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WO2009005077A1 - ４－｛３－［４－（３－｛４－［アミノ（ブトキシカルボニルイミノ）メチル］フェノキシ｝プロピル）－１－ピペリジニル］プロポキシ｝－ｎ’－（ブトキシカルボニル）ベンズアミジンの新規な結晶 - Google Patents

４－｛３－［４－（３－｛４－［アミノ（ブトキシカルボニルイミノ）メチル］フェノキシ｝プロピル）－１－ピペリジニル］プロポキシ｝－ｎ’－（ブトキシカルボニル）ベンズアミジンの新規な結晶 Download PDF

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Publication number
WO2009005077A1
WO2009005077A1 PCT/JP2008/061944 JP2008061944W WO2009005077A1 WO 2009005077 A1 WO2009005077 A1 WO 2009005077A1 JP 2008061944 W JP2008061944 W JP 2008061944W WO 2009005077 A1 WO2009005077 A1 WO 2009005077A1
Authority
WO
WIPO (PCT)
Prior art keywords
crystals
butoxycarbonylimino
benzamidine
butoxycarbonyl
piperidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/061944
Other languages
English (en)
French (fr)
Inventor
Junichi Mitsuyama
Naokatu Aoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK08790795.2T priority Critical patent/DK2189446T3/da
Priority to CA2691954A priority patent/CA2691954C/en
Priority to MX2009013913A priority patent/MX2009013913A/es
Priority to JP2009521645A priority patent/JP5261386B2/ja
Priority to SI200830819T priority patent/SI2189446T1/sl
Priority to BRPI0813104-0A2A priority patent/BRPI0813104A2/pt
Priority to US12/667,179 priority patent/US8158800B2/en
Priority to PL08790795T priority patent/PL2189446T3/pl
Priority to AU2008272124A priority patent/AU2008272124B2/en
Priority to NZ582187A priority patent/NZ582187A/en
Priority to HRP20120796AT priority patent/HRP20120796T1/hr
Priority to CN2008800232444A priority patent/CN101730682B/zh
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to EP08790795A priority patent/EP2189446B1/en
Priority to ES08790795T priority patent/ES2391319T3/es
Publication of WO2009005077A1 publication Critical patent/WO2009005077A1/ja
Priority to IL202804A priority patent/IL202804A/en
Priority to ZA2010/00027A priority patent/ZA201000027B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　４－｛３－［４－（３－｛４－［アミノ（ブトキシカルボニルイミノ）メチル］フェノキシ｝プロピル）－１－ピペリジニル］プロポキシ｝－Ｎ’－（ブトキシカルボニル）ベンズアミジンのII型結晶、III型結晶およびIV型結晶は、優れた抗真菌剤の原薬として有用である。
PCT/JP2008/061944 2007-07-04 2008-07-02 ４－｛３－［４－（３－｛４－［アミノ（ブトキシカルボニルイミノ）メチル］フェノキシ｝プロピル）－１－ピペリジニル］プロポキシ｝－ｎ’－（ブトキシカルボニル）ベンズアミジンの新規な結晶 Ceased WO2009005077A1 (ja)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CA2691954A CA2691954C (en) 2007-07-04 2008-07-02 Novel 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}-n'-(butoxycarbonyl) benzamidine crystals
MX2009013913A MX2009013913A (es) 2007-07-04 2008-07-02 Cristales nuevos de 4-{ 3- [ 4- ( 3- { 4- (amino(butoxicarbonilimi no) metil) fenoxi } propil -1- piperidinil ] propoxi } -n'-(butoxicarbonil) benzamidina.
JP2009521645A JP5261386B2 (ja) 2007-07-04 2008-07-02 ４−｛３−［４−（３−｛４−［アミノ（ブトキシカルボニルイミノ）メチル］フェノキシ｝プロピル）−１−ピペリジニル］プロポキシ｝−ｎ’−（ブトキシカルボニル）ベンズアミジンの新規な結晶
SI200830819T SI2189446T1 (sl) 2007-07-04 2008-07-02 Novi kristali 4-(3-(4-(3-(4-(amino(butoksikarbonilimino)metil)fenoksi)propil)-1- piperidinil)propoksi)-n'-(butoksikarbonil)benzamidina
BRPI0813104-0A2A BRPI0813104A2 (pt) 2007-07-04 2008-07-02 Composto
US12/667,179 US8158800B2 (en) 2007-07-04 2008-07-02 4-{3-[4-(3-{4-[amino (butoxycarbonylimino) methyl] phenoxy} propyl)-1-piperidinyl] propoxy}-N'-(butoxycarbonyl) benzamidine crystals
PL08790795T PL2189446T3 (pl) 2007-07-04 2008-07-02 Nowe kryształy 4-{3-[4-(3-{4-[amino(butoksykarbonyloimino) metylo]fenoksy}propylo)-1-piperydynylo]propoksy}-N'-(butoksykarbonylo)benzamidyny
NZ582187A NZ582187A (en) 2007-07-04 2008-07-02 Novel 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl] phenoxy}propyl)-1-piperidinyl]propoxy]-n'-(butoxycarbonyl)benzamidine crystals
AU2008272124A AU2008272124B2 (en) 2007-07-04 2008-07-02 Novel 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy]-N'-(butoxycarbonyl)benzamidine crystals
DK08790795.2T DK2189446T3 (da) 2007-07-04 2008-07-02 Nye 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy]-N´-(butoxycarbonyl)benzadimin-krystaller
CN2008800232444A CN101730682B (zh) 2007-07-04 2008-07-02 4-{3-[4-(3-{4-[氨基(丁氧基羰基亚氨基)甲基]苯氧基}丙基)-1-哌啶基]丙氧基}-n’-(丁氧基羰基)苯甲脒晶体
HRP20120796AT HRP20120796T1 (hr) 2007-07-04 2008-07-02 Novi 4-{3-[4-(3-{4-[amino(butoksikarbonilimino)metil]fenoksi}propil)-1-piperidinil]propoksi}-n'-(butoksikarbonil) benzamidin kristali
EP08790795A EP2189446B1 (en) 2007-07-04 2008-07-02 Novel 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy]-n'-(butoxycarbonyl)benzamidine crystals
ES08790795T ES2391319T3 (es) 2007-07-04 2008-07-02 Nuevos cristales de 4-{3-[4-(3-{4-[amino(butoxicarbonilimino)metil]fenoxi}propil)-1-piperidinil]propoxi]-N'-(butoxicarbonil)benzamidina
IL202804A IL202804A (en) 2007-07-04 2009-12-17 4– {3– [4– (3– {4– [Amino (Botoxicarbonylamino) Methyl) Phenoxy} Profile) –1 – Pipridinyl} Proposky} - 'n– (Botoxicarbonyl) Crystal Benzamidine
ZA2010/00027A ZA201000027B (en) 2007-07-04 2010-01-04 Novel 4-{3[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy]-n'-(butoxycarbonyl)benzamidine crystals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-176106 2007-07-04
JP2007176106 2007-07-04

