UA35636C2 - Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців - Google Patents
Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавцівInfo
- Publication number
- UA35636C2 UA35636C2 UA96114479A UA96114479A UA35636C2 UA 35636 C2 UA35636 C2 UA 35636C2 UA 96114479 A UA96114479 A UA 96114479A UA 96114479 A UA96114479 A UA 96114479A UA 35636 C2 UA35636 C2 UA 35636C2
- Authority
- UA
- Ukraine
- Prior art keywords
- leu
- mammals
- val
- pharmaceutical composition
- ile
- Prior art date
Links
- 229940066294 lung surfactant Drugs 0.000 title abstract 3
- 239000003580 lung surfactant Substances 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000015227 regulation of liquid surface tension Effects 0.000 title abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DKEXFJVMVGETOO-LURJTMIESA-N Gly-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)CN DKEXFJVMVGETOO-LURJTMIESA-N 0.000 abstract 2
- JEXPNDORFYHJTM-IHRRRGAJSA-N Arg-Leu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCN=C(N)N JEXPNDORFYHJTM-IHRRRGAJSA-N 0.000 abstract 1
- VSVZIEVNUYDAFR-YUMQZZPRSA-N Gly-Ala-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)CN VSVZIEVNUYDAFR-YUMQZZPRSA-N 0.000 abstract 1
- BHPQOIPBLYJNAW-NGZCFLSTSA-N Gly-Ile-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)CN BHPQOIPBLYJNAW-NGZCFLSTSA-N 0.000 abstract 1
- YHFPHRUWZMEOIX-CYDGBPFRSA-N Ile-Val-Val Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)N YHFPHRUWZMEOIX-CYDGBPFRSA-N 0.000 abstract 1
- JKSIBWITFMQTOA-XUXIUFHCSA-N Leu-Ile-Val Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(O)=O JKSIBWITFMQTOA-XUXIUFHCSA-N 0.000 abstract 1
- DGDCSVGVWWAJRS-AVGNSLFASA-N Pro-Val-His Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@@H]2CCCN2 DGDCSVGVWWAJRS-AVGNSLFASA-N 0.000 abstract 1
- DJQIUOKSNRBTSV-CYDGBPFRSA-N Val-Ile-Val Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](C(C)C)N DJQIUOKSNRBTSV-CYDGBPFRSA-N 0.000 abstract 1
- 108010000434 glycyl-alanyl-leucine Proteins 0.000 abstract 1
- 108010050848 glycylleucine Proteins 0.000 abstract 1
- 108010025306 histidylleucine Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Винахід належить до легеневих поверхнево-активних поліпептидів, способу їх отримання і до композицій, що містять їх. Поліпептид з активністю легеневої поверхнево-активної речовини, загальної формули I: 0 1 2 3 4 5 6 7 8 9 10 (A) Gly Ile Pro B B Pro Val His Leu Lys 11 12 13 14 15 16 17 18 19 20 Arg Leu Leu Ile Val Val Val Val Val Val 21 22 23 24 25 26 27 28 29 30 Leu Ile Val Val Val Ile Val Gly Ala Leu 31 32 33 34 Leu C Gly Leu (1) де А означає Н або Phe, В означає Phe або Тгр і С означає Ile, Leu або Ser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4418936A DE4418936A1 (de) | 1994-05-31 | 1994-05-31 | Polypeptid |
| PCT/EP1995/002028 WO1995032992A1 (de) | 1994-05-31 | 1995-05-27 | Synthetische peptidanaloge des lungenoberflächenproteins sp-c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA35636C2 true UA35636C2 (uk) | 2001-04-16 |
Family
ID=6519392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA96114479A UA35636C2 (uk) | 1994-05-31 | 1995-05-27 | Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5874406A (uk) |
| EP (1) | EP0764172B1 (uk) |
| JP (1) | JP3359638B2 (uk) |
| KR (1) | KR100355626B1 (uk) |
| CN (1) | CN1130374C (uk) |
| AT (1) | ATE275154T1 (uk) |
| AU (1) | AU690280B2 (uk) |
| BG (1) | BG63210B1 (uk) |
| BR (1) | BR9507811B1 (uk) |
