FR2845900A1 - COSMETIC COMPOSITION FOR PREVENTING AND / OR CORRECTING FUNCTIONAL DISORDERS OF THE PILO-SEBACEOUS UNIT OF MAMMALS - Google Patents

Abstract

The present invention relates to a cosmetic composition suitable for oral administration and intended to prevent and / or correct functional disorders of the pilosebaceous unit of mammals, in particular by fighting against cutaneous activation of androgens over time, said composition comprising polyunsaturated fatty acids, flavonoids and stilbenes. A subject of the invention is also a cosmetic process using such a composition, as well as the use of such a composition for the preparation of a food supplement intended to prevent and / or correct functional disorders of the pilosebaceous unit. mammals.

Claims (40)

The cosmetic invention to prevent eti correct the functional disorders of the pilo-sebaceous unit of mammals The present invention is part of the development of 5 new products and treatment methods for cosmetic purposes intended for humans and animal. In particular, the invention relates to the field of cosmetic products which can be administered orally, such as food supplements. Thus, the subject of the invention is a cosmetic composition suitable for oral administration and intended to prevent and / or correct functional disorders of the pilosebaceous unit of mammals, in particular by fighting against the cutaneous activation of androgens over time, said composition comprising polyunsaturated fatty acids, flavonodes and stilbenes. The present invention also relates to a cosmetic process using such a composition, for preventing and / or correcting functional disorders of the pilosebaceous unit of mammals. Finally, the invention relates to the use of a composition comprising polyunsaturated fatty acids, flavonodes and stilbenes for the preparation of a food supplement intended to prevent and / or correct functional disorders of the pilosebaceous unit mammals. The hairs of mammals in general, the hairs and hair of men in particular, are keratinized filaments of variable length. In the remainder of the text, we will designate by "hair", both the hair of the animal or of man, and the hair of man. Consequently, the adjective "pilous" could refer to the hair as such, or to the hair, or even to the hair and the hair. In any case, the meaning to be given to this adjective will emerge clearly and unambiguously from the context. In the sense of the present invention, the term "man" is understood, in the absence of other details, to designate both the man and the woman. The hairs comprise a fixed or root part, implanted in an invagination of the epidermis, the hair follicle, and a free part or stem, more or less tapered at its end. The hair root adheres to the hair follicle and forms, at its base, a hollow bulb in its center where the dermal papilla rich in capillaries with nourishing function is housed. At the base of each hair is attached a sebaceous gland. The latter secretes a semi-liquid fatty substance, sebum, a mixture of fatty acids, triglycerides, cholesterol, cholesterol derivatives and cellular debris (Stewart, M.E. Semin Dermatol 11, 100-105 (1992)). In humans, for example, the sebaceous glands cover the whole body, excluding the palms of the hands and the soles of the feet. Besides the scalp, these glands are particularly prevalent around the nose, mouth, forehead, cheekbones, chin and neck, where their density can vary between about 400 and 900 glands per square centimeter. The sebum, secreted by the sebaceous gland at the level of the hair follicle, lubricates the surface of the skin, the hair and the hair. It forms a slightly acidic fatty film, intended to protect the skin against external aggressions and drying, this thanks to its antiseptic properties, its "barrier" function vis-à-vis the outside and its capacity to retain the water. However, when the sebum is secreted in excessive quantity, the skin, the hairs and the hair take on a shiny appearance which can prove to be particularly unsightly. We then speak of "alterations", "disorders", "disturbances" or "functional disorders" of the pilosebaceous unit. In the present context, it is understood that the terms "unit", "organ" and "apparatus" pilosebaceous can be used interchangeably to designate the assembly constituted by the hair follicles and the associated sebaceous glands. The above-mentioned disorders can sometimes prove to be severe, a simple sebaceous or seborrhea hypersecretion, which can progress to more or less extensive forms of alopecia. In mammals, the development and functioning of the 5 sebaceous glands are governed by complex mechanisms involving the endocrine system (Mercurio et al .; J. Gend Specif Med 2000 May-Jun; 3 (4): 59-64). The endocrine system groups together the endocrine glands, the secretion products of which, the