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WO2002000703A3 - REGULATION OF HUMAN GLUTAMYL-tRNA (Gln) AMIDOTRANSFERASE-LIKE ENZYME - Google Patents

REGULATION OF HUMAN GLUTAMYL-tRNA (Gln) AMIDOTRANSFERASE-LIKE ENZYME Download PDF

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Publication number
WO2002000703A3
WO2002000703A3 PCT/EP2001/007327 EP0107327W WO0200703A3 WO 2002000703 A3 WO2002000703 A3 WO 2002000703A3 EP 0107327 W EP0107327 W EP 0107327W WO 0200703 A3 WO0200703 A3 WO 0200703A3
Authority
WO
WIPO (PCT)
Prior art keywords
amidotransferase
trna
gln
enzyme
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007327
Other languages
French (fr)
Other versions
WO2002000703A2 (en
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001269099A priority Critical patent/AU2001269099A1/en
Publication of WO2002000703A2 publication Critical patent/WO2002000703A2/en
Publication of WO2002000703A3 publication Critical patent/WO2002000703A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Reagents which regulate human glutamyl-tRNA (Gln) amidotransferase-like enzyme and reagents which bind to human glutamyl-tRNA (Gln) amidotransferase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer.
PCT/EP2001/007327 2000-06-27 2001-06-27 REGULATION OF HUMAN GLUTAMYL-tRNA (Gln) AMIDOTRANSFERASE-LIKE ENZYME Ceased WO2002000703A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269099A AU2001269099A1 (en) 2000-06-27 2001-06-27 Regulation of human glutamyl-trna (gln) amidotransferase-like enzyme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21448300P 2000-06-27 2000-06-27
US60/214,483 2000-06-27

Publications (2)

Publication Number Publication Date
WO2002000703A2 WO2002000703A2 (en) 2002-01-03
WO2002000703A3 true WO2002000703A3 (en) 2002-06-27

Family

ID=22799241

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007327 Ceased WO2002000703A2 (en) 2000-06-27 2001-06-27 REGULATION OF HUMAN GLUTAMYL-tRNA (Gln) AMIDOTRANSFERASE-LIKE ENZYME

Country Status (2)

Country Link
AU (1) AU2001269099A1 (en)
WO (1) WO2002000703A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033925A1 (en) * 1997-02-03 1998-08-06 Yale University Glutrnagln amidotransferase - a novel essential translational component
WO2001038371A1 (en) * 1999-11-24 2001-05-31 Bioroad Gene Development Ltd. Shanghai A NOVEL POLYPEPTIDE-HUMAN GLUTAMATE tRNA SYNTHETASE 58 AND THE POLYNUCLEOTIDE ENCODING SAID POLYPEPTIDE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033925A1 (en) * 1997-02-03 1998-08-06 Yale University Glutrnagln amidotransferase - a novel essential translational component
WO2001038371A1 (en) * 1999-11-24 2001-05-31 Bioroad Gene Development Ltd. Shanghai A NOVEL POLYPEPTIDE-HUMAN GLUTAMATE tRNA SYNTHETASE 58 AND THE POLYNUCLEOTIDE ENCODING SAID POLYPEPTIDE

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CURNOW A W ET AL.: "tRNA-dependent amino acid transformations", NUCLEIC ACIDS SYMPOSIUM SERIES, no. 36, 1997, pages 2 - 4, XP002066352, ISSN: 0261-3166 *
DATABASE EM_EST EMBL; 13 September 1999 (1999-09-13), NCI/NINDS-CGAP: "wz93a11.x1 NCI_CGAP_Brn25 Homo sapiens cDNA clone IMAGE:2566364 3' similar to TR:O84006 O84006 GLU-TRNA GLN AMIDASE ;, mRNA sequence.", XP002193979 *
DATABASE EM_HUM EMBL; 1 June 1998 (1998-06-01), PEARCE A: "Human DNA sequence from clone 968D22 on chromosome 1q24.1-24.3. Contains a putative novel gene, a pseudogene similar to bacterial and archae bacterial Glu-tRNA Gln Amidase (Amidotransferase), ESTs, STSs and GSSs.", XP002193980 *
DATABASE EM_HUM EMBL; 22 February 2000 (2000-02-22), ISOGAI T ET AL.: "Homo sapiens cDNA FLJ10989 fis, clone PLACE1001989, weakly similar to PUTATIVE AMIDASE (EC 3.5.1.4).", XP002193978 *
DATABASE SWALL EMBL; 30 May 2000 (2000-05-30), ANDERSSON S G E ET AL.: "GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A (EC 6.3.5.-) (GLU-ADT SUBUNIT A).", XP002193981 *
DATABASE WPI Section Ch Week 200137, Derwent World Patents Index; Class B04, AN 2001-355891, XP002193982 *
IBBA M ET AL.: "Aminoacyl-tRNA synthesis: divergent routes to a common goal", TRENDS IN BIOCHEMICAL SCIENCES, vol. 22, no. 2, 1 February 1997 (1997-02-01), pages 39 - 42, XP004050125, ISSN: 0968-0004 *
JAHN D ET AL.: "Purification and functional characterization of the Glu-tRNA Gln amidotransferase from Chlamydomonas reinhardtii", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 26, no. 14, 15 May 1990 (1990-05-15), pages 8059 - 8064, XP002066355, ISSN: 0021-9258 *
SCHÖN A ET AL.: "Protein biosynthesis in organelles requires misaminoacylation of tRNA", NATURE, vol. 331, 14 January 1988 (1988-01-14), pages 187 - 190, XP002194615 *

Also Published As

Publication number Publication date
AU2001269099A1 (en) 2002-01-08
WO2002000703A2 (en) 2002-01-03

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