MX2009008509A - Compuesto de anillo puenteado-aza. - Google Patents
Compuesto de anillo puenteado-aza.Info
- Publication number
- MX2009008509A MX2009008509A MX2009008509A MX2009008509A MX2009008509A MX 2009008509 A MX2009008509 A MX 2009008509A MX 2009008509 A MX2009008509 A MX 2009008509A MX 2009008509 A MX2009008509 A MX 2009008509A MX 2009008509 A MX2009008509 A MX 2009008509A
- Authority
- MX
- Mexico
- Prior art keywords
- aza
- bridged
- muscarinic
- receptor
- antagonistic activity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 102000007202 Muscarinic M3 Receptor Human genes 0.000 abstract 4
- 108010008405 Muscarinic M3 Receptor Proteins 0.000 abstract 4
- 230000003042 antagnostic effect Effects 0.000 abstract 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 208000006673 asthma Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se proporciona un compuesto que tiene una actividad antagónica en el receptor M3 muscarínico, y por consiguiente es útil como un ingrediente activo de un agente profiláctico y/o terapéutico para una enfermedad inflamatoria tal como enfermedad pulmonar obstructiva crónica (COPD) y asma. Se realizó un estudio en un compuesto que tiene una actividad antagónica en el enlace de un receptor M3 muscarínico. Como consecuencia, se descubrió que un compuesto de anillo puenteado-aza representado por la fórmula (1) o una sal del mismo, tiene una actividad antagónica en el enlace de un receptor M3 muscarínico. El compuesto de anillo puenteado-aza tiene una actividad antagónica en el enlace de un receptor M3 muscarínico y por consiguiente se puede utilizar como un agente profiláctico y/o terapéutico para una enfermedad inflamatoria tal como enfermedad pulmonar obstructiva crónica (COPD) y asma, (1) en donde R1 representa -H o un C1-6 alquilo; R2 representa un anillo puenteado-aza seleccionado del grupo que consiste en los anillos representados por las fórmulas (a), (b), (c) y (d) que se encuentran más adelante; y R3 representa un tienilo, un fenilo, un piridilo, un pirazinilo, un tiazolilo o un pirazolilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007030963 | 2007-02-09 | ||
| PCT/JP2008/052189 WO2008096870A1 (ja) | 2007-02-09 | 2008-02-08 | アザ架橋環化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008509A true MX2009008509A (es) | 2009-08-20 |
Family
ID=39681769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008509A MX2009008509A (es) | 2007-02-09 | 2008-02-08 | Compuesto de anillo puenteado-aza. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8367696B2 (es) |
| EP (1) | EP2119716A4 (es) |
| JP (1) | JP5293192B2 (es) |
| KR (1) | KR20090107567A (es) |
| CN (1) | CN101605784B (es) |
| AU (1) | AU2008212171A1 (es) |
| BR (1) | BRPI0806972A2 (es) |
| CA (1) | CA2678193A1 (es) |
| IL (1) | IL200152A0 (es) |
| MX (1) | MX2009008509A (es) |
| RU (1) | RU2441868C2 (es) |
| WO (1) | WO2008096870A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| ES2363998T3 (es) * | 2007-03-23 | 2011-08-22 | Abbott Laboratories | Derivados ester y carbamato de azaadamantano y métodos de uso de los mismos. |
| US9464078B2 (en) | 2010-09-23 | 2016-10-11 | Abbvie Inc. | Monohydrate of azaadamantane derivatives |
| JOP20130273B1 (ar) * | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
| WO2014051055A1 (ja) * | 2012-09-28 | 2014-04-03 | 東レ株式会社 | キヌクリジンウレア誘導体及びその医薬用途 |
| AU2014292722B2 (en) * | 2013-07-13 | 2017-03-09 | Beijing Showby Pharmaceutical Co., Ltd. | Quinine compounds, and optical isomers, preparation method and medical use thereof |
| KR101538846B1 (ko) * | 2013-07-30 | 2015-07-22 | 동아에스티 주식회사 | 신규한 바이페닐 유도체 및 그의 제조방법 |
| WO2017114377A1 (zh) * | 2015-12-29 | 2017-07-06 | 四川海思科制药有限公司 | 一种苯基杂环衍生物及其在医药上的用途 |
| PH12019500380B1 (en) * | 2016-08-26 | 2024-04-17 | Dong A St Co Ltd | Novel salt of (r)-(1-methylpyrrolidine-3-yl)methyl(3`-chloro-4`fluoro-[1,1`-biphenyl]-2-yl)carbamate and a crystal form thereof |
| KR102239776B1 (ko) * | 2016-08-26 | 2021-04-13 | 동아에스티 주식회사 | (r)-(1-메틸피롤리딘-3-일)메틸(3'-클로로-4'-플루오로-[1,1'-비페닐]-2-일)카바메이트의 신규염 및 이의 결정형 |