hormones, are directly discharged into the blood. As the chemical messengers of the body, the hormones thus produced generally act on a specific target organ or tissue. Hormones are not a homogeneous chemical class. In fact, under this generic name are gathered compounds of structures as different as proteins, peptides, sterodes, aromatic compounds and amines. In particular, the sex hormones, such as testosterone, estrogens or progesterone, belong to the family of sterodes, hormonal compounds derived from cholesterol. Among these, there are in particular 20 male sex hormones, androgens. It has been found that the hair density of mammals changes over time. Regarding hair, the number and diameter of hair rods decrease with age. Some male subjects even go so far as to develop androgenetic alopecia. In addition, these alterations of the hair are sometimes accompanied by a change in the condition of the scalp, such as an overabundant production of sebum. In women, age can show hair abnormalities, for example excess hair on the legs, arms, or hair growth on the beard or mustache. Studies have shown that active hormones, including sex sterodes, are formed by conversion of inactive precursors in target peripheral tissues, such as the mammary glands, prostate, uterus, bones and skin. Thus, the androgenic and estrogenic hormones exert an activity in these tissues. In fact, the abovementioned pilosebaceous changes are essentially due to an abnormal metabolism of sterodian hormones, in particular androgens (Labrie et al .; Horm Res 2000; 54 (5-6): 218-29). More specifically, said alterations are due to local activation, ie, cutaneous, androgens, and in particular testosterone over time (Labrie et al .; Horm Res 2000; 54 (56): 21829; Example 1 , infra). At the present time, functional disorders of the pilosebaceous apparatus of mammals remain difficult to treat cosmetically. On the one hand, the topical route proves to be unsuitable, insofar as it is most often large areas to be treated and at least daily treatment frequencies. On the other hand, the products which can be administered orally and which are currently available on the market have significant side effects, in particular sexual. Their use therefore requires regular monitoring and close supervision by qualified medical personnel. Also there is a need for products active against the abovementioned disorders, said products having to be suitable for administration by the oral route and devoid of side effects. The present invention aims precisely to satisfy such a need. The invention relates in fact to a cosmetic composition useful for the prevention and / or the correction of functional disorders of the pilosebaceous unit of mammals, said composition being intended for administration by the oral route and comprising polyunsaturated fatty acids, flavonodes and stilbenes. Such a composition makes it possible to combat the cutaneous activation of androgens, including testosterone, over time. Preferably, the composition according to the invention is a food or nutritional supplement. In the context of the present invention, the term "mammal" should be understood in accordance with the usual general meaning. However, the term "mammals" within the meaning of the invention advantageously targets domestic animals and / or humans. Preferably, the polyunsaturated fatty acids and / or the flavonoids and / or the stilbenes contained in a composition according to the invention are of natural origin. More preferably, all of these compounds are of natural origin. The term "natural origin" means a compound in the pure state or in solution at variable concentrations, said compound being obtained by various extraction methods, known to those skilled in the art, from '' a natural element, for example a plant or an animal. Polyunsaturated fatty acids are, essentially, polyethylenic acids, i.e., comprising at least two carbon double bonds. There are in fact few polyunsaturated fatty acids in nature containing carbon-carbon triple bonds. According to a first aspect of the composition according to the invention, the polyunsaturated fatty acids which it contains are so-called essential fatty acids. These fatty acids, although not synthesizable by the mammals themselves, are essential for the normal metabolism of said mammals (growth, development and integrity of the skin, reproductive functions, in particular gestation and lactation, etc.). Essential fatty acids must therefore be drawn from the diet. Polyunsaturated fatty acids of food origin are defined by the length of the carbon chain and the position of the double bonds. Thus they are classified into two groups, with no metabolic transformation or possible functional substitution from one to the other, said groups being distinguished by the position of the unsaturation closest to the terminal methyl