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WO2008102678A1 - 含フッ素ピラゾールカルボニトリル誘導体およびその製造方法、並びに該含フッ素ピラゾールカルボニトリル誘導体を利用して得られる含フッ素ピラゾールカルボン酸誘導体およびその製造方法。 - Google Patents

含フッ素ピラゾールカルボニトリル誘導体およびその製造方法、並びに該含フッ素ピラゾールカルボニトリル誘導体を利用して得られる含フッ素ピラゾールカルボン酸誘導体およびその製造方法。 Download PDF

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Publication number
WO2008102678A1
WO2008102678A1 PCT/JP2008/052357 JP2008052357W WO2008102678A1 WO 2008102678 A1 WO2008102678 A1 WO 2008102678A1 JP 2008052357 W JP2008052357 W JP 2008052357W WO 2008102678 A1 WO2008102678 A1 WO 2008102678A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluorine
derivative
producing
same
pyrazolecarbonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/052357
Other languages
English (en)
French (fr)
Inventor
Hideki Umetani
Takeshi Kakimoto
Yoji Aoki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009500150A priority Critical patent/JP5117485B2/ja
Priority to MX2009008858A priority patent/MX2009008858A/es
Priority to US12/527,739 priority patent/US7884216B2/en
Priority to EP08711215.7A priority patent/EP2128139B1/en
Priority to AU2008218130A priority patent/AU2008218130B2/en
Priority to BRPI0807955-2A priority patent/BRPI0807955B1/pt
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Priority to CN2008800053020A priority patent/CN101627015B/zh
Priority to PL08711215T priority patent/PL2128139T3/pl
Publication of WO2008102678A1 publication Critical patent/WO2008102678A1/ja
Priority to IL200444A priority patent/IL200444A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　含フッ素ピラゾールカルボニトリル誘導体およびその製造法、並びに該含フッ素ピラゾールカルボニトリル誘導体を利用して得られる含フッ素ピラゾールカルボン酸誘導体およびその製造方法を提供する。 　含フッ素アシル誘導体とアミノアクリロニトリル誘導体から含フッ素アシルアクリロニトリル誘導体を調製した後に、ヒドラジン誘導体と反応させることにより、下記一般式（１） （式中、Ｒｆは少なくとも１つのフッ素原子で置換されている炭素数１～６のアルキル基を表し、Ｒ１は炭素数１～６のアルキル基等を表し、Ｒ２は、水素原子、炭素数１～６のアルキル基等を表す。）で表される含フッ素ピラゾールカルボニトリル誘導体を製造する。 　また、一般式（１）で表される化合物と水とを反応させることで、含フッ素ピラゾールカルボン酸誘導体を製造する。
PCT/JP2008/052357 2007-02-20 2008-02-13 含フッ素ピラゾールカルボニトリル誘導体およびその製造方法、並びに該含フッ素ピラゾールカルボニトリル誘導体を利用して得られる含フッ素ピラゾールカルボン酸誘導体およびその製造方法。 Ceased WO2008102678A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
MX2009008858A MX2009008858A (es) 2007-02-20 2008-02-13 Derivado de pirazolcarbonitrilo que contiene fluor y el metodo para producirlo y derivado del acido pirazolcarboxilico que contiene fluor obtenido utilizando el derivado de pirazolcarbonitrilo que contiene fluor y el método para producirlo.
US12/527,739 US7884216B2 (en) 2007-02-20 2008-02-13 Fluorine-containing pyrazolecarbonitrile derivative and method for producing the same, and fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and method for producing the same
EP08711215.7A EP2128139B1 (en) 2007-02-20 2008-02-13 Fluorine-containing pyrazolecarbonitrile derivative and method for producing the same, and fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and method for producing the same
AU2008218130A AU2008218130B2 (en) 2007-02-20 2008-02-13 Fluorine-containing pyrazolecarbonitrile derivative and method for producing the same, and fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and method for producing the same
BRPI0807955-2A BRPI0807955B1 (pt) 2007-02-20 2008-02-13 Derivado de pirazolcarbonitrila que contém flúor e método para a produção do mesmo, e derivado de ácido pirazolcarboxílico que contém flúor obtido pelo uso do derivado de pirazolcarbonitrila que contém flúor e método para a produção do mesmo
JP2009500150A JP5117485B2 (ja) 2007-02-20 2008-02-13 含フッ素ピラゾールカルボニトリル誘導体およびその製造方法、並びに該含フッ素ピラゾールカルボニトリル誘導体を利用して得られる含フッ素ピラゾールカルボン酸誘導体およびその製造方法。
CN2008800053020A CN101627015B (zh) 2007-02-20 2008-02-13 含氟吡唑腈衍生物及其制备方法、以及利用该含氟吡唑腈衍生物得到的含氟吡唑甲酸衍生物及其制备方法
PL08711215T PL2128139T3 (pl) 2007-02-20 2008-02-13 Zawierająca fluor pochodna pirazolokarbonitrylowa i sposób jej otrzymywania, oraz zawierająca fluor pochodna kwasu pirazolokarboksylowego, otrzymana przy użyciu zawierającej fluor pochodnej pirazolokarbonitrylowej i sposób jej otrzymywania
IL200444A IL200444A (en) 2007-02-20 2009-08-17 History (3-fluoroalkyl-pyrazole-4-yl) nitrile and their use in the production of history (3-fluoroalkyl-pyrazole-4-yl) - carboxylic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007039744 2007-02-20
JP2007-039744 2007-02-20

