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WO2008153077A1 - 抗ノロウイルス剤およびこれを含有する組成物 - Google Patents

抗ノロウイルス剤およびこれを含有する組成物 Download PDF

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Publication number
WO2008153077A1
WO2008153077A1 PCT/JP2008/060705 JP2008060705W WO2008153077A1 WO 2008153077 A1 WO2008153077 A1 WO 2008153077A1 JP 2008060705 W JP2008060705 W JP 2008060705W WO 2008153077 A1 WO2008153077 A1 WO 2008153077A1
Authority
WO
WIPO (PCT)
Prior art keywords
norovirus
agent
extract
composition
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/060705
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English (en)
French (fr)
Inventor
Tadashi Shimamoto
Toru Tsuji
Yoshiaki Nakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hiroshima University NUC
Altan Co Ltd
Original Assignee
Hiroshima University NUC
Altan Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hiroshima University NUC, Altan Co Ltd filed Critical Hiroshima University NUC
Priority to CN2008800197262A priority Critical patent/CN101730536B/zh
Priority to US12/599,450 priority patent/US8431168B2/en
Priority to JP2009519288A priority patent/JP5092145B2/ja
Priority to CA2687172A priority patent/CA2687172C/en
Priority to EP08777143.2A priority patent/EP2153838B1/en
Publication of WO2008153077A1 publication Critical patent/WO2008153077A1/ja
Anticipated expiration legal-status Critical
Priority to US13/612,930 priority patent/US8790718B2/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dentistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

　本発明は、ノロウイルスの不活性化作用に優れかつ人体に対する安全性の高い抗ノロウイルス剤、およびこの抗ノロウイルス剤を含有しノロウイルスの消毒や感染予防のためのに有用な抗ノロウイルス用組成物等を提供することを目的とする。このような本発明の抗ノロウイルス剤は、タンニンを含有するカキノキ属（Diospyros）の植物の抽出物（以下「カキ抽出物」という。）、望ましくはカキノキ属の植物の果実の搾汁または抽出液を加熱またはアルコールにより処理して得られたカキ抽出物を有効成分とすることを特徴とする。また、本発明の抗ノロウイルス用組成物は、上記抗ノロウイルス剤と、アルコール、界面活性剤、殺菌剤、保湿剤および化粧品用油脂類からなる群より選ばれた少なくとも１種とを含有することを特徴とし、さらにクエン酸等の有機酸および／またはその塩やビタミンＣ類を含有することが好ましい。
PCT/JP2008/060705 2007-06-12 2008-06-11 抗ノロウイルス剤およびこれを含有する組成物 Ceased WO2008153077A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN2008800197262A CN101730536B (zh) 2007-06-12 2008-06-11 抗诺罗病毒剂以及含有其的组合物
US12/599,450 US8431168B2 (en) 2007-06-12 2008-06-11 Anti-norovirus agent and composition containing the same
JP2009519288A JP5092145B2 (ja) 2007-06-12 2008-06-11 抗ノロウイルス剤およびこれを含有する組成物
CA2687172A CA2687172C (en) 2007-06-12 2008-06-11 Anti-norovirus agent and composition containing the same
EP08777143.2A EP2153838B1 (en) 2007-06-12 2008-06-11 Anti-norovirus agent, and composition comprising the same
US13/612,930 US8790718B2 (en) 2007-06-12 2012-09-13 Method of disinfection or infection control against norovirus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007155780 2007-06-12
JP2007-155780 2007-06-12
JP2008035038 2008-02-15
JP2008-035038 2008-02-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/599,450 A-371-Of-International US8431168B2 (en) 2007-06-12 2008-06-11 Anti-norovirus agent and composition containing the same
US13/612,930 Division US8790718B2 (en) 2007-06-12 2012-09-13 Method of disinfection or infection control against norovirus

Publications (1)

Publication Number Publication Date
WO2008153077A1 true WO2008153077A1 (ja) 2008-12-18

Family

ID=40129682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060705 Ceased WO2008153077A1 (ja) 2007-06-12 2008-06-11 抗ノロウイルス剤およびこれを含有する組成物

Country Status (6)

