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WO2007039781A3 - Nouveaux composes - Google Patents

Nouveaux composes Download PDF

Info

Publication number
WO2007039781A3
WO2007039781A3 PCT/HU2006/000087 HU2006000087W WO2007039781A3 WO 2007039781 A3 WO2007039781 A3 WO 2007039781A3 HU 2006000087 W HU2006000087 W HU 2006000087W WO 2007039781 A3 WO2007039781 A3 WO 2007039781A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
alkyl
compounds
oxadioi
clutamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2006/000087
Other languages
English (en)
Other versions
WO2007039781A2 (fr
Inventor
Krisztina GÁL
Csaba WÉBER
Gábor András WÁGNER
Attila HORVÁTH
Györgyné NYÉKI
Mónika VASTAG
György KESERÜ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of WO2007039781A2 publication Critical patent/WO2007039781A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007039781A3 publication Critical patent/WO2007039781A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de formule (I) dans laquelle Y1 et Y2 sont sélectionnés dans le groupe constitué par hydrogène, atome halogène; C1-4 alkyle, C1-4 alkoxy, cyano et un groupe trifluorométhyle, Q représente le groupe -CH- ou N; X1 et X2 sont différents et sont sélectionnés indépendamment dans le groupe N et O; Z désigne le groupe -(CH2)n- ou S; n est égal à 1 ou à 2; R est sélectionné dans le groupe constitué par C1-7 alkyle, C1-4 haloalkyle, C1-4 hydroxyalkyle, C1-4 cyanoalkyle, C1-3 OC1-3 alkyle, C2-7 alcényle, C2-7 alkynyle, C0-2(NR1R2)alkyle éventuellement substitués; par un cycloalkyle éventuellement substitué en C3-7, aryle, hétéroaryle ou hétérocyclyle saturés; R1 et R2 sont sélectionnés indépendamment dans le groupe constitué par hydrogène, C1-7 alkyle ou C1-6 alkanoyle; par des énantiomères et/ou des racémates et/ou des diastéréoisomères et/ou des isomères géométriques et/ou des sels pharmaceutiquement acceptables formés d'acides et de bases; l'invention concerne également des procédés de production desdits composés, des compositions pharmaceutiques renfermant lesdits composés et leur utilisation dans la prévention et/ou le traitement de troubles induits par le récepteur de mGluR5.
PCT/HU2006/000087 2005-10-05 2006-10-05 Nouveaux composes Ceased WO2007039781A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0500920A HUP0500920A2 (en) 2005-10-05 2005-10-05 Oxadiazole derivatives, process for their preparation and their use
HUP0500920 2005-10-05

Publications (2)

Publication Number Publication Date
WO2007039781A2 WO2007039781A2 (fr) 2007-04-12
WO2007039781A3 true WO2007039781A3 (fr) 2010-08-26

Family

ID=89986317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2006/000087 Ceased WO2007039781A2 (fr) 2005-10-05 2006-10-05 Nouveaux composes

Country Status (2)

