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WO2009066309A9 - Process for preparation of omeprazole - Google Patents

Process for preparation of omeprazole Download PDF

Info

Publication number
WO2009066309A9
WO2009066309A9 PCT/IN2008/000445 IN2008000445W WO2009066309A9 WO 2009066309 A9 WO2009066309 A9 WO 2009066309A9 IN 2008000445 W IN2008000445 W IN 2008000445W WO 2009066309 A9 WO2009066309 A9 WO 2009066309A9
Authority
WO
WIPO (PCT)
Prior art keywords
omeprazole
preparation
pyridinyl
methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000445
Other languages
French (fr)
Other versions
WO2009066309A2 (en
WO2009066309A3 (en
Inventor
Dhimant Jasubhai Patel
Mahesh Shankarbhai Patel
Shriprakash Dhar Dwivedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of WO2009066309A2 publication Critical patent/WO2009066309A2/en
Publication of WO2009066309A3 publication Critical patent/WO2009066309A3/en
Anticipated expiration legal-status Critical
Publication of WO2009066309A9 publication Critical patent/WO2009066309A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses a process for preparing 2- [(pyridinyl)methyl]sulfinyl-substituted benzimidazoles of Formula (I) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. More particularly, the present invention relates to the process for oxidation of 2-[(pyridinyl)methyl]thio- substituted benzimidazoles of Formula (II).
PCT/IN2008/000445 2007-07-12 2008-07-11 Process for preparation of omeprazole Ceased WO2009066309A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1335MU2007 2007-07-12
IN1335/MUM/2007 2007-07-12

Publications (3)

Publication Number Publication Date
WO2009066309A2 WO2009066309A2 (en) 2009-05-28
WO2009066309A3 WO2009066309A3 (en) 2010-01-07
WO2009066309A9 true WO2009066309A9 (en) 2010-05-14

Family

ID=40667935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000445 Ceased WO2009066309A2 (en) 2007-07-12 2008-07-11 Process for preparation of omeprazole

Country Status (1)

Country Link
WO (1) WO2009066309A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4053125B1 (en) * 2019-10-31 2024-12-04 Kumiai Chemical Industry Co., Ltd. Process for the production of a pyroxasulfone herbicide
CN112229920B (en) * 2020-09-17 2022-10-21 海南中玉药业有限公司 Method for detecting potential genotoxic impurities of esomeprazole sodium
CN115785067A (en) * 2023-01-19 2023-03-14 北京京卫燕康药物研究所有限公司 Preparation method of impurity compound of esomeprazole thioether

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK171989B1 (en) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Process for the preparation of 2- (2-pyridylmethylsulfinyl) benzimidazoles
ES2026761A6 (en) * 1990-10-31 1992-05-01 Genesis Para La Investigacion A process for the preparation of omeprazol.
ES2036948B1 (en) * 1991-11-21 1994-09-01 Genesis Para La Investigacion PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
AT408546B (en) * 1999-04-13 2001-12-27 Dsm Fine Chem Austria Gmbh SINGLET OXYGEN OXIDATION OF ORGANIC SUBSTRATES
GB9921578D0 (en) * 1999-09-13 1999-11-17 Cipla Limited Omeprazole synthesis
ES2163372B1 (en) * 2000-03-13 2003-05-01 Esteve Quimica Sa OXIDATION PROCEDURE OF A SULFOXIDE TIOETER GROUP.
ES2441970T3 (en) * 2004-09-13 2014-02-07 Takeda Pharmaceutical Company Limited Method of producing lansoprazole
TW200619198A (en) * 2004-12-10 2006-06-16 Ind Tech Res Inst Method for preparing 2-(2-pyridylmethylsulphinyl)benzimidazoles
EP2030973A1 (en) * 2007-08-31 2009-03-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing 2-sulfinyl-1H-benzimidazoles

Also Published As

Publication number Publication date
WO2009066309A2 (en) 2009-05-28
WO2009066309A3 (en) 2010-01-07

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