UA97500U - Лікарський засіб церебропротекторної дії - Google Patents
Лікарський засіб церебропротекторної дії Download PDFInfo
- Publication number
- UA97500U UA97500U UAU201309184U UAU201309184U UA97500U UA 97500 U UA97500 U UA 97500U UA U201309184 U UAU201309184 U UA U201309184U UA U201309184 U UAU201309184 U UA U201309184U UA 97500 U UA97500 U UA 97500U
- Authority
- UA
- Ukraine
- Prior art keywords
- mexidol
- meldonium
- diseases
- drug
- action
- Prior art date
Links
- 230000009471 action Effects 0.000 title description 5
- IKMNOGHPKNFPTK-UHFFFAOYSA-N 2-ethyl-6-methylpyridin-1-ium-3-ol;4-hydroxy-4-oxobutanoate Chemical compound OC(=O)CCC(O)=O.CCC1=NC(C)=CC=C1O IKMNOGHPKNFPTK-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 18
- PVBQYTCFVWZSJK-UHFFFAOYSA-N meldonium Chemical compound C[N+](C)(C)NCCC([O-])=O PVBQYTCFVWZSJK-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002937 meldonium Drugs 0.000 claims abstract description 18
- 229940079593 drug Drugs 0.000 claims abstract description 16
- 230000001966 cerebroprotective effect Effects 0.000 claims abstract description 7
- 239000000126 substance Substances 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 description 17
- 230000002490 cerebral effect Effects 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 230000017531 blood circulation Effects 0.000 description 12
- 239000000203 mixture Substances 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- 230000003078 antioxidant effect Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 230000004060 metabolic process Effects 0.000 description 7
- 206010021143 Hypoxia Diseases 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 229940126601 medicinal product Drugs 0.000 description 6
- 208000019553 vascular disease Diseases 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 5
- 230000007954 hypoxia Effects 0.000 description 5
- 230000000302 ischemic effect Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 4
- 208000007848 Alcoholism Diseases 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229960004203 carnitine Drugs 0.000 description 4
- 208000026106 cerebrovascular disease Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- JHPNVNIEXXLNTR-UHFFFAOYSA-O 4-(trimethylammonio)butanoic acid Chemical class C[N+](C)(C)CCCC(O)=O JHPNVNIEXXLNTR-UHFFFAOYSA-O 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- 208000017667 Chronic Disease Diseases 0.000 description 3
- 208000037111 Retinal Hemorrhage Diseases 0.000 description 3
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 3
- 206010048010 Withdrawal syndrome Diseases 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- -1 acylcarnitine Chemical class 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000003340 mental effect Effects 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 208000010125 myocardial infarction Diseases 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 208000014644 Brain disease Diseases 0.000 description 2
- 206010058842 Cerebrovascular insufficiency Diseases 0.000 description 2
- 208000014094 Dystonic disease Diseases 0.000 description 2
- 208000032274 Encephalopathy Diseases 0.000 description 2
- 102000006587 Glutathione peroxidase Human genes 0.000 description 2
- 108700016172 Glutathione peroxidases Proteins 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 201000007930 alcohol dependence Diseases 0.000 description 2
- 230000000141 anti-hypoxic effect Effects 0.000 description 2
- 208000037849 arterial hypertension Diseases 0.000 description 2
- 230000003143 atherosclerotic effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000006931 brain damage Effects 0.000 description 2
- 231100000874 brain damage Toxicity 0.000 description 2
- 208000029028 brain injury Diseases 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 206010013663 drug dependence Diseases 0.000 description 2
- 208000010118 dystonia Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 150000004668 long chain fatty acids Chemical class 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
- 239000001384 succinic acid Substances 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- GRFNBEZIAWKNCO-UHFFFAOYSA-N 3-pyridinol Chemical class OC1=CC=CN=C1 GRFNBEZIAWKNCO-UHFFFAOYSA-N 0.000 description 1
- 206010007558 Cardiac failure chronic Diseases 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 108010067121 Gamma-butyrobetaine dioxygenase Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000017442 Retinal disease Diseases 0.000 description 1
