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WO2009066326A3 - Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts - Google Patents

Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2009066326A3
WO2009066326A3 PCT/IN2008/000773 IN2008000773W WO2009066326A3 WO 2009066326 A3 WO2009066326 A3 WO 2009066326A3 IN 2008000773 W IN2008000773 W IN 2008000773W WO 2009066326 A3 WO2009066326 A3 WO 2009066326A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutically acceptable
acceptable salts
prasugrel
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000773
Other languages
French (fr)
Other versions
WO2009066326A2 (en
Inventor
Reddy Manne Satyanarayana
Sajja Eswaraiah
Reddy Ghojala Venkat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of WO2009066326A2 publication Critical patent/WO2009066326A2/en
Publication of WO2009066326A3 publication Critical patent/WO2009066326A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to an improved process for the preparation of prasugrel compound of formula- 1 and its pharmaceutically acceptable salts thereof.
PCT/IN2008/000773 2007-11-19 2008-11-18 Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts Ceased WO2009066326A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2683/CHE/2007 2007-11-19
IN2683CH2007 2007-11-19

Publications (2)

Publication Number Publication Date
WO2009066326A2 WO2009066326A2 (en) 2009-05-28
WO2009066326A3 true WO2009066326A3 (en) 2009-07-30

Family

ID=40667947

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000773 Ceased WO2009066326A2 (en) 2007-11-19 2008-11-18 Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts

Country Status (1)

Country Link
WO (1) WO2009066326A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129983A1 (en) * 2008-04-21 2009-10-29 Ratiopharm Gmbh Acid addition salts of prasugrel and pharmaceutical compositions comprising the same
CZ2008748A3 (en) * 2008-11-26 2010-06-02 Zentiva, A. S Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel)
KR20110015254A (en) * 2009-08-07 2011-02-15 한미홀딩스 주식회사 Prasugrel Disulfonate and Its Crystals
CN101993447A (en) * 2009-08-26 2011-03-30 浙江华海药业股份有限公司 Method for synthesizing Prasugrel artificially
KR20110024057A (en) * 2009-09-01 2011-03-09 한미홀딩스 주식회사 Polycrystalline Forms of Novel Prasugrel Hydrogen Sulfate
EP2499147A4 (en) * 2009-10-07 2013-03-06 Msn Lab Ltd Improved processes for preparing prasugrel and pharmaceutically acceptable salts theroeof
CZ2009762A3 (en) 2009-11-16 2011-05-25 Zentiva, K. S. Novel salts of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and process of their preparation
CZ302833B6 (en) * 2009-11-16 2011-11-30 Zentiva, K. S. Hydrobromide of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and process for preparing thereof
CZ2009763A3 (en) * 2009-11-16 2011-05-25 Zentiva, K. S. Process for preparing extreme pure 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate known under unprotected name prasugrel and its novel pharmaceutically acceptable salts
CZ2009828A3 (en) 2009-12-09 2011-06-22 Zentiva, K.S. Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride (prasugrelu hydrochloride in polymorphous B form
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) * 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN101735241A (en) * 2009-12-24 2010-06-16 浙江普洛家园药业有限公司 Prasugrel intermediate and preparation method thereof
EP2883877A1 (en) 2010-04-08 2015-06-17 Teva Pharmaceutical Industries, Ltd. Crystalline forms of prasugrel salts
CN101812070B (en) * 2010-04-16 2012-01-11 海南美大制药有限公司 Prasugrel compound and new preparation method thereof
WO2012001486A1 (en) 2010-06-28 2012-01-05 Mayuka Labs Pvt. Ltd. An improved process for the preparation of prasugrel hydrochloride and its intermediates
CN101948479B (en) * 2010-09-29 2013-01-30 横店集团家园化工有限公司 Prasugrel intermediate and preparation method thereof
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN101985451B (en) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 Preparation method of prasugrel intermediate
CN102002056B (en) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 Preparation method of prasugrel intermediate
CN101985450B (en) * 2010-11-02 2012-07-11 北京赛科药业有限责任公司 Prasugrel salt and preparation method thereof
CN102101827B (en) * 2010-11-15 2013-07-03 山东新华制药股份有限公司 Method for preparing Prasugrel intermediate alpha-cyclopropyl carbonyl-2-fluorobenzyl halide
CN102503954B (en) * 2011-10-20 2013-11-27 天津药物研究院 Imidazole derivative and preparation method and application thereof
CN102329326B (en) * 2011-10-20 2014-04-09 天津药物研究院 Pyrrole derivatives and preparation method and application thereof
CN103304577A (en) * 2012-03-07 2013-09-18 辽宁亿灵科创生物医药科技有限公司 Prasugrel acid addition salts, and preparation methods and medicinal applications thereof
CN103570741B (en) * 2012-07-26 2017-06-09 石药集团中奇制药技术（石家庄）有限公司 Prasugrel novel crystal forms and preparation method thereof
CN103848844A (en) * 2012-12-07 2014-06-11 天津市汉康医药生物技术有限公司 Prasugrel salt-forming compound and preparation method thereof
HU230649B1 (en) 2013-01-24 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Improved process for producing pharmaceutical agent prasugrel and 2-(2-fluorophenyl)-1-cyclopropylethanone intermediate
CN104418718B (en) * 2013-08-28 2018-04-13 山东新时代药业有限公司 A kind of 2 bromine 2 of cyclopropyl（2 fluorophenyls）The preparation method of ethyl ketone
CN105884793A (en) * 2016-06-09 2016-08-24 青岛辰达生物科技有限公司 Preparation method of antiplatelet medicine Prasugrel
HU231079B1 (en) * 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Process for the preparation of high-purity prasugrel by the elimination of the bromopentyl impurity
CN110950885B (en) * 2019-12-06 2022-04-15 南京恒道医药科技有限公司 Method and device for continuously preparing prasugrel intermediate through countercurrent extraction
CN112964794B (en) * 2019-12-13 2022-10-18 武汉武药制药有限公司 Method for separating and detecting 4,5,6,7-tetrahydrothiophene [3,2-c ] pyridine hydrochloride and related substances thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515951A (en) * 1980-11-28 1985-05-07 Sanofi Preparation of 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one compounds
US4740510A (en) * 1985-01-31 1988-04-26 Sanofi (S.A.) Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno[3,2-c]5-pyridyl) phenyl acetic acid, and their use as platelet and thrombotic aggregation inhibitors
WO2007114526A1 (en) * 2006-04-06 2007-10-11 Daiichi Sankyo Company, Limited Process for producing high-purity prasugrel and acid addition salt thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515951A (en) * 1980-11-28 1985-05-07 Sanofi Preparation of 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one compounds
US4740510A (en) * 1985-01-31 1988-04-26 Sanofi (S.A.) Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno[3,2-c]5-pyridyl) phenyl acetic acid, and their use as platelet and thrombotic aggregation inhibitors
WO2007114526A1 (en) * 2006-04-06 2007-10-11 Daiichi Sankyo Company, Limited Process for producing high-purity prasugrel and acid addition salt thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DOGGRELL, S.A. ET AL.: "CS-747 and R-99224", DRUGS FUT, vol. 26, no. 9, 2001, pages 835 - 841 *

Also Published As

Publication number Publication date
WO2009066326A2 (en) 2009-05-28

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