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WO2009145673A2 - Inhalateur de poudre - Google Patents

Inhalateur de poudre Download PDF

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Publication number
WO2009145673A2
WO2009145673A2 PCT/RU2009/000265 RU2009000265W WO2009145673A2 WO 2009145673 A2 WO2009145673 A2 WO 2009145673A2 RU 2009000265 W RU2009000265 W RU 2009000265W WO 2009145673 A2 WO2009145673 A2 WO 2009145673A2
Authority
WO
WIPO (PCT)
Prior art keywords
powder
container
movable plate
dispenser
inhalator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2009/000265
Other languages
English (en)
Russian (ru)
Other versions
WO2009145673A3 (fr
Inventor
Владимир Евгеньевич НЕБОЛЬСИН
Александр Григорьевич ЧУЧАЛИН
Евrений Викторович БАБАРСКОВ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EA201001864A priority Critical patent/EA017662B1/ru
Publication of WO2009145673A2 publication Critical patent/WO2009145673A2/fr
Publication of WO2009145673A3 publication Critical patent/WO2009145673A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the invention relates to medical equipment, and in particular to devices intended for the individual administration of powdered drugs into the respiratory tract and lungs of a person, that is, to powder inhalers.
  • the currently known powder inhalers for example, CYCLOXALEP by PULMOMED [2] are mainly intended for the administration of drugs in the form into the patient’s lungs powder mixtures of fine particles of the active component with coarse particles of an inert carrier, for example, such as lactose.
  • an inert carrier for example, such as lactose.
  • the mass fraction of the carrier introduced into the mixture reaches 99 percent or more, and its particles have sizes of 50-100 microns.
  • the active component for example, salbutamol, budesonide, beclomethasone, makes up a small mass fraction of the initial powder mixture and mainly includes particles of respirable sizes with aerodynamic diameters of less than 5-7 microns, which are able to penetrate the distal parts of the lungs.
  • GLAXO SMITH KLINE manufactures the Ceratid preparation, which is a powder composition of fluticasone and salmeterol, pre-packaged in a blister tape - 60 doses, placed in an ACCUHALER inhaler (MULTIDISK) [3].
  • the company ASTRA ZENECA produces the drug "Symbicort", which represents a powder composition of budesonide and formoterol, placed in a metered-dose inhaler SIMBICORT TURBUHALER (SIMBICORT TURVUALER) [4].
  • the closest analogue is a powder inhaler [5], which includes a housing covered with a protective cover with openings for air inlet and aerosol outlet connected by an air duct, in which booster channels connected to the dispersant are made, a powder container and a dispenser made in the form of a movable plate with a measured a hole for supplying a dose of powder to the booster channel, an additional measuring hole is made in the movable plate of the dispenser, identical to the first, located at the same distance from the axis of rotation of the dispenser and offset by an angle of 90 ° relative to the first hole so that when the dispenser is rotated, each of the measuring holes is alternately placed either under the hole in the base of the powder container or in one of the acceleration channels, each of which is divided a partition extending from one of the walls of the booster channel at its exit, tightly adjacent to the movable plate of the dispenser, and passing above the measuring hole, into two channels so that only one of the channels is connected to the dispersant, and d
  • the other channel communicates with
  • the technical result is the creation of such a powder inhaler that would be metered, uncomplicated during operation, and which would provide an effective, regulated introduction into the patient's lungs of two active components stored in isolated sections of the container.
  • a powder inhaler comprising a housing covered by a protective cover, with openings for air inlet and aerosol exit, connected by an air duct in which two opposite accelerating channels are made, each of of which is connected to the dispersant, a powder container and a dispenser made in the form of a movable plate with two measuring holes offset relative to each other by a rotation angle of 90 degrees, characterized in that the container is made in the form of two isolated sections, at the base of each of which a hole for supplying powder is made, and in the movable plate of the dispenser there are additionally two measured holes arranged diametrically opposite to those available so that when the movable plate of the dispenser is rotated through an angle of 90 degrees In one of the directions for feeding a dose of powder or when the metering plate is turned 90 degrees in the opposite direction to supply a subsequent dose of powder, two of the four measuring holes are located under the holes in the bases of two sections of the container, and two other measuring holes are located in the bases two booster
  • FIG. 1 is a schematic diagram of a powder inhaler device.
  • a powder inhaler including a housing 2 covered by a protective cover 1, with openings for air inlet 3 and aerosol exit 4, connected by an air duct in which two opposite accelerating channels 5 are made, each of which is connected to dispersant 6, a powder container 7 and a dispenser 8 made in the form of a movable plate with two measuring holes 9, 12 offset, relative to each other, by a rotation angle of 90 degrees, differs from the analogue in that the powder container 7 is made in the form of two isolated sections 10, Based on each of which an opening 11 for supplying powder and a slide plate dispenser additionally made two measuring holes 9, 12, located diametrically opposite to those available so that when the movable plate of the dispenser 8 is rotated by an angle of 90 degrees in one direction to supply a dose of powder or when the movable plate of the dispenser 8 is rotated by an angle of 90 degrees in the opposite direction for feeding of the subsequent dose of powder, two of the four measured openings 9, 12 are located under the holes 11 in the bases of two sections 10 of the container 7, and two other measured openings 9,