| CA (1) | CA2191344C (uk) |
| CY (1) | CY2552B1 (uk) |
| CZ (1) | CZ286976B6 (uk) |
| DE (2) | DE4418936A1 (uk) |
| DK (1) | DK0764172T3 (uk) |
| EE (1) | EE03775B1 (uk) |
| ES (1) | ES2227548T3 (uk) |
| FI (1) | FI118126B (uk) |
| HU (1) | HU220191B (uk) |
| NO (1) | NO317149B1 (uk) |
| NZ (1) | NZ287447A (uk) |
| PL (1) | PL181234B1 (uk) |
| PT (1) | PT764172E (uk) |
| RO (1) | RO118752B1 (uk) |
| RU (1) | RU2145611C1 (uk) |
| SI (1) | SI0764172T1 (uk) |
| SK (1) | SK282441B6 (uk) |
| UA (1) | UA35636C2 (uk) |
| WO (1) | WO1995032992A1 (uk) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2322097A (en) * | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| DE19851119C2 (de) | 1998-11-06 | 2001-05-31 | Byk Gulden Lomberg Chem Fab | Behälter und Vorrichtung zur Blindung der Verabreichung von nicht festen pharmazeutischen Darreichungsformen bei der klinischen Prüfung |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| WO2000076535A1 (en) * | 1999-06-11 | 2000-12-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c) |
| ES2278609T3 (es) * | 1999-06-17 | 2007-08-16 | Altana Pharma Ag | Esteres tensioactivos de la proteina c. |
| AU6083899A (en) | 1999-09-16 | 2001-04-17 | Aventis Behring Gmbh | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| AU2003201A (en) * | 1999-12-01 | 2001-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel use of lung surfactant |
| JP2003522138A (ja) * | 2000-02-11 | 2003-07-22 | アルタナ ファルマ アクチエンゲゼルシャフト | 慢性肺疾患の予防および治療のための肺表面活性剤の新規使用 |
| US6660833B1 (en) * | 2000-02-29 | 2003-12-09 | Harbor-Ucla Research And Education Institute | Respiratory distress syndrome therapy with peptide analogs of human SP-B |
| US20040254112A1 (en) * | 2000-04-12 | 2004-12-16 | Dietrich Hafner | Use of pulmonary surfactant for the early treatment of acute pulmonary diseases |
| DE10018022A1 (de) * | 2000-04-12 | 2001-10-31 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant zur Prophylaxe oder Frühbehandlung von akuten Lungenerkrankungen |
| JP2003530356A (ja) * | 2000-04-12 | 2003-10-14 | アルタナ ファルマ アクチエンゲゼルシャフト | 急性肺疾患の予防又は早期治療のための肺表面活性物質の新規使用 |
| RU2161501C1 (ru) * | 2000-06-29 | 2001-01-10 | Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" | Способ получения пептидов, обладающих тканеспецифической активностью, и фармацевтические композиции на их основе |
| EP1435994B1 (de) | 2001-10-11 | 2010-05-19 | Nycomed GmbH | Neue verwendung von lungensurfactant |
| WO2003053455A1 (en) | 2001-12-12 | 2003-07-03 | Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
| ATE457736T1 (de) | 2004-08-06 | 2010-03-15 | Nycomed Gmbh | Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
| US8337815B2 (en) | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
| SI1841458T1 (sl) | 2005-01-06 | 2012-04-30 | Discovery Lab Inc | Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije |
| DE102005014650B3 (de) | 2005-03-31 | 2006-08-17 | Altana Pharma Ag | Anordnung aus Katheter und Anschlussstück sowie Ventil zum Durchführen eines Katheters |
| DE102005016229B3 (de) | 2005-04-08 | 2006-06-14 | Altana Pharma Ag | Trockenvernebler |
| EP2063903A1 (en) * | 2006-09-19 | 2009-06-03 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations and methods for promoting mucus clearance |
| US7951781B2 (en) | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
| EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