Publications (1)

Publication Number Publication Date
WO2008102678A1 true WO2008102678A1 (ja) 2008-08-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052357 Ceased WO2008102678A1 (ja) 2007-02-20 2008-02-13 含フッ素ピラゾールカルボニトリル誘導体およびその製造方法、並びに該含フッ素ピラゾールカルボニトリル誘導体を利用して得られる含フッ素ピラゾールカルボン酸誘導体およびその製造方法。

Country Status (12)

Country Link
US (1) US7884216B2 (ja)
EP (1) EP2128139B1 (ja)
JP (1) JP5117485B2 (ja)
CN (1) CN101627015B (ja)
AU (1) AU2008218130B2 (ja)
BR (1) BRPI0807955B1 (ja)
IL (1) IL200444A (ja)
MX (1) MX2009008858A (ja)
PL (1) PL2128139T3 (ja)
RU (1) RU2009133453A (ja)
TW (1) TW200900383A (ja)
WO (1) WO2008102678A1 (ja)

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JP2009001504A (ja) * 2007-06-19 2009-01-08 Mitsui Chemicals Inc ピラゾール類の合成方法
WO2009116435A1 (ja) * 2008-03-18 2009-09-24 三井化学アグロ株式会社 含フッ素アシル酢酸誘導体の製造方法、含フッ素ピラゾールカルボン酸エステル誘導体の製造方法及び含フッ素ピラゾールカルボン酸誘導体の製造方法
US20100204483A1 (en) * 2007-09-26 2010-08-12 Sergii Pazenok Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives
WO2012065905A1 (en) 2010-11-15 2012-05-24 Bayer Cropscience Ag Cyanoenamines and their use as fungicides
JP2016535771A (ja) * 2013-11-01 2016-11-17 エスアールエフ リミテッド ピラゾール誘導体の製造方法
WO2019224677A1 (en) 2018-05-21 2019-11-28 Pi Industries Ltd. Method for preparing substituted heterocyclic compounds
US10639306B2 (en) 2010-07-16 2020-05-05 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
WO2024150100A1 (en) * 2023-01-09 2024-07-18 Fluorinnovation L.L.C-Fz New process for manufacturing of 3-halomethyl-substituted 1-methyl-1h-pyrazole-4-carbonitriles and of derivatives thereof, and intermediates therefore

