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WO2009041643A1 - Cdrのアミノ酸置換により抗体の等電点を改変する方法 - Google Patents

Cdrのアミノ酸置換により抗体の等電点を改変する方法 Download PDF

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Publication number
WO2009041643A1
WO2009041643A1 PCT/JP2008/067534 JP2008067534W WO2009041643A1 WO 2009041643 A1 WO2009041643 A1 WO 2009041643A1 JP 2008067534 W JP2008067534 W JP 2008067534W WO 2009041643 A1 WO2009041643 A1 WO 2009041643A1
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WIPO (PCT)
Prior art keywords
isoelectric point
antibody
modifying
cdr
amino acid
Prior art date
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Ceased
Application number
PCT/JP2008/067534
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English (en)
French (fr)
Inventor
Tomoyuki Igawa
Hiroyuki Tsunoda
Tatsuhiko Tachibana
Taichi Kuramochi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40511523&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009041643(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2008304778A priority Critical patent/AU2008304778B9/en
Priority to BRPI0817294 priority patent/BRPI0817294A2/pt
Priority to JP2009534435A priority patent/JP5334319B2/ja
Priority to US12/679,922 priority patent/US9096651B2/en
Priority to ES08834150.8T priority patent/ES2595638T3/es
Priority to EP24152324.0A priority patent/EP4339294A3/en
Priority to RU2010116208/10A priority patent/RU2510400C9/ru
Priority to MX2010003443A priority patent/MX336725B/es
Priority to SI200831671A priority patent/SI2202245T1/sl
Priority to EP24152321.6A priority patent/EP4368721A3/en
Priority to CN200880118639.2A priority patent/CN101874042B9/zh
Priority to CN201610952615.3A priority patent/CN106519025B/zh
Priority to DK08834150.8T priority patent/DK2202245T3/en
Priority to EP08834150.8A priority patent/EP2202245B1/en
Priority to CA2700701A priority patent/CA2700701C/en
Priority to EP20159129.4A priority patent/EP3689912A1/en
Priority to MX2015011591A priority patent/MX369784B/es
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to TW097147078A priority patent/TWI599577B/zh
Priority to TW106122356A priority patent/TWI682938B/zh
Priority to ARP090100676A priority patent/AR070633A1/es
Priority to PE2009000282A priority patent/PE20100268A1/es
Priority to CL2009000441A priority patent/CL2009000441A1/es
Priority to ARP090100709A priority patent/AR070716A1/es
Publication of WO2009041643A1 publication Critical patent/WO2009041643A1/ja
Priority to IL204242A priority patent/IL204242A/en
Anticipated expiration legal-status Critical
Priority to US14/741,786 priority patent/US9828429B2/en
Priority to IL246040A priority patent/IL246040B/en
Priority to IL251826A priority patent/IL251826B/en
Priority to US15/725,692 priority patent/US11248053B2/en
Priority to IL267546A priority patent/IL267546B/en
Priority to US17/578,524 priority patent/US20220389105A1/en
Priority to ARP230100368A priority patent/AR128541A2/es
Priority to US18/425,859 priority patent/US12122840B2/en
Priority to US18/432,567 priority patent/US12116414B2/en
Priority to US18/883,787 priority patent/US20250011443A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明者らは、相補性決定領域（CDR）の表面に露出し得る少なくとも１つのアミノ酸残基の電荷を改変することにより、抗体の抗原への結合活性を保持しつつ等電点を改変する方法を提供する。本発明はまた、等電点の改変により多重特異性抗体を精製する方法および等電点が改変された抗体の血漿中薬物動態を改善する方法を提供する。さらに本発明は、等電点が改変された抗体、当該抗体を有効成分として含有する医薬組成物、および、その製造方法を提供する。
PCT/JP2008/067534 2007-09-26 2008-09-26 Cdrのアミノ酸置換により抗体の等電点を改変する方法 Ceased WO2009041643A1 (ja)

Priority Applications (34)

