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WO2008125337A3 - Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln - Google Patents

Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln Download PDF

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Publication number
WO2008125337A3
WO2008125337A3 PCT/EP2008/002994 EP2008002994W WO2008125337A3 WO 2008125337 A3 WO2008125337 A3 WO 2008125337A3 EP 2008002994 W EP2008002994 W EP 2008002994W WO 2008125337 A3 WO2008125337 A3 WO 2008125337A3
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WO
WIPO (PCT)
Prior art keywords
production
pharmaceuticals
receptor ligands
vanilloid receptor
novel vanilloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/EP2008/002994
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English (en)
French (fr)
Other versions
WO2008125337A2 (de
Inventor
Robert Frank
Gregor Bahrenberg
Thomas Christoph
Klaus Schiene
Vry Jean De
Derek Saunders
Michael Przewosny
Bernd Sundermann
Jeewoo Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ580381A priority Critical patent/NZ580381A/en
Priority to KR1020097023888A priority patent/KR101497357B1/ko
Priority to MX2009011139A priority patent/MX2009011139A/es
Priority to CN200880020516.5A priority patent/CN101687799B/zh
Priority to EP08735252A priority patent/EP2146962A2/de
Priority to BRPI0810031-4A2A priority patent/BRPI0810031A2/pt
Priority to RU2009142024/04A priority patent/RU2487120C2/ru
Priority to CA002683910A priority patent/CA2683910A1/en
Priority to JP2010503393A priority patent/JP5557734B2/ja
Priority to AU2008238245A priority patent/AU2008238245B2/en
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of WO2008125337A2 publication Critical patent/WO2008125337A2/de
Publication of WO2008125337A3 publication Critical patent/WO2008125337A3/de
Priority to ZA2009/07096A priority patent/ZA200907096B/en
Priority to IL201506A priority patent/IL201506A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Abstract

Die vorliegende Erfindung betrifft neue Vanilloid-Rezeptor-Liganden der allgemeinen Formel (I), Verfahren zu ihrer Herstellung, Arzneimittel enthaltend diese Verbindungen und die Verwendung dieser Verbindungen zur Herstellung von Arzneimitteln für die Behandlung von Migräne; Depressionen; neurodegenerativen Erkrankungen; kognitiven Erkrankungen; Angstzuständen; Epilepsie; Husten; Diarrhöe; Pruritus; Entzündungen; Störungen des kardiovaskulären Systems; Störungen der Nahrungsaufnahme; Medikamentenabhängigkeit; Medikamentenmißbrauch und insbesondere Harninkontinenz.
PCT/EP2008/002994 2007-04-16 2008-04-15 Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln Ceased WO2008125337A2 (de)

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JP2010503393A JP5557734B2 (ja) 2007-04-16 2008-04-15 新規バニロイド受容体リガンド及び医薬の製造におけるその使用
MX2009011139A MX2009011139A (es) 2007-04-16 2008-04-15 Ligandos de receptor vainilloide novedosos y el uso de los mismos para la produccion de farmacos.
CN200880020516.5A CN101687799B (zh) 2007-04-16 2008-04-15 香草素受体配体及其在制备药物中的用途
EP08735252A EP2146962A2 (de) 2007-04-16 2008-04-15 Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln
BRPI0810031-4A2A BRPI0810031A2 (pt) 2007-04-16 2008-04-15 Ligantes do receptor vanilóide e seu uso para a fabricação de fármacos
RU2009142024/04A RU2487120C2 (ru) 2007-04-16 2008-04-15 Новые лиганды ванилоидных рецепторов и их применение для изготовления лекарственных средств
CA002683910A CA2683910A1 (en) 2007-04-16 2008-04-15 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
NZ580381A NZ580381A (en) 2007-04-16 2008-04-15 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
KR1020097023888A KR101497357B1 (ko) 2007-04-16 2008-04-15 신규한 바닐로이드 수용체 리간드 및 약제의 제조를 위한 이의 용도
AU2008238245A AU2008238245B2 (en) 2007-04-16 2008-04-15 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
ZA2009/07096A ZA200907096B (en) 2007-04-16 2009-10-12 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals
IL201506A IL201506A0 (en) 2007-04-16 2009-10-14 Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals

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DE102007018151A DE102007018151A1 (de) 2007-04-16 2007-04-16 Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
DE102007018151.7 2007-04-16

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WO2008125337A3 true WO2008125337A3 (de) 2009-02-26

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CA (1) CA2683910A1 (de)
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DE (1) DE102007018151A1 (de)
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WO2012158844A1 (en) * 2011-05-17 2012-11-22 Shionogi & Co., Ltd. Heterocyclic compounds
JP2013014534A (ja) * 2011-07-04 2013-01-24 Daicel Corp ベンゾイルギ酸化合物、及びその製造方法
US9029378B2 (en) 2011-07-26 2015-05-12 Gruenenthal Gmbh Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands
EP2736882A1 (de) 2011-07-26 2014-06-04 Grünenthal GmbH Substituierte heterocyclische azaderivate
WO2013068462A1 (en) * 2011-11-09 2013-05-16 Grünenthal GmbH Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands
MX2014005610A (es) * 2011-11-09 2014-07-30 Grünenthal GmbH Derivados de carboxamida y urea, basados en pirazolilo sustituido, que presentan una porcion fenilo sustituida con un grupo que contiene o como ligando de receptor vainilloide.
WO2020017569A1 (ja) 2018-07-17 2020-01-23 日本ケミファ株式会社 Ｔ型カルシウムチャネル阻害剤
EP3950059A4 (de) 2019-03-29 2023-01-11 Nippon Chemiphar Co., Ltd. Verwendung eines kalziumkanalblockers vom t-typ zur behandlung von pruritus
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе
CN115417809A (zh) * 2022-09-05 2022-12-02 天津药明康德新药开发有限公司 一种4,4-二吡咯-2,2-联吡啶的制备方法

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KR101497357B1 (ko) 2015-03-02
CN101687799A (zh) 2010-03-31
CN101687799B (zh) 2014-07-23
BRPI0810031A2 (pt) 2014-10-14
US20110184020A1 (en) 2011-07-28
NZ599254A (en) 2013-07-26
US8642775B2 (en) 2014-02-04
WO2008125337A2 (de) 2008-10-23
RU2009142024A (ru) 2011-05-27
CO6220938A2 (es) 2010-11-19
ECSP099693A (es) 2009-11-30
DE102007018151A1 (de) 2008-10-23
MX2009011139A (es) 2009-10-30
RU2487120C2 (ru) 2013-07-10
NZ580381A (en) 2012-05-25
AU2008238245A1 (en) 2008-10-23
CA2683910A1 (en) 2008-04-16
EP2146962A2 (de) 2010-01-27
JP2010523726A (ja) 2010-07-15
ZA200907096B (en) 2013-03-27
US8791268B2 (en) 2014-07-29
KR20100016594A (ko) 2010-02-12
IL201506A0 (en) 2010-05-31
US20080262039A1 (en) 2008-10-23
JP5557734B2 (ja) 2014-07-23

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