it will rather be a so-called "preventive" treatment, in which the composition will be applied to the hair, left on the hair for a laying time generally between 1 and 10 minutes, before to be removed by subsequent rinsing of the hair. For the purposes of the present invention, the term "preventive" is intended to mean a treatment carried out before the whitening of the hair has appeared, in order to prevent them from becoming whitened.

In the case of a lotion, it will rather be a so-called "regenerative" treatment, in which the composition will be applied to the hair, preferably without subsequent rinsing. By "regenerative" is meant in the sense of the present invention a treatment performed on already bleached hair, to restore their original color.

It is considered that an average dose of shampoo or lotion corresponds to 20 ml. Whatever the embodiment of the invention, the extract of the root Radix Polygoni Multiflori represents from 0.1 to 20%, preferably from 1 to 10%, and more particularly from 2.5 to 5% by weight relative to the total weight of the composition intended for topical administration in which it is included, and the active promoting or maintaining hair growth or preventing or limiting the hair and hair loss represents 0, 1 to 20%, preferably from 0.5 to 6%, and more particularly from 1 to 5% by weight relative to the total weight of the composition intended for topical administration in which it is included.

Preferably, in the product corresponding to the first and second embodiments of the invention, said product comprising the root extract Radix Polygoni Multiflori and the active promoting or maintaining hair growth in a single composition intended for a administered topically or in two separate compositions for topical administration, the weight ratio of the root extract Radix Polygoni Multiflori to the active promoting or maintaining hair growth is between 0.5: 99.5 and 99.5: 0.5. Among the preferred ratios are reports 5:95 to 20:80, 35:65 to 45:55, and 70:30 to 95: 5.

The compositions intended for topical administration according to the invention are generally applied once or twice a day (morning and / or evening) over a period of at least 4 weeks, or even 4 to 10 weeks, with possibly one or several periods of interruption.

There are many embodiments of compositions for oral administration. Their formulation is carried out by the usual methods for producing, for example, dragees, capsules, gels, emulsions, tablets, capsules or liquid solutions, for example drinkable ampoules.

In particular, the compositions intended for oral administration according to the invention can be incorporated in any form of food supplements or fortified foods, for example food bars or powders, compacted or not. The powders can be for example diluted in water, in soda, in dairy products or in products derived from soya, or be incorporated in food bars.

The composition may comprise excipients or conventional components for the formulation of such compositions or food supplements intended for oral administration, namely in particular fatty and / or aqueous components, humectants, thickeners, preservatives, texture, flavor and / or coating, antioxidants and dyes common in the field of food.

The compositions intended for oral administration according to the invention, whatever their formulation, can be ingested in a single dose, but are generally ingested in a daily dose over a period of at least 4 weeks, or even 4 to 10 weeks, with possibly one or more periods of interruption, in a quantity and / or number appropriate according to their form so that the asset promoting or maintaining hair growth is ingested at a rate of 0.1 to 5 g per day, preferably from 0.3 to 1 g per day. The invention relates to the use of the composition according to the invention, for preventing or treating hair whitening, while avoiding their fall.

The invention also relates to the topical use of an extract of Radix polygoni multiflori, in particular of a root extract, or to the use of a cosmetic composition comprising an extract of the root Radix Poligoni Multiflori in an effective amount to prevent, delay or treat bleaching of eyelashes, hair or hair.

The invention also relates to a cosmetic product for topical application comprising an effective amount of a single active agent capable of preventing, delaying or treating whitening of hair, eyelashes or hair, said single active agent consisting of in an extract of Radix Poligoni Multiflori.

A further object of the invention relates to the use of an extract of Radix Root Poligoni Multiflori for the manufacture of a product intended to prevent canities and / or to prevent or limit the whitening of eyelashes, hair or hair .

The invention also relates to the use of a combination of at least (i) an extract of the root of Radix Poligoni Multiflori and (ii) at least one other active that decreases or prevents hair loss or promotes their growth, for promote growth or prevent hair loss or limit the heterogeneity of capillary diameters and / or delay or limit the natural whitening of hair or hair.

Another object of the invention is the use of a combination consisting of (i) an extract of the root of Radix Poligoni Multiflori and (ii) at least one active diminishing or preventing hair loss or promoting or maintaining growth pilaire for the manufacture of a product to prevent bleaching of eyelashes, hair or hair while maintaining or promoting hair growth. A further object according to the invention is a product comprising, in an effective amount, the combination of (i) an extract of Radix Poligoni Multiflori and (ii) an active promoting or maintaining hair growth to prevent, delay or treat bleaching. hair, eyelashes and hair and / or to maintain or promote hair growth.

