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WO2009066309A3 - Process for preparation of omeprazole - Google Patents

Process for preparation of omeprazole Download PDF

Info

Publication number
WO2009066309A3
WO2009066309A3 PCT/IN2008/000445 IN2008000445W WO2009066309A3 WO 2009066309 A3 WO2009066309 A3 WO 2009066309A3 IN 2008000445 W IN2008000445 W IN 2008000445W WO 2009066309 A3 WO2009066309 A3 WO 2009066309A3
Authority
WO
WIPO (PCT)
Prior art keywords
omeprazole
preparation
pyridinyl
methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000445
Other languages
French (fr)
Other versions
WO2009066309A9 (en
WO2009066309A2 (en
Inventor
Dhimant Jasubhai Patel
Mahesh Shankarbhai Patel
Shriprakash Dhar Dwivedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of WO2009066309A2 publication Critical patent/WO2009066309A2/en
Publication of WO2009066309A3 publication Critical patent/WO2009066309A3/en
Anticipated expiration legal-status Critical
Publication of WO2009066309A9 publication Critical patent/WO2009066309A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses a process for preparing 2- [(pyridinyl)methyl]sulfinyl-substituted benzimidazoles of Formula (I) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. More particularly, the present invention relates to the process for oxidation of 2-[(pyridinyl)methyl]thio- substituted benzimidazoles of Formula (II).
PCT/IN2008/000445 2007-07-12 2008-07-11 Process for preparation of omeprazole Ceased WO2009066309A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1335MU2007 2007-07-12
IN1335/MUM/2007 2007-07-12

Publications (3)

Publication Number Publication Date
WO2009066309A2 WO2009066309A2 (en) 2009-05-28
WO2009066309A3 true WO2009066309A3 (en) 2010-01-07
WO2009066309A9 WO2009066309A9 (en) 2010-05-14

Family

ID=40667935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000445 Ceased WO2009066309A2 (en) 2007-07-12 2008-07-11 Process for preparation of omeprazole

Country Status (1)

Country Link
WO (1) WO2009066309A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112969697A (en) * 2019-10-31 2021-06-15 组合化学工业株式会社 Process for producing herbicide and intermediate thereof
CN112229920B (en) * 2020-09-17 2022-10-21 海南中玉药业有限公司 Method for detecting potential genotoxic impurities of esomeprazole sodium
CN115785067A (en) * 2023-01-19 2023-03-14 北京京卫燕康药物研究所有限公司 Preparation method of impurity compound of esomeprazole thioether

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302720A1 (en) * 1987-08-04 1989-02-08 Takeda Chemical Industries, Ltd. Production of 2-(2-Pyridylmethylsulfinyl)-benzimidazole compounds
EP0484265A1 (en) * 1990-10-31 1992-05-06 Centro Genesis Para La Investigacion, S.L. A process for the preparation of omeprazol
ES2036948A1 (en) * 1991-11-21 1993-06-01 Genesis Para La Investigacion Procedure for obtaining compounds derived from pyridine.
EP1085019A1 (en) * 1999-09-13 2001-03-21 Cipla Limited Omeprazole synthesis
EP1270555A1 (en) * 2000-03-13 2003-01-02 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
US6956137B1 (en) * 1999-04-13 2005-10-18 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Singlet oxygen oxidation of organic substrates
US20060128964A1 (en) * 2004-12-10 2006-06-15 Industrial Technology Research Institute Method for preparing 2- (2-pyridylmethylsulphinyl) benzimidazoles
EP1790647A1 (en) * 2004-09-13 2007-05-30 Takeda Pharmaceutical Company Limited Method and apparatus for producing oxidized compound
EP2030973A1 (en) * 2007-08-31 2009-03-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing 2-sulfinyl-1H-benzimidazoles

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302720A1 (en) * 1987-08-04 1989-02-08 Takeda Chemical Industries, Ltd. Production of 2-(2-Pyridylmethylsulfinyl)-benzimidazole compounds
EP0484265A1 (en) * 1990-10-31 1992-05-06 Centro Genesis Para La Investigacion, S.L. A process for the preparation of omeprazol
ES2036948A1 (en) * 1991-11-21 1993-06-01 Genesis Para La Investigacion Procedure for obtaining compounds derived from pyridine.
US6956137B1 (en) * 1999-04-13 2005-10-18 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Singlet oxygen oxidation of organic substrates
EP1085019A1 (en) * 1999-09-13 2001-03-21 Cipla Limited Omeprazole synthesis
EP1270555A1 (en) * 2000-03-13 2003-01-02 Esteve Quimica, S.A. Method for oxidizing a thioether group into a sulfoxide group
EP1790647A1 (en) * 2004-09-13 2007-05-30 Takeda Pharmaceutical Company Limited Method and apparatus for producing oxidized compound
US20060128964A1 (en) * 2004-12-10 2006-06-15 Industrial Technology Research Institute Method for preparing 2- (2-pyridylmethylsulphinyl) benzimidazoles
EP2030973A1 (en) * 2007-08-31 2009-03-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing 2-sulfinyl-1H-benzimidazoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHMURZYNSKI L: "Studies on correlations of acid-base properties of substituted pyridine N-oxides in solutions. Correlations of cationic homoconjugation constants and pK(a) values in non-aqueous media", ANALYTICA CHIMICA ACTA 19961120 NL, vol. 334, no. 1-2, 20 November 1996 (1996-11-20), pages 155 - 159, XP002536936, ISSN: 0003-2670 *
MADESCLAIRE M: "SYNTHESIS OF SULFOXIDES BY OXIDATION OF THIOETHERS", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 42, no. 20, 1 January 1986 (1986-01-01), pages 5459 - 5495, XP001026077, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
WO2009066309A9 (en) 2010-05-14
WO2009066309A2 (en) 2009-05-28

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