| US8048043B2 (en) | 2007-06-08 | 2011-11-01 | Chiesi Farmaceutici S. P. A. | Method of administration of a pulmonary surfactant |
| WO2010068754A2 (en) | 2008-12-10 | 2010-06-17 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
| WO2011029525A1 (en) | 2009-09-08 | 2011-03-17 | Chiesi Farmaceutici S.P.A. | A therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes |
| RU2415676C1 (ru) * | 2009-12-09 | 2011-04-10 | Общество С Ограниченной Ответственностью "Гармония" | Способ получения средства, обладающего тканеспецифической активностью, и средство, полученное данным способом (варианты) |
| CN103052380B (zh) | 2010-08-23 | 2015-11-25 | 塔科达有限责任公司 | 包含治疗活性物质的湿润颗粒 |
| WO2013120058A2 (en) * | 2012-02-09 | 2013-08-15 | University Of Rochester | Novel sp-b & sp-c peptides, synthetic lung surfactants, and use thereof |
| US20130303726A1 (en) * | 2012-04-17 | 2013-11-14 | Chiesi Farmaceutici S.P.A. | Method for the preparation of surfactant peptides |
| WO2013188016A2 (en) | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
| AU2015226287B2 (en) | 2014-03-05 | 2019-01-31 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Humidifier for humidifying an aerosol |
| EP3106090A1 (en) | 2015-06-15 | 2016-12-21 | CHIESI FARMACEUTICI S.p.A. | System for effective breath-synchronized delivery of medicament to the lungs |
| HK1247140A1 (zh) | 2015-04-22 | 2018-09-21 | 奇斯药制品公司 | 用於药物有效地呼吸同步递送到肺部的方法和系统 |
| US11311691B2 (en) | 2015-04-28 | 2022-04-26 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
| WO2016174269A1 (en) | 2015-04-30 | 2016-11-03 | University Of Bremen | A novel skin medical and cosmetic care product |
| EP3490649A1 (en) | 2016-07-28 | 2019-06-05 | Chiesi Farmaceutici S.p.A. | Method and system for delivery of an aerosolized medicament |
| CN109890446B (zh) | 2016-10-26 | 2022-03-22 | 奇斯药制品公司 | 用于帮助通过导管向肺给送药剂的装置 |
| CA3043792A1 (en) | 2016-12-22 | 2018-06-28 | Chiesi Farmaceutici S.P.A. | A therapeutic combination comprising a pulmonary surfactant and a steroid for the treatment of evolving bpd |
| CN107163148A (zh) * | 2017-05-15 | 2017-09-15 | 重庆理工大学 | 肺表面活性蛋白b前肽的重组蛋白及其制备方法和应用 |
| TW201927286A (zh) | 2017-12-15 | 2019-07-16 | 義大利商凱西製藥公司 | 用於噴霧投藥之包含肺表面張力素的藥學調配物 |
| WO2019115771A1 (en) | 2017-12-15 | 2019-06-20 | Pari Pharma Gmbh | Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method |
| JP7378425B2 (ja) | 2018-04-23 | 2023-11-13 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | 肺サーファクタントおよびｂｐｄの予防のためのステロイドを含む治療的組合せ |
| CN109001466A (zh) * | 2018-07-19 | 2018-12-14 | 新疆维吾尔自治区人民医院 | 一种用于osa的肺表面活性蛋白试剂盒及其应用 |
| EP3666315A1 (en) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosol delivery device and method of operating the aerosol delivery device |
| EP3666316A1 (en) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosol delivery device and method of operating the aerosol delivery device |
| EP3843105A1 (en) | 2019-12-23 | 2021-06-30 | PARI Pharma GmbH | Control device for aerosol nebulizer system |
| US20230257446A1 (en) | 2020-01-28 | 2023-08-17 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
| EP4411745A1 (en) | 2023-02-01 | 2024-08-07 | Pari Medical Holding GmbH | Medical evaluation method, aerosol nebulizer and medical evaluation system |
| EP4464354A1 (en) | 2023-05-15 | 2024-11-20 | Pari Medical Holding GmbH | Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process/breath guiding |
