[go: up one dir, main page]

TW200734338A - 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives - Google Patents

6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives

Info

Publication number
TW200734338A
TW200734338A TW096100360A TW96100360A TW200734338A TW 200734338 A TW200734338 A TW 200734338A TW 096100360 A TW096100360 A TW 096100360A TW 96100360 A TW96100360 A TW 96100360A TW 200734338 A TW200734338 A TW 200734338A
Authority
TW
Taiwan
Prior art keywords
imidazo
pyridine
phenyl
carbonitrile derivatives
derivatives
Prior art date
Application number
TW096100360A
Other languages
English (en)
Inventor
Jia-Qiang Cai
Zoran Rankovix
Philip Stephen Jones
David Jonathan Bennett
Iain Cumming
Jonathan Gillespie
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of TW200734338A publication Critical patent/TW200734338A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW096100360A 2006-01-16 2007-01-04 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives TW200734338A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06100357 2006-01-16

Publications (1)

Publication Number Publication Date
TW200734338A true TW200734338A (en) 2007-09-16

Family

ID=35987201

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096100360A TW200734338A (en) 2006-01-16 2007-01-04 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives

Country Status (20)

Country Link
EP (1) EP1979351B1 (zh)
JP (1) JP5203968B2 (zh)
KR (1) KR20080098484A (zh)
CN (1) CN101374838B (zh)
AR (1) AR059018A1 (zh)
AT (1) ATE463496T1 (zh)
AU (1) AU2007204311B2 (zh)
BR (1) BRPI0706570A2 (zh)
CA (1) CA2635982A1 (zh)
DE (1) DE602007005775D1 (zh)
EC (1) ECSP088654A (zh)
ES (1) ES2342021T3 (zh)
IL (1) IL192133A0 (zh)
NO (1) NO20082791L (zh)
NZ (1) NZ569296A (zh)
PE (1) PE20080003A1 (zh)
RU (1) RU2400482C2 (zh)
TW (1) TW200734338A (zh)
WO (1) WO2007080191A1 (zh)
ZA (1) ZA200805566B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200911803A (en) * 2007-07-16 2009-03-16 Organon Nv 6-phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
US7932251B2 (en) 2007-07-16 2011-04-26 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
US8283360B2 (en) 2008-12-19 2012-10-09 Merck Sharp & Dohme Corp. Bicyclic heterocyclic derivatives and methods of use thereof
TW201035094A (en) 2009-01-16 2010-10-01 Organon Nv 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
US8026236B2 (en) 2009-01-16 2011-09-27 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
CN104284895B (zh) 2012-04-17 2016-08-31 安斯泰来制药株式会社 含氮双环式芳香族杂环化合物
US10183938B2 (en) 2014-12-16 2019-01-22 Axovant Sciences Gmbh Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors
JP2018516973A (ja) 2015-06-10 2018-06-28 フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物
EP3334740A4 (en) 2015-08-12 2019-02-06 Axovant Sciences GmbH GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS
EP3946332A1 (en) 2019-04-05 2022-02-09 Université de Bretagne Occidentale Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
CN116514813A (zh) * 2021-12-31 2023-08-01 轩竹生物科技股份有限公司 酪氨酸激酶抑制剂及其中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU566842A1 (ru) * 1976-01-06 1977-07-30 Донецкое Отделение Физико-Органической Химии Института Физической Химии Им.Л.В.Писаржевского Ан Украинской Сср Способ получени замещенных имидазопиридинов
UA62972C2 (en) * 1997-07-03 2004-01-15 Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
DE19845153A1 (de) * 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
SE0201980D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
US20070197510A1 (en) * 2004-03-10 2007-08-23 Kazuyuki Ohmoto Nitriles and medicinal compositions containing the same as the active ingredient

Also Published As

Publication number Publication date
CN101374838B (zh) 2013-04-03
ZA200805566B (en) 2009-04-29
RU2008133588A (ru) 2010-02-27
BRPI0706570A2 (pt) 2011-04-05
JP5203968B2 (ja) 2013-06-05
DE602007005775D1 (en) 2010-05-20
ATE463496T1 (de) 2010-04-15
ES2342021T3 (es) 2010-06-30
WO2007080191A1 (en) 2007-07-19
NZ569296A (en) 2010-04-30
ECSP088654A (es) 2008-08-29
IL192133A0 (en) 2008-12-29
AU2007204311B2 (en) 2011-07-14
KR20080098484A (ko) 2008-11-10
EP1979351B1 (en) 2010-04-07
AU2007204311A8 (en) 2008-07-31
CA2635982A1 (en) 2007-07-19
CN101374838A (zh) 2009-02-25
JP2009523717A (ja) 2009-06-25
EP1979351A1 (en) 2008-10-15
AU2007204311A1 (en) 2007-07-19
RU2400482C2 (ru) 2010-09-27
AR059018A1 (es) 2008-03-05
PE20080003A1 (es) 2008-01-30
NO20082791L (no) 2008-10-14

Similar Documents

Publication Publication Date Title
NO20082791L (no) 6-fenyl-1H-imidazo[4,5-C]-pyridin-4-karbonitrilderivater som Cathepsin K- og S-inhibitorer
WO2009016410A3 (en) Chemical compounds 831
EA201101243A1 (ru) 3h-имидазо[4,5-c]пиридин-6-карбоксамиды в качестве противовоспалительных средств
MX2009004745A (es) Derivados de 1,2,3-triazol como inhibidores del receptor sigma.
WO2005046575A3 (en) Amino acid prodrugs
WO2008064018A8 (en) Thienopyrimidinones for treatment of inflammatory disorders and cancers
WO2008002621A3 (en) Benzyl-substituted quinolone m1 receptor positive allosteric modulators
WO2008154083A3 (en) Compounds, compositions and methods for the treatment of synucleinopathies
MX2010001236A (es) Derivados de 5-fenil-isoxazol-3-carboxamida como moduladores del receptor de potencial transitorio v1 (trpv1).
WO2006067445A3 (en) Csf-1r kinase inhibitors
WO2009003110A3 (en) Metap-2 inhibitor polϋmersomes for therapeutic administration
WO2008086014A3 (en) Bis-aryl amide derivatives useful for the treatment of cancer
WO2007109192A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2007109172A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2008097924A3 (en) Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders
NO20070146L (no) 4-fenylpyrimidin-2-karbonitril-derivater
WO2010142766A3 (en) Pyrimidine derivatives as zap-70 inhibitors
WO2007109154A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2011058027A3 (en) N-9-substituted purine compounds, compositions and methods of use
WO2007005668A3 (en) Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer
WO2005115470A3 (fr) COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES DE β-­CARBOLINE, ET LEUR UTILISATION POUR LE TRAITEMENT DES CANCERS
WO2005037798A3 (en) Amide or thiomide derivatives and their use in the treatment of pain
WO2007048801A3 (en) Sexual desire enhancing medicaments comprising benzimidazolone derivatives
TNSN08321A1 (en) Dimers of artemisinin derivatives, preparation thereof and therapeutic use thereof
ECSP109966A (es) Derivados de 6-fenil-1h-imidazo-[4,5-c] piridina-4-carbonitrilo como inhibidores de catepsina