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WO2007065999B1 - Procede d'obtention de solutions injectables par degazage de liquides et son application a la stabilisation de substances sensibles a l'oxydation - Google Patents

Procede d'obtention de solutions injectables par degazage de liquides et son application a la stabilisation de substances sensibles a l'oxydation

Info

Publication number
WO2007065999B1
WO2007065999B1 PCT/FR2006/002654 FR2006002654W WO2007065999B1 WO 2007065999 B1 WO2007065999 B1 WO 2007065999B1 FR 2006002654 W FR2006002654 W FR 2006002654W WO 2007065999 B1 WO2007065999 B1 WO 2007065999B1
Authority
WO
WIPO (PCT)
Prior art keywords
degassing
solutions
dispersions according
aqueous
bubbling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2006/002654
Other languages
English (en)
Other versions
WO2007065999A3 (fr
WO2007065999A2 (fr
Inventor
Francois Dietlin
Daniele Fredj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMATOP
Original Assignee
PHARMATOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMATOP filed Critical PHARMATOP
Priority to AU2006323914A priority Critical patent/AU2006323914A1/en
Priority to US12/086,216 priority patent/US20090044700A1/en
Priority to CA002632705A priority patent/CA2632705A1/fr
Priority to EP06841862A priority patent/EP1962987A2/fr
Priority to JP2008543865A priority patent/JP2009518367A/ja
Publication of WO2007065999A2 publication Critical patent/WO2007065999A2/fr
Publication of WO2007065999A3 publication Critical patent/WO2007065999A3/fr
Publication of WO2007065999B1 publication Critical patent/WO2007065999B1/fr
Priority to IL191933A priority patent/IL191933A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J10/00—Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles, or apparatus specially adapted therefor
    • B01J10/002—Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles, or apparatus specially adapted therefor carried out in foam, aerosol or bubbles
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/704—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
    • A23B2/708—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O
    • A23B2/712—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O in which an absorbent is placed or used
    • A23B2/717—Oxygen absorbent
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/704—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
    • A23B2/721—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/90—Preservation of foods or foodstuffs, in general by drying or kilning; Subsequent reconstitution
    • A23B2/97—Preservation of foods or foodstuffs, in general by drying or kilning; Subsequent reconstitution using irradiation or electric treatment, e.g. ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0005—Degasification of liquids with one or more auxiliary substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0036—Flash degasification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0073—Degasification of liquids by a method not covered by groups B01D19/0005 - B01D19/0042
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0073—Degasification of liquids by a method not covered by groups B01D19/0005 - B01D19/0042
    • B01D19/0078—Degasification of liquids by a method not covered by groups B01D19/0005 - B01D19/0042 by vibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/20—Treatment of water, waste water, or sewage by degassing, i.e. liberation of dissolved gases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Physical Water Treatments (AREA)

Abstract

La présente invention se rapporte au domaine de la chimie et plus particulièrement à celui de la pharmacotechnie. Elle a plus particulièrement pour objet un procédé de dégazage, notamment de désoxygénation de liquides et en particulier de milieux aqueux en associant simultanément le barbotage d'un gaz inerte, la mise sous vide poussée de la solution et l'action des ultrasons ainsi qu' une phase de chauffage allant de 35 à 60pC. Application du procédé selon l'invention à l'obtention de milieux aqueux ne contenant plus que de 4 à 0.4 mg/1 d'oxygène pour la production de solutions aqueuses stable de produits alimentaires ou pharmaceutiques.

Claims

REVENDICATIONS MODIFIEES reçues par le Bureau international le 19 septembre 2007 (19.09.2007)REVENDICATIONS
1. Procédé de dégazage de solutions ou de dispersions aqueuses de substances phénoliques sensibles à l'oxygène, caractérisé en ce qu'on soumet le liquide à la fois à l'action des ultrasons et à au moins une action choisie parmi le vide et un micro bullage, pour obtenir une teneur résiduelle en gaz, notamment en oxygène, de l'ordre de 0,4 à 4 mg/1.
2. Procédé de dégazage de solutions ou de dispersions aqueuses selon la revendication 1, dans lequel on associe aux traitements auxquels le liquide a été soumis, une phase supplémentaire de chauffage à une température de l'ordre de 30 à 6O0C.
3. Procédé de dégazage de solutions ou de dispersions aqueuses selon la revendication 1 et la revendication 2, dans lequel le chauffage s'effectue entre 40 et 500C
4. Procédé de dégazage de solutions ou de dispersions aqueuses selon l'une des revendications 1 à 3, dans lequel le micro bullage est réalisé par barbotage d'un gaz différent que celui qu'on commence à éliminer.
5. Procédé de dégazage de solutions ou de dispersions aqueuses selon la revendication 4, dans lequel le gaz de bullage est l'argon ou l'azote.
6. Procédé de dégazage de solutions ou de dispersions aqueuses selon l'une des revendications précédentes, dans lequel les sonotrodes (transducteurs à ultrasons) délivrent une puissance variant de 0 à 130 W.
7. Procédé de dégazage de solutions ou de dispersions aqueuses selon la revendication 6, dans lequel la puissance délivrée par les sonotrodes varie de 15 à 50 W, et spécifiquement de 15 à 25 W ou de 35 à 50 W.
PCT/FR2006/002654 2005-12-06 2006-12-05 Procede d'obtention de solutions injectables par degazage de liquides et son application a la stabilisation de substances sensibles a l'oxydation Ceased WO2007065999A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2006323914A AU2006323914A1 (en) 2005-12-06 2006-12-05 Method for producing injectable solutions by degassing liquids and the use thereof for stabilising oxidation-sensitive substances
US12/086,216 US20090044700A1 (en) 2005-12-06 2006-12-05 Process for Producing Injectable Solutions by Degassing Liquids and the Use Thereof for Stabilizing Oxidation-Sensitive Substances
CA002632705A CA2632705A1 (fr) 2005-12-06 2006-12-05 Procede d'obtention de solutions injectables par degazage de liquides et son application a la stabilisation de substances sensibles a l'oxydation
EP06841862A EP1962987A2 (fr) 2005-12-06 2006-12-05 Procede d'obtention de solutions injectables par degazage de liquides et son application a la stabilisation de substances sensibles a l'oxydation
JP2008543865A JP2009518367A (ja) 2005-12-06 2006-12-05 液体を脱気することによる注射溶液の製造方法及び酸化感受性物質の安定化のためのその使用
IL191933A IL191933A0 (en) 2005-12-06 2008-06-03 Method for producing injectable solutions by degassing liquids and the use thereof for stabilising oxidation-sensitive substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512366 2005-12-06
FR0512366A FR2894154B1 (fr) 2005-12-06 2005-12-06 Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation.

