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UA97795C2 - Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки - Google Patents

Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки

Info

Publication number
UA97795C2
UA97795C2 UAA200811184A UAA200811184A UA97795C2 UA 97795 C2 UA97795 C2 UA 97795C2 UA A200811184 A UAA200811184 A UA A200811184A UA A200811184 A UAA200811184 A UA A200811184A UA 97795 C2 UA97795 C2 UA 97795C2
Authority
UA
Ukraine
Prior art keywords
compounds
catecholamine derivatives
deuterated catecholamine
well
medicaments
Prior art date
Application number
UAA200811184A
Other languages
English (en)
Russian (ru)
Inventor
Рудольф-Гізберт Алкен
Франк Шнайдер
Original Assignee
Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз filed Critical Бьордз Фарма Гмбх Бероліна Інновейтів Ресерч Унд Девелопмент Сервісіз
Publication of UA97795C2 publication Critical patent/UA97795C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Представлений винахід стосується дейтерованих похідних катехоламіну, також як і фармацевтичних препаратів, що містять ці сполуки. Крім того, винахід стосується застосування дейтерованих похідних катехоламіну, також як і їх фізіологічно прийнятних солей, а також фармацевтичних композицій, які містять ці сполуки, а також комбінації з інгібіторами ферменту, для лікування допаміндефіцитних захворювань або захворювань, які базуються на порушенні транспорту тирозину або порушенні тирозиндекарбоксилази, також як і інших розладів.
UAA200811184A 2006-02-17 2007-02-16 Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки UA97795C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006008316 2006-02-17
PCT/EP2007/001555 WO2007093450A2 (en) 2006-02-17 2007-02-16 Deuterated catecholamine derivatives and medicaments comprising said compounds

Publications (1)

Publication Number Publication Date
UA97795C2 true UA97795C2 (uk) 2012-03-26

Family

ID=38236462

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200811184A UA97795C2 (uk) 2006-02-17 2007-02-16 Дейтеровані похідні катехоламіну і медикаменти, що містять згадані сполуки

Country Status (24)

Country Link
US (2) US8247603B2 (uk)
EP (2) EP1991522B1 (uk)
JP (1) JP5248331B2 (uk)
KR (1) KR101411422B1 (uk)
CN (1) CN101384545B (uk)
AU (1) AU2007214622B2 (uk)
BR (1) BRPI0708071A8 (uk)
CA (1) CA2642593C (uk)
CY (1) CY1117995T1 (uk)
DK (1) DK1991522T3 (uk)
EA (1) EA017983B1 (uk)
ES (1) ES2587368T3 (uk)
HR (1) HRP20161039T1 (uk)
HU (1) HUE028777T2 (uk)
IL (1) IL193102A (uk)
LT (1) LT1991522T (uk)
ME (1) ME02508B (uk)
PL (1) PL1991522T3 (uk)
PT (1) PT1991522T (uk)
RS (1) RS55142B1 (uk)
SI (1) SI1991522T1 (uk)
UA (1) UA97795C2 (uk)
WO (1) WO2007093450A2 (uk)
ZA (1) ZA200806568B (uk)

