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WO2009010660A3 - Indazoles substitues, leur preparation et leur utilisation en therapeutique - Google Patents

Indazoles substitues, leur preparation et leur utilisation en therapeutique Download PDF

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Publication number
WO2009010660A3
WO2009010660A3 PCT/FR2008/000843 FR2008000843W WO2009010660A3 WO 2009010660 A3 WO2009010660 A3 WO 2009010660A3 FR 2008000843 W FR2008000843 W FR 2008000843W WO 2009010660 A3 WO2009010660 A3 WO 2009010660A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
group
heterocycloalkyl
alkenyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/000843
Other languages
English (en)
Other versions
WO2009010660A2 (fr
Inventor
Michel Aletru
Dominique Damour
Catherine Monseau
Patrick Mougenot
Claudie Namane
Frederico Nardi
Patrick Nemecek
Christophe Philippo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39126183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009010660(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to EP08826411A priority Critical patent/EP2170865A2/fr
Priority to JP2010512736A priority patent/JP2010530402A/ja
Publication of WO2009010660A2 publication Critical patent/WO2009010660A2/fr
Publication of WO2009010660A3 publication Critical patent/WO2009010660A3/fr
Priority to US12/636,357 priority patent/US20100298377A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention est relative à des composés de formule (I) dans laquelle : E désigne un groupement : (i) de formule -NT-CO-O- ou -NT-CX-NT'- dans laquelle X désigne =O ou =S et T et T', pouvant être identiques ou différents, sont choisis indépendamment parmi H ou un groupe alkyle ou (ii) formant un cycle à 5 ou 6 chaînons qui est rattaché en position 5 ou 6 au noyau indazole par -NT- ou par l'atome d'azote N1; R1 représente un ou plusieurs substituant(s), choisis indépendamment l'un de l'autre lorsqu'il y en a plusieurs, pouvant être : un atome d'halogène, un groupe alkyle, alkényle, alkynyle, halogénoalkyle, halogénoalcoxy, aryle, hétéroaryle, hétérocycloalkyle, cycloalkyle, CN, NRR', OR, NO2, COOR, CONRR', NRCOR'; R2 représente un atome d'hydrogène, un groupe alkyle, alkényle ou alkynyle; R3 représente un ou plusieurs substituant(s), choisis indépendamment l'un de l'autre lorsqu'il y en a plusieurs et pouvant être : un atome d'halogène, un groupe alkyle, alkényle, alkynyle, halogénoalcoxy, aryle, hétéroaryle, cycloalkyle, hétérocycloalkyle, CN, NRR', CF3, OR, NO2, COOR, CONRR', NRCOR'; R4 désigne un atome d'hydrogène ou d'halogène, un groupe alkyle, alkényle, alkynyle, aryle, hétéroaryle, hétérocycloalkyle, -NR-CO-R', COOR, NRR', CHO, CONR(OR'); R et R', pouvant être identiques ou différents, désignent indépendamment l'un de l'autre : un atome d'hydrogène, un groupe alkyle, aryle, hétérocycloalkyle, cycloalkyle ou hétéroaryle; n1 représente un nombre entier allant de 0 à 5 et n3 un nombre entier allant de 0 à 3.
PCT/FR2008/000843 2007-06-21 2008-06-18 Indazoles substitues, leur preparation et leur utilisation en therapeutique Ceased WO2009010660A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08826411A EP2170865A2 (fr) 2007-06-21 2008-06-18 Indazoles substitues, leur preparation et leur utilisation en therapeutique
JP2010512736A JP2010530402A (ja) 2007-06-21 2008-06-18 置換インダゾール類、それらの調製および治療におけるその使用
US12/636,357 US20100298377A1 (en) 2007-06-21 2009-12-11 Novel substituted indazoles, the preparation thereof and use of same in therapeutics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0704422A FR2917735B1 (fr) 2007-06-21 2007-06-21 Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
FR0704422 2007-06-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/636,357 Continuation US20100298377A1 (en) 2007-06-21 2009-12-11 Novel substituted indazoles, the preparation thereof and use of same in therapeutics

Publications (2)

Publication Number Publication Date
WO2009010660A2 WO2009010660A2 (fr) 2009-01-22
WO2009010660A3 true WO2009010660A3 (fr) 2009-04-16

Family

ID=39126183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000843 Ceased WO2009010660A2 (fr) 2007-06-21 2008-06-18 Indazoles substitues, leur preparation et leur utilisation en therapeutique

Country Status (11)

Country Link
US (1) US20100298377A1 (fr)
EP (1) EP2170865A2 (fr)
JP (1) JP2010530402A (fr)
AR (1) AR067051A1 (fr)
CL (1) CL2008001815A1 (fr)
FR (1) FR2917735B1 (fr)
PA (1) PA8785301A1 (fr)
PE (1) PE20090369A1 (fr)
TW (1) TW200909425A (fr)
UY (1) UY31166A1 (fr)
WO (1) WO2009010660A2 (fr)

Families Citing this family (46)

