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WO2008001201A3 - Pharmaceutical compositions of clopidogrel - Google Patents

Pharmaceutical compositions of clopidogrel Download PDF

Info

Publication number
WO2008001201A3
WO2008001201A3 PCT/IB2007/001753 IB2007001753W WO2008001201A3 WO 2008001201 A3 WO2008001201 A3 WO 2008001201A3 IB 2007001753 W IB2007001753 W IB 2007001753W WO 2008001201 A3 WO2008001201 A3 WO 2008001201A3
Authority
WO
WIPO (PCT)
Prior art keywords
clopidogrel
pharmaceutical compositions
relates
compositions
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/001753
Other languages
French (fr)
Other versions
WO2008001201A2 (en
Inventor
Narayanan Murali
Anandkrishna Laxmikan Kulkarni
Abdul Rehman Khan
Girish Kumar Jain
Amol Prasadrao Ujjainkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of WO2008001201A2 publication Critical patent/WO2008001201A2/en
Anticipated expiration legal-status Critical
Publication of WO2008001201A3 publication Critical patent/WO2008001201A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to pharmaceutical compositions of clopidogrel or pharmaceutically acceptable salts thereof. The invention also relates to processes for the preparation of such compositions.
PCT/IB2007/001753 2006-06-28 2007-06-27 Pharmaceutical compositions of clopidogrel Ceased WO2008001201A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN1016/MUM/2006 2006-06-28
IN1016MU2006 2006-06-28
IN1021/MUM/2006 2006-06-28
IN1021MU2006 2006-06-28
IN1973MU2006 2006-12-01
IN1973/MUM/2006 2006-12-01
IN1974/MUM/2006 2006-12-01
IN1974MU2006 2006-12-01

Publications (2)

Publication Number Publication Date
WO2008001201A2 WO2008001201A2 (en) 2008-01-03
WO2008001201A3 true WO2008001201A3 (en) 2009-04-23

Family

ID=38846027

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/001753 Ceased WO2008001201A2 (en) 2006-06-28 2007-06-27 Pharmaceutical compositions of clopidogrel

Country Status (1)

Country Link
WO (1) WO2008001201A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008129468A2 (en) * 2007-04-20 2008-10-30 Wockhardt Research Centre Pharmaceutical compositions of clopidogrel
CN102240269B (en) * 2010-05-12 2013-04-10 天津泰普药品科技发展有限公司 Preparation method of crystalline clopidogrel bisulfate tablets
CN103417502B (en) * 2013-08-05 2015-09-23 青岛市中心医院 A kind of clopidogrel hydrogen sulfate tablet and preparation method thereof
CN105380916A (en) * 2015-12-18 2016-03-09 北京华禧联合科技发展有限公司 Tablets containing clopidogrel hydrogen sulfate and preparation method thereof
KR20190003805A (en) * 2016-05-27 2019-01-09 한미약품 주식회사 A pharmaceutical composition comprising an amine derivative or a pharmaceutically acceptable salt thereof and a stabilizer having a low melting point which inhibits cancer cell growth
CN108186604A (en) * 2018-03-28 2018-06-22 北京睿悦生物医药科技有限公司 A kind of bisulfate clopidogrel particle and preparation method thereof
CN110339178B (en) * 2019-06-28 2021-07-02 广州白云山天心制药股份有限公司 Preparation method of clopidogrel hydrogen sulfate solid preparation
CN113057944B (en) * 2019-12-13 2022-09-16 华益泰康药业股份有限公司 Preparation method of tablets with improved performance
CN114732788A (en) * 2022-04-14 2022-07-12 浙江高跖医药科技股份有限公司 Clopidogrel hydrogen sulfate solid preparation and preparation process thereof
CN115737578A (en) * 2022-11-23 2023-03-07 石家庄四药有限公司 Clopidogrel hydrogen sulfate and aspirin compound tablet and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050030004A1 (en) * 2001-11-26 2005-02-10 Toshinori Takatsuka Current sensor
US20050152975A1 (en) * 1999-03-17 2005-07-14 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050152975A1 (en) * 1999-03-17 2005-07-14 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical composition
US20050030004A1 (en) * 2001-11-26 2005-02-10 Toshinori Takatsuka Current sensor

Also Published As

Publication number Publication date
WO2008001201A2 (en) 2008-01-03

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