  • a powder inhaler works as follows.
  • two of the four measuring openings 9, 12 are filled with powders of the active components.
  • the movable plate of the dispenser 8 is rotated through an angle of 90 °, the filled measuring holes 9, 12 are moved to the bases of two opposite accelerating channels 5, while the other two measuring holes 9, 12 are moved under the holes 11 in the bases of two isolated sections 10 of the container 7.
  • two of the four measured openings 9, 12 filled with powders of the active components are moved into opposite accelerating channels 5, and the emptied measured openings 9, 12 are located under the openings 11 in the bases of the insulated sections 10 of the container 7 and are filled with powders of the active components.
  • a powder inhaler is proposed, which is covered with a protective cover covering the case, with openings for air inlet and aerosol exit, connected by an air duct, in which two opposing accelerating channels are made, each of which is connected to a dispersant, a powder container and a dispenser made in the form of a movable plate with two measured openings, offset relative to each other, by a rotation angle of 90 degrees.
  • the container is made in the form of two isolated sections for placing various active components in them, a hole for supplying powder is made at the base of each section, and two measured openings are additionally made in the movable plate of the dispenser located diametrically opposite to the already existing measured openings so that when rotating the metering plate at an angle of 90 degrees in one of the directions for feeding a dose of powder or when rotating the metering plate at an angle of 90 degrees cos a reverse direction to feed the powder dose follow, two of the four dimensional apertures are arranged under the holes in the bases of the two container sections and the other two-dimensional hole located in the bases of two accelerating channel.
  • the measured openings located under the openings in the base of the insulated sections of the container are filled with powders of the active components.
  • the filled measuring holes move to the bases of two opposite booster channels, while the other two measuring holes move under the holes in the bases of two isolated sections of the container.
  • atmospheric air enters the accelerating channels of the air duct, at the base of which measured openings filled with powders of active components are located.
  • the air flows in the booster channels carry the powders of the active components and enter the dispersant, where as a result of repeated collisions between themselves and with the walls of the dispersant, particle conglomerates are destroyed and respirable particle fractions of the active components are generated.
  • the aerosol mixture thus formed from the active components enters the patient's lungs through the aerosol exit port.
  • the dispenser 90 ° in the opposite direction In order to introduce the next dose of the combined drug in the form of a powder, it is necessary to turn the dispenser 90 ° in the opposite direction.
  • measured openings filled with powders of active components move into opposite accelerating channels, and emptied measured openings are located under the openings in the bases of insulated sections of the container and are filled with powders of active components.
  • the proposed powder inhaler is metered, easy to use and provides an effective, regulated introduction into the patient’s lungs of two active components stored in isolated sections of the container, which excludes their physicochemical interactions.
  • the invention relates to medical equipment, and in particular to devices intended for the individual administration of powdered drugs into the respiratory tract and lungs of a person, that is, to powder inhalers.
  • the use of the proposed powder inhaler which is metered, easy to use and provides an effective, regulated introduction into the patient’s lungs of two active components stored in isolated sections of the container, which excludes their physicochemical interactions, compared with sets of dosing one-component powder inhalers, is significantly more economical and ergonomic.
  • the proposed powder inhaler has a fairly simple device that allows you to quickly establish its serial production, as it can be made of transparent and opaque polymeric and other similar materials.
  • the powder inhaler can be filled with various medicinal powder mixtures manufactured by pharmaceutical companies.
  • the present invention greatly simplifies the use of a powder inhaler in comparison with the known capsular powder inhalers, in which unit doses of the powders of the active components are factory-packed in gelatin or plastic capsules and must be removed from the device and replaced with new ones after each inhalation. Due to the ease of use and impact efficiency, as well as the simple manufacturing process, the proposed powder inhaler can take its rightful place in the consumer market.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nozzles (AREA)