Publications (1)

Publication Number Publication Date
WO2009005077A1 true WO2009005077A1 (ja) 2009-01-08

Family

ID=40226120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061944 Ceased WO2009005077A1 (ja) 2007-07-04 2008-07-02 ４－｛３－［４－（３－｛４－［アミノ（ブトキシカルボニルイミノ）メチル］フェノキシ｝プロピル）－１－ピペリジニル］プロポキシ｝－ｎ’－（ブトキシカルボニル）ベンズアミジンの新規な結晶

Country Status (22)

Country Link
US (1) US8158800B2 (ja)
EP (1) EP2189446B1 (ja)
JP (1) JP5261386B2 (ja)
KR (1) KR20100027176A (ja)
CN (1) CN101730682B (ja)
AU (1) AU2008272124B2 (ja)
BR (1) BRPI0813104A2 (ja)
CA (1) CA2691954C (ja)
CY (1) CY1113210T1 (ja)
DK (1) DK2189446T3 (ja)
ES (1) ES2391319T3 (ja)
HR (1) HRP20120796T1 (ja)
IL (1) IL202804A (ja)
MX (1) MX2009013913A (ja)
NZ (1) NZ582187A (ja)
PL (1) PL2189446T3 (ja)
PT (1) PT2189446E (ja)
RU (1) RU2456272C2 (ja)
SI (1) SI2189446T1 (ja)
TW (1) TWI395735B (ja)
WO (1) WO2009005077A1 (ja)
ZA (1) ZA201000027B (ja)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006003881A1 (ja) 2004-06-30 2006-01-12 Toyama Chemical Co., Ltd. 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤
WO2007074868A1 (ja) 2005-12-29 2007-07-05 Toyama Chemical Co., Ltd. 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤
WO2008044562A1 (en) 2006-10-06 2008-04-17 Toyama Chemical Co., Ltd. Pharmaceutical composition comprising phenylamidine derivative and method of using the pharmaceutical composition in combination with antifungal agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2367359T3 (es) * 2002-03-06 2011-11-02 Toyama Chemical Co., Ltd. Nuevo derivado de arilamidina o sal del mismo.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006003881A1 (ja) 2004-06-30 2006-01-12 Toyama Chemical Co., Ltd. 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤
WO2007074868A1 (ja) 2005-12-29 2007-07-05 Toyama Chemical Co., Ltd. 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤
WO2008044562A1 (en) 2006-10-06 2008-04-17 Toyama Chemical Co., Ltd. Pharmaceutical composition comprising phenylamidine derivative and method of using the pharmaceutical composition in combination with antifungal agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2189446A4

Also Published As

Publication number Publication date
ES2391319T3 (es) 2012-11-23
CN101730682B (zh) 2012-08-08
DK2189446T3 (da) 2012-09-24
CA2691954C (en) 2014-10-28
US8158800B2 (en) 2012-04-17
IL202804A (en) 2013-10-31
BRPI0813104A2 (pt) 2014-12-23
EP2189446B1 (en) 2012-08-22
TWI395735B (zh) 2013-05-11
ZA201000027B (en) 2011-03-30
US20110046381A1 (en) 2011-02-24
JPWO2009005077A1 (ja) 2010-08-26
JP5261386B2 (ja) 2013-08-14
EP2189446A4 (en) 2010-10-20
SI2189446T1 (sl) 2012-12-31
IL202804A0 (en) 2010-06-30
PL2189446T3 (pl) 2013-01-31
TW200914421A (en) 2009-04-01
NZ582187A (en) 2011-03-31
CY1113210T1 (el) 2016-04-13
EP2189446A1 (en) 2010-05-26
RU2010103672A (ru) 2011-08-10
CA2691954A1 (en) 2009-01-08
AU2008272124B2 (en) 2012-08-23
HRP20120796T1 (hr) 2012-10-31
PT2189446E (pt) 2012-10-25
MX2009013913A (es) 2010-03-10
KR20100027176A (ko) 2010-03-10
AU2008272124A1 (en) 2009-01-08
RU2456272C2 (ru) 2012-07-20
CN101730682A (zh) 2010-06-09

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