group. These groups are conventionally called n-3 (or è3 or "omega-3") and n-6 (or ò6 or "omega-6"). For example, fatty acids of group n-3 are cc-linolenic acid [18 (number of 5 carbon atoms): 3 (number of unsaturations) n-3] and stearidonic acid ( 18: 4 n3). N-6 group fatty acids are, for example, linoleic acid (18: 2 n-6) and y-linolenic acid (18: 3 n-6). Among the essential fatty acids suitable for producing a composition according to the invention, those skilled in the art will preferably choose 10 polyunsaturated fatty acids belonging to the n-6 group. In particular, the y-linolenic acid will advantageously be chosen. As indicated above, the fatty acids contained in a composition in accordance with the invention are preferably extracted from natural animal or plant sources. In this regard, mention may be made of black currant seed oil, evening primrose, borage and hemp oil as oils of vegetable origin, spirulina extracts, in particular Spirula maxima and S. platensis, and fish and seafood oils as animal oils. Obviously, these oils can be used alone or in the form of mixtures. Preferably, those skilled in the art will choose black currant seed oil as a source of polyunsaturated fatty acids. According to another aspect of the composition according to the invention, it contains flavonoids, in particular isoflavonodes. Flavonodes are polyphenols which, depending on their structure and the degree of oxidation to which they are subjected, divide into flavonols, flavons, catechins, proanthocyanidins, and their analogs and derivatives. The natural sources of flavonodes are mainly vegetable, in particular among the representatives of the families of umbelliferae, rosaceae, legumes, and other compounds. There are also flavonodes in products from the vine and tea. Isoflavonodes are a subclass of flavonoids. They are formed of a 3-phenylchroman skeleton which can include various substituents as well as different oxidation levels. Unlike flavonodes, isoflavonoids are only found in a very limited number of plants. In fact, the term "isoflavonode" designates a set of classes of compounds, including isoflavones, isoflavanones, rotenofdes, pterocarpans, isoflavanes, isoflavanes-3-enes, 3-arylcoumarins, 3-aryl-4 -hydroxycoumarins, coumestanes, coumaronochromones, a-methyldoxyoxyenzones or 2arylbenzofurans. For a complete review of isoflavonofdes, their methods of analysis and their sources, those skilled in the art can refer to Chapter 5 entitled "Isoflavonods" from the book "The Flavonofds" (Dewick, PM Harbone Ed. Pp. 125 -157 (1988)). Isoflavonofdes which are particularly suitable for use in the context of the present invention are, for example, dadzein, formononetin, cuneatin, genistein, isoprunetin and prunetin, cajanin, orobol, pratensinin, sandalwood, junipegenin A, glycitein, afrormosin, retusin, tectorigenin, irisolidone, jamaicin, as well as their analogs and / or derivatives. In the context of the invention, among the isoflavonodes, isoflavones will preferably be used, and more preferably, the simplest forms of aglycones, among which dadzein, genistein and their mixture. These two compounds are especially present in the Glycina max soy extract. According to another aspect of the composition according to the invention, the latter contains stilbenes, in particular hydroxystilbenes. Stilbenes, possibly glycosylated, are produced by plants, mainly spermatophytes, and belong to the class 30 of antibiotic molecules called phytoalexins. Among these, mention may be made of resveratrol or 3,5,4'-trihydroxystilbene. Resveratrol is produced by many fruits and plants, in a simple (trihydroxystilbene) or glycosylated (piceid, polydatin, or 4 ', 5dihydroxystilbene-3-O-p-mono-D-glucoside, for example) form. Simple and glycosylated forms of resveratrol are present in particular in the skin of grapes (Vrhovsek et al. Am J Enol Vitic 48 (2) (1997)), or in supernatants from in vitro cultures of Vitis vinifera (Teguo et al. J Nat Prod 61, 655-657 (1998)). Cosmetic compositions comprising resveratrol have already been described in the context of combating the signs of skin aging (WO 99/04747 in the name of Unilever, N.V.). Likewise, a process has been described for obtaining ester derivatives of resveratrol and the use of the latter in cosmetic compositions as precursors of resveratrol (WO 99/03816 in the name of Caudalie). Finally, the Applicant has described the advantageous use of derivatives of glycosylated hydroxystilbenes, more stable and more soluble than the corresponding hydroxystilbenes, as precursors of the latter, for the preparation of cosmetic, dermatological or pharmaceutical compositions intended for an application. topical (France patent application No. 0010008 filed July 28, 2000). The hydroxystilbenes can be extracted from plants or plant materials containing them, among