Country Link
HU (1) HUP0500920A2 (fr)
WO (1) WO2007039781A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2672616A1 (fr) 2006-12-15 2008-06-26 Abbott Laboratories Composes d'oxadiazole innovants
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
CA2758731A1 (fr) * 2009-04-23 2010-10-28 Merck Sharp & Dohme Corp. Modulateurs du recepteur mglur5 fourres de 2-alkyl piperidines
CA2808582A1 (fr) 2009-08-14 2011-02-17 University Of Virginia Patent Foundation Imidamides inhibiteurs de sphingosine kinase
WO2011082010A1 (fr) * 2009-12-29 2011-07-07 Eli Lilly And Company Composés de tétrahydrotriazolopyridine en tant que potentialisateurs sélectifs de récepteur mglu5 utiles pour le traitement de la schizophrénie
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
WO2011092293A2 (fr) 2010-02-01 2011-08-04 Novartis Ag Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf
CN102753527B (zh) 2010-02-02 2014-12-24 诺华股份有限公司 用作crf受体拮抗剂的环己基酰胺衍生物
CN103313977B (zh) * 2010-10-21 2015-06-03 拜耳知识产权有限责任公司 1-(杂环羰基)哌啶
AR091257A1 (es) 2012-06-04 2015-01-21 Actelion Pharmaceuticals Ltd Derivados de bencimidazol-prolina
EA201500399A1 (ru) 2012-10-10 2015-09-30 Актелион Фармасьютиклз Лтд. Антагонисты рецептора орексина, которые представляют собой производные [орто-би-(гетеро)арил]-[2-(мета-би-(гетеро)арил)пирролидин-1-ил]метанона
EP2970241A1 (fr) 2013-03-12 2016-01-20 Actelion Pharmaceuticals Ltd. Dérivés d'amide d'azétidine en tant qu'antagonistes des récepteurs d'oréxine
DK3077391T3 (en) 2013-12-04 2018-10-22 Idorsia Pharmaceuticals Ltd USE OF BENZIMIDAZOLE PROLINE DERIVATIVES
EP3914592A1 (fr) * 2019-01-25 2021-12-01 University of Virginia Patent Foundation Inhibiteurs de l'homologue 2 de spinster (spns2) destinés à être utilisés en thérapie
KR20220085798A (ko) * 2019-10-17 2022-06-22 지보당 에스아 Trmp8 조절제로서의 치환된 아자사이클
GB202012170D0 (en) * 2020-08-05 2020-09-16 Givaudan Sa Organic compounds
EP4210824A1 (fr) * 2020-09-09 2023-07-19 University of Virginia Patent Foundation Inhibiteurs de l'homologue de spinster 2 (spns2) à utiliser en thérapie

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017652A1 (fr) * 1996-10-18 1998-04-30 Boehringer Ingelheim Pharma Kg Oxadiazoles, procedes permettant de les preparer et leur utilisation comme medicaments
WO2000039125A1 (fr) * 1998-12-23 2000-07-06 Pfizer Limited Piperidines utilises comme modulateurs de ccr5
WO2002092086A1 (fr) * 2001-03-27 2002-11-21 F. Hoffmann-La Roche Ag Derives d'imidazo (1,2-a)-pyridine tenant lieu d'antagonistes mglur5
WO2004014902A2 (fr) * 2002-08-09 2004-02-19 Astrazeneca Ab Nouveaux composes
WO2005044797A1 (fr) * 2003-11-06 2005-05-19 Addex Pharmaceuticals Sa Modulateurs allosteriques de recepteurs glutamate metabotropiques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017652A1 (fr) * 1996-10-18 1998-04-30 Boehringer Ingelheim Pharma Kg Oxadiazoles, procedes permettant de les preparer et leur utilisation comme medicaments
WO2000039125A1 (fr) * 1998-12-23 2000-07-06 Pfizer Limited Piperidines utilises comme modulateurs de ccr5
WO2002092086A1 (fr) * 2001-03-27 2002-11-21 F. Hoffmann-La Roche Ag Derives d'imidazo (1,2-a)-pyridine tenant lieu d'antagonistes mglur5
WO2004014902A2 (fr) * 2002-08-09 2004-02-19 Astrazeneca Ab Nouveaux composes
WO2005044797A1 (fr) * 2003-11-06 2005-05-19 Addex Pharmaceuticals Sa Modulateurs allosteriques de recepteurs glutamate metabotropiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BING YAN ET AL.: "Quality control on combinatorial chemistry:", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 5, no. 5, 2003, pages 547 - 559, XP002413033 *

Also Published As

Publication number Publication date
HU0500920D0 (en) 2005-12-28
WO2007039781A2 (fr) 2007-04-12
HUP0500920A2 (en) 2007-07-30

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