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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
HUE037974T2 (hu) 2008-06-06 2018-09-28 Pharma Two B Ltd Gyógyászati kompozíció Parkinson-kór kezelésére
BRPI0916769A2 (pt) 2008-07-15 2017-09-26 Theracos Inc derivados de benzilbenzeno deuterados e métodos de uso
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
HK1212232A1 (en) 2012-09-18 2016-06-10 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9763904B2 (en) 2013-02-05 2017-09-19 Teva Pharmaceuticals International Gmbh Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
US9567289B2 (en) * 2013-02-05 2017-02-14 Ratiopharm Gmbh Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds
WO2014174425A2 (en) * 2013-04-24 2014-10-30 Mahesh Kandula Compositions and methods for the treatment of orthostasis and neurological diseases
HK1221713A1 (zh) 2013-07-08 2017-06-09 Auspex Pharmaceuticals, Inc. 二羟苯基神经递质化合物、组合物以及方法
WO2015077520A1 (en) * 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Methods of treating abnormal muscular activity
EP3424504A1 (en) 2013-12-03 2019-01-09 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds
MX2016010213A (es) 2014-02-07 2017-04-13 Auspex Pharmaceuticals Inc Formulaciones farmaceuticas novedosas.
EP2918266A1 (en) 2014-03-11 2015-09-16 CDRD Berolina AB Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease
GB201420341D0 (en) * 2014-11-17 2014-12-31 Evolution Valves Ltd Valve arrangement
CN114796209A (zh) 2015-03-06 2022-07-29 奥斯拜客斯制药有限公司 氘代丁苯那嗪或包含氘代丁苯那嗪的组合物
CN106343013A (zh) * 2015-07-19 2017-01-25 中国科学院上海有机化学研究所 一种粮食储存方法
CN105360267B (zh) * 2015-10-09 2017-11-10 青岛振坤食品机械有限公司 一种全自动穿串机
BR112018007118A2 (pt) 2015-10-09 2018-12-11 Teva Pharmaceuticals Int Gmbh método para tratar um distúrbio de deficiência de dopamina, método para melhorar o tempo motor ativo sem discinesia num paciente com doença de parkinson, método para reduzir discinesia num indivíduo com um distúrbio de deficiência de dopamina, método para reduzir o tempo motor inativo num indivíduo com um distúrbio de deficiência de dopamina, método para reduzir flutuações de nível de dopamina estriatal num indivíduo com um distúrbio de deficiência de dopamina, método para reduzir discinesia num indivíduo com um distúrbio de deficiência de dopamina após um tratamento de longo prazo, composição farmacêutica e embalagem
CN105862897B (zh) * 2016-04-11 2018-01-16 江苏省华建建设股份有限公司 砂质泥岩地基浅基础原槽浇筑施工工法
KR20210061355A (ko) 2018-09-13 2021-05-27 유니버시티 오브 캔버라 저해 방법
CA3121513A1 (en) * 2018-12-06 2020-06-11 Senda Biosciences, Inc. Decarboxylase inhibitors for treating parkinson's disease

Family Cites Families (11)

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US3699158A (en) 1969-08-25 1972-10-17 Merck & Co Inc Selective deuteration of tyrosine, aspartic and glutamic acids
DE2049807A1 (en) 1970-10-10 1972-04-13 Hartmeyer H Conversion of closed cell plastics foam to - open cell structure
DE2049115C3 (de) 1970-10-06 1981-07-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa)
ATE76747T1 (de) * 1986-06-10 1992-06-15 Chiesi Farma Spa Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
IT1226902B (it) 1988-07-12 1991-02-21 Mini Ricerca Scient Tecnolog Processo per la sintesi del levodopa
US5354885A (en) * 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
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DE10261807A1 (de) * 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
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Also Published As

Publication number Publication date
USRE46555E1 (en) 2017-09-19
ZA200806568B (en) 2009-07-29
LT1991522T (lt) 2016-09-26
DK1991522T3 (en) 2016-08-29
ME02508B (me) 2017-06-20
IL193102A0 (en) 2009-02-11
CA2642593A1 (en) 2007-08-23
CN101384545A (zh) 2009-03-11
EP1991522B1 (en) 2016-05-18
CY1117995T1 (el) 2017-05-17
AU2007214622B2 (en) 2012-02-23
IL193102A (en) 2015-01-29
EA017983B1 (ru) 2013-04-30
PT1991522T (pt) 2016-08-23
JP5248331B2 (ja) 2013-07-31
WO2007093450A3 (en) 2007-09-27
AU2007214622A1 (en) 2007-08-23
HRP20161039T1 (hr) 2016-11-04
BRPI0708071A8 (pt) 2017-12-26
WO2007093450A2 (en) 2007-08-23
BRPI0708071A2 (pt) 2011-05-17
EP3101001A1 (en) 2016-12-07
HUE028777T2 (en) 2017-01-30
RS55142B1 (sr) 2016-12-30
SI1991522T1 (sl) 2016-10-28
EP1991522A2 (en) 2008-11-19
CA2642593C (en) 2014-11-04
KR20080106539A (ko) 2008-12-08
EP3101001B1 (en) 2020-04-01
PL1991522T3 (pl) 2017-07-31
US8247603B2 (en) 2012-08-21
EA200801826A1 (ru) 2009-02-27
ES2587368T3 (es) 2016-10-24
KR101411422B1 (ko) 2014-07-03
CN101384545B (zh) 2014-09-03
US20090018191A1 (en) 2009-01-15
JP2009526799A (ja) 2009-07-23

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