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WO2002044351A3 - Regulation of human fatty acid coa ligase - Google Patents

Regulation of human fatty acid coa ligase Download PDF

Info

Publication number
WO2002044351A3
WO2002044351A3 PCT/EP2001/013795 EP0113795W WO0244351A3 WO 2002044351 A3 WO2002044351 A3 WO 2002044351A3 EP 0113795 W EP0113795 W EP 0113795W WO 0244351 A3 WO0244351 A3 WO 0244351A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
coa ligase
acid coa
human fatty
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/013795
Other languages
French (fr)
Other versions
WO2002044351A2 (en
Inventor
Alex Smolyar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002227949A priority Critical patent/AU2002227949A1/en
Publication of WO2002044351A2 publication Critical patent/WO2002044351A2/en
Publication of WO2002044351A3 publication Critical patent/WO2002044351A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human fatty acid CoA ligase and reagents which bind to human fatty acid CoA ligase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, CNS disorders, cardiovascular disorders, and cancer.
PCT/EP2001/013795 2000-12-01 2001-11-27 Regulation of human fatty acid coa ligase Ceased WO2002044351A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002227949A AU2002227949A1 (en) 2000-12-01 2001-11-27 Regulation of human fatty acid coa ligase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25012300P 2000-12-01 2000-12-01
US60/250,123 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002044351A2 WO2002044351A2 (en) 2002-06-06
WO2002044351A3 true WO2002044351A3 (en) 2002-11-21

Family

ID=22946378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013795 Ceased WO2002044351A2 (en) 2000-12-01 2001-11-27 Regulation of human fatty acid coa ligase

Country Status (2)

Country Link
AU (1) AU2002227949A1 (en)
WO (1) WO2002044351A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138832A1 (en) * 2001-12-19 2003-07-24 Kadyk Lisa C. Modulating insulin receptor signaling through targeting FACL

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
[online] EBI; 1 August 1998 (1998-08-01), "SA gene", XP002213134, retrieved from EMBL Database accession no. O60363 *
[online] EBI; 15 April 1994 (1994-04-15), "Human SA mRNA for SA gene product, acetyl-CoA synthetase homologue", XP002213135, retrieved from EMBL Database accession no. D16350 *
[online] EBI; 2 February 1995 (1995-02-02), "H. sapiens SA mRNA", XP002213136, retrieved from EMBL Database accession no. X80062 *
[online] EBI; 27 November 1998 (1998-11-27), "Mus musculus SA protein mRNA", XP002213137, retrieved from EMBL Database accession no. AF068246 *
[online] EBI; 4 June 1999 (1999-06-04), "Bos taurus mitochondrial mRNA for xenobiotic/medium chain fatty acid:CoA ligase from XL-III", XP002213138, retrieved from EMBL Database accession no. AJ132751 *
FUJINO TAKAHIRO ET AL: "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 38, 21 September 2001 (2001-09-21), pages 35961 - 35966, XP001094129, ISSN: 0021-9258 *
IWAI NAOHARU ET AL: "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension.", CIRCULATION, vol. 105, no. 1, January 1-8, 2002, pages 41 - 47, XP001105333, ISSN: 0009-7322 *
IWAI NAOHARU ET AL: "Human SA gene locus as a candidate locus for essential hypertension.", HYPERTENSION (DALLAS), vol. 23, no. 3, March 1994 (1994-03-01), pages 375 - 380, XP001097389, ISSN: 0194-911X *
KNIGHTS K M ET AL: "Xenobiotic-CoA ligases: Kinetic and molecular characterization.", CURRENT DRUG METABOLISM, vol. 1, no. 1, July 2000 (2000-07-01), July, 2000, pages 49 - 66, XP001105301, ISSN: 1389-2002 *
LOFTUS BRENDAN J ET AL: "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.", GENOMICS, vol. 60, no. 3, 15 September 1999 (1999-09-15), pages 295 - 308, XP002177511, ISSN: 0888-7543 *
NABIKA TORU ET AL: "Evaluation of the SA Locus in Human Hypertension.", HYPERTENSION (DALLAS), vol. 25, no. 1, 1995, pages 6 - 13, XP001104818, ISSN: 0194-911X *

Also Published As

Publication number Publication date
AU2002227949A1 (en) 2002-06-11
WO2002044351A2 (en) 2002-06-06

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