Application Number Priority Date Filing Date Title
AU2008304778A AU2008304778B9 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
BRPI0817294 BRPI0817294A2 (pt) 2007-09-26 2008-09-26 Método de modificação do ponto isoelétrico de anticorpo via substituição de aminoácido em cdr.
JP2009534435A JP5334319B2 (ja) 2007-09-26 2008-09-26 Ｃｄｒのアミノ酸置換により抗体の等電点を改変する方法
US12/679,922 US9096651B2 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
ES08834150.8T ES2595638T3 (es) 2007-09-26 2008-09-26 Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR
EP24152324.0A EP4339294A3 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in cdr
RU2010116208/10A RU2510400C9 (ru) 2007-09-26 2008-09-26 Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr
MX2010003443A MX336725B (es) 2007-09-26 2008-09-26 Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
SI200831671A SI2202245T1 (sl) 2007-09-26 2008-09-26 Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR
EP24152321.6A EP4368721A3 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in cdr
CN200880118639.2A CN101874042B9 (zh) 2007-09-26 2008-09-26 利用cdr的氨基酸取代来改变抗体等电点的方法
CN201610952615.3A CN106519025B (zh) 2007-09-26 2008-09-26 利用cdr的氨基酸取代来改变抗体等电点的方法
DK08834150.8T DK2202245T3 (en) 2007-09-26 2008-09-26 A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
EP08834150.8A EP2202245B1 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in cdr
CA2700701A CA2700701C (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in cdr
EP20159129.4A EP3689912A1 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in cdr
MX2015011591A MX369784B (es) 2007-09-26 2008-09-26 Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
TW097147078A TWI599577B (zh) 2008-09-26 2008-12-04 Methods to alter the isoelectric point of antibodies using amino acid substitutions of CDR regions
TW106122356A TWI682938B (zh) 2007-09-26 2008-12-04 利用置換ｃｄｒ區胺基酸來改變抗體等電點的方法
CL2009000441A CL2009000441A1 (es) 2007-09-26 2009-02-26 Metodo para modificar el punto isoelectrico (pl) de un péptido que comprende una region variable de un anticuerpo mediante la sustitucion de aminoacidos en la region cdr, anticuerpos que tiene un pl modificados en las regiones cdr, util para aumentar el tiempo de residencia en el plasma.
ARP090100676A AR070633A1 (es) 2007-09-26 2009-02-26 Metodos para modificar el punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en la region de determinacion de la complementariedad (cdr)
PE2009000282A PE20100268A1 (es) 2007-09-26 2009-02-26 Metodos para modificar el punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en la region de determinacion de la complementariedad (cdr)
ARP090100709A AR070716A1 (es) 2007-09-26 2009-02-27 Metodos para modificar el punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en la region de determinacion de la complementariedad (cdr)
IL204242A IL204242A (en) 2007-09-26 2010-03-02 METHOD OF CHANGE ISOELECTRIC POINT OF ANTIBODY BY TRANSMISSION OF AMINIC ACID IN CDR
US14/741,786 US9828429B2 (en) 2007-09-26 2015-06-17 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
IL246040A IL246040B (en) 2007-09-26 2016-06-05 A method for changing the isoelectric point of an antibody through the conversion of an amino acid in cdr
IL251826A IL251826B (en) 2007-09-26 2017-04-20 A method for changing the isoelectric point of an antibody through the conversion of an amino acid in cdr
US15/725,692 US11248053B2 (en) 2007-09-26 2017-10-05 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
IL267546A IL267546B (en) 2007-09-26 2019-06-20 A method for changing the isoelectric point of an antibody through the conversion of an amino acid in cdr
US17/578,524 US20220389105A1 (en) 2007-09-26 2022-01-19 Method of modifying isoelectric point of antibody via amino acid substitution in cdr
ARP230100368A AR128541A2 (es) 2007-09-26 2023-02-16 Métodos para modificar el punto isoeléctrico de anticuerpos mediante la sustitución de aminoácidos en la región de determinación de la complementariedad (cdr)
US18/425,859 US12122840B2 (en) 2007-09-26 2024-01-29 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US18/432,567 US12116414B2 (en) 2007-09-26 2024-02-05 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US18/883,787 US20250011443A1 (en) 2007-09-26 2024-09-12 Method of modifying isoelectric point of antibody via amino acid substitution in cdr

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-250165 2007-09-26
JP2007250165 2007-09-26
JP2007256063 2007-09-28
JP2007-256063 2007-09-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/679,922 A-371-Of-International US9096651B2 (en) 2007-09-26 2008-09-26 Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US14/741,786 Continuation US9828429B2 (en) 2007-09-26 2015-06-17 Method of modifying isoelectric point of antibody via amino acid substitution in CDR

