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WO2008058118A3 - Preparation of montelukast and its salts - Google Patents

Preparation of montelukast and its salts Download PDF

Info

Publication number
WO2008058118A3
WO2008058118A3 PCT/US2007/083756 US2007083756W WO2008058118A3 WO 2008058118 A3 WO2008058118 A3 WO 2008058118A3 US 2007083756 W US2007083756 W US 2007083756W WO 2008058118 A3 WO2008058118 A3 WO 2008058118A3
Authority
WO
WIPO (PCT)
Prior art keywords
montelukast
preparation
salts
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/083756
Other languages
French (fr)
Other versions
WO2008058118A2 (en
Inventor
Pratap Reddy Padi
Satyanarayana Bollikonda
Narsimha Naidu
Debasish Ghosh
Kandirelli Kiran Kumar Venkata
Rajender Reddy Jinna
Ravi Kumar Kasturi
Saravanan Mohanarangam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Original Assignee
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd, Dr Reddys Laboratories Inc filed Critical Dr Reddys Laboratories Ltd
Priority to EP07844907A priority Critical patent/EP2094665A4/en
Publication of WO2008058118A2 publication Critical patent/WO2008058118A2/en
Publication of WO2008058118A3 publication Critical patent/WO2008058118A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There is provided a process for the preparation of montelukast of the Formula (I).
PCT/US2007/083756 2006-11-06 2007-11-06 Preparation of montelukast and its salts Ceased WO2008058118A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07844907A EP2094665A4 (en) 2006-11-06 2007-11-06 Preparation of montelukast and its salts

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN2042/CHE/2006 2006-11-06
IN2042CH2006 2006-11-06
IN142/CHE/2007 2007-01-22
IN142CH2007 2007-01-22
US89021507P 2007-02-16 2007-02-16
US60/890,215 2007-02-16
US91486207P 2007-04-30 2007-04-30
US60/914,862 2007-04-30

Publications (2)

Publication Number Publication Date
WO2008058118A2 WO2008058118A2 (en) 2008-05-15
WO2008058118A3 true WO2008058118A3 (en) 2008-07-10

Family

ID=39365306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/083756 Ceased WO2008058118A2 (en) 2006-11-06 2007-11-06 Preparation of montelukast and its salts

Country Status (2)

Country Link
EP (1) EP2094665A4 (en)
WO (1) WO2008058118A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090015186A (en) 2005-07-05 2009-02-11 테바 파마슈티컬 인더스트리즈 리미티드 Purification of montelukast
WO2008035379A2 (en) * 2006-09-19 2008-03-27 Aptuit Laurus Private Limited Process for and intermediates of leukotriene antagonists
EP2552892A1 (en) 2010-03-31 2013-02-06 KRKA, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
CN102702097A (en) * 2012-05-16 2012-10-03 浙江大学 Preparation method of montelukast sodium intermediate
CN104109122B (en) * 2013-04-16 2017-03-29 浙江奥翔药业股份有限公司 For synthesizing midbody compound of montelukast and preparation method thereof
CN103288695B (en) * 2013-06-18 2016-01-13 成都迈斯克医药科技有限公司 The preparation method of 1-thiopurine methyltransferase cyclopropaneacetic acid
CN103554016B (en) * 2013-08-23 2015-09-23 南通正达农化有限公司 A kind of complete processing of non-hormone antiphlogiston intermediate
CN103554017B (en) * 2013-10-25 2014-12-17 河北序能生物技术有限公司 Preparation method of montelukast chiral intermediate
CN106456535B (en) 2014-04-25 2020-07-03 R.P.谢勒技术有限公司 Stable montelukast solutions
CN104592110A (en) * 2015-01-26 2015-05-06 中山奕安泰医药科技有限公司 A kind of technique for synthesizing 2-[3-(S)-[3-[2-(7-chloro-2-quinolyl) vinyl] phenyl]-3-hydroxypropyl] methyl benzoate
CN109020830A (en) * 2018-08-29 2018-12-18 广州康瑞泰药业有限公司 A kind of methylol cyclopropyl acetonitrile derivative and its methods for making and using same
CN114702416B (en) * 2022-03-30 2024-07-05 重庆普佑生物医药有限公司 Method for efficiently preparing montelukast sodium side chain intermediate
CN116789595A (en) * 2023-04-28 2023-09-22 江苏阿尔法药业股份有限公司 Preparation process of special intermediate of montelukast sodium
CN116606250A (en) * 2023-04-28 2023-08-18 江苏阿尔法药业股份有限公司 Preparation method of key intermediate of montelukast sodium

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5614632A (en) * 1993-12-28 1997-03-25 Merck & Co., Inc. Process for the preparation of leukotriene anatgonists
US5869673A (en) * 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
US20010007040A1 (en) * 1999-12-24 2001-07-05 Andreas Harthun Process for the preparation of 1,1-cyclopropanedicarboxylic diesters
US20050234241A1 (en) * 2004-04-15 2005-10-20 Venkataraman Sundaram Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021974A1 (en) * 2004-08-23 2006-03-02 Morepen Laboratories Limited A process for synthesizing diol (viii)-an intermediate of montelukast sodium

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5614632A (en) * 1993-12-28 1997-03-25 Merck & Co., Inc. Process for the preparation of leukotriene anatgonists
US5869673A (en) * 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
US20010007040A1 (en) * 1999-12-24 2001-07-05 Andreas Harthun Process for the preparation of 1,1-cyclopropanedicarboxylic diesters
US20050234241A1 (en) * 2004-04-15 2005-10-20 Venkataraman Sundaram Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (montelukast) and its pharmaceutically acceptable salts

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUNDU ET AL.: "5-(Acetylthynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5-(Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities", EUR. J. MED. CHEM., vol. 34, 1999, pages 389 - 398, XP004180346 *
SASSIAN ET AL.: "Solvation Effects in the Grignard Reacion with Carbonyl Compounds", HELVETICA CHIMICA ACTA, vol. 86, 2003, pages 82 - 90, XP008109226 *
See also references of EP2094665A4 *

Also Published As

Publication number Publication date
EP2094665A2 (en) 2009-09-02
WO2008058118A2 (en) 2008-05-15
EP2094665A4 (en) 2010-11-24

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