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Publication number Priority date Publication date Assignee Title
PL2464232T3 (pl) 2009-08-10 2016-04-29 Samumed Llc Indazolowe inhibitory szlaku sygnałowego Wnt i ich zastosowania terapeutyczne
CA2785037C (fr) * 2009-12-21 2018-01-16 Samumed, Llc 1h-pyrazolo[3,4-b]pyridines et leurs utilisations therapeutiques
EP2694060A4 (fr) * 2011-04-01 2014-09-10 Univ Utah Res Found Analogues de 3-(1h-benzo[d]imidazol-2-yl)-1h-indazole substitués en tant qu'inhibiteurs de la pdk1 kinase
US9221793B2 (en) 2011-09-14 2015-12-29 Samumed, Llc Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors
KR20130073822A (ko) 2011-12-23 2013-07-03 가부시키가이샤 한도오따이 에네루기 켄큐쇼 이온 액체, 비수 전해질 및 축전 장치
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
PE20142365A1 (es) 2012-05-04 2015-01-30 Samumed Llc 1h-pirazolo[3,4-b]piridinas y usos terapeuticos de las mismas
CA2897400A1 (fr) 2013-01-08 2014-07-17 Samumed, Llc Inhibiteurs de 3-(benzoimidazol-2-yl)-indazole de la voie de signalisation par wnt et leurs utilisations therapeutiques
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
WO2016040182A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine et ses utilisations thérapeutiques
WO2016040193A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040180A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040181A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040190A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040188A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040184A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040185A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine et ses utilisations thérapeutiques
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
WO2017023986A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-indazoles et leurs utilisations thérapeutiques
WO2017024004A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques
US10206908B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017024003A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques
WO2017024021A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles et leurs utilisations thérapeutiques
US10188634B2 (en) 2015-08-03 2019-01-29 Samumed, Llc 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023996A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques
WO2017023980A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines et leurs utilisations thérapeutiques
US10195185B2 (en) 2015-08-03 2019-02-05 Samumed, Llc 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10329309B2 (en) 2015-08-03 2019-06-25 Samumed, Llc 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024025A1 (fr) 2015-08-03 2017-02-09 Sunil Kumar Kc 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
US10226448B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
US10226453B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023975A1 (fr) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines et leus utilisations thérapeutiques
US10392383B2 (en) 2015-08-03 2019-08-27 Samumed, Llc 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10166218B2 (en) 2015-08-03 2019-01-01 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
KR20180080262A (ko) 2015-11-06 2018-07-11 사뮤메드, 엘엘씨 골관절염의 치료
HUE060797T2 (hu) 2016-06-01 2023-04-28 Biosplice Therapeutics Inc Eljárás N-(5-(3-(7-(3-fluorfenil)-3H-imidazo[4,5-c]piridin-2-il)-1H-indazol-5-il)- piridin-3-il)-3-metilbutánamid elõállítására
JP2019535672A (ja) 2016-10-21 2019-12-12 サミュメッド リミテッド ライアビリティ カンパニー インダゾール−３−カルボキサミドの使用方法およびｗｎｔ／β−カテニンシグナル伝達経路阻害剤としてのそれらの使用
WO2018085865A1 (fr) 2016-11-07 2018-05-11 Samumed, Llc Formulations injectables à dose unique prêtes à l'emploi
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903827D0 (en) * 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB201903832D0 (en) * 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods

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WO2002010137A2 (fr) * 2000-07-31 2002-02-07 Signal Pharmaceuticals, Inc. Derives d'indazole utilises comme inhibiteurs de jnk et compositions et methodes associees a ceux-ci
FR2836914A1 (fr) * 2002-03-11 2003-09-12 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
WO2005037792A1 (fr) * 2003-10-17 2005-04-28 Sanofi-Aventis Derives de n-``phenyl(piperidin-2-yl)methyl !benzamide, leur preparation et leur application en therapeutique
WO2006135383A2 (fr) * 2004-08-04 2006-12-21 Myriad Genetics, Inc. Indazoles

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WO2002010137A2 (fr) * 2000-07-31 2002-02-07 Signal Pharmaceuticals, Inc. Derives d'indazole utilises comme inhibiteurs de jnk et compositions et methodes associees a ceux-ci
FR2836914A1 (fr) * 2002-03-11 2003-09-12 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
WO2003078402A1 (fr) * 2002-03-11 2003-09-25 Aventis Pharma S.A. Indazoles substitues avec une activite anticancereuse
WO2005037792A1 (fr) * 2003-10-17 2005-04-28 Sanofi-Aventis Derives de n-``phenyl(piperidin-2-yl)methyl !benzamide, leur preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
CL2008001815A1 (es) 2009-09-11
PA8785301A1 (es) 2009-01-23
JP2010530402A (ja) 2010-09-09
WO2009010660A2 (fr) 2009-01-22
FR2917735A1 (fr) 2008-12-26
PE20090369A1 (es) 2009-04-30
AR067051A1 (es) 2009-09-30
TW200909425A (en) 2009-03-01
US20100298377A1 (en) 2010-11-25
UY31166A1 (es) 2009-01-30
FR2917735B1 (fr) 2009-09-04
EP2170865A2 (fr) 2010-04-07

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