Country Link
US (2) US8431168B2 (ja)
EP (1) EP2153838B1 (ja)
JP (1) JP5092145B2 (ja)
CN (1) CN101730536B (ja)
CA (1) CA2687172C (ja)
WO (1) WO2008153077A1 (ja)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009150021A (ja) * 2007-12-21 2009-07-09 Shikibo Ltd ノロウイルスを不活化する性能を備えた繊維又は繊維製品及びその製造方法
WO2009084211A1 (ja) * 2007-12-27 2009-07-09 Johnsondiversey Co., Ltd. 殺菌消毒剤組成物およびこれを含有する殺菌消毒材、ならびにこれらを用いた殺菌消毒方法
JP2009174095A (ja) * 2008-01-25 2009-08-06 Shikibo Ltd ノロウイルスを不活化する性能を備えた繊維又は繊維製品及びその製造方法
WO2009123183A1 (ja) * 2008-03-31 2009-10-08 国立大学法人広島大学 抗ウイルス剤および抗ウイルス用組成物
WO2010067873A1 (ja) * 2008-12-12 2010-06-17 国立大学法人広島大学 抗ウイルス性衛生用繊維製品
JP2011111695A (ja) * 2009-11-27 2011-06-09 Suminoe Textile Co Ltd アレルゲン低減化機能を有する繊維布帛及びその製造方法
WO2011129230A1 (ja) * 2010-04-14 2011-10-20 グンゼ株式会社 抗ウイルスフィルター
JP2013047196A (ja) * 2011-08-29 2013-03-07 Settsu Seiyu Kk 殺ノロウイルス組成物
JP2013087102A (ja) * 2011-10-20 2013-05-13 Hiroshima Univ バナナ等抽出物を有効成分とする非エンベロープウイルスに対する抗ウイルス剤
JP2013087101A (ja) * 2011-10-20 2013-05-13 Hiroshima Univ カリン等抽出物を有効成分とする非エンベロープウイルスに対する抗ウイルス剤
JP2013249263A (ja) * 2012-05-30 2013-12-12 Ajinomoto Co Inc ガロタンニン含有組成物
WO2015125961A1 (ja) * 2014-02-21 2015-08-27 国立大学法人東京海洋大学 ノロウィルス不活化剤及びその製造方法、ノロウィルス不活化方法、ノロウィルス不活化用リゾチーム類の製造方法、ノロウィルス感染の予防薬又は治療薬、並びにノロウィルス不活化用皮膚外用剤
WO2015155903A1 (ja) * 2014-04-07 2015-10-15 孝男 中村 ニガヨモギから得られたウイルス拡散防止剤
JP2016141659A (ja) * 2015-02-04 2016-08-08 国立大学法人東京海洋大学 ノロウイルス不活化剤及びその製法
JP6053241B1 (ja) * 2016-08-31 2016-12-27 株式会社ニイタカ 消毒液及び衛生資材
JP2017077232A (ja) * 2015-10-20 2017-04-27 Ｍｃフードスペシャリティーズ株式会社 ノンエンベロープウイルスの遺伝情報を消失させる方法
JP2017193520A (ja) * 2016-04-22 2017-10-26 株式会社ユーグレナ 抗ウイルス剤及び抗ウイルス用食品組成物
JP2018035097A (ja) * 2016-08-31 2018-03-08 株式会社ニイタカ ウイルス不活性化剤組成物及び衛生資材
JP2018197195A (ja) * 2017-05-23 2018-12-13 株式会社セハージャパン エタノール製剤
JP2020180102A (ja) * 2019-04-26 2020-11-05 セッツ株式会社 抗ノロウイルス剤、消毒剤及び洗浄剤
JP2021059537A (ja) * 2019-10-07 2021-04-15 セッツ株式会社 抗ノロウイルス剤、消毒剤及び洗浄剤
JPWO2021095636A1 (ja) * 2019-11-15 2021-05-20
CN116058388A (zh) * 2023-02-01 2023-05-05 徐宝华 一种可杀菌和抑制病毒的组合物及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393252B2 (en) 2013-03-12 2016-07-19 Ecolab Usa Inc. Aromatic carboxylic acids in combination with aromatic hydroxyamides for inactivating non-enveloped viruses
US9808435B2 (en) 2013-03-12 2017-11-07 Ecolab Usa Inc. Antiviral compositions and methods for inactivating non-enveloped viruses using alkyl 2-hydroxycarboxylic acids
WO2014165240A1 (en) * 2013-03-13 2014-10-09 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For & On Behalf Of Synbodies for detection of human norovirus
WO2015120216A1 (en) 2014-02-07 2015-08-13 Gojo Industries, Inc. Compositions and methods with efficacy against spores and other organisms
US9578879B1 (en) 2014-02-07 2017-02-28 Gojo Industries, Inc. Compositions and methods having improved efficacy against spores and other organisms
FR3023165A1 (fr) * 2014-07-04 2016-01-08 Alain Salou Dispositif appliquant une nouvelle technique de traitement de fumeur de foyer bacterien resistant par deux absorptions appliquees simultanement enthalpie thermique et deshydratation
CN108472283A (zh) 2015-12-25 2018-08-31 烧津水产化学工业株式会社 抗诺如病毒组合物及其利用
CN110088650B (zh) 2016-12-28 2021-09-07 Dic株式会社 分散体和使用其的喷墨用油墨组合物、光转换层、和液晶显示元件
DE102017114735B4 (de) * 2017-06-30 2019-07-04 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Desinfektion
JP7309043B2 (ja) * 2019-08-30 2023-07-14 サルヴェオ、 インコーポレイテッド 病原性制御組成物及び方法
IT202000013858A1 (it) * 2020-06-10 2021-12-10 Sinergy Pharma S R L Composizione liquida antimicrobica

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CN101730536B (zh) 2012-07-18
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US8431168B2 (en) 2013-04-30
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