The skilled person, through his general knowledge and the implementation of routine experiments, can determine the effective amount of Radix Poligoni Multiflori extract and / or asset promoting or maintaining hair growth to be used for the implementation of the various aspects of the present invention. The effective amount of Radix Poligoni extract

Multiflori and active promoting or maintaining hair growth may vary depending on the desired technical effect and depending on the cosmetic medium used. For the asset promoting or maintaining hair growth, the effective dose to be used will vary depending on the chosen route of administration (ie, topical or oral route) and on the basis of its intrinsic biological activity.

Other characteristics and advantages of the invention will emerge more clearly from the examples which follow, given by way of illustration and not limitation. EXAMPLES

Example 1: Action of the BSW on the pigmentation of the whole hair follicle in vitro

Before looking at the effect of BSW on hair follicle pigmentation, the cytotoxicity of BSW was determined on in vitro melanocyte culture. As shown in FIG. 1, the LDH signal, a reflection of membrane damage and / or cytotoxicity, is observed in the presence of BSW at the concentration of 1 mg / ml and slightly in the presence of BSW at the concentration of 0.5 mg / ml. This signal completely disappears in the presence of BSW at a concentration of 0.1 mg / ml. The choice for the study of hair follicle pigmentation is therefore to use BSW at a concentration of 0.1 mg / ml. As for the positive reference, forskolin is used at a concentration of 1 μM.

Firstly, human hair follicles, from volunteer donors who have undergone surgery, are harvested according to a dissection method described in L'Oréal patent FR 2 736 721. They are then placed individually in a survival medium of defined composition. To each follicle is added a defined amount of either survival medium or forskolin or an aqueous extract of BSW. The radioactive tracer of pigmentation is then introduced into the survival medium. Potential tracers are described by Larsson BS in Melanoma Res., 1991, 1 (2): 85-90. 2-thiouracil [ ¹⁴ C] was chosen in our case. After a determined survival period, at 37 ° C., under 5% CO ₂ and 100% humidity, each follicle undergoes after washing a total lysis by immersion in soluene-350, for 1 h 15 to 1 h 30, at 50 ^° C. Each lysate is then introduced into a volume of scintillating liquid and the activity is measured after stirring for 10 to 15 minutes. The reading of the activity, which depends on the incorporation of thiouracil [ ¹⁴ C], is carried out using the TRILUX 1450 Micro-Beta device. Since this activity is correlated with the amount of neo-synthesized melanin, this method can be applied to the study of the effect of a compound on the pigmentation of the hair. This is precisely described in the publication of Michelet JF et al (Experimental Dermatology, 2009, 18; 4, 414-416). As shown in Figure 2, BSW has a very strong positive effect on the incorporation of thiouracil [ ¹⁴ C] into a human hair follicle model in vitro survival, after 5 and 4 days of incubation, respectively. Statistical analyzes are performed using the Poisson's law.

Example 2: Effect of BSW, a C-glycoside derivative, and the combination of the two, on the growth of the entire hair follicle in vitro Initially, human hair follicles, from volunteer donors having undergone surgery, are harvested according to a dissection method described in L'Oréal patent FR 2 736 721. They are then placed individually in a survival medium of defined composition (Williams E medium supplemented with glutamine, insulin (10 μg / ml), hydrocortisone and antibiotic). To each follicle is added a defined amount of either survival medium, BSW, a C-glycoside derivative, or a mixture of BSW and a C-glycoside derivative. The lengthening of each of the follicles is noted and mean elongation curves are plotted. The lengthening of the hair follicles in the presence of BSW, a C-glycoside derivative, or the combination of the two, is compared to that of the hair follicles of the control group.

As shown in Figure 3, BSW alone has no effect on the growth of human hair follicles in vitro survival. On the other hand, as shown in FIG. 4, a C-glycoside derivative alone makes it possible to maintain a constant rate of growth of the hair follicle over time. FIG. 4 very clearly illustrates the synergistic effect on the growth of the entire hair follicle in vitro, which exists between, on the one hand, a hair growth promoting active agent such as C-β-D-xylopyranoside-2-hydroxy-propane and on the other hand, an excerpt from BSW. In this example, C-β-D-xylopyranoside-2-hydroxy-propane is used at the concentration of 2 mM and the BSW extract is used at the concentration of 0.02 or 0.1 mg / ml. Thus the combination of BSW and an active promoting or maintaining hair growth such as a C-glycoside derivative allows a strengthening of the hair coloring effects of BSW by a synergistic effect exerted on the growth parameter. These properties take all their meaning in vivo by ensuring abundant and more pigmented hair.

Example 3 Examples of Compositions Constituting the Products According to the Invention

Example 3 shows different formulations of compositions for administering the product according to the invention.

