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WO2001079466A3 - Regulation of human epithin-like serine protease - Google Patents

Regulation of human epithin-like serine protease Download PDF

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Publication number
WO2001079466A3
WO2001079466A3 PCT/EP2001/004134 EP0104134W WO0179466A3 WO 2001079466 A3 WO2001079466 A3 WO 2001079466A3 EP 0104134 W EP0104134 W EP 0104134W WO 0179466 A3 WO0179466 A3 WO 0179466A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
regulation
epithin
human epithin
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/004134
Other languages
French (fr)
Other versions
WO2001079466A2 (en
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001268967A priority Critical patent/AU2001268967A1/en
Priority to EP01947220A priority patent/EP1287124A2/en
Publication of WO2001079466A2 publication Critical patent/WO2001079466A2/en
Publication of WO2001079466A3 publication Critical patent/WO2001079466A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Isolated human epithin-like serine protease. Human epithin-like serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation, atherosclerosis, neurodegenerative diseases, and pathogenic infections.
PCT/EP2001/004134 2000-04-18 2001-04-11 Regulation of human epithin-like serine protease Ceased WO2001079466A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001268967A AU2001268967A1 (en) 2000-04-18 2001-04-11 Regulation of human epithin-like serine protease
EP01947220A EP1287124A2 (en) 2000-04-18 2001-04-11 Regulation of human epithin-like serine protease

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19786500P 2000-04-18 2000-04-18
US60/197,865 2000-04-18
US25520100P 2000-12-13 2000-12-13
US60/255,201 2000-12-13
US26175501P 2001-01-17 2001-01-17
US60/261,755 2001-01-17

Publications (2)

Publication Number Publication Date
WO2001079466A2 WO2001079466A2 (en) 2001-10-25
WO2001079466A3 true WO2001079466A3 (en) 2002-06-06

Family

ID=27393792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004134 Ceased WO2001079466A2 (en) 2000-04-18 2001-04-11 Regulation of human epithin-like serine protease

Country Status (3)

Country Link
EP (1) EP1287124A2 (en)
AU (1) AU2001268967A1 (en)
WO (1) WO2001079466A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001278488A1 (en) * 2000-07-25 2002-02-05 Bayer Aktiengesellschaft Regulation of human matriptase-like serine protease
WO2003064641A1 (en) * 2002-01-30 2003-08-07 Geneprot, Inc. Gene encoding serine proteases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042120A1 (en) * 1998-02-20 1999-08-26 The Board Of Trustees Of The University Of Arkansas Tadg-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2000055350A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human cancer associated gene sequences and polypeptides
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042120A1 (en) * 1998-02-20 1999-08-26 The Board Of Trustees Of The University Of Arkansas Tadg-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
WO2000055350A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human cancer associated gene sequences and polypeptides
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EBI 23 June 2000 (2000-06-23), XP002192906 *
DATABASE EBI 29 September 1996 (1996-09-29), XP002192905 *
DATABASE EBI 8 October 1999 (1999-10-08), XP002192904 *
DATABASE EBI EMBL; 6 July 1999 (1999-07-06), XP002192903 *
LIN C-Y ET AL: "Molecular cloning of cDNA for Matriptase, a matrix-degrading serine protease with trypsin-like activity", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 26, 25 June 1999 (1999-06-25), pages 8231 - 18236, XP002139963, ISSN: 0021-9258 *
UNDERWOOD L J ET AL: "CLONING OF TUMOR-ASSOCIATED DIFFERENTIALLY EXPRESSED GENE-14, A NOVEL SERINE PROTEASE OVEREXPRESSED BY OVARIAN CARCINOMA", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 17, 1 September 1999 (1999-09-01), pages 4435 - 4439, XP000982596, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2001079466A2 (en) 2001-10-25
AU2001268967A1 (en) 2001-10-30
EP1287124A2 (en) 2003-03-05

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