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WO2001072973A3 - Regulation of human heparanase-like enzyme - Google Patents

Regulation of human heparanase-like enzyme Download PDF

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Publication number
WO2001072973A3
WO2001072973A3 PCT/EP2001/001997 EP0101997W WO0172973A3 WO 2001072973 A3 WO2001072973 A3 WO 2001072973A3 EP 0101997 W EP0101997 W EP 0101997W WO 0172973 A3 WO0172973 A3 WO 0172973A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulation
human heparanase
enzyme
reagents
regulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/001997
Other languages
French (fr)
Other versions
WO2001072973A2 (en
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU50331/01A priority Critical patent/AU5033101A/en
Publication of WO2001072973A2 publication Critical patent/WO2001072973A2/en
Publication of WO2001072973A3 publication Critical patent/WO2001072973A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human heparanase-like enzyme activity and reagents which bind to human heparanase-like enzyme gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation, atherosclerosis, neurodegenerative diseases, and pathogenic infections.
PCT/EP2001/001997 2000-02-24 2001-02-22 Regulation of human heparanase-like enzyme Ceased WO2001072973A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50331/01A AU5033101A (en) 2000-02-24 2001-02-22 Regulation of human heparanase-like enzyme

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18466000P 2000-02-24 2000-02-24
US60/184,660 2000-02-24
US25291300P 2000-11-27 2000-11-27
US60/252,913 2000-11-27

Publications (2)

Publication Number Publication Date
WO2001072973A2 WO2001072973A2 (en) 2001-10-04
WO2001072973A3 true WO2001072973A3 (en) 2002-06-06

Family

ID=26880358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/001997 Ceased WO2001072973A2 (en) 2000-02-24 2001-02-22 Regulation of human heparanase-like enzyme

Country Status (2)

Country Link
AU (1) AU5033101A (en)
WO (1) WO2001072973A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021814A1 (en) * 1999-09-23 2001-03-29 Merck Patent Gmbh Heparanase-2, a member of the heparanase protein family
WO2001046392A2 (en) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Homologues of human heparanase and splice variants thereof
WO2001048161A2 (en) * 1999-12-23 2001-07-05 Schering Aktiengesellschaft Human heparanase-related polypeptide and nucleic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021814A1 (en) * 1999-09-23 2001-03-29 Merck Patent Gmbh Heparanase-2, a member of the heparanase protein family
WO2001046392A2 (en) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Homologues of human heparanase and splice variants thereof
WO2001048161A2 (en) * 1999-12-23 2001-07-05 Schering Aktiengesellschaft Human heparanase-related polypeptide and nucleic acid

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 18 October 1999 (1999-10-18), HATTORI M ET AL: "Homo sapiens genomic DNA, chromosome 21q", XP002193530 *
DATABASE EMBL 18 October 1999 (1999-10-18), HATTORI M ET AL: "Homo sapiens genomic DNA, chromosome 21q", XP002193531 *
DATABASE EMBL 28 October 1998 (1998-10-28), STRAUSBERG R: "national Cancer Institute, Cancer Genome Anatomy Project", XP002193532 *
MCKENZIE EDWARD ET AL: "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 276, no. 3, 5 October 2000 (2000-10-05), pages 1170 - 1177, XP002193529, ISSN: 0006-291X *

Also Published As

Publication number Publication date
AU5033101A (en) 2001-10-08
WO2001072973A2 (en) 2001-10-04

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