| EP4464236A1 (en) | 2023-05-15 | 2024-11-20 | Pari Medical Holding GmbH | Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process feedback |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5104853A (en) * | 1984-12-11 | 1992-04-14 | California Biotechnology Inc. | Alveolar surfactant proteins having cys to ser mutations |
| US4933280A (en) * | 1984-12-11 | 1990-06-12 | California Biotechnology Inc. | Recombinant DNA sequence encoding Alveolar Surfactant Protein |
| US5169761A (en) * | 1984-12-11 | 1992-12-08 | California Biotechnology Inc. | Dna encoding and expression systems for alveolar surfactant proteins |
| US4659805A (en) * | 1984-12-11 | 1987-04-21 | California Biotechnology, Inc. | Recombinant alveolar surfactant protein |
| US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
| ATE163013T1 (de) * | 1987-11-04 | 1998-02-15 | Byk Gulden Lomberg Chem Fab | Alveolare oberflächenaktive proteine |
| US5260273A (en) * | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| SE8803713D0 (sv) * | 1988-10-18 | 1988-10-18 | Kabigen Ab | Biologically active lipoprotein and its use |
| DE3921954A1 (de) * | 1989-07-04 | 1991-01-17 | Thomae Gmbh Dr K | Niedrig-viskose, hochkonzentrierte surfactant-suspension |
| JPH05294996A (ja) * | 1992-04-17 | 1993-11-09 | Tokyo Tanabe Co Ltd | 合成ペプチド、それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤 |
-
1994
- 1994-05-31 DE DE4418936A patent/DE4418936A1/de not_active Withdrawn
-
1995
- 1995-05-27 CA CA002191344A patent/CA2191344C/en not_active Expired - Lifetime
- 1995-05-27 UA UA96114479A patent/UA35636C2/uk unknown
- 1995-05-27 CN CN95194374A patent/CN1130374C/zh not_active Expired - Lifetime
- 1995-05-27 AT AT95920906T patent/ATE275154T1/de active
- 1995-05-27 US US08/750,194 patent/US5874406A/en not_active Expired - Lifetime
- 1995-05-27 ES ES95920906T patent/ES2227548T3/es not_active Expired - Lifetime
- 1995-05-27 JP JP50030596A patent/JP3359638B2/ja not_active Expired - Lifetime
- 1995-05-27 AU AU26169/95A patent/AU690280B2/en not_active Expired
- 1995-05-27 DK DK95920906T patent/DK0764172T3/da active
- 1995-05-27 HU HU9603249A patent/HU220191B/hu unknown
- 1995-05-27 PL PL95317420A patent/PL181234B1/pl unknown
- 1995-05-27 BR BRPI9507811-8A patent/BR9507811B1/pt not_active IP Right Cessation
- 1995-05-27 DE DE59510941T patent/DE59510941D1/de not_active Expired - Lifetime
- 1995-05-27 EP EP95920906A patent/EP0764172B1/de not_active Expired - Lifetime
- 1995-05-27 WO PCT/EP1995/002028 patent/WO1995032992A1/de not_active Ceased
- 1995-05-27 SI SI9530712T patent/SI0764172T1/xx unknown
- 1995-05-27 NZ NZ287447A patent/NZ287447A/en not_active IP Right Cessation
- 1995-05-27 EE EE9600175A patent/EE03775B1/xx unknown
- 1995-05-27 CZ CZ19963502A patent/CZ286976B6/cs not_active IP Right Cessation
- 1995-05-27 SK SK1524-96A patent/SK282441B6/sk not_active IP Right Cessation
- 1995-05-27 RU RU96124768A patent/RU2145611C1/ru active
- 1995-05-27 PT PT95920906T patent/PT764172E/pt unknown
- 1995-05-27 KR KR1019960706778A patent/KR100355626B1/ko not_active Expired - Lifetime
- 1995-05-27 RO RO96-02248A patent/RO118752B1/ro unknown
-
1996
- 1996-11-27 NO NO19965052A patent/NO317149B1/no not_active IP Right Cessation
- 1996-11-29 FI FI964766A patent/FI118126B/fi not_active IP Right Cessation
- 1996-12-04 BG BG101028A patent/BG63210B1/bg unknown
-
2006
- 2006-02-20 CY CY0600006A patent/CY2552B1/xx unknown
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