which the following families of plants, cited for illustrative purposes only: , pinaceae, 25 crupressaceae, cesalpiniaceae, poaceae and solanaceae. In particular, they can be isolated from tissues of V. vinifera or Polygonum cuspidatum. Those skilled in the art will choose the skin of grapes or products derived from grapes, such as wine, as preferred sources of hydroxystilbenes. For example, the grape extracts can be obtained from the grape marc, seeds and / or husks of the grains, and / or, optionally, grape stalks. Thus, in the present context, extracts of red wine or grape seeds, rich in polyphenolic components of the resveratrol type and proanthocyanidins, can be advantageously used. According to one embodiment of a composition in accordance with the invention, it is packaged in the form of unit doses suitable for administration by the oral route, said administration being carried out at a rate of 1 to 6 doses or units per day. Preferably, it is recommended to take 3 units / day. The daily doses recommended in accordance with the invention are between 0.5 and 2600 mg / day, preferably between 5 and 1200 mg / day of polyunsaturated fatty acids, between 0.5 and 1000 mg / day, preferably between 20 and 300 mg / day of flavonodes, and between 0.5 and 1000 mg / day, preferably between 10 and 200 mg / day of stilbenes. These recommended daily doses are such that a composition 15 according to the invention comprises the following quantities, by weight per unit dose of 1 g: - from 0.1% to 99%, preferably from 5 to 60%, and so still more preferred from 40% polyunsaturated fatty acids; - from 0.1% to 99%, preferably from 5 to 60%, and more preferably from 10 to 30% of flavonodes; - from 0.1% to 99%, preferably from 5 to 40%, and more preferably from 10 to 25% of stilbenes. The composition according to the invention can be presented in all conceivable dosage forms, as long as these are suitable for oral administration. Thus, there may be mentioned, by way of nonlimiting example, an oral solution, a syrup, a tablet, a dragee, a capsule, a capsule, or even an enriched food such as a cookie, a food bar or a powder, possibly compacted. The powders can be diluted in water, soda, dairy or soy products, or incorporated into bars or cookies, for example. According to another embodiment of a composition in accordance with the invention, it comprises, in addition to the polyunsaturated fatty acids, flavonodes and stilbenes, at least one excipient suitable for oral administration. In this regard, formulating agents, adjuvants and excipients for oral compositions, in particular for food supplements, are known to those skilled in the art. Mention may be made, among others and in a purely illustrative manner, of lubricants such as magnesium stearate, products for instant solubilization, gelling agents, thickeners, humectants, fatty and / or aqueous components, preservatives, 10 texture agents, of flavor and / or coating, antioxidants and colorants customary in the food sector. The composition according to the present invention can also comprise one or more vitamins and / or trace elements. As such, the following active agents can, for example, be used alone or in combination: zinc and its salts, including zinc sulfate and glucanate, vitamins B5, B6, B8, C, E or PP, 1-carotene and carotenoids, garlic extracts in particular in the form of allyl or ajoen sulfide, selenium, curcumin, curcuminodes, niacin, lithospermic acid and adenosine. It is understood that a person skilled in the art will choose such active agents and, where appropriate, combine them in the direction of improving the expected effects of the composition which is the subject of the invention, while preventing the activity of interest sought is either inhibited or attenuated. The subject of the invention is also a cosmetic method for the prevention and / or correction of functional disorders of the sebaceous pilo25 unit of mammals, in particular men and domestic animals, said method consisting in administering orally a composition such as described above. The present invention finally relates to the use of a composition as referred to above, comprising polyunsaturated fatty acids, flavonoids and stilbenes, for the preparation of a food supplement intended for preventing and / or correcting functional disorders of the pilosebaceous unit of mammals, in particular humans and domestic animals. The present invention is illustrated, without being limited, by the following figures: Figure 1: evolution of the size of the costo-vertebral organ (hereinafter CVO) of the hamster under the effect of a topical application of testosterone (illustration of the "testosterone effect"). D50 corresponds to the start of the daily applications of testosterone on the right CVO. Figure 2: inhibition of the "testosterone effect" by polyunsaturated