Mixed lotion

It is a composition comprising both the BSW and the active promoting or maintaining hair growth. Such a composition is intended only for topical application.

A composition comprising the following constituents: C-β-D-xylopyranoside-2-hydroxy-propane, in solution at 30% by weight in a water / propylene glycol mixture (60:40): 10 g; or C-β-D-xylopyranoside-2-hydroxypropane: 3 g

BSW: 2.5 g

Ethanol / Propylene Glycol / Water: 50/20/30 (v / v / v), qs 100 g Lotion 1

It is a composition comprising the asset promoting or maintaining hair growth, but not the BSW. Such a composition is intended only for topical application, in combination with lotion 2 below.

A composition is prepared comprising the following constituents:

C-β-D-xylopyranoside-2-hydroxy-propane, in solution at 30% by weight in a water / propylene glycol mixture (60:40): 10 g; or C-β-D-xylopyranoside-2-hydroxypropane: 3 g

Ethanol / Propylene Glycol / Water: 50/20/30 (v / v / v), qs 100 g

Lotion 2

It is a composition comprising BSW, but not the asset promoting or maintaining hair growth. Such a composition is intended only for topical application, in combination with lotion 1 above or dragee hereafter. A composition is prepared comprising the following constituents:

BSW: 2.5 g

Ethanol / Propylene Glycol / Water: 50/20/30 (v / v / v), qs 100 g

Shampoo II is a composition comprising both BSW and the active promoting or maintaining hair growth. Such a composition is intended only for topical application, such as the mixed lotion above.

A composition is prepared comprising the following constituents:

C-β-D-xylopyranoside-2-hydroxy-propane, in solution at 30% by weight in a water / propylene glycol mixture (60:40): 5 g; or C-β-D-xylopyranoside-2-hydroxypropane: 1.5 g

BSW: 1 g

Polyglycerol-3-hydroxylaurylether: 26 g (active ingredient)

Hydroxypropylcellulose (Klucell of Hercules): 2 g

Preservative: 50 g Triethanolamine: qsp pH 7.5

Water: qs 100 g

Sugar Plum

It is a composition comprising the asset promoting or maintaining hair growth, but not the BSW. Such a composition is intended only for topical application, in combination with lotion 2 above. This type of sugar can be taken 1 to 2 times a day. A composition is prepared comprising the following constituents: Epigallocatechin-3-gallate: 400 mg Coating Core Excipient: Microcrystalline Cellulose: 70 mg Encompress: 60 mg Magnesium Stearate: 3 mg Colloidal Silica Anhydrous: 1 mg Coating Agent: Shellac: 5 mg Talc: 61 mg Sucrose: 250 mg Polyvidone: 6 mg Titanium dioxide: 0.3 mg Coloring agent: 5 mg

Claims

1. A product for the prevention or treatment of whitening of hair, eyelashes and hair, and more particularly hair, characterized in that it comprises: (i) an extract of the root Radix Polygoni Multiflori and (ii) an active agent promoting or maintaining hair growth selected from the group consisting of C-glycoside derivatives, taurine, esters of sugars and fatty acids, nicotinic acid-derived rufousers, cysteine, prostaglandins specific or non-specific inhibitors of 15-PGDH, 2,4-diaminopyrimidine oxide or an organic or inorganic acid salt thereof, and mixtures thereof; the Radix Polygoni Multiflori extract and the hair growth promoting or promoting active substance being both contained in a single composition or each separately in two separate compositions, and characterized in that the composition comprising the extract of the root Radix Polygoni Multiflori is intended for topical administration only and not for oral administration. 2. Product according to claim 2 characterized in that the asset promoting or maintaining hair growth is selected from the group of derivatives of C-glycosides having the following formula: S-CH ₂ -XR wherein: S represents a monosaccharide or a polysaccharide comprising up to 6 sugar units in pyranose and / or furanose form, and L and / or D series, said monosaccharide or polysaccharide having at least one hydroxyl function which is necessarily free, and optionally one or more amino functions possibly protected; the S-CH ₂ -X bond represents a C-anomeric bond, which may be α or β; X represents a radical chosen from the groups -CO-, -CH (NR ₁ R ₂ ) -, -C (= CHR ₃ ) - and -CH (R ₄ ) -, where R ₁ , R ₂ and R ₃ represent , independently of one another, a hydrogen atom or an R radical, and wherein R ₄ represents a hydrogen atom, an OH group or an R radical; and R represents a saturated C ₁ to C ₂₀ linear alkyl radical, a C ₂ to C ₂₀ unsaturated linear alkyl radical, a saturated or unsaturated C ₃ to C ₂₀ branched or cyclic alkyl radical or a hydrofluoroalkyl or perfluoroalkyl radical; linear saturated C ₁ to C ₂₀ a linear hydrofluoroalkyl radical or perfluoroalkyl unsaturated C ₂ to C ₂₀ a radical hydrofluoroalkyl or perfluoroalkyl, branched or cyclic, saturated or unsaturated, C ₃ to C _20, and a phenyl or benzyl radical; the hydrocarbon chain of said radicals possibly being interrupted by one or more heteroatoms chosen from oxygen, sulfur, nitrogen and silicon, and possibly being substituted with at least one radical chosen from -OR ₅ , -SR ₅ , -NR ₅ R ₆ , -COOR ₅ , -CONHR ₅ , -CN, a halogen atom, a C ₁ -C ₆ hydrofluoroalkyl or perfluoroalkyl radical, a C ₃ -C ₈ cycloalkyl or heterocycloalkyl radical, and / or by at least one cycloalkyl radical, or heterocyclic aryl, C ₅ to C _8, optionally substituted, wherein R ₅ and R ₆ may represent, independently of one another, a hydrogen atom, an alkyl, perfluoroalkyl or hydrofluoroalkyl, saturated linear C ₁ to C ₃₀ , or linear unsaturated C ₂ to C ₃₀ , or branched or cyclic, saturated or unsaturated, C ₃ to C ₃ o; 3. Product according to claim 2 characterized in that: S represents a monosaccharide X represents a group chosen from -CO-, -CH (OH) -, -CH (NH ₂ ) -, -CH (NHCH ₂ CH ₂ CH ₂ OH) - -CH (NHPh) - and -CH (CH ₃ ) -; and R represents a linear C ₁ -C ₄ saturated alkyl radical optionally substituted with -OH, -COOH or -COOR ₇ , R ₇ being a linear saturated alkyl radical;

