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TW200710091A - (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors - Google Patents

(1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors

Info

Publication number
TW200710091A
TW200710091A TW095112590A TW95112590A TW200710091A TW 200710091 A TW200710091 A TW 200710091A TW 095112590 A TW095112590 A TW 095112590A TW 95112590 A TW95112590 A TW 95112590A TW 200710091 A TW200710091 A TW 200710091A
Authority
TW
Taiwan
Prior art keywords
phenyl
benzoxazin
pyrazolo
viral replication
present
Prior art date
Application number
TW095112590A
Other languages
English (en)
Inventor
Abdellah Tahri
Li-Li Hu
Dominique Louis Nestor Ghislain Surleraux
Piet Tom Bert Paul Wigerinck
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of TW200710091A publication Critical patent/TW200710091A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW095112590A 2005-04-11 2006-04-10 (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors TW200710091A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05102847 2005-04-11

Publications (1)

Publication Number Publication Date
TW200710091A true TW200710091A (en) 2007-03-16

Family

ID=35170050

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095112590A TW200710091A (en) 2005-04-11 2006-04-10 (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors

Country Status (11)

Country Link
US (2) US7465727B2 (zh)
EP (1) EP1871777A1 (zh)
JP (1) JP5078874B2 (zh)
CN (1) CN101155816B (zh)
AR (1) AR056652A1 (zh)
AU (1) AU2006233922B2 (zh)
CA (1) CA2604686C (zh)
MX (1) MX2007012630A (zh)
RU (1) RU2416615C2 (zh)
TW (1) TW200710091A (zh)
WO (1) WO2006108828A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
TWI494133B (zh) * 2007-03-14 2015-08-01 Tibotec Pharm Ltd 重組用粉末
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
CN101318968A (zh) * 2008-07-18 2008-12-10 青岛黄海制药有限责任公司 一种苯并噁嗪并吡唑类及开环化合物
CA2864331C (en) 2012-02-14 2018-10-09 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between rac gtpase and p67(phox)
ES2774901T3 (es) 2012-02-15 2020-07-23 Cydex Pharmaceuticals Inc Proceso para la fabricación de derivados de ciclodextrina
US10851184B2 (en) * 2014-08-22 2020-12-01 Cydex Pharmaceuticals, Inc. Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
DE4210939A1 (de) * 1992-04-02 1993-10-07 Bayer Ag Verwendung von 7-Oxo-7H-pyrido[1,2,3-de][1,4]benzoxacin-6-carbonsäuren und -estern als Arzneimittel
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
SG48049A1 (en) 1993-10-01 1998-04-17 Astra Ab Process i
CN1165291C (zh) 1996-05-20 2004-09-08 詹森药业有限公司 具有改进的生物利用度的抗真菌组合物
AU4802797A (en) * 1996-10-02 1998-04-24 Du Pont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv rever se transcriptase inhibitors and intermediates and processes for making the same
SI1225874T1 (sl) 1999-09-24 2006-06-30 Janssen Pharmaceutica Nv Protivirusne trdne disperzije
AR048650A1 (es) * 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih

Also Published As

Publication number Publication date
CN101155816A (zh) 2008-04-02
US7745432B2 (en) 2010-06-29
US20080214534A1 (en) 2008-09-04
AU2006233922A1 (en) 2006-10-19
RU2007141639A (ru) 2009-05-20
AU2006233922B2 (en) 2012-05-17
EP1871777A1 (en) 2008-01-02
JP2008535894A (ja) 2008-09-04
JP5078874B2 (ja) 2012-11-21
US7465727B2 (en) 2008-12-16
WO2006108828A1 (en) 2006-10-19
CN101155816B (zh) 2011-07-27
US20090048242A1 (en) 2009-02-19
RU2416615C2 (ru) 2011-04-20
AR056652A1 (es) 2007-10-17
CA2604686A1 (en) 2006-10-19
CA2604686C (en) 2014-08-26
MX2007012630A (es) 2007-11-23

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