fatty acids, flavonodes and stilbenes, alone or in combination. --- ô --- Witnesses Blackcurrant seed Soy extract enriched with 40% isoflavones 15 -R- Wine concentrate Association The characteristics of the invention mentioned above, as well as others not mentioned in detail in the foregoing , will emerge clearly in the light of the following examples. These examples are intended to illustrate the object of the invention, without limiting its scope. EXAMPLES Example 1: Demonstration of the effect of a topical application of testosterone at the level of the pilosebaceous unit - In vivo test: 1-Principle of the CVO test: The CVO of the hamster is a skin region rich in pilosebaceous units. The CVO test consists in determining the anti-androgenic action of 10 different compounds on CVO, ie, in determining whether said compounds prevent the action of testosterone (Liao S. et al. Arch Dermatol Res 293 (4), 200-205 (2001)).   1-B- Results of the control experiments: observation of the "testosterone effect": FIG. 1 represents the evolution of the size of the CVO in control animals, having received no food supplementation, in the event of topical application of testosterone. More specifically, FIG. 1 shows the difference in surface area between the right CVO, having received testosterone, and the left CVO (negative control). Hence, this figure illustrates the "effect testosterone ".   From the fiftieth day (dotted arrow), testosterone has   applied daily to the right CVO.   As shown in Figure 1, testosterone induced over time an increase in the size of the right CVO compared to that of the CVO left.   Example 2 Demonstration of the Inhibition of the "Testosterone Effect" by a Composition in Accordance with the Invention: 2-A- Products Tested: The following products were used in the context of the in vivo CVO test as defined above. These products have been tested as   as food supplements, alone or in combination.   (a) the natural aroma of red wine rich in resveratrol (stilbenes) and proanthocyanidins (flavonoldes), at a rate of 0.11 g in 43 g of food (18% polyphenols); (b) a soy extract containing 40% of isoflavonodes, in an amount of 0.02 g of extract in 44 g of food (40% of isoflavones); (c) blackcurrant seed oil rich in ylinolenic acid (polyunsaturated fatty acid 18: 3 n-6), at a rate of 10% by weight in the food; 15 and   (d) the combination of the above three products.   2-B- Results: The product (b), namely a soy extract rich in isoflavonodes, did not prevent the "testosterone effect" as observed in the context of the control experiments (Example 1-B), as illustrated in FIG. 2 by the "control" and "enriched soy extract 40% isoflavones ".   On the other hand, it appears from FIG. 2 that the products (a) and (c), as well as the combination of the products (a), (b) and (c), reduced   considerable difference in size CVO right vs CVO left.   The curve observed with the natural aroma of red wine (product (a))   however retains an upward slope, suggesting that the "testosterone effect", although advantageously slowed down, remains susceptible to an evolution in time contrary to the desired effect.   The curve observed with product (c), corresponding to the oil containing polyunsaturated fatty acids, reflects a particularly strong, even brutal, inhibitory activity of the "testosterone effect" from approximately the 20th day of administration. The disadvantage linked to the use of the only product 5 (c) results from the fact that the difference in size between right and left CVOs was increased compared to the controls ("control" curve) during the five   first few days of treatment approximately.   Ultimately, only the combination of products (a), (b) and (c), corresponding to a composition comprising polyunsaturated fatty acids, flavonodes and stilbenes in accordance with the present invention, made it possible to observe the profile of expected inhibition, namely a sharp reduction in the "testosterone effect" from the start of treatment, followed by a gradual slowing down of this effect, only to tend during   time towards a zero or almost zero effect.   In addition, no effect of the various compounds tested, alone or in combination, has been demonstrated on the sexual organs of male animals. Indeed, it was found that the various products tested did not alter the weight of the seminal vesicles and the prostate (results not shown). These observations indicate that a cosmetic composition in accordance with the invention should not exhibit the side effects.   undesirable compositions already known.   