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WO2009025169A1 - 光学活性α－フルオロカルボン酸エステルの精製方法 - Google Patents

光学活性α－フルオロカルボン酸エステルの精製方法 Download PDF

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Publication number
WO2009025169A1
WO2009025169A1 PCT/JP2008/064016 JP2008064016W WO2009025169A1 WO 2009025169 A1 WO2009025169 A1 WO 2009025169A1 JP 2008064016 W JP2008064016 W JP 2008064016W WO 2009025169 A1 WO2009025169 A1 WO 2009025169A1
Authority
WO
WIPO (PCT)
Prior art keywords
optically active
ester
purification
fluorocarboxylic acid
acid esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/064016
Other languages
English (en)
French (fr)
Inventor
Akihiro Ishii
Hideyuki Tsuruta
Yuzuru Morino
Mikihiro Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Central Glass Co Ltd
Original Assignee
Central Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Glass Co Ltd filed Critical Central Glass Co Ltd
Priority to EP08792202.7A priority Critical patent/EP2189438B1/en
Priority to US12/673,956 priority patent/US8748653B2/en
Priority to CN200880103038A priority patent/CN101778813A/zh
Publication of WO2009025169A1 publication Critical patent/WO2009025169A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　開示されているのは、式［１］ 【化３０】 ［式中、Ｒ1は炭素数１から６のアルキル基を表し、Ｒ2は炭素数１から４のアルキル基を表し、＊は不斉炭素を表す］で示される光学活性α－フルオロカルボン酸エステルに含まれるフッ化物イオンを低減除去する精製方法であって、有機塩基の存在下に蒸留することを特徴とする、光学活性α－フルオロカルボン酸エステルの精製方法である。この方法により、光学活性α－フルオロカルボン酸エステル中に含まれるフッ化物イオン痕の濃度を、比較的容易な操作で大幅に低減することができる。有機塩基の中でも、第三級アミンが好ましく、中でもトリｎ－ブチルアミンが特に好ましい。
PCT/JP2008/064016 2007-08-17 2008-08-05 光学活性α－フルオロカルボン酸エステルの精製方法 Ceased WO2009025169A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08792202.7A EP2189438B1 (en) 2007-08-17 2008-08-05 Method for purification of optically active -fluorocarboxylic acid esters
US12/673,956 US8748653B2 (en) 2007-08-17 2008-08-05 Method for purification of optically active α-fluorocarboxylic acid esters
CN200880103038A CN101778813A (zh) 2007-08-17 2008-08-05 光学活性α-氟代羧酸酯的精制方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007212686 2007-08-17
JP2007-212686 2007-08-17
JP2008191444A JP5326400B2 (ja) 2007-08-17 2008-07-24 光学活性α−フルオロカルボン酸エステルの精製方法
JP2008-191444 2008-07-24

Publications (1)

Publication Number Publication Date
WO2009025169A1 true WO2009025169A1 (ja) 2009-02-26

Family

ID=40378077

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064016 Ceased WO2009025169A1 (ja) 2007-08-17 2008-08-05 光学活性α－フルオロカルボン酸エステルの精製方法

Country Status (5)