Abstract

L'invention se rapporte à l'équipement médical, notamment à des dispositifs conçus pour l’administration individuelle de médicaments en poudre dans les voies respiratoires et les poumons d’un patient, et notamment à des inhalateurs de poudre. L'invention vise à créer un inhalateur de poudre qui permet d’effectuer le dosage, qui a un fonctionnement simple et qui permet l'introduction efficace et réglementée dans les poumons du patient de deux composants actifs stockés dans des compartiments isolés d’un récipient. L'inhalateur de poudre de l’invention comprend un corps recouvert par un étui de protection avec des trous d'entrée d'air et de sortie de l'aérosol. Ces trous sont reliés par une conduite d'air qui comporte deux canaux opposés d’accélération d’air, chaque canal étant relié à un disperseur. Le récipient pour poudre et le doseur se présentent comme une plaque mobile avec deux trous de mesure, décalés entre eux à 90°. Il se distingue en ce que le récipient se présente comme deux compartiments isolés dans la base de laquelle on a réalisé un trou d’amenée de poudre. La plaque mobile du doseur comporte en outre deux trous de mesure diamétralement opposés de sorte que lors de la rotation de la plaque mobile du doseur à 90° dans une des directions d’amenée de poudre, ou à un angle 90° dans une direction opposée, pour la distribution de la portion de poudre suivante, deux sur quatre trous de mesure se situent sous les trous dans les bases des deux compartiments du récipient, et que les deux autres trous de mesure se situent dans les bases des deux canaux d'accélération.
PCT/RU2009/000265 2008-05-27 2009-05-27 Inhalateur de poudre Ceased WO2009145673A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201001864A EA017662B1 (ru) 2008-05-27 2009-05-27 Порошковый ингалятор

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2008120838 2008-05-27
RU2008120838/14A RU2376040C1 (ru) 2008-05-27 2008-05-27 Порошковый ингалятор

Publications (2)

Publication Number Publication Date
WO2009145673A2 true WO2009145673A2 (fr) 2009-12-03
WO2009145673A3 WO2009145673A3 (fr) 2010-01-21

Family

ID=41377824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2009/000265 Ceased WO2009145673A2 (fr) 2008-05-27 2009-05-27 Inhalateur de poudre

Country Status (3)

Country Link
EA (1) EA017662B1 (fr)
RU (1) RU2376040C1 (fr)
WO (1) WO2009145673A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161901A1 (fr) * 2013-04-03 2014-10-09 Sanofi Sa Élément de dosage pour un dispositif d'inhalation et ensemble destiné à un dispositif d'inhalation comprenant un élément de dosage
WO2015150517A1 (fr) * 2014-04-03 2015-10-08 Iconovo Ab Inhalateur de poudre sèche
WO2015150519A1 (fr) * 2014-04-03 2015-10-08 Iconovo Ab Inhalateur de poudre sèche
WO2015150518A1 (fr) * 2014-04-03 2015-10-08 Iconovo Ab Inhalateur de poudre sèche
WO2016180753A1 (fr) * 2015-05-08 2016-11-17 Iconovo Ab Inhalateur à poudre sèche

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3168027A1 (fr) 2020-03-31 2021-10-07 Jurgen Rawert Distribution d'aerosol d'au moins deux compositions liquides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
ATE228024T1 (de) * 1994-09-16 2002-12-15 Glaxosmithkline Lab Sas Inhalator
RU2080883C1 (ru) * 1994-11-22 1997-06-10 Александр Григорьевич Чучалин Ингалятор
RU2163149C1 (ru) * 1999-06-25 2001-02-20 Чучалин Александр Григорьевич Ингалятор для введения лекарственных средств в виде порошка
RU2258539C1 (ru) * 2004-03-23 2005-08-20 Чучалин Александр Григорьевич Порошковый ингалятор

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161901A1 (fr) * 2013-04-03 2014-10-09 Sanofi Sa Élément de dosage pour un dispositif d'inhalation et ensemble destiné à un dispositif d'inhalation comprenant un élément de dosage
WO2015150517A1 (fr) * 2014-04-03 2015-10-08 Iconovo Ab Inhalateur de poudre sèche
WO2015150519A1 (fr) * 2014-04-03 2015-10-08 Iconovo Ab Inhalateur de poudre sèche
WO2015150518A1 (fr) * 2014-04-03 2015-10-08 Iconovo Ab Inhalateur de poudre sèche
CN106163596A (zh) * 2014-04-03 2016-11-23 艾克诺韦公司 干粉吸入器
CN113616884A (zh) * 2014-04-03 2021-11-09 艾克诺韦公司 干粉吸入器
WO2016180753A1 (fr) * 2015-05-08 2016-11-17 Iconovo Ab Inhalateur à poudre sèche
US11000652B2 (en) 2015-05-08 2021-05-11 Iconovo Ab Dry powder inhaler

Also Published As

Publication number Publication date
RU2376040C1 (ru) 2009-12-20
WO2009145673A3 (fr) 2010-01-21
EA017662B1 (ru) 2013-02-28
EA201001864A1 (ru) 2011-06-30

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