Example 3: Preparation of a composition according to the invention Examples of formulation: 3-A- Draped type formulation: The amounts of the various compounds are indicated in mg per dragee. Coating core excipient: microcrystalline cellulose 70 - EncompressTm 60 - magnesium stearate 3 - anhydrous collodal silica 1 Coating agent: - shellac 5 - talc 61 - sucrose 250 - polyvidone 6 - titanium dioxide 0.3 - agent color 5 Active ingredient: - blackcurrant seed oil 0.5 - red wine extract containing 18% polyphenols 2 - enriched soy extract with 40% isoflavones content 2 A unit dose according to the invention corresponds to the species at a sugared almond.   3-B- Formulation of vegetable or animal gelatin capsule type: The amounts of the various compounds are indicated in mg per capsule. Excipient: - starch 128 - magnesium stearate 2.5 Active ingredient.   - blackcurrant seed oil 200 - red wine extract containing 18% polyphenols 100 - enriched soy extract with 40% isoflavones 50   The unit dose as defined in the above description corresponds to a capsule.   3-C- Formulations of the qel single-dose type: The following quantities are expressed in% of the total weight of the final product.   According to this formulation, the unit dose is equivalent to 200 ml 200 g.   a) Single-dose gel 1: Excipient: - sugar syrup 30 - maltodextrin 17 xanthan gum 0.8 - sodium benzoate 0.2 - water qs 100 Active ingredient: - blackcurrant seed oil 20 - red wine extract containing 18% depolyphenols 10 20 - soy extract enriched with 40% isoflavones 20 b) Single-dose gel 2: Excipient: - sugar syrup 50 - maltodextrin 17 xanthan gum 0.8 - sodium benzoate 0.2-water qs 100 Vitamins and trace elements: - antioxidant complex * Active ingredient: - blackcurrant seed oil 10 - red wine extract containing 18% polyphenols 12 soy extract enriched with 40% isoflavones 24 * The antioxidant complex includes , for 200 ml of gel: - vitamin C 120 mg - selenium 100 pg - vitamin E 30 mg - zinc 20 mg - P- carotene 6 mg 3-D- Capsule type formulation:   The following amounts are expressed in mg per capsule.   According to this formulation, a unit dose corresponds to a capsule.   a) Capsule 1: Excipient: - glycerin 150 - magnesium stearate 0.02 water qs 900 Trace element: - zinc gluconate 160 Active ingredient: - black currant seed oil 300 - red wine extract containing 18% polyphenols 200 - soy extract enriched with 40% isoflavones 200 b) Capsule 2: Excipient: - glycerin 150 - magnesium stearate 0.02 - water qs 900 Vitamins and trace elements: - vitamin complex * - zinc gluconate 160 Principle active: - blackcurrant seed oil 400 - red wine extract containing 18% polyphenols 100 - enriched soy extract with 40% isoflavones 300 * The vitamin complex includes, per capsule: - vitamin C 60 mg - selenium 50 pg - vitamin E 15 mg - zinc 10 mg - lycopene 3 mg 3-E- Soft capsule type formulation:   The quantities below are expressed in mg per soft capsule.   Excipient: - soybean oil 40 - wheat germ oil 85 - soy lecithin 25 Vitamins: - natural tocopherols 3 - vitamin C 60 Active ingredient: - black currant seed oil 200 - red wine extract containing 18% polyphenols 100 30 - enriched soy extract with 40% isoflavones 100   In this case, a unit dose is equivalent to a soft capsule.   1. Cosmetic composition useful for the prevention and / or correction of functional disorders of the pilosebaceous unit of mammals 5 and intended for oral administration, characterized in that it comprises polyunsaturated fatty acids, flavonodes and stilbenes.   2. Composition according to claim 1, characterized in that it is intended to combat the cutaneous activation of androgens, in   especially testosterone, over time.   3. Composition according to claim 1, characterized in that it is a food supplement.   4. Composition according to claim 1, characterized in that said   mammals are domestic animals.   5. Composition according to claim 1, characterized in that said mammals are human beings.   6. Composition according to any one of claims 1 to 3,   characterized in that said polyunsaturated fatty acids and / or said flavonoids and / or said stilbenes are of natural origin. 25   7. Composition according to any one of claims 1 to 3,   characterized in that said polyunsaturated fatty acids, said   flavonodes and said stilbenes are of natural origin.   8. Composition according to claim 6 or 7, characterized in that   said polyunsaturated fatty acids are from the n-6 group.   9. Composition according to claim 8, characterized in that said   polyunsaturated fatty acids correspond to y-Iinolenic acid.   10. Composition according to claim 8 or 9, characterized in that said polyunsaturated fatty acids are contained in an oil or an extract chosen from blackcurrant seed oil, evening primrose oil, borage oil, I hemp oil, spirulina extracts, fish oils and seafood oils, preferably black currant seed oil. 11. Composition according to claim 6 or 7, characterized in that said flavonoids are isoflavonodes, preferably isoflavones. 12. Composition according to claim 11, characterized in that said isoflavones are chosen from dadzein, genistein and their mixture.   