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WO2009134165A1 - Ensemble antioxydant et anti-hypoxie à base de dihydroquercetine destiné aux produits de beauté - Google Patents

Ensemble antioxydant et anti-hypoxie à base de dihydroquercetine destiné aux produits de beauté Download PDF

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Publication number
WO2009134165A1
WO2009134165A1 PCT/RU2009/000192 RU2009000192W WO2009134165A1 WO 2009134165 A1 WO2009134165 A1 WO 2009134165A1 RU 2009000192 W RU2009000192 W RU 2009000192W WO 2009134165 A1 WO2009134165 A1 WO 2009134165A1
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WO
WIPO (PCT)
Prior art keywords
water
antioxidant
weight
antihypoxants
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2009/000192
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English (en)
Russian (ru)
Inventor
Владимир Петрович ТИХОНОВ
Дмитрий Павлович СИДЛЯРОВ
Татьяна Леонидовна ЗАВЕЩЕВСКАЯ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Borovichsky Kombinat Ogneuporov OAO
Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya "Diod"
Original Assignee
Borovichsky Kombinat Ogneuporov OAO
Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya "Diod"
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Publication date
Application filed by Borovichsky Kombinat Ogneuporov OAO, Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya "Diod" filed Critical Borovichsky Kombinat Ogneuporov OAO
Publication of WO2009134165A1 publication Critical patent/WO2009134165A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the invention relates to the pharmaceutical industry, in particular to the creation of biologically active complexes based on natural raw materials, which may find application in the composition of cosmetic products used in the cosmetic industry and medical and preventive medicine.
  • the present invention is the creation of a complex concentrate for the production of a variety of cosmetic products with a wide range of biological effects.
  • compositions have been proposed in liposome form with antioxidant and antihypoxic properties, including oil-soluble ingredients such as phospholipids, dihydroquercetin (taxifolin), tocopherols (vitamin E), tetrahydroquinoline derivatives (6-ethoxy-2,2,4-trimethyl) , 2,3, 4-tetrahydroxinolin, 6-hydroxy-2, 2, 4-trimethyl-1,2,3,4-tetrahydroxinolin and others), 2,6-Di-tert-butyl-4-methylphenol, rutin and water-soluble ingredients, such as derivatives of hydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate and others), etc.
  • oil-soluble ingredients such as phospholipids, dihydroquercetin (taxifolin), tocopherols (vitamin E), tetrahydroquinoline derivatives (6-ethoxy-2,2,4-trimethyl) , 2,3, 4-tetrahydroxinolin, 6-hydroxy-2, 2, 4-trimethyl-1,2,3,
  • tetrahydroquinoline hydrochloride derivatives (6-ethoxy-2,2,4-trimethyl-l, 2,3,4-tetrahydroxinoline hydrochloride and others), 1-hydroxyhermatran, as well as magnesium ascorbyl phosphate, water-soluble plant extracts selected from the group of plants: Gingko-biloba, Ginseng, Arnica, Iglitsa, Licorice, Chamomile, Badan, St. John's wort, Horse chestnut, Nettle, Soy, Green tea, Calendula, Milk Thistle, Sabelnik, Scutellaria, Sage and troxerutin in the following components, in weight.
  • water-soluble plant extracts selected from the group of plants Gingko-biloba, Zhen-Shen, Arnica, Iglitsa, Licorice, Chamomile, Frankincense, St. John's wort,
  • the technical result consists in obtaining an additional effect of transdermal transfer during topical application of antioxidant and antihypoxic properties.
  • the total number of homogenization cycles is from 6 to 14.
  • the pH value is in the range of 5.0 - 7.5.
  • the total number of homogenization cycles is from 5 to 10.
  • the total number of homogenization cycles is from 5 to 12.
  • the obtained liposome concentrate with various compositions can be used in cosmetic products for gel and foot cream, hand cream, face serum, head masks, etc.
  • Liposomal concentrate does not have side effects. Tests were conducted on volunteers aged 20 to 54 years. The course of taking various cosmetic products showed that due to the combination of oil and water-soluble antioxidants and antihypoxants in the liposome form and the systemic interaction of the above ingredients in this composition, the result is that the rate of transdermal transfer of the oil-oil complex is increased by 20 - 50% and water soluble antioxidants and antihypoxants.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L’invention concerne l’industrie chimico-pharmaceutique et de produits de beauté. L’ensemble antioxydant et anti-hypoxie à base de dihydroquercetine destiné aux produits de beauté comprend les composants suivants, en % en poids : phospholipides de soja avec de la phosphatidylcholine (lecithine) 50 à 100 % 6,0-16,0 %; extraits végétaux hydrosolubles 0,5 - 12,0; hydrates de carbone 2,0-5,0 %; glycérine distillée 2,0-5,0 %; dihydroquercetine 0,5-2,5 %; vitamine PP (nicotinamide) 0,1-1,0 %; antioxydants hydrosolubles à action anti-hypoxie 0,05-0,5 %; antioxydants à action anti-hypoxie solubles dans l’huile 0,05-0,5 %; agent de conservation 0,1-1,0 %; alcool éthylique 6,0-14,0 %; l’eau désionisée constituant le reste, jusqu’à 1000.
PCT/RU2009/000192 2008-04-28 2009-04-23 Ensemble antioxydant et anti-hypoxie à base de dihydroquercetine destiné aux produits de beauté Ceased WO2009134165A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2008116295 2008-04-28
RU2008116295/15A RU2367409C1 (ru) 2008-04-28 2008-04-28 Антиоксидантный и антигипоксантный комплекс на основе дигидрокверцетина для косметических изделий

