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UA114602C2 - Способи лікування або попередження пов'язаних із холестерином розладів - Google Patents

Способи лікування або попередження пов'язаних із холестерином розладів

Info

Publication number
UA114602C2
UA114602C2 UAA201314464A UAA201314464A UA114602C2 UA 114602 C2 UA114602 C2 UA 114602C2 UA A201314464 A UAA201314464 A UA A201314464A UA A201314464 A UAA201314464 A UA A201314464A UA 114602 C2 UA114602 C2 UA 114602C2
Authority
UA
Ukraine
Prior art keywords
methods
treating
related disorders
cholesterol related
preventing cholesterol
Prior art date
Application number
UAA201314464A
Other languages
English (en)
Inventor
Джойс Чі Йі Чан
Джон Пі. Гіббс
Клептон Ес. Діас
Скотт Вассерман
Роберт Ендрю Доналд Скотт
Крісті Ел. Клогстон
Тімоті Девід Осслунд
Еван Ей. Стейн
Original Assignee
Амджен Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46124771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA114602(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Амджен Інк. filed Critical Амджен Інк.
Publication of UA114602C2 publication Critical patent/UA114602C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Винахід стосується стабільної композиції, що містить: моноклональне антитіло, яке специфічно зв'язується з PCSK9, натрію ацетат, стабілізатор, вибраний з групи, що складається з проліну або сахарози, полісорбат 20 або полісобрат 80, причому рН композиції становить від 5,0 до 5,5. Винахід також стосується застосування такої композиції для лікування або попередження пов'язаних з холестерином розладів.
UAA201314464A 2011-05-10 2012-05-10 Способи лікування або попередження пов'язаних із холестерином розладів UA114602C2 (uk)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161484610P 2011-05-10 2011-05-10
US201161562303P 2011-11-21 2011-11-21
US201261595526P 2012-02-06 2012-02-06
US201261614417P 2012-03-22 2012-03-22
US201261642363P 2012-05-03 2012-05-03
PCT/US2012/037394 WO2012154999A1 (en) 2011-05-10 2012-05-10 Methods of treating or preventing cholesterol related disorders

Publications (1)

Publication Number Publication Date
UA114602C2 true UA114602C2 (uk) 2017-07-10

Family

ID=46124771

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201703902A UA126229C2 (uk) 2011-05-10 2012-05-10 Застосування анти-pcsk9 антитіла у виробництві лікарського засобу для зниження рівня холестерину
UAA201314464A UA114602C2 (uk) 2011-05-10 2012-05-10 Способи лікування або попередження пов'язаних із холестерином розладів

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201703902A UA126229C2 (uk) 2011-05-10 2012-05-10 Застосування анти-pcsk9 антитіла у виробництві лікарського засобу для зниження рівня холестерину

Country Status (36)

Country Link
US (2) US20130064825A1 (uk)
EP (2) EP3597218A1 (uk)
JP (3) JP6166717B2 (uk)
KR (5) KR20230066480A (uk)
CN (3) CN103841992B (uk)
AP (1) AP2013007303A0 (uk)
AR (1) AR086344A1 (uk)
AU (5) AU2012253434B2 (uk)
CA (1) CA2835294C (uk)
CL (2) CL2013003214A1 (uk)
CR (1) CR20130640A (uk)
CY (1) CY1122967T1 (uk)
DK (1) DK2707029T3 (uk)
EA (1) EA031228B1 (uk)
ES (1) ES2781749T3 (uk)
HR (1) HRP20200545T1 (uk)
HU (1) HUE049018T2 (uk)
IL (4) IL288048B2 (uk)
JO (2) JOP20200043A1 (uk)
LT (1) LT2707029T (uk)
ME (1) ME03765B (uk)
MX (2) MX378241B (uk)
MY (2) MY198324A (uk)
PE (3) PE20141159A1 (uk)
PH (2) PH12013502287A1 (uk)
PL (1) PL2707029T3 (uk)
PT (1) PT2707029T (uk)
RS (1) RS60292B1 (uk)
SG (1) SG194855A1 (uk)
SI (1) SI2707029T1 (uk)
SM (1) SMT202000183T1 (uk)
TW (5) TWI877669B (uk)
UA (2) UA126229C2 (uk)
UY (1) UY34063A (uk)
WO (1) WO2012154999A1 (uk)
ZA (1) ZA201309173B (uk)

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