13. Composition according to claim 1 1 or 12, characterized in that said flavonodes are contained in plant extracts, such   vines, tea, fruit, soy, and preferably soy.   14. Composition according to claim 6 or 7, characterized in that said stilbenes are hydroxystilbenes.   15. Composition according to claim 14, characterized in that   said hydroxystilbenes are chosen from resveratrol and derivatives thereof, in particular esters and glycosylated derivatives thereof.   16. Composition according to any one of claims 14 to 15,   characterized in that the said stilbenes are extracted from the grape, in particular from the skin of the grape, and / or from products derived from the grape, including wine.   17. Composition according to any one of claims 1 to 3, 6 and 7,   characterized in that it is packaged in the form of unit doses, for administration at a rate of 1 to 6 units / day, of preferably 3 units / day.   18. Composition according to claim 17, characterized in that it contains from 0.1% to 99% by weight of polyunsaturated fatty acids by unit dose.   19. Composition according to Claim 18, characterized in that it contains from 5 to 60%, preferably from 10 to 40% by weight of acids.   polyunsaturated fat per unit dose.   20. Composition according to claim 17, characterized in that it contains from 0.1% to 99% by weight of flavonodes per unit dose.   21. Composition according to claim 20, characterized in that it contains from 5 to 60%, preferably from 10 to 30% by weight of flavonodes per unit dose.   22. Composition according to claim 17, characterized in that it   contains 0.1% to 99% by weight of stilbenes per unit dose.   23. Composition according to claim 22, characterized in that it contains from 5 to 40%, preferably from 10 to 25% by weight of stilbenes per unit dose.   24. Composition according to any one of claims 1 to 23,   characterized in that it further comprises at least one excipient   suitable for oral administration.   25. Composition according to any one of claims 1 to 24,   characterized in that it further comprises one or more vitamins and / or trace elements.   26. Cosmetic method for the prevention and / or correction of functional disorders of the pilosebaceous unit of mammals, in particular of men and domestic animals, consisting in administering orally a composition according to any one from claims 1 to 25.   27. The method of claim 26, characterized in that the administration of said composition, conditioned in the form of unit doses, is carried out at a rate of 1 to 6 units / day, preferably 3 units / day.   28. Use of a composition comprising fatty acids   polyunsaturated, flavonodes and stilbenes, for the preparation of a food supplement intended to prevent and / or correct functional disorders of the pilosebaceous unit of mammals, in particular men and domestic animals.   29. Use according to claim 28, characterized in that said polyunsaturated fatty acids and / or said flavonoids and / or said   stilbenes are of natural origin.   30. Use according to claim 28, characterized in that said polyunsaturated fatty acids, said flavonodes and said stilbenes are of natural origin.   31. Use according to claim 29 or 30, characterized in that said polyunsaturated fatty acids are from the n-6 group, such as ylinolenic acid. 32. Use according to claim 29 or 30, characterized in that said flavonodes are isoflavonodes, preferably isoflavones, such as isoflavones chosen from dadzein, genistein and their mixture.   33. Use according to claim 29 or 30, characterized in that said stilbenes are hydroxystilbenes, such as the hydroxystilbenes chosen from resveratrol and the derivatives thereof, in particular the   esters and glycosylated derivatives thereof.   34. Use according to claim 28, characterized in that said composition is packaged in the form of unit doses for oral administration at a rate of 1 to 6 units / day, preferably 3 units / day.   35. Use according to claim 34, characterized in that said composition contains from 0.1% to 99% by weight of fatty acids polyunsaturated per unit dose.   36. Use according to claim 35, characterized in that said   composition contains from 5 to 60%, preferably from 10 to 40% by weight of polyunsaturated fatty acids per unit dose.   37. Use according to claim 34, characterized in that said composition contains from 0.1% to 99% by weight of flavonodes per unit dose.   38. Use according to claim 37, characterized in that said composition contains from 5 to 60%, preferably from 10 to 30% in   weight of flavonodes per unit dose.   39. Use according to claim 34, characterized in that said composition contains from 0.1% to 99% by weight of stilbenes per unit dose. 40. Use according to claim 39, characterized in that said   composition contains from 5 to 40%, preferably from 10 to 25% by weight of stilbenes per unit dose.