RU2376040C1 - Порошковый ингалятор - Google Patents

Порошковый ингалятор Download PDF

Info

Publication number: RU2376040C1
Authority: RU; Russia
Prior art keywords: powder; container; holes; movable plate; sections
Prior art date: 2008-05-27

Application number

RU2008120838/14A

Other languages

English (en)

Russian (ru)

Inventor

Александр Григорьевич Чучалин (RU)

Александр Григорьевич Чучалин

Евгений Викторович Бабарсков (RU)

Евгений Викторович Бабарсков

Владимир Евгеньевич Небольсин (RU)

Владимир Евгеньевич Небольсин

Original Assignee

Александр Григорьевич Чучалин

Евгений Викторович Бабарсков

Владимир Евгеньевич Небольсин

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-05-27

Filing date

2008-05-27

Publication date

2009-12-20

2008-05-27 Application filed by Александр Григорьевич Чучалин, Евгений Викторович Бабарсков, Владимир Евгеньевич Небольсин filed Critical Александр Григорьевич Чучалин

2008-05-27 Priority to RU2008120838/14A priority Critical patent/RU2376040C1/ru

2009-05-27 Priority to EA201001864A priority patent/EA017662B1/ru

2009-05-27 Priority to PCT/RU2009/000265 priority patent/WO2009145673A2/fr

2009-12-20 Application granted granted Critical

2009-12-20 Publication of RU2376040C1 publication Critical patent/RU2376040C1/ru

Links

239000000843 powder Substances 0.000 title claims abstract description 78
239000000443 aerosol Substances 0.000 claims abstract description 11
230000001681 protective effect Effects 0.000 claims abstract description 6
239000002270 dispersing agent Substances 0.000 claims description 9
210000004072 lung Anatomy 0.000 abstract description 15
239000003814 drug Substances 0.000 abstract description 14
230000000694 effects Effects 0.000 abstract description 4
239000000126 substance Substances 0.000 abstract description 2
239000000203 mixture Substances 0.000 description 14
229940079593 drug Drugs 0.000 description 12
239000002245 particle Substances 0.000 description 12
230000001105 regulatory effect Effects 0.000 description 4
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 3
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 3
229960004436 budesonide Drugs 0.000 description 3
230000003993 interaction Effects 0.000 description 3
229960004017 salmeterol Drugs 0.000 description 3
PJFHZKIDENOSJB-UHFFFAOYSA-N Budesonide/formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1.C1CC2=CC(=O)C=CC2(C)C2C1C1CC3OC(CCC)OC3(C(=O)CO)C1(C)CC2O PJFHZKIDENOSJB-UHFFFAOYSA-N 0.000 description 2
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
230000001133 acceleration Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
210000002345 respiratory system Anatomy 0.000 description 2
229940035073 symbicort Drugs 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
241001132374 Asta Species 0.000 description 1
206010011224 Cough Diseases 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
206010013952 Dysphonia Diseases 0.000 description 1
208000000059 Dyspnea Diseases 0.000 description 1
206010013975 Dyspnoeas Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
206010050346 Oropharyngeal candidiasis Diseases 0.000 description 1
YYAZJTUGSQOFHG-IAVNQIGZSA-N [(6s,8s,10s,11s,13s,14s,16r,17r)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]eth Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)C1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O YYAZJTUGSQOFHG-IAVNQIGZSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
229940092705 beclomethasone Drugs 0.000 description 1
NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000011362 coarse particle Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
229960002714 fluticasone Drugs 0.000 description 1
MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
229960000289 fluticasone propionate Drugs 0.000 description 1
WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 1
229960002848 formoterol Drugs 0.000 description 1
BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000004199 lung function Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229940071648 metered dose inhaler Drugs 0.000 description 1
210000003300 oropharynx Anatomy 0.000 description 1
238000005192 partition Methods 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
238000000926 separation method Methods 0.000 description 1
208000013220 shortness of breath Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000012780 transparent material Substances 0.000 description 1

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Anesthesiology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nozzles (AREA)