- 206010038923 Retinopathy Diseases 0.000 description 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 108091006003 carbonylated proteins Proteins 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 102000052653 gamma-Butyrobetaine Dioxygenase Human genes 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 230000002276 neurotropic effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000003244 pro-oxidative effect Effects 0.000 description 1
- 150000003227 pyridoxines Chemical group 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000006442 vascular tone Effects 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU201309184U UA97500U (xx) | 2013-07-22 | 2013-07-22 | Лікарський засіб церебропротекторної дії |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAU201309184U UA97500U (xx) | 2013-07-22 | 2013-07-22 | Лікарський засіб церебропротекторної дії |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA97500U true UA97500U (xx) | 2015-03-25 |
Family
ID=53501075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAU201309184U UA97500U (xx) | 2013-07-22 | 2013-07-22 | Лікарський засіб церебропротекторної дії |
Country Status (1)
| Country | Link |
|---|---|
| UA (1) | UA97500U (xx) |
-
2013
- 2013-07-22 UA UAU201309184U patent/UA97500U/uk unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0871440B1 (en) | Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists | |
| ES2579990T3 (es) | Métodos y composiciones para tratar el síndrome metabólico | |
| KR20020081459A (ko) | 당뇨병성 합병증 및 신경 장애용 약제와 이의 용도 | |
| RU2125448C1 (ru) | Фармацевтическая композиция и способ ее получения, способ лечения нарушений, развивающихся вследствие нейродегенеративных процессов | |
| ES2895073T3 (es) | Composición farmacéutica tópica que comprende al menos amitriptilina, para el tratamiento de dolores neuropáticos periféricos | |
| BR112014027983B1 (pt) | Uso de inibidores de aquaporina seletivos | |
| RU2426535C2 (ru) | Применение бета-гидроксибутирата или его фармацевтически приемлемых солей для приготовления лекарственного средства, обладающего цитопротекторной активностью, включающей нейропротекторную, кардиопротекторную, противоишемическую, антигипоксическую, антистрессорную, актопротекторную и адаптогенную активности, лекарственное средство и способ профилактики, купирования и лечения с помощью этого лекарственного средства | |
| JP2025061540A (ja) | テトラヒドロ-n,n-ジメチル-2,2-ジフェニル-3-フランメタンアミン(anavex2-73)のエナンチオマーならびにシグマ1レセプターにより調節されるアルツハイマー型および他の傷害の処置におけるその使用 | |
| WO2014180238A1 (zh) | 一种抗缺氧的药物组合物及其应用 | |
| RU2519228C1 (ru) | Способ предупреждения ишемии головного мозга при реконструктивных операциях на прецеребральных сосудах | |
| Hawryluk et al. | Design of acute neuroprotection studies | |
| JP2732109B2 (ja) | 痴呆治療剤 | |
| CN103169694B (zh) | 正丁烯基苯酞在制造用于治疗肝损伤和改善肝功能的药物中的用途及药物组合物 | |
| RU2398583C2 (ru) | Антиоксидантное и антигипоксантное средство на основе 6-метил-2-этил-3-гидроксипиридина сукцината | |
| WO2021198216A1 (en) | New method to treat the hepatotoxicity induced by amanitins | |
| UA97500U (xx) | Лікарський засіб церебропротекторної дії | |
| WO2015012780A1 (ru) | Лекарственное средство церебропротекторного действия | |
| UA117899C2 (uk) | Фармацевтична композиція церебропротекторної дії | |
| US20170368018A1 (en) | Use of ellagic acid dihydrate in pharmaceutical formulations to regulate blood glucose levels | |
| Chen | A COMPARATIVE STUDY OF EPHEDRINE, PSEUDO-EPHEDRINE AND ß-PHENYL-ETHYLAMINE: WITH REFERENCE TO THEIR EFFECTS ON THE PUPIL AND ON THE BLOOD PRESSURE | |
| CN101785753B (zh) | 一种治疗中枢神经系统疾病的天麻苷元透皮凝胶剂 | |
| BR112020007341A2 (pt) | composto e composição para uso no tratamento preventivo e/ou curativo de doenças do sistema nervoso central caracterizadas por um declínio da plasticidade neuronal, em particular caracterizadas por um declínio da plasticidade sináptica | |
| UA117898C2 (uk) | Фармацевтична композиція кардіопротекторної дії | |
| RU2331414C1 (ru) | Инъекционная лекарственная форма, обладающая нейропротекторными свойствами | |
| EA020800B1 (ru) | Фармацевтическая композиция, обладающая нейропротекторным, ноотропным, антиамнестическим действием, и способ профилактики и/или лечения состояний, связанных с нарушением мозгового кровообращения, цереброваскулярных и нейродегенеративных заболеваний |