4. Product according to claim 3 characterized in that the asset promoting or maintaining hair growth is selected from C-β-D-xylopyranoside-2-hydroxy-propane and C-α-D-xylopyranoside-2-hydroxy -propane 5. Product according to any one of claims 1 to 4, characterized in that the extract of the root Radix Polygoni Multiflori and the active promoting or maintaining hair growth are both packaged in a single composition for a topical administration. 6. Product according to any one of claims 1 to 4, characterized in that the extract of the root Radix Polygoni Multiflori and the active promoting or maintaining the hair growth are each packaged separately in two separate compositions both intended for topical administration. 7. Product according to any one of claims 1 to 4, characterized in that the extract of the root Radix Polygoni Multiflori is packaged in a composition intended for topical administration, while the asset promoting or maintaining hair growth is packaged in a separate composition for oral administration, which does not include Radix Polygoni Multiflori root extract. 8. Product according to any one of claims 5 to 7, characterized in that the extract of the root Radix Polygoni Multiflori represents from 0.1 to 20% by weight relative to the total weight of the composition intended for administration by topical way in which it is understood; and the asset promoting or maintaining hair growth is from 0.1 to 20% by weight based on the total weight of the composition for topical administration in which it is included. 9. Product according to one of claims 5 or 6, characterized in that the weight ratio of the root extract Radix Polygoni Multiflori on the active promoting or maintaining hair growth is between 0.5: 99.5 and 99.5: 0.5. 10. Product according to one of claims 6 or 7, characterized in that it is presented in a box associating the two compositions. Product according to any one of the preceding claims, characterized in that any composition intended for topical administration is formulated in the form of a shampoo or a lotion. 12. Process for the administration of a product according to claim 5, characterized in that it comprises the steps of: a) providing a composition comprising the root extract Radix Polygoni Multiflori and the active promoting or now hair growth, and b) topically administering the composition of step a). 13. Method for the administration of a product according to claim 6, characterized in that it comprises the steps of: a) providing a composition comprising the extract of the root Radix Polygoni Multiflori, b) providing a composition comprising the active promoting or maintaining hair growth, c) mixing the composition of step a) and the composition of step b), and d) topically administering the composition resulting from step c). 14. Process for the administration of a product according to claim 6, characterized in that it comprises the steps of: a) providing a composition comprising the extract of the Radix Polygoni Multiflori root, b) providing a composition comprising the asset promoting or maintaining hair growth, and c) administering one after the other topically the composition of the step a) and the composition of step b), in any order. 15. Process for the administration of a product according to claim 7, characterized in that it comprises the steps of: a) providing a composition comprising the extract of the root Radix Polygoni Multiflori, b) providing a composition comprising the asset promoting or maintaining hair growth, c) topically administering the composition of step a) and orally the composition of step b), the moment when the composition of step a) is administered being totally independent of the one where the composition of step b) is administered. 16. Use of the product according to any one of claims 1 to 1 1, to prevent or treat hair whitening, while avoiding their fall.