| WO2019096226A1 (en) | 2017-11-16 | 2019-05-23 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Pasylated vegfr/pdgfr fusion proteins and their use in therapy |
| WO2019110521A1 (en) | 2017-12-04 | 2019-06-13 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Fluorophenyl substituted muscarinic receptor ligands with selectivity for m3 over m2 |
| CN115427038A (zh) | 2020-02-03 | 2022-12-02 | 建新公司 | 治疗与溶酶体贮积病相关的神经系统症状的方法 |
| AU2021311131A1 (en) | 2020-07-24 | 2023-03-23 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ224237A (en) | 1987-04-15 | 1991-04-26 | Beecham Group Plc | Bicyclic compounds (n bridged compounds) |
| AU7545894A (en) | 1993-09-02 | 1995-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| CN1140447A (zh) * | 1994-02-10 | 1997-01-15 | 山之内制药株式会社 | 新的氨基甲酸酯衍生物及其药物组合物 |
| KR970701174A (ko) | 1994-02-10 | 1997-03-17 | 오노다 마사요시 | 신규한 카바메이트 유도체 및 이의 의약 조성물(Novel carbamate derivative and medicinal composition containing the same) |
| WO1995024399A1 (en) | 1994-03-11 | 1995-09-14 | Yamanouchi Pharmaceutical Co., Ltd. | 5-ht3 receptor agonist, novel thiazole derivative, and intermediate therefor |
| JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
| SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| UY25225A1 (es) | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| US6916828B2 (en) | 2000-06-27 | 2005-07-12 | Laboratorios S.A.L.V.A.T., S.A. | Carbamates derivatived from arylakylamines |
| AU2002228015B2 (en) | 2000-12-22 | 2007-08-23 | Almirall, S.A. | Quinuclidine carbamate derivatives and their use as M3 antagonists |
| PT1353919E (pt) | 2000-12-28 | 2006-11-30 | Almirall Prodesfarma Ag | Novos derivados de quinuclidina e composições medicinais contendo os mesmos |
| JP2003267977A (ja) * | 2002-03-14 | 2003-09-25 | Yamanouchi Pharmaceut Co Ltd | キヌクリジン誘導体 |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| TW200410951A (en) | 2002-08-06 | 2004-07-01 | Glaxo Group Ltd | M3 muscarinic acetylcholine receptor antagonists |
| DE10255040A1 (de) | 2002-11-26 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Carbaminsäureester mit anticholinerger Wirksamkeit |
| TW200538095A (en) | 2004-03-11 | 2005-12-01 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2006005057A2 (en) | 2004-06-30 | 2006-01-12 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| EP1904446A2 (en) | 2005-07-11 | 2008-04-02 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
| WO2008041184A2 (en) | 2006-10-03 | 2008-04-10 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
-
2008
- 2008-02-08 CN CN2008800044089A patent/CN101605784B/zh not_active Expired - Fee Related
- 2008-02-08 EP EP08711068A patent/EP2119716A4/en not_active Withdrawn
- 2008-02-08 BR BRPI0806972-7A2A patent/BRPI0806972A2/pt not_active IP Right Cessation
- 2008-02-08 KR KR1020097018755A patent/KR20090107567A/ko not_active Ceased
- 2008-02-08 MX MX2009008509A patent/MX2009008509A/es not_active Application Discontinuation
- 2008-02-08 JP JP2008557177A patent/JP5293192B2/ja not_active Expired - Fee Related
- 2008-02-08 US US12/524,758 patent/US8367696B2/en not_active Expired - Fee Related
- 2008-02-08 CA CA002678193A patent/CA2678193A1/en not_active Abandoned
- 2008-02-08 WO PCT/JP2008/052189 patent/WO2008096870A1/ja not_active Ceased
- 2008-02-08 AU AU2008212171A patent/AU2008212171A1/en not_active Abandoned
- 2008-02-08 RU RU2009133781/04A patent/RU2441868C2/ru not_active IP Right Cessation
-
2009
- 2009-07-30 IL IL200152A patent/IL200152A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL200152A0 (en) | 2010-04-15 |
| CN101605784B (zh) | 2013-04-10 |
| US20100105658A1 (en) | 2010-04-29 |
| JP5293192B2 (ja) | 2013-09-18 |
| BRPI0806972A2 (pt) | 2014-04-08 |
| EP2119716A4 (en) | 2011-06-01 |
| AU2008212171A1 (en) | 2008-08-14 |
| US8367696B2 (en) | 2013-02-05 |
| KR20090107567A (ko) | 2009-10-13 |
| RU2441868C2 (ru) | 2012-02-10 |
| RU2009133781A (ru) | 2011-03-20 |
| EP2119716A1 (en) | 2009-11-18 |
| WO2008096870A1 (ja) | 2008-08-14 |
| CN101605784A (zh) | 2009-12-16 |
| JPWO2008096870A1 (ja) | 2010-05-27 |
| CA2678193A1 (en) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |