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WO2002000702A3 - Regulation of human epidermis-specific serine protease - Google Patents

Regulation of human epidermis-specific serine protease Download PDF

Info

Publication number
WO2002000702A3
WO2002000702A3 PCT/EP2001/007292 EP0107292W WO0200702A3 WO 2002000702 A3 WO2002000702 A3 WO 2002000702A3 EP 0107292 W EP0107292 W EP 0107292W WO 0200702 A3 WO0200702 A3 WO 0200702A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
human epidermis
regulation
specific serine
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007292
Other languages
French (fr)
Other versions
WO2002000702A2 (en
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001269097A priority Critical patent/AU2001269097A1/en
Publication of WO2002000702A2 publication Critical patent/WO2002000702A2/en
Anticipated expiration legal-status Critical
Publication of WO2002000702A3 publication Critical patent/WO2002000702A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human epidermis-specific serine protease activity and reagents which bind to human epidermis-specific serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation, atherosclerosis, neurodegenerative diseases, and pathogenic infections.
PCT/EP2001/007292 2000-06-26 2001-06-26 Regulation of human epidermis-specific serine protease Ceased WO2002000702A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269097A AU2001269097A1 (en) 2000-06-26 2001-06-26 Regulation of human epidermis-specific serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21425900P 2000-06-26 2000-06-26
US60/214,259 2000-06-26

Publications (2)

Publication Number Publication Date
WO2002000702A2 WO2002000702A2 (en) 2002-01-03
WO2002000702A3 true WO2002000702A3 (en) 2003-02-13

Family

ID=22798397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007292 Ceased WO2002000702A2 (en) 2000-06-26 2001-06-26 Regulation of human epidermis-specific serine protease

Country Status (2)

Country Link
AU (1) AU2001269097A1 (en)
WO (1) WO2002000702A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012788A2 (en) * 1999-08-18 2001-02-22 Zymogenetics, Inc. Tryptase-like polypeptide ztryp1

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012788A2 (en) * 1999-08-18 2001-02-22 Zymogenetics, Inc. Tryptase-like polypeptide ztryp1

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 28 February 2001 (2001-02-28), PRESNELL SR AND TAFT DW: "Tryptase-like polypeptide ztryp1", XP002215253, retrieved from E.B.I., HINXTON, U.K. Database accession no. AX082990 *
DATABASE EMBL [online] 28 February 2001 (2001-02-28), PRESNELL SR AND TAFT DW: "Tryptase-like polypeptide ztryp1", XP002215254, retrieved from E.B.I., HINXTON, U.K. Database accession no. AX082991 *
DATABASE EMBL [online] 3 August 1999 (1999-08-03), NCI-CGAP: "wd26a04.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE:2329230 3' similar to SW:MCT7_MOUSE Q02844 MAST CELL PROTEASE 7 PRECURSOR mRNA sequence.", XP002215255, retrieved from E.B.I., HINXTON, U.K. Database accession no. AI935051 *
MIN HAE-KI ET AL: "Human mouse mast cell protease 7-like tryptase genes are pseudogenes.", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 107, no. 2 Part 2, February 2001 (2001-02-01), pages 315 - 321, XP008008869, ISSN: 0091-6749 *
PALLAORO MICHELE ET AL: "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 6, 5 February 1999 (1999-02-05), pages 3355 - 3362, XP002177260, ISSN: 0021-9258 *
VANDERSLICE P ET AL: "HUMAN MAST CELL TRYPTASE: MULTIPLE CDNAS AND GENES REVEAL A MULTIGENE SERINE PROTEASE FAMILY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 87, 1 May 1990 (1990-05-01), pages 3811 - 3815, XP002073694, ISSN: 0027-8424 *
WONG G W ET AL: "Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 43, 22 October 1999 (1999-10-22), pages 30784 - 30793, XP002177259, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2001269097A1 (en) 2002-01-08
WO2002000702A2 (en) 2002-01-03

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