Publications (1)

Publication Number Publication Date
WO2009041643A1 true WO2009041643A1 (ja) 2009-04-02

Family

ID=40511523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067534 Ceased WO2009041643A1 (ja) 2007-09-26 2008-09-26 Cdrのアミノ酸置換により抗体の等電点を改変する方法

Country Status (22)

Country Link
US (7) US9096651B2 (ja)
EP (5) EP3127921A1 (ja)
JP (11) JP5334319B2 (ja)
KR (1) KR101575914B1 (ja)
CN (2) CN106519025B (ja)
AR (3) AR070633A1 (ja)
AU (1) AU2008304778B9 (ja)
BR (1) BRPI0817294A2 (ja)
CA (1) CA2700701C (ja)
CL (1) CL2009000441A1 (ja)
DK (1) DK2202245T3 (ja)
ES (1) ES2595638T3 (ja)
HU (1) HUE029635T2 (ja)
IL (4) IL204242A (ja)
MX (2) MX336725B (ja)
PE (1) PE20100268A1 (ja)
PL (1) PL2202245T3 (ja)
RU (1) RU2510400C9 (ja)
SI (1) SI2202245T1 (ja)
TW (1) TWI682938B (ja)
WO (1) WO2009041643A1 (ja)
ZA (1) ZA201804148B (ja)

Cited By (98)

* Cited by examiner, † Cited by third party
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WO2009077569A1 (en) * 2007-12-19 2009-06-25 General Electric Company Biokinetics of fast-clearing polypeptides
WO2010064456A1 (ja) * 2008-12-05 2010-06-10 中外製薬株式会社 抗nr10抗体、およびその利用
WO2010064697A1 (ja) * 2008-12-05 2010-06-10 中外製薬株式会社 抗nr10抗体、およびその利用
WO2010106812A1 (en) * 2009-03-19 2010-09-23 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical formulation containing improved antibody molecules
WO2010131733A1 (ja) 2009-05-15 2010-11-18 中外製薬株式会社 抗axl抗体
US20110033452A1 (en) * 2004-10-26 2011-02-10 Chugai Seiyaku Kabushiki Kaisha Anti-Glypican 3 Antibody Having Modified Sugar Chain
US20110104157A1 (en) * 2008-04-04 2011-05-05 Chugai Seiyaku Kabushiki Kaisha Liver cancer drug
WO2011092989A1 (ja) 2010-01-29 2011-08-04 東レ株式会社 ポリ乳酸系樹脂シート
WO2011108714A1 (ja) 2010-03-04 2011-09-09 中外製薬株式会社 抗体定常領域改変体
US8062635B2 (en) 2003-10-10 2011-11-22 Chugai Seiyaku Kabushiki Kaisha Bispecific antibody substituting for functional proteins
US8124725B2 (en) 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
WO2012142662A1 (en) 2011-04-21 2012-10-26 Garvan Institute Of Medical Research Modified variable domain molecules and methods for producing and using them b
JP2013508308A (ja) * 2009-10-23 2013-03-07 ガーバン インスティテュート オブ メディカル リサーチ 修飾可変ドメイン分子、ならびにその産生および使用方法
JP2013509862A (ja) * 2009-11-04 2013-03-21 メルク・シャープ・アンド・ドーム・コーポレーション 操作型抗ｔｓｌｐ抗体本出願は、米国特許仮出願第６１／２９７，００８号（２０１０年１月２１日出願）、および米国特許仮出願第６１／２５８，０５１号（２００９年１１月４日出願）の利益を主張し、該仮出願は各々、引用によりその全体が本明細書に組み込まれる。
US8431127B2 (en) 2007-12-05 2013-04-30 Chugai Seiyaku Kabushiki Kaisha Method for treating pruritus comprising administering an NR10 antagonist
JP2013518280A (ja) * 2010-01-29 2013-05-20 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 凝集体決定法
JP2013529076A (ja) * 2010-05-11 2013-07-18 アベオ ファーマシューティカルズ， インコーポレイテッド 抗ｆｇｆｒ２抗体
WO2013118858A1 (ja) 2012-02-09 2013-08-15 中外製薬株式会社 抗体のFc領域改変体
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