RU2008120838/14A 2008-05-27 2008-05-27 Порошковый ингалятор RU2376040C1 (ru)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
RU2008120838/14A RU2376040C1 (ru)	2008-05-27	2008-05-27	Порошковый ингалятор
EA201001864A EA017662B1 (ru)	2008-05-27	2009-05-27	Порошковый ингалятор
PCT/RU2009/000265 WO2009145673A2 (fr)	2008-05-27	2009-05-27	Inhalateur de poudre

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
RU2008120838/14A RU2376040C1 (ru)	2008-05-27	2008-05-27	Порошковый ингалятор

Publications (1)

Publication Number	Publication Date
RU2376040C1 true RU2376040C1 (ru)	2009-12-20

Family

ID=41377824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2008120838/14A RU2376040C1 (ru)	2008-05-27	2008-05-27	Порошковый ингалятор

Country Status (3)

Country	Link
EA (1)	EA017662B1 (fr)
RU (1)	RU2376040C1 (fr)
WO (1)	WO2009145673A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2833773C1 (ru) *	2020-03-31	2025-01-28	инвоКС Белджиум НВ	Ингаляционное устройство для образования аэрозоля из по меньшей мере двух жидких композиций, способ (варианты) лечения субъекта, страдающего от заболевания, с использованием ингаляционного устройства, применение комбинации первой и второй жидких композиций в способе лечения субъекта, страдающего от заболевания, с использованием ингаляционного устройства, первый резервуар, содержащий первую жидкую композицию, содержащую бета-агонист длительного действия, и второй резервуар, содержащий вторую жидкую композицию, выполненные с возможностью использования с ингаляционным устройством, применение ингаляционного устройства или первого резервуара, содержащего первую жидкую композицию, содержащую бета-агонист длительного действия, и способ доставки по меньшей мере двух жидких композиций субъекту
US12478748B2 (en)	2020-03-31	2025-11-25	Invox Belgium Nv	Aerosol delivery of at least two liquid compositions

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR095222A1 (es) *	2013-04-03	2015-09-30	Sanofi Sa	Elemento de medición para un dispositivo de inhalación y montaje para un dispositivo de inhalación que comprende un elemento de medición
SE538399C2 (sv) *	2014-04-03	2016-06-14	Iconovo Ab	Torrpulverinhalator
SE538400C2 (sv) *	2014-04-03	2016-06-14	Iconovo Ab	Torrpulverinhalator
SE539930C2 (sv) *	2014-04-03	2018-01-23	Iconovo Ab	Torrpulverinhalator
EP3294390B1 (fr) *	2015-05-08	2022-10-05	Iconovo AB	Inhalateur de poudre sèche

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0505321A3 (en) *	1991-03-21	1993-01-27	Ciba-Geigy Ag	Inhaler
RU2157251C2 (ru) *	1994-09-16	2000-10-10	Лаборатуар Глаксо Велльком С.А.	Устройство для ингаляции
RU2258539C1 (ru) *	2004-03-23	2005-08-20	Чучалин Александр Григорьевич	Порошковый ингалятор

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2080883C1 (ru) *	1994-11-22	1997-06-10	Александр Григорьевич Чучалин	Ингалятор
RU2163149C1 (ru) *	1999-06-25	2001-02-20	Чучалин Александр Григорьевич	Ингалятор для введения лекарственных средств в виде порошка

2008
- 2008-05-27 RU RU2008120838/14A patent/RU2376040C1/ru not_active IP Right Cessation
2009
- 2009-05-27 WO PCT/RU2009/000265 patent/WO2009145673A2/fr not_active Ceased
- 2009-05-27 EA EA201001864A patent/EA017662B1/ru not_active IP Right Cessation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0505321A3 (en) *	1991-03-21	1993-01-27	Ciba-Geigy Ag	Inhaler
RU2157251C2 (ru) *	1994-09-16	2000-10-10	Лаборатуар Глаксо Велльком С.А.	Устройство для ингаляции
RU2258539C1 (ru) *	2004-03-23	2005-08-20	Чучалин Александр Григорьевич	Порошковый ингалятор

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2833773C1 (ru) *	2020-03-31	2025-01-28	инвоКС Белджиум НВ	Ингаляционное устройство для образования аэрозоля из по меньшей мере двух жидких композиций, способ (варианты) лечения субъекта, страдающего от заболевания, с использованием ингаляционного устройства, применение комбинации первой и второй жидких композиций в способе лечения субъекта, страдающего от заболевания, с использованием ингаляционного устройства, первый резервуар, содержащий первую жидкую композицию, содержащую бета-агонист длительного действия, и второй резервуар, содержащий вторую жидкую композицию, выполненные с возможностью использования с ингаляционным устройством, применение ингаляционного устройства или первого резервуара, содержащего первую жидкую композицию, содержащую бета-агонист длительного действия, и способ доставки по меньшей мере двух жидких композиций субъекту
US12478748B2 (en)	2020-03-31	2025-11-25	Invox Belgium Nv	Aerosol delivery of at least two liquid compositions

Also Published As

Publication number	Publication date
WO2009145673A2 (fr)	2009-12-03
WO2009145673A3 (fr)	2010-01-21
EA017662B1 (ru)	2013-02-28
EA201001864A1 (ru)	2011-06-30

Publication	Publication Date	Title
JP4405688B2 (ja)	2010-01-27	複合薬剤用の粉末吸入器
Atkins	2005	Dry powder inhalers: an overview
Lavorini et al.	2017	Recent advances in capsule-based dry powder inhaler technology
AU760749B2 (en)	2003-05-22	Powder inhaler for combined medicament
CN101384288B (zh)	2012-09-05	干粉吸入器设备
US20090250058A1 (en)	2009-10-08	Inhalation System and Delivery Device for the Administration of a Drug in the Form of Dry Powder
JP5404618B2 (ja)	2014-02-05	ドライパウダー薬剤
EP1744800B1 (fr)	2016-06-22	Inhalateur
RU2376040C1 (ru)	2009-12-20	Порошковый ингалятор
JP2009537199A (ja)	2009-10-29	簡易吸入器
CN102596297B (zh)	2014-09-10	药物产品、干粉吸入器和多流碰撞器布置
Yang et al.	2001	Drug delivery performance of the mometasone furoate dry powder inhaler
CN110494181A (zh)	2019-11-22	用于输送干粉药物的装置和方法
CN116615201A (zh)	2023-08-18	丙酸氟替卡松和硫酸沙丁胺醇的可吸入制剂
EP3125977B1 (fr)	2020-07-29	Inhalateur de poudre sèche
SE527200C2 (sv)	2006-01-17	Inhalatoranordning samt kombinerade doser av formaterol och fluticason
Hejduk et al.	2018	Technical challenges in obtaining an optimized powder/DPI combination for inhalation delivery of a bi-component generic drug
RU2258539C1 (ru)	2005-08-20	Порошковый ингалятор
CN116077471A (zh)	2023-05-09	一种供吸入用的粉雾剂组合物及其制备方法和应用
WO2004110491A1 (fr)	2004-12-23	Doses combinees
WO2011110970A1 (fr)	2011-09-15	Inhalateur de poudre sèche à dose unique
Patel et al.	2021	Devices for Dry Powder Drug Delivery to the Lung
Asif et al.	2017	Dry powder inhaler devices
Hrindo et al.	2010	Advanced drug delivery through an inhaler utilizing a venturi
Kadu et al.	0	Journal of Advanced Drug Delivery (JADD) ISSN NO: 2348-3278

Legal Events

Date	Code	Title	Description
2012-03-20	MM4A	The patent is invalid due to non-payment of fees	Effective date: 20110528

RU2376040C1 - Порошковый ингалятор - Google Patents

Info

Links

Images

Classifications

Landscapes

Priority Applications (3)

Applications Claiming Priority (1)

Publications (1)

Family

ID=41377824

Family Applications (1)

Country Status (3)

Cited By (2)

Families Citing this family (5)

Citations (3)

Family Cites Families (2)

Patent Citations (3)

Cited By (2)

Also Published As

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