Country Link
US (1) US8748653B2 (ja)
EP (1) EP2189438B1 (ja)
JP (1) JP5326400B2 (ja)
CN (1) CN101778813A (ja)
WO (1) WO2009025169A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011152155A1 (ja) * 2010-06-03 2011-12-08 セントラル硝子株式会社 （２Ｒ）－２－フルオロ－２－Ｃ－メチル－Ｄ－リボノ－γ－ラクトン類前駆体の製造方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5217927B2 (ja) * 2008-11-12 2013-06-19 セントラル硝子株式会社 ジフルオロ酢酸エステルの製造方法
TWI632235B (zh) 2012-06-20 2018-08-11 美商先進精鍊科技有限公司 用於殘渣油徑原料之加氫脫硫反應的觸媒及其製備方法
CN112897488B (zh) * 2021-03-19 2023-10-24 常州高优纳米新材料有限公司 一种微通道反应器制备双氟磺酰亚胺的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271249A (ja) * 1985-05-28 1986-12-01 Daicel Chem Ind Ltd 光学活性α−クロルカルボン酸エステルの精製方法
JP2006290870A (ja) * 2005-03-18 2006-10-26 Central Glass Co Ltd スルフリルフルオリドを用いるフッ素化反応
JP2007212495A (ja) 2006-02-07 2007-08-23 Seiko Epson Corp レンズシートおよびプリンタ
WO2008090755A1 (ja) * 2007-01-23 2008-07-31 Central Glass Company, Limited 光学活性α－フルオロカルボン酸エステルの製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001354622A (ja) * 2000-04-11 2001-12-25 F-Tech Inc ２−フルオロ−３−オキソアルキルカルボン酸エステルの精製分離方法
WO2003031387A1 (en) * 2000-04-12 2003-04-17 Tosoh F-Tech, Inc. Method of purifying and separating 2-fluoro-3-oxoalkylcarboxylic acid ester
CN1976891B (zh) * 2004-08-18 2011-05-25 中央硝子株式会社 光学活性α-氟代羧酸酯衍生物的制造方法
JP4839724B2 (ja) 2004-08-18 2011-12-21 セントラル硝子株式会社 光学活性α−フルオロカルボン酸エステル誘導体の製造方法
FR2876100B1 (fr) 2004-10-04 2006-12-08 Rhodia Chimie Sa Procede de preparation stereoselectif d'une molecule comportant un fluor en alpha d'un groupe ester ou cetone
DE102004060493A1 (de) 2004-12-16 2006-07-06 Lanxess Deutschland Gmbh Verfahren zur Herstellung von enantiomerenangereicherten 2-Fluorcarbonsäureestern
JP5007494B2 (ja) 2005-07-04 2012-08-22 セイコーエプソン株式会社 電子デバイスの製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271249A (ja) * 1985-05-28 1986-12-01 Daicel Chem Ind Ltd 光学活性α−クロルカルボン酸エステルの精製方法
JP2006290870A (ja) * 2005-03-18 2006-10-26 Central Glass Co Ltd スルフリルフルオリドを用いるフッ素化反応
JP2007212495A (ja) 2006-02-07 2007-08-23 Seiko Epson Corp レンズシートおよびプリンタ
WO2008090755A1 (ja) * 2007-01-23 2008-07-31 Central Glass Company, Limited 光学活性α－フルオロカルボン酸エステルの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2189438A4

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011152155A1 (ja) * 2010-06-03 2011-12-08 セントラル硝子株式会社 （２Ｒ）－２－フルオロ－２－Ｃ－メチル－Ｄ－リボノ－γ－ラクトン類前駆体の製造方法
JP2012144511A (ja) * 2010-06-03 2012-08-02 Central Glass Co Ltd （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類前駆体の製造方法
CN102933570A (zh) * 2010-06-03 2013-02-13 中央硝子株式会社 (2R)-2-氟-2-C-甲基-D-核糖酸-γ-内酯类前体的制造方法
US8669382B2 (en) 2010-06-03 2014-03-11 Central Glass Company, Limited Method for producing (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor
CN102933570B (zh) * 2010-06-03 2014-07-16 中央硝子株式会社 (2R)-2-氟-2-C-甲基-D-核糖酸-γ-内酯类前体的制造方法

Also Published As

Publication number Publication date
EP2189438B1 (en) 2015-10-07
EP2189438A1 (en) 2010-05-26
US20110021809A1 (en) 2011-01-27
JP5326400B2 (ja) 2013-10-30
US8748653B2 (en) 2014-06-10
CN101778813A (zh) 2010-07-14
JP2009067776A (ja) 2009-04-02
EP2189438A4 (en) 2013-09-04

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