YU62504A - Triciklična 2-pirimidonska jedinjenja korisna kao inhibitori hiv reverzne transkriptoze - Google Patents
Triciklična 2-pirimidonska jedinjenja korisna kao inhibitori hiv reverzne transkriptozeInfo
- Publication number
- YU62504A YU62504A YU62504A YUP62504A YU62504A YU 62504 A YU62504 A YU 62504A YU 62504 A YU62504 A YU 62504A YU P62504 A YUP62504 A YU P62504A YU 62504 A YU62504 A YU 62504A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- tricyclic
- reverse transcriptase
- hiv reverse
- compounds useful
- transcriptase inhibitors
- Prior art date
Links
- 150000008319 1H-pyrimidin-2-ones Chemical class 0.000 title abstract 2
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title abstract 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Ovaj pronalazak se odnosi na triciklična jedinjenja 2-pirimidona formule (I), ili na njihove stereoizomerne oblike, stereoizomerne mešavine ili farmaceutski prihvatljive oblike soli, koja su korisna kao inhibitori HIV reverzne transkriptaze i, na farmaceutske smeše i dijagnostičke komplete koji sadrže ista i, postupke korišćenja istih u lečenju virusne infekcije ili kao test standarda ili reagensa.[The present invention relates to tricyclic 2-pyrimidone compounds of formula (I), or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34964102P | 2002-01-18 | 2002-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU62504A true YU62504A (sh) | 2006-08-17 |
Family
ID=27613304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU62504A YU62504A (sh) | 2002-01-18 | 2003-01-16 | Triciklična 2-pirimidonska jedinjenja korisna kao inhibitori hiv reverzne transkriptoze |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6844340B2 (sh) |
| EP (1) | EP1474424A4 (sh) |
| JP (1) | JP2005519910A (sh) |
| KR (1) | KR20040077735A (sh) |
| CN (1) | CN1642954A (sh) |
| AR (1) | AR038164A1 (sh) |
| BR (1) | BR0306927A (sh) |
| CA (1) | CA2473420A1 (sh) |
| CO (1) | CO5590961A2 (sh) |
| HR (1) | HRP20040643A2 (sh) |
| IL (1) | IL162743A0 (sh) |
| IS (1) | IS7341A (sh) |
| MX (1) | MXPA04006948A (sh) |
| NO (1) | NO20043424L (sh) |
| PE (1) | PE20030987A1 (sh) |
| PL (1) | PL371418A1 (sh) |
| RU (1) | RU2004125151A (sh) |
| TW (1) | TW200306192A (sh) |
| WO (1) | WO2003062238A1 (sh) |
| YU (1) | YU62504A (sh) |
| ZA (1) | ZA200405139B (sh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2002000136A (es) | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
| US7094909B2 (en) | 2001-06-11 | 2006-08-22 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis |
| US7169932B2 (en) | 2001-06-11 | 2007-01-30 | Pfizer Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis |
| TW200306192A (en) * | 2002-01-18 | 2003-11-16 | Bristol Myers Squibb Co | Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors |
| AR039540A1 (es) | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
| US20070021449A1 (en) * | 2003-02-07 | 2007-01-25 | Jan Heeres | Pyrimidine derivatives for the prevention of hiv infection |
| WO2008004100A2 (en) | 2006-07-05 | 2008-01-10 | Pfizer Products Inc. | Therapeutic compounds |
| US20080119552A1 (en) * | 2006-11-17 | 2008-05-22 | Novus International Inc. | Matrix-embedded compositions having organic acids and fatty acids |
| AU2009206368B2 (en) | 2008-01-25 | 2014-12-11 | Vtv Therapeutics Llc | Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors |
| SG10201408512RA (en) | 2009-12-23 | 2015-02-27 | Univ Leuven Kath | Novel antiviral compounds |
| WO2012066442A1 (en) | 2010-11-15 | 2012-05-24 | Pfizer Limited | Inhibitors of hiv replication |
| BR112013011737A2 (pt) | 2010-11-15 | 2016-08-09 | Univ Leuven Kath | composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv |
| CN103130787B (zh) * | 2011-11-24 | 2015-06-10 | 南开大学 | 嘧啶酮酰胺类化合物及其制备方法、抗hiv活性和抗tmv活性 |
| GB201509663D0 (en) * | 2015-06-03 | 2015-07-15 | Johnson Matthey Plc | Benzo(h)quinoline ligands and complexes thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593337B1 (en) * | 1999-10-19 | 2003-07-15 | Bristol-Myers Squibb Pharma Company | Tricyclic compounds useful as HIV reverse transcriptase inhibitors |
| US6596729B2 (en) | 2000-07-20 | 2003-07-22 | Bristol-Myers Squibb Company | Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors |
| TW200306192A (en) * | 2002-01-18 | 2003-11-16 | Bristol Myers Squibb Co | Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors |
-
2003
- 2003-01-14 TW TW092100706A patent/TW200306192A/zh unknown
- 2003-01-16 IL IL16274303A patent/IL162743A0/xx unknown
- 2003-01-16 KR KR10-2004-7011080A patent/KR20040077735A/ko not_active Withdrawn