Publications (1)

Publication Number Publication Date
WO2009134165A1 true WO2009134165A1 (fr) 2009-11-05

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PCT/RU2009/000192 Ceased WO2009134165A1 (fr) 2008-04-28 2009-04-23 Ensemble antioxydant et anti-hypoxie à base de dihydroquercetine destiné aux produits de beauté

Country Status (2)

Country Link
RU (1) RU2367409C1 (fr)
WO (1) WO2009134165A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2473348C1 (ru) * 2011-12-22 2013-01-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт фармакологии Сибирского отделения РАМН (НИИ фармакологии СО РАМН) Средство, обладающее гемореологической активностью
CN114890385A (zh) * 2021-07-01 2022-08-12 中国科学院上海硅酸盐研究所 一种高效抗氧化二维氢锗烯纳米片及其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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RU2424580C1 (ru) * 2009-11-30 2011-07-20 Государственное Образовательное Учреждение Высшего Профессионального Образования Амурская Государственная Медицинская Академия Росздрава Способ повышения антиоксидантного статуса теплокровного организма в условиях ультрафиолетового облучения
RU2457713C2 (ru) * 2010-08-24 2012-08-10 Алексей Юрьевич Колесник Премикс для пищевых продуктов
RU2683770C1 (ru) * 2018-01-23 2019-04-02 Федеральное государственное бюджетное образовательное учреждение высшего образования "Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва" Способ получения липосомальной формы соли 2-этил-6-метил-3-гидроксипиридина с никотиновой кислотой, ее применение для улучшения микроциркуляции в коже
RU2709724C1 (ru) * 2018-11-26 2019-12-19 Федеральное Государственное Бюджетное Учреждение Научно-Исследовательский Институт Проблем Хранения Федерального Агентства По Государственным Резервам (Фгбу Ниипх Росрезерва) Антиоксидантная композиция для производства рыбных консервов с пролонгированным сроком годности и способ ее получения
WO2022203547A1 (fr) * 2021-03-24 2022-09-29 Общество с ограниченной ответственностью "Научная Компания "Фламена" Utilisation d'émulsion phospholipidique pour traiter des gestoses du premier trimestre

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RU2058133C1 (ru) * 1992-06-24 1996-04-20 Парфюмерно-косметическая фабрика "Виорика" Крем для лица
RU2053763C1 (ru) * 1992-12-25 1996-02-10 Товарищество с ограниченной ответственностью "Фитолон" Биологически-активная добавка для косметических изделий
RU2139041C1 (ru) * 1998-07-10 1999-10-10 Ставропольское научно-производственное объединение "Пульс" Гидратантный регенерирующий крем и способ его получения
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2473348C1 (ru) * 2011-12-22 2013-01-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт фармакологии Сибирского отделения РАМН (НИИ фармакологии СО РАМН) Средство, обладающее гемореологической активностью
CN114890385A (zh) * 2021-07-01 2022-08-12 中国科学院上海硅酸盐研究所 一种高效抗氧化二维氢锗烯纳米片及其制备方法和应用
CN114890385B (zh) * 2021-07-01 2023-09-08 中国科学院上海硅酸盐研究所 一种高效抗氧化二维氢锗烯纳米片及其制备方法和应用

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Publication number Publication date
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