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WO2002036753A3 - Human triacylglycerol lipase - Google Patents

Human triacylglycerol lipase Download PDF

Info

Publication number
WO2002036753A3
WO2002036753A3 PCT/EP2001/012381 EP0112381W WO0236753A3 WO 2002036753 A3 WO2002036753 A3 WO 2002036753A3 EP 0112381 W EP0112381 W EP 0112381W WO 0236753 A3 WO0236753 A3 WO 0236753A3
Authority
WO
WIPO (PCT)
Prior art keywords
triacylglycerol lipase
human triacylglycerol
reagents
human
hypoalphalipoproteinemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/012381
Other languages
French (fr)
Other versions
WO2002036753A2 (en
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002219063A priority Critical patent/AU2002219063A1/en
Publication of WO2002036753A2 publication Critical patent/WO2002036753A2/en
Publication of WO2002036753A3 publication Critical patent/WO2002036753A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human triacylglycerol lipase and reagents which bind to human triacylglycerol lipase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, CNS disorders, COPD, obesity, diabetes, and cardiovascular disorders, particularly dyslipidemia leading to arteriosclerosis and especially hypertriglyceridemia, hypercholesterolemia, and hypoalphalipoproteinemia.
PCT/EP2001/012381 2000-10-31 2001-10-26 Human triacylglycerol lipase Ceased WO2002036753A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002219063A AU2002219063A1 (en) 2000-10-31 2001-10-26 Human triacylglycerol lipase

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US24418000P 2000-10-31 2000-10-31
US60/244,180 2000-10-31
US25050600P 2000-12-04 2000-12-04
US60/250,506 2000-12-04
US25139900P 2000-12-06 2000-12-06
US60/251,399 2000-12-06
US25804900P 2000-12-27 2000-12-27
US60/258,049 2000-12-27

Publications (2)

Publication Number Publication Date
WO2002036753A2 WO2002036753A2 (en) 2002-05-10
WO2002036753A3 true WO2002036753A3 (en) 2002-10-10

Family

ID=27500145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012381 Ceased WO2002036753A2 (en) 2000-10-31 2001-10-26 Human triacylglycerol lipase

Country Status (2)

Country Link
AU (1) AU2002219063A1 (en)
WO (1) WO2002036753A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003016518A1 (en) * 2001-08-13 2003-02-27 Bayer Healthcare Ag Regulation of human triacylglycerol lipase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001532A1 (en) * 1984-08-21 1986-03-13 Celltech Limited Polypeptide and polypeptide composition
WO1986003778A1 (en) * 1984-12-21 1986-07-03 The Brewing Research Foundation Precursor polypeptide, dna sequence coding therefor, vectors, host organisms, and processes involving same
WO2001002563A2 (en) * 1999-07-02 2001-01-11 Sagami Chemical Research Center HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001532A1 (en) * 1984-08-21 1986-03-13 Celltech Limited Polypeptide and polypeptide composition
WO1986003778A1 (en) * 1984-12-21 1986-07-03 The Brewing Research Foundation Precursor polypeptide, dna sequence coding therefor, vectors, host organisms, and processes involving same
WO2001002563A2 (en) * 1999-07-02 2001-01-11 Sagami Chemical Research Center HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 25 January 2001 (2001-01-25), KATO & KIMURA: "Human proteins having hydrophobic domains and DNAs encoding these proteins", XP002208985, Database accession no. AX068259 *

Also Published As

Publication number Publication date
WO2002036753A2 (en) 2002-05-10
AU2002219063A1 (en) 2002-05-15

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