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EP2105434A4 (en) * 2006-12-28 2012-02-29 Mitsui Chemicals Agro Inc 2-FLUORED ACYL-3-AMINOACRYLONITRILE DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF
US8658552B2 (en) 2009-12-23 2014-02-25 Harbison-Walker Refractories Company Chromia-containing refractory
GB201004299D0 (en) * 2010-03-15 2010-04-28 Syngenta Participations Ag Process
FR2972452B1 (fr) * 2011-03-09 2013-03-15 Rhodia Operations Procede de preparation du difluoroacetonitrile et de ses derives
CN102718712B (zh) * 2012-06-29 2015-04-29 江苏威耳化工有限公司 3-二氟甲基吡唑-4-羧酸和3-三氟甲基吡唑-4-羧酸的制备方法
CN103351339A (zh) * 2013-07-12 2013-10-16 雅本化学股份有限公司 3-氟代烷基-1-取代吡唑-4-羧酸及其制备方法
CN103467379A (zh) * 2013-08-23 2013-12-25 江苏恒安化工有限公司 3-三氟甲基-1-甲基吡唑-4-甲酸的制备方法
CN104016920B (zh) * 2014-06-16 2016-08-24 联化科技股份有限公司 一种含氟甲基吡唑类化合物的联产方法
CN104163800B (zh) * 2014-08-19 2016-09-28 一帆生物科技集团有限公司 一种3-二氟甲基-1-甲基-1h-吡唑-4-羧酸的制备方法
CN104529899A (zh) * 2014-12-19 2015-04-22 浙江泰达作物科技有限公司 高区域选择性制备1-烷基-3-卤代烷基吡唑衍生物的方法
CN106478508B (zh) * 2015-07-09 2019-08-16 江苏中旗科技股份有限公司 一种含卤素吡唑甲腈衍生物的合成方法
CN112119063B (zh) * 2018-05-18 2023-10-17 富士胶片株式会社 3-二氟甲基吡唑化合物的制造方法及3-二氟甲基吡唑-4-羧酸化合物的制造方法以及吡唑烷化合物
CN114790173B (zh) * 2022-04-29 2023-08-01 浙江南郊化学有限公司 1-甲基-3-二氟甲基吡唑-4-甲酸绿色合成工艺

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009001504A (ja) * 2007-06-19 2009-01-08 Mitsui Chemicals Inc ピラゾール類の合成方法
US8258335B2 (en) * 2007-09-26 2012-09-04 Bayer Cropscience Ag Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives
US20100204483A1 (en) * 2007-09-26 2010-08-12 Sergii Pazenok Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives
JP2010540477A (ja) * 2007-09-26 2010-12-24 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト ２−ジハロアシル−３−アミノアクリル酸誘導体の調製方法
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JP5199337B2 (ja) * 2008-03-18 2013-05-15 三井化学アグロ株式会社 含フッ素アシル酢酸誘導体の製造方法、含フッ素ピラゾールカルボン酸エステル誘導体の製造方法及び含フッ素ピラゾールカルボン酸誘導体の製造方法
US10639306B2 (en) 2010-07-16 2020-05-05 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
WO2012065905A1 (en) 2010-11-15 2012-05-24 Bayer Cropscience Ag Cyanoenamines and their use as fungicides
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JP2016535771A (ja) * 2013-11-01 2016-11-17 エスアールエフ リミテッド ピラゾール誘導体の製造方法
WO2019224677A1 (en) 2018-05-21 2019-11-28 Pi Industries Ltd. Method for preparing substituted heterocyclic compounds
WO2024150100A1 (en) * 2023-01-09 2024-07-18 Fluorinnovation L.L.C-Fz New process for manufacturing of 3-halomethyl-substituted 1-methyl-1h-pyrazole-4-carbonitriles and of derivatives thereof, and intermediates therefore

Also Published As

Publication number Publication date
EP2128139A4 (en) 2011-08-31
AU2008218130B2 (en) 2011-04-28
CN101627015A (zh) 2010-01-13
BRPI0807955A2 (pt) 2018-09-25
IL200444A (en) 2015-02-26
MX2009008858A (es) 2009-10-20
RU2009133453A (ru) 2011-03-27
CN101627015B (zh) 2012-02-29
PL2128139T3 (pl) 2014-01-31
US20100016612A1 (en) 2010-01-21
BRPI0807955B1 (pt) 2019-05-07
IL200444A0 (en) 2010-04-29
US7884216B2 (en) 2011-02-08
EP2128139A1 (en) 2009-12-02
JP5117485B2 (ja) 2013-01-16
JPWO2008102678A1 (ja) 2010-05-27
EP2128139B1 (en) 2013-08-07
AU2008218130A1 (en) 2008-08-28
TW200900383A (en) 2009-01-01

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