Publications (3)

Publication Number Publication Date
WO2007065999A2 WO2007065999A2 (fr) 2007-06-14
WO2007065999A3 WO2007065999A3 (fr) 2007-09-20
WO2007065999B1 true WO2007065999B1 (fr) 2007-11-08

Family

ID=37192291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002654 Ceased WO2007065999A2 (fr) 2005-12-06 2006-12-05 Procede d'obtention de solutions injectables par degazage de liquides et son application a la stabilisation de substances sensibles a l'oxydation

Country Status (9)

Country Link
US (1) US20090044700A1 (fr)
EP (1) EP1962987A2 (fr)
JP (1) JP2009518367A (fr)
AU (1) AU2006323914A1 (fr)
CA (1) CA2632705A1 (fr)
FR (1) FR2894154B1 (fr)
IL (1) IL191933A0 (fr)
WO (1) WO2007065999A2 (fr)
ZA (1) ZA200805335B (fr)

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US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions
CN102711726A (zh) * 2009-12-10 2012-10-03 特克尼梅德医疗技术股份公司 用于制备扑热息痛稳定液体制剂的方法和组合物
ES2526824B1 (es) 2012-08-09 2016-02-12 Universidad Miguel Hernández De Elche Equipo de expansión instantánea a vacío y ultrasonidos
KR101703980B1 (ko) * 2013-12-30 2017-02-08 주식회사 삼양바이오팜 항산화제를 함유하지 않는 약학 조성물 및 그의 제조방법
UY35988A (es) 2014-02-27 2015-09-30 Sint Sa Proceso para la producción de una solución inyectable de noradrenalina de baja concentración
US20170202793A1 (en) 2014-07-25 2017-07-20 Terumo Kabushiki Kaisha Packaged acetaminophen injection solution preparation
US11185507B2 (en) 2014-10-08 2021-11-30 Boston Biopharm Inc. Compositions and methods for increasing the bioavailability of one or more compounds
US20250177328A1 (en) 2017-01-30 2025-06-05 Nevakar Injectables Inc. Norepinephrine compositions and methods therefor
CA3051467C (fr) 2017-01-30 2022-11-29 Nevakar, Inc Compositions de norepinephrine et procedes associes
US10959961B2 (en) * 2018-12-14 2021-03-30 Natural Extraction Systems, LLC Methods of administering anionic cannabinoid molecules dissolved in water
US10609944B1 (en) 2018-12-14 2020-04-07 Natural Extraction Systems, LLC Compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
CN113874092A (zh) 2019-06-06 2021-12-31 法玛通股份有限公司 用于核电站的脱气系统和对反应堆冷却剂流进行脱气的方法
JPWO2021010437A1 (fr) * 2019-07-17 2021-01-21
US12097170B2 (en) 2020-03-06 2024-09-24 Baxter International Inc. Packaged, sealed container system for stable storage of an oxygen sensitive pharmaceutical formulation
US12349706B2 (en) 2020-07-31 2025-07-08 Natural Extraction Systems, LLC Compositions and methods related to excipients and cannabinoid formulations

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US3676983A (en) * 1970-07-29 1972-07-18 Walter E Nold Apparatus and method for degassing a liquid
US3904392A (en) * 1973-03-16 1975-09-09 Eastman Kodak Co Method of and apparatus for debubbling liquids
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Also Published As

Publication number Publication date
EP1962987A2 (fr) 2008-09-03
WO2007065999A3 (fr) 2007-09-20
FR2894154B1 (fr) 2008-03-14
US20090044700A1 (en) 2009-02-19
CA2632705A1 (fr) 2007-06-14
FR2894154A1 (fr) 2007-06-08
IL191933A0 (en) 2009-08-03
JP2009518367A (ja) 2009-05-07
ZA200805335B (en) 2009-10-28
WO2007065999A2 (fr) 2007-06-14
AU2006323914A1 (en) 2007-06-14

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