- 2003-01-16 YU YU62504A patent/YU62504A/sh unknown
- 2003-01-16 JP JP2003562115A patent/JP2005519910A/ja not_active Withdrawn
- 2003-01-16 CN CNA038060566A patent/CN1642954A/zh active Pending
- 2003-01-16 HR HR20040643A patent/HRP20040643A2/hr not_active Application Discontinuation
- 2003-01-16 MX MXPA04006948A patent/MXPA04006948A/es unknown
- 2003-01-16 PL PL03371418A patent/PL371418A1/xx not_active Application Discontinuation
- 2003-01-16 WO PCT/US2003/001604 patent/WO2003062238A1/en not_active Ceased
- 2003-01-16 BR BR0306927-3A patent/BR0306927A/pt not_active IP Right Cessation
- 2003-01-16 CA CA002473420A patent/CA2473420A1/en not_active Abandoned
- 2003-01-16 EP EP03702165A patent/EP1474424A4/en not_active Withdrawn
- 2003-01-16 RU RU2004125151/04A patent/RU2004125151A/ru not_active Application Discontinuation
- 2003-01-17 AR ARP030100142A patent/AR038164A1/es not_active Application Discontinuation
- 2003-01-17 US US10/346,613 patent/US6844340B2/en not_active Expired - Lifetime
- 2003-01-20 PE PE2003000060A patent/PE20030987A1/es not_active Application Discontinuation
-
2004
- 2004-06-28 ZA ZA200405139A patent/ZA200405139B/en unknown
- 2004-06-30 IS IS7341A patent/IS7341A/is unknown
- 2004-07-15 US US10/891,974 patent/US7186830B2/en not_active Expired - Lifetime
- 2004-07-16 CO CO04068142A patent/CO5590961A2/es not_active Application Discontinuation
- 2004-08-17 NO NO20043424A patent/NO20043424L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR038164A1 (es) | 2004-12-29 |
| IL162743A0 (en) | 2005-11-20 |
| RU2004125151A (ru) | 2006-02-20 |
| HRP20040643A2 (en) | 2005-04-30 |
| US7186830B2 (en) | 2007-03-06 |
| JP2005519910A (ja) | 2005-07-07 |
| EP1474424A4 (en) | 2005-12-28 |
| IS7341A (is) | 2004-06-30 |
| PL371418A1 (en) | 2005-06-13 |
| CN1642954A (zh) | 2005-07-20 |
| CA2473420A1 (en) | 2003-07-31 |
| WO2003062238A1 (en) | 2003-07-31 |
| CO5590961A2 (es) | 2005-12-30 |
| US6844340B2 (en) | 2005-01-18 |
| NO20043424L (no) | 2004-08-18 |
| EP1474424A1 (en) | 2004-11-10 |
| PE20030987A1 (es) | 2003-11-15 |
| BR0306927A (pt) | 2004-11-09 |
| US20040266778A1 (en) | 2004-12-30 |
| US20030162800A1 (en) | 2003-08-28 |
| TW200306192A (en) | 2003-11-16 |
| MXPA04006948A (es) | 2004-12-06 |
| KR20040077735A (ko) | 2004-09-06 |
| ZA200405139B (en) | 2006-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1049150A1 (zh) | 用作hiv逆转录酶抑制剂的稠合1，5-二氮杂萘 | |
| WO2001064678A3 (en) | Inhibitors of hepatitis c virus ns3 protease | |
| AU4802797A (en) | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv rever se transcriptase inhibitors and intermediates and processes for making the same | |
| ATE365740T1 (de) | Substituierte pyrazolopyrimidine | |
| YU62504A (sh) | Triciklična 2-pirimidonska jedinjenja korisna kao inhibitori hiv reverzne transkriptoze | |
| WO2004002940A8 (en) | Inhibitors of hcv ns5b polymerase | |
| SG149067A1 (en) | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | |
| DE60212949D1 (de) | Antivirale pyrazolopyridin verbindungen | |
| WO2004002410A3 (en) | 2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors | |
| DK1448562T3 (da) | Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer | |
| WO2005051318A3 (en) | Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases | |
| MXPA03000434A (es) | Compuestos de 2-piridona triciclicos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana (vih). | |
| BR0208987A (pt) | Composto tricìclicos úteis como inibidores de transcriptase reserva de hiv | |
| TW200518742A (en) | Entry inhibitors | |
| TR200003065T2 (tr) | Nöraminidazların inhibitörleri olarak pirolidinler. | |
| ATE274515T1 (de) | Pyrazolopyridinderivate | |
| TW200710091A (en) | (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors | |
| SE9904128D0 (sv) | Novel compounds | |
| WO2005105810A3 (en) | (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5- c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as hiv viral replication inhibitors | |
| WO2004043911A3 (en) | N-cycloalkylglycines as hiv protease inhibitors | |
| WO2000073284A3 (en) | 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors | |
| PL333421A1 (en) | 1-(3-aminoindazol-5-yl)-3-butyl cyclic ureas useful as inhibitors of hiv protease | |
| TW200603782A (en) | (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as hiv viral replication inhibitors | |
| WO2004043355A3 (en) | Alpha, alpha-disubstituted benzylglycine derivatives as hiv protease inhibitors | |
| BR9712755A (pt) | Composto, composição farmacêutica, método para o tratamento de infecção por hiv e kit